drug metabolism drug interaction studies in the drug development process studies in vitro guidance 1998
Báo cáo y học: "Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer" ppt
... induced in either tumor cell line, only the interaction of MDA-MB231 with fibroblasts released a soluble factor into the medium capable of inducing an interferon response We speculated that the ... can induce the fibroblasts to express type I interferons, resulting, in turn, in induction of interferon-response genes in the tumor cells and to a lesser extent in the fibroblasts (Figure 5) In ... I interferon (IFNα and IFNβ) (2) They in turn induce the interferon response genes predominantly in the tumor cells (3) persist through many passages of in vitro cultivation, the source of the...
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Organizing marketing activities for Vietnamese-Owned automobile assemblers in the present development process of Vietnamese economy
... study: The organizing marketing activities in automobile industry in generally, and especially in member of VAMA The main contents are including organizing the marketing activities and organizing ... plan in after, the thesis focus on analyze the main factors in the marketing program through distinguish the marketing oriented organization and non-marketing oriented organization And then thesis ... Advantage and the Value Chain A firm may create a cost advantage either by reducing the cost of individual value chain activities or by reconfiguring the value chain Once the value chain is defined,...
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1818.Knox, S. (1998), Loyalty‐based segmentation and the customer development process, European Management Journal, Vol. 16 No. 6, pp. 729‐737.
... over the past five years, followed by nomination of the properties which they had stayed in They were then asked to indicate which of these hotels they considered they would stay at again in the ... for the brand (Dick & Basu, 1994) Loyalty in the hotel context Several studies have previously focused on the issue of loyalty specifically in the hotel industry Knutson (1988) investigated the ... Relationship Marketing (Consumer) 82 general They would definitely switch to competitors if they had trouble with the hotel in question and they hold no firm intentions to more business with the hotel...
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Mining of textual databases within the product development process
... used In general these data mining operations are used for characterizing the general properties of the database or performing inference on the current data in order 15 Data Mining Within the Product ... information found in electronic notebooks since 22 Data Mining Within the Product Development Process Chapter it is captured as it is generated, thereby, capturing the design process They investigated ... numerous processes/activities involved in production 23 Data Mining Within the Product Development Process Chapter Further, amongst the papers surveyed, it was found that the use of data mining is...
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The product development process
... are involved in the development, they will also behave knowledgeably and willingly in the delivery of the service Therefore the design process in service development The product development process ... reduce the time for the project (Karlsson et al., 1998) Certainly the ingredient processor can be developing the process for the ingredient at the same time as the manufacturer is developing the ... service development With growth in the service industries in the 1980s and 1990s and the increasing need for new ‘products’, there grew an interest in the method of developing new services In the...
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Báo cáo hóa học: " Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug " pot
... of the F2L region of VV Δ F2L-gfp The F2L gene in VV strain WR (shaded arrow in the top line) was replaced with the gfp gene driven by the synthetic E/L promoter (black arrow in the bottom line) ... A recombinant virus lacking only the dUTPase gene was constructed by homologous recombination in the WR strain of VV In this virus, F2L was replaced with the gfp gene driven by the synthetic E/L ... recombinant plaques were plaque purified three times to eliminate any contaminating wild type (wt) parental virus The insertion of the gfp resulted in the deletion of most of the F2L open reading...
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Báo cáo y học: "Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury" potx
... hepatic drug metabolism These varying results are consistent with the findings of studies investigating the effects of CKD on drug metabolism [11-13,15] When interpreting the findings presented in ... necessarily be the same Specifically, during glycerol-induced AKI in rats, there was a significant increase in CYP3A4 activity in the intestine despite a significant decrease in CYP3A4 activity in the liver ... hepatic CYP3A1 in the liver, enzymes in the intestine and/or kidneys may not be affected or may be inhibited Extrapolating the findings presented in Table to humans is complicated by the fact that...
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In vitro metabolic drug interaction study of warfarin with sildenafil citrate
... clotting proteins Differences in the binding affinity of warfarin to the receptor site on the epoxide reductase and in the amount of vitamin K1 in the liver influence the sensitivity to warfarin ... mainly designed to investigate the in vitro drug interaction between these two agents The in vitro drug interaction study was carried out using both rat and human liver microsomes Moreover, the ... Warfarin isomers have different binding affinities to their binding sites [46, 47] S-warfarin has higher binding affinity for the primary binding sites [50, 51] while R-warfarin has greater binding...
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Tài liệu Lipases and Phospholipases in Drug Development pptx
... 81 Mg2+-independent Neutral Sphingomyelinases 84 Alkaline Sphingomyelinase from the Intestinal Tract 85 Bacterial Sphingomyelinase-phospholipase C 85 Sphingomyelinase Mechanism 85 Binding of Magnesium ... Ions 85 Binding of Substrate 85 Mechanism of Catalysis 86 Sphingomyelinase Assay 88 Sphingomyelinase Inhibitors 89 Sphingomyelinase–Membrane Interactions 89 Lipid Effects on Sphingomyelinase Activity ... direction in the column 1.5.1.1 Mobile Phase The mobile phase is the interstitial space in the packed column The mass balance for a solute in the mobile phase can be obtained from the continuity...
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lc ms applications in drug development
... Combinatorial Mixture Screening / 103 In Vivo Drug Screening / 106 Pharmacokinetics / 109 In Vitro Drug Screening / 115 Metabolic Stability Screening / 118 Membrane Permeability / 119 Drug- Drug Interaction ... to accelerated development target the activities involved with converting (or eliminating) the drug candidate through the various development stages within the pipeline Using the same 12-month ... that reaches the development stage Preclinical Development The preclinical stage of drug development focuses on activities necessary for filing an IND/CTA The completed IND/CTA contains information...
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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt
... particles containing no Cu (left) The difference between the amount released at 48 h and that contained in the original loading solution determined Cu loading, resulting in values ranging between ... functionalizing the nanoparticle with carboxylate ligands to bind Cu 2+ ; however, other metal/ligand/polymer combinations could be synthesized including those employing other polymers routinely used in ... change in the water after the first 24 h The particle concentration after purification was determined by lyophilizing a known volume and then weighing the resulting solid, which resulted in a final...
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Báo cáo hóa học: " Novel Strategy to Fabricate PLA/Au Nanocomposites as an Efficient Drug Carrier for Human Leukemia Cells in Vitro" pdf
... doxorubicin was contained in the culture to maintain K562/AO2 cells’ drug resistance in its daily culture The inhibition of cell growth was measured by MTT (Microculture Tetrazolium) assay Initially, ... much higher intracellular drug concentration in the target cells, resulting in the remarkable enhancement of the intracellular fluorescence of drug- resistant leukemia cells (Shown in Figure 4b ... incorporated into the target system, PLA/Au nanocomposites have an apparent synergistic effect on the drug uptake of DNR in the respective cancer cells, where the intracellular fluorescence intensity...
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Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx
... result from the design stage, particularly during the drug development process Consider the drug development sequence from the perspective of the sponsor A promising agent is found Then, there are ... pharmacological studies, pharmacokinetic studies, animal studies, initial studies in humans, dose ranging studies, toxicity studies, and others (Fig 1) Most potential medications fail to pass these hurdles ... accept the trial upon the pooled expectation for the RCT arms and not upon the value of any single arm The principle of ‘equal uncertainty between the arms of the RCT’ must be replaced with the principle...
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Multiple antibiotics in combination against extreme drug resistant acinetobacter baumannii in an in vitro pharmacokinetic pharmacodynamic model
... (FIC) index is the mathematical expression used to represent the interactions The FIC is determined for each drug by dividing the minimum inhibitory concentration (MIC) of each drug when used in ... drug A in combination/MIC of drug A alone, FIC of drug B = MIC of drug B in combination/MIC of drug B alone The FICI was defined as the FIC of drug A added to the FIC of drug B The definition of ... resulted in the revival of the polymyxins, which are increasingly used as the last line of defence against such difficult-to-treat infections Inevitably, growing reports of polymyxin (often the last...
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Predicting in vivo anti hepatofibrotic drug efficacy based on in vitro high content analysis
... single parameter is used For example, one study measured the binding affinities of 19 opioid drugs A ranking based on the magnitude of these binding affinities was done for developing labeling ... with lower in vitro scores (e.g colchicine and silymarin) Furthermore, drugs with lower in vitro scores generally have fewer in vivo publications than drugs with higher in vitro scores Since anti-hepatofibrotic ... of the drug effects in human trials The group of drugs with higher in vitro scores (e.g pioglitazone and glycyrrhizin) gave more promising results in human clinical trials than the group of drugs...
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In vitro drug release mechanism from cholesteryl ester composed liquid crystalline system
... matrix These factors include temperature, initial drug loading, water content, the structure of the system as well as the physical properties of the incorporated drug These factors are critical in ... globular protein has same size as the dimensions of water channels in the bicontinuous cubic phases Protein entrapment in the cubic phase depends on the type of protein, its interaction with the lipid ... releases drugs in a controlled manner in response to changes in temperature The specific objectives of the project are: (a) investigate in vitro drug release mechanism from the liquid crystalline...
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Addressing the bariers to pediatric drug development
... combining incentives and requirements for the conduct of pediatric research into one process; • increasing transparency throughout the clinical research enterprise; • increasing training for the ... determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, ... other non-life-threatening disease.) • Needed information For what age groups is information needed? What studies are required to obtain the information? Are there other ways to obtain the information?...
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Tài liệu Báo cáo khoa học: Abstract Integration of Metabolism and Survival PP-1 The metabolic switch in liver methionine metabolism pptx
... ‘below’ the Q119 guanidiniums of the four domains, holding the domains together and blocking the channel Adding charges (one proton per domain) breaks the plug, the side chains separate, and the ... vivo Furthermore, the two VRK2 isoforms interact by its N-terminal domain with JIP1 in vitro, binding the C-terminal region of JIP1 The kinase activity of VRK2 is not necessary for the interaction, ... mediates the suppression of the brain in ammation in the LPSinduced experimental brain in ammation model in vivo PP-27 Transglutaminase inhibition promotes sensitivity to the chemotherapy in cancer...
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RNA Interference Technology FROM BASIC SCIENCE TO DRUG DEVELOPMENT ppt
... expanding at an extraordinarily rapid rate, yet the field is in its infancy There is great interest in using RNAi as a means of exploring gene function during embryonic development and in the adult ... strategies in the pre-clinical drug discovery process within the biotech and pharmaceutical industries We are now beginning to exploit the information gleaned from the genome sequencing projects ... Nirenberg RNA interference is a powerful tool that has been used to inhibit gene function either by increasing the destruction of mRNA corresponding to the gene, or in some cases, by inhibiting the transcription...
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Báo cáo khoa học: Definition of the residues required for the interaction between glycine-extended gastrin and transferrin in vitro pptx
... for the binding of gastrin, and of the regions in gastrin required for the interaction with transferrin, is obviously essential to a full understanding of the interaction The independent involvement ... crosslinking have been used to explore whether Ggly interacts with transferrin in vitro, to investigate whether iron is required for the Ggly–transferrin interaction, to define the domains ⁄ residues ... with the difference in the circulating concentrations of Gamide and transferrin In the present study, we explored further the interaction between Gamide and transferrin, and characterized the interaction...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25