expression of her 2 and epidermal growth factor receptor as clinical markers for response to targeted therapy
Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx
... T (1984) C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor- stimulated tyrosine protein kinase activity J Biol Chem 25 9, 25 53 25 58 31 Downward, ... Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor Effect on tyrosine kinase activity and ligand binding affinity J Biol Chem 26 0, 14538– 14546 32 Lee, ... chemotherapeutic intervention in growth factor- responsive tumors Pharmacol Ther 88, 22 9 27 9 15 Treisman, R (1996) Regulation of transcription by MAP kinase cascades Curr Opin Cell Biol 8, 20 5 21 5...
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Báo cáo khoa học: A (1fi3)-b-D-glucan recognition protein from the sponge Suberites domuncula Mediated activation of fibrinogen-like protein and epidermal growth factor gene expression pot
... epidermal growth factor: expression and site-directed mutagenesis of epidermal growth factor gene Biochemistry 27 , 728 9– 729 5 52 Engler, D.A., Montelione, G.T & Niyogi, S.K (1990) Human epidermal growth ... in response to curdlan Therefore, it was then studied whether inhibition of tyrosine kinase-mediated phosphorylation resulted also in a reduction of expression of the three genes studied here As ... contains an ORF, from nucleotides 100–1 02 to nucleotides 22 42 22 44(stop); the Ó FEBS 20 04 Activation of sponge cells by (1fi3)-b-D-glucan (Eur J Biochem 27 1) 1 929 Fig The Suberites domuncula potential...
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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... FEBS 20 02 Ligand specificities of ErbB-1/ErbB-4 chimeras (Eur J Biochem 26 9) 23 25 contain N-terminal portions of the extracellular region of ErbB-1 ( )24 to 479, )24 to 311, and )24 to 163) and ... of the receptor [19 ,22 ] The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ligand binds to domain III of the receptor Recently, Gly441 of the ErbB-1 domain III was ... 40-kDa epidermal growth factor/ transforming growth factor a-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor J Biol Chem 26 8, 1976–1981...
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Báo cáo khoa học: Mutation of epidermal growth factor receptor is associated with MIG6 expression docx
... Christofori G (20 08) Modulation of endocrine pancreas development but not FEBS Journal 27 6 (20 09) 523 9– 525 1 ª 20 09 The Authors Journal compilation ª 20 09 FEBS T Nagashima et al 24 25 26 27 28 29 ... BW, Harris PL, Haserlat SM, Supko JG, Haluska FG et al (20 04) Activating 525 0 15 16 17 18 19 20 21 22 23 mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell ... EGF-inducible, as was observed for ERRFI1 expression, this was not the case Rather, we found that MIG6 expression was static and correlated with basal phosphorylation levels of EGFR and SHC, and was negatively...
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Báo cáo y học: "Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte" pptx
... to hyperplasia of the synovial lining, where synovial cells display increased expression of the EGF receptor ErbB -2 (also known as c-neu or HER2 ) [7,13,14] and amplify IL-1-mediated release of ... Scranton V, Cheng HC: Roles of transforming growth factor- α and epidermal growth factor in chick limb development Dev Biol 1998, 20 2:43-55 Bernier SM, Goltzman D: Regulation of expression of the ... maintained in the presence of tumor necrosis factor Cell viability is and/ or epidermal growth factor (EGF) alpha (TNF-α) and/ or epidermal growth factor (EGF) Subconfluent monolayers of chondrocytes were...
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Báo cáo khoa học: " Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma" docx
... chemotherapy in Her2 -positive breast cancer N Engl J Med 20 05, 353(16):1659-16 72 Sanfilippo JS, Rao CV, Guarnascelli JJ: Detection of epidermal growth factor and transforming growth factor alpha ... Hughes JT: Epidermal Growth Factor Receptor expression in 72 meningiomas Cancer 1990, 66(1):1 52- 155 Dorward NL, Hawkins RA, Whittle IR: Epidermal growth factor receptor activity and clinical outcome ... activation of epidermal growth factor receptors in meningiomas J Neurosurg 1997, 87 (2) :315- 323 Diedrich U, Lucius J, Baron E, Behnke J, Pabst B, Zoll B: Distribution of epidermal growth factor receptor...
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Báo cáo y học: " Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc" pot
... T, Masuda K: Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells Spine 20 07, 32: 635-6 42 37 Hattori A, Iwasaki S, Murase K, Tsujimoto M, ... Ross ER, O'Brien JP, Hoyland JA: Nerve growth factor expression and innervation of the painful intervertebral disc J Pathol 20 02, 197 :28 6 -29 2 Macfarlane GJ, Thomas E, Croft PR, Papageorgiou AC, ... SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor- regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor...
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Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer pdf
... 22 36 -22 50 del E746-A750 del 5'-TCCCAGAAGGTGAGAAAGTTAAAATTCCCGTCGCTATCAAG-3' 41 mer 22 37 -22 54 del E746-T751 del 5'-(T )20 AGTTAAAATTCCCGTCGCTATCAAGG-3' 46 mer 22 40 -22 57 del L747-S7 52 del 5'-(T )23 AGTTAAAATTCCCGTCGCTATCAAGGAAT-3 ... Case(s) with EGFR mutation(s) L747-S7 52 del L858R -21 6 G/T 22 35 -22 49 del E746-A750 del 22 36 -22 50 del 22 40 -22 57 del 25 73 T>G Adenocarcinoma (n = 26 ) 3 Bronchioloalveolar carcinoma (n = 6) 0 Squamous ... of Figure Detection of wild-type and mutant EGFR by primer extension analysis NSCLC DNA samples of wild-type EGFR and ones containing the following mutations: -21 6 G/T, 22 35 -22 49 del, 22 36 -22 50...
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báo cáo khoa học: "Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case report" docx
... treatment of HER2 overexpressing metastatic breast cancer J Clin Oncol 20 02, 20 :719- 726 Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ: Mechanisms of disease: understanding resistance to HER2 -targeted ... and 60 mg/m2, respectively) was started as first-line metastatic therapy in February 20 02 for four months The chemotherapy regimen was then changed to 40 mg/m2 vinorelbine plus 600 mg/m2 gemcitabine ... human breast cancer xenografts on therapy with humanized monoclonal antibody to HER- 2 receptor and DNA-reactive drugs Oncogene 1998, 17 :22 35 -22 49 Falkson G, Gelman RS, Pandya KJ, et al: Eastern...
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Quantification of epidermal growth factor receptor dynamics and interactions in living cells by fluorescent correlation and cross correlation spectroscopy
... Dimerization of EGFR 14 1.1.7 EGFR and lipid raft 16 1.1.8 EGFR and the cytoskeleton 22 1 .2 Other members of ErbB family 25 1 .2. 1 ErbB2 25 1 .2. 2 ErbB3 ... binds to receptors, receptors are able to form a 2: 2 back-toback dimer with ligands embedded in each of their ligand-binding pocket formed by domain L1 and L2 (Ferguson 20 08) This leads to the allosteric ... al 20 10) However, inherent and acquired resistance is still a threat and this emphasizes the need for new drugs and therapy development 1 .2. 2 ErbB3 In contrast to ErbB2, ErbB3 has the ligand-binding...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... 13306–13311 12 Mitsudomi T & Yatabe Y (20 07) Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity ... Sliwkowski MX (20 06) Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib ... mechanism for activation of the kinase domain of epidermal growth factor receptor Cell 125 , 1137–1149 Voldborg BR, Damstrup L, Spang-Thomsen M & Poulsen HS (1997) Epidermal growth factor receptor (EGFR)...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... Streuli CH (20 02) Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor J Biol Chem 27 7, 27 643 27 650 10 Janmaat ... JF & Arteaga CL (20 01) Epidermal growth factor receptor (HER1 ) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2 ⁄ neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo Cancer ... Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer Cancer Lett 191, 22 9 23 7 57 Takeuchi K, Motoda Y & Ito F (20 06) Role of transcription factor activator protein...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... HP & Dittmann K (20 08) Activation of protein kinase Ce stimulates DNA-repair via epidermal growth factor 3 42 124 125 126 127 128 129 130 receptor nuclear accumulation Radiother Oncol 86, 383–390 ... EGFR( 622 -660) and its interaction with Ca2+ ⁄ calmodulin Biochemistry 45, 127 04– 127 14 59 Yamane K, Toyoshima C & Nishimura S (19 92) Ligand-induced functions of the epidermal growth factor receptor ... transactivation of epidermal growth factor receptor mediated by PKC FEBS Lett 517, 20 6 21 0 Li H, Ruano MJ & Villalobo A (20 04) Endogenous calmodulin interacts with the epidermal growth factor receptor in...
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Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx
... 1536 21 710 11 620 315 27 2 29 20 21 505 5450 28 71 43 82 16 23 6 68 82 9 822 14 071 13 905 723 7 666 394 7853 5148 22 8 506 1 125 8048 6490 1077 12 060 596 10 155 521 8 4989 26 3 5093 23 8 17 29 8 120 7 120 3 ... M & Kuwano M (20 06) Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs Clin Cancer Res 12, 724 2– 725 1 18 Ioriol ... Stuart Salmon J et al (20 05) Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer Cancer Res 65, 22 6 23 5 Prenzel N, Fischer OM, Streit S,...
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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... is localized to the cytoplasmic surface of early endosomes J Biol Chem 27 2, 20 538 20 544 27 Ebner, R & Derynck, R (1991) Epidermal growth factor and transforming growth factor- alpha: differential ... PDGF receptor and members of the src family of tyrosine kinases Cell 62, 481–4 92 Dahl, M.E., Arai, K.I & Watanabe, S (20 00) Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common ... in rat fibroblasts J Cell Sci 109, 20 05 20 12 Steen, H., Kuster, B., Fernandez, M., Pandey, A & Mann, M (20 02) Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling...
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báo cáo hóa học: " Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia" potx
... 22 23 24 25 26 27 28 29 Suh HS, Choi S, Khattar P, Choi N, Lee SC: Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and ... production of PGE2 and PGD2 in LPS-activated microglia (Fig 1C) To investigate whether the enhancement of PGE2 was due to an increase in the expression of other prostaglandin synthases, we investigated ... synthesis of PGE2 and PGD2 was also strongly enhanced (Fig 4C) We further investigated whether NVP-BEZ235 increases COX -2 and mPGES-1, as well as prostaglandin synthesis, in absence of LPS As shown...
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Báo cáo khoa học: " The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications" pptx
... kinases: association with epidermal growth factor receptor/ transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti -epidermal growth factor receptor ... targets for radiation therapy: bringing preclinical data into clinical trials Clin Cancer Res 20 03, 9:3518-3 520 Sartor C: Mechanisms of Disease: radiosensitization by epidermal growth factor receptor ... on survival and pattern of relapse in patients with Page of (page number not for citation purposes) Radiation Oncology 20 06, 1:11 21 22 23 24 25 26 27 28 29 30 31 32 33 advanced head and neck carcinoma...
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báo cáo khoa học: " Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome " pptx
... caspase-7, and caspase-9, as a result, inhibits apoptosis [19 -21 ] Survivin can also bind the effector cell death proteases caspases-3 and -7 and inhibit caspase activity and cell death Furthermore, ... significance was noted and whether the Bcl-xL gene is Figure The effect of oxymatrine on release of mitochondrial cytochrome c and activation of caspase-3 The effect of oxymatrine on release of mitochondrial ... Oxymatrine releasing cytochrome c and activated caspase-3 Oxymatrine treatment led to a dose-dependent release of cytochrome c and activation of caspase-3 (Figure 5) A remarkable increase of cytochrome...
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Báo cáo y học: "Role of epidermal growth factor receptor activation in regulating mucin synthesis" pdf
... cell hyperplasia with mucus accumulation in the 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 airways of patients who died of severe asthma attack Chest 19 92, 1101:916– 921 Burgel P-R, ... Amishima M, Munakata M , Nasuhara Y, Sato A, Takahashi T, Homma Y, Kawakami Y: Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway ... of EGF receptor expression to goblet cell hyperplasia in nasal polyps J Allergy Clin Immunol 20 00, 106:705–7 12 Boucher RC, Knowles MR, Yankaskas JR: Cystic fibrosis.7 In: Textbook of Respiratory...
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Báo cáo y học: "Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling" pdf
... 27 7:38431-38440 Oguri T, Nemoto K, Bansal P, Wipf P, Lazo JS: Induction of Cdc25B expression by epidermal growth factor and transforming growth factor- alpha Biochem Pharmacol 20 04, 68 :22 21 -22 27 Kim MJ, Jo DG, ... Genome Biology 20 06, 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 Volume 7, Issue 6, Article R48 Zak et al ectal cancer Clin Cancer Res 20 05, 11:1757-1764 Panda S, Antoch MP, Miller ... profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia Blood 20 05, 106 :28 27 -28 36 Gutacker C, Klock G, Diel P, Koch-Brandt C: Nerve growth factor and epidermal growth...
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