design and interpretation of tests on new drug substances and dosage forms
Presentation introduction on new drug development Prof. JanHasker G. Jonkman
... INTRODUCTION ON NEW DRUG DEVELOPMENT (INT-S.) INTRODUCTION ON NEW DRUG DEVELOPMENT TABLE OF CONTENTS • • • • • • • • • • • • • • Worldwide Sales of Medicines Costs of Research and Development New Drug ... INTRODUCTION ON NEW DRUG DEVELOPMENT (INT-S.) INTRODUCTION ON NEW DRUG DEVELOPMENT TABLE OF CONTENTS • • • • • • • • • • • • • • Worldwide Sales of Medicines Costs of Research and Development New Drug ... INTRODUCTION ON NEW DRUG DEVELOPMENT (INT-S.) INTRODUCTION ON NEW DRUG DEVELOPMENT TABLE OF CONTENTS • • • • • • • • • • • • • • Worldwide Sales of Medicines Costs of Research and Development New Drug...
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TPP CGE analysis of impact on new zealand, report
... rulings on customs classification and valuation; and common rules of origin Of course, the reduction and elimination of tariffs themselves will remove a major motivation for customs officials ... efficient and seamless; encouragement of the participation of small and medium business enterprises in regional trade; enhance domestic and regional competitiveness and promotion of economic growth and ... Approach and Limitations Review of Existing Studies Organisation of the Report Modelling Framework and Scenarios Model and Database Liberalisation Scenarios Potential Impacts of TPP on New Zealand...
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Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx
... VERSUS Valuation Decision Randomization Personal societal interest and selfinterest Accept trial VERSUS Randomization Decision Node Decline trial Expected outcomes of usual care Personal, societal ... interest and selfinterest Presentation of a randomized trial protocol for consideration by a patient This presents an idealized sequence of invitation, factual evaluation, ethical valuation, decision, ... decision, and randomization Note that factual evaluation contrasts benefits and risks of usual care versus the expected benefits and risks of the trial after pooling all arms, and that the decision...
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Optimization of design and operating parameters on the year round performance of a multi-stage evacuated solar desalination system using transient mathematical analysis
... also because of the absence of non-condensable gases heat transfer by radiation and natural convection are limited Thus, heat transfer between the hot saline water bed and the condensation surface ... variation of global solar radiation and the ambient temperature for the months of January to June Figure shows the variation of global solar radiation and the ambient temperature for the months of July ... month of March 5.6 Effect of series and parallel combination of flat plate collectors The combination of flat plate collectors in both series and parallel are considered and its effect on the...
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báo cáo hóa học:" Influence of prosthesis design and implantation technique on implant stresses after cementless revision THR" docx
... load sharing conditions after reconstruction [21,22] By applying a combination of these techniques, it seems possible to investigate how specific combinations of design and surgeon related factors ... each of the four different implantation configurations Implantation Configuration 1,3 large bone defect (type IIIa) 1,2,3,4 extended bone defect (type IIIb) 1,2,3,4,5 Hip Contact Force Component ... http://www.josr-online.com/content/6/1/20 Page of Figure Implant stresses within the standard design prosthesis as a function of the extent of the bone defect This figures shows the effect of the extent of...
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báo cáo hóa học:" Influence of prosthesis design and implantation technique on implant stresses after cementless revision THR" pdf
... load sharing conditions after reconstruction [21,22] By applying a combination of these techniques, it seems possible to investigate how specific combinations of design and surgeon related factors ... each of the four different implantation configurations Implantation Configuration 1,3 large bone defect (type IIIa) 1,2,3,4 extended bone defect (type IIIb) 1,2,3,4,5 Hip Contact Force Component ... http://www.josr-online.com/content/6/1/20 Page of Figure Implant stresses within the standard design prosthesis as a function of the extent of the bone defect This figures shows the effect of the extent of...
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Báo cáo hóa học: " A new interpretation of Jensen’s inequality and geometric properties of -means" pptx
... lc, ,ψ is monotone increasing (resp strictly monotone increasing) on I\{c}, then lc, ,ψ ∘ -1 is also monotone increasing (resp strictly monotone increasing) on (I) \{ (c)} and hence by (1) and Lemma ... Inequalities and Applications 2011, 2011:48 http://www.journalofinequalitiesandapplications.com/content/2011/1/48 Page of 15 Main results In this section, we first give a new interpretation of Jensen’s ... that f is non-constant and , ψ Î Csm,f (I) Then (i) If either ψ ∘ -1 is convex (resp strictly convex) on (I) and ψ ∈ C+ (I)or ψ ∘ -1 sm is concave (resp strictly concave) on (I) and ψ ∈ C−...
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Báo cáo hóa học: " Research Article Design and Experimental Evaluation of a Vehicular Network Based on NEMO and MANET" pdf
... the previous section, the range of the available access points and VANET links are estimated considering a simplification of the driving speed and the time of connection This section presents more ... these conditions are only present in this segment, since the rest of roads have a clear space on one side This fact enables the reflection of signals on the various walls Moreover, the second interesting ... Milagro, a “Experimental demonstration of the viability of IEEE 802.11b based inter-vehicle communications,” in Proceedings of the 4th International Conference on Testbeds and Research Infrastructures...
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báo cáo hóa học:" Research Article Evaluation and Design Space Exploration of a Time-Division Multiplexed NoC on FPGA for Image Analysis Applications" docx
... application requires four types of operations: (i) acquisition operations, (ii) storage operations, (iii) processing operations, (iv) control operations A characteristic of image analysis applications ... optimization of the number of resources leads to the choice of version whereas version is adapted to higher bandwith requirements 4.5 DSE of the Proposed NoC The knowledge of the design space of architectures ... to the implementation constraints, area, and speed, the designer chooses one version and can adapt the communication to optimize the area/bandwidth/latency tradeoff Adaptation consists in adding...
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Báo cáo hóa học: " Research Article Design and Implementation of Numerical Linear Algebra Algorithms on Fixed Point DSPs" pot
... SELECTION The vitality of the field of matrix computation stems from its importance to a wide area of scientific and engineering applications on the one hand, and the advances in computer technology on ... bits of X accurate 27 fractional bits of X accurate 26 fractional bits of X accurate 25 fractional bits of X accurate 24 fractional bits of X accurate 23 fractional bits of X accurate 22 fractional ... number of computations takes its toll on LU decomposition in case of 30 × 30 matrices During LU decomposition calculations of the elements of L matrix require division by the elements on main diagonal...
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Báo cáo hóa học: " Design and Realization of a New Signal Security System for Multimedia Data Transmission" ppt
... rotation on D5 U/D rotation on D5 Load D8/output D5 L/R rotation on D8 U/D rotation on D8 — — — Load D3 L/R rotation on D3 U/D rotation on D3 Load D6/output D3 L/R rotation on D6 U/D rotation on ... rotation on D1 U/D rotation on D1 Load D4/output D1 L/R rotation on D4 U/D rotation on D4 Load D7/output D4 L/R rotation on D7 U/D rotation on D7 — — — Load D2 L/R rotation on D2 U/D rotation on D2 ... Transmission 1295 Table 1: The complexity of the proposed TDCEA on a signal of length N Operation Multiplication Addition/subtraction Condition test or Step Equation (3) of Step Equation (4) of Step...
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Báo cáo lâm nghiệp: "The effects of lifting on mobilisation and new assimilation of C and N during regrowth of transplanted Corsican pine seedlings. A dual 13C and 15N labelling approach" docx
... effect on N content of needles and old stem The N content of new components, and particularly new roots, was significantly decreased by lifting 3.3 Characterisation of C and N sources for new growth ... with time and lifting Partitioning of total C to new components increased with time Forty-one days after transplanting, new roots and new shoots of intact seedlings contained ca and 9% of total ... et al Table II Effects of lifting and time on changes in content and partitioning of total, old and new elements (C and N) in the various components of intact or lifted one-year-old Corsican pine...
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Báo cáo y học: " A systematic review of the use of theory in the design of guideline dissemination and implementation strategies and interpretation of the results of rigorous evaluations" pps
... intervention has been carried out Additional file 1: Use of theories and constructs in studies Details of the studies that used theories (and constructs), the theories and constructs used and level and ... effect of the construct it should be measured pre- and postintervention (or post-intervention only in both a control and study group) and changes in the construct should be analysed in relation to ... of studies that provided an explicit rationale for their interventions Conclusion Greater use of explicit theory to understand barriers, design interventions, and explore mediating pathways and...
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báo cáo khoa học: " A systematic review of the use of theory in the design of guideline dissemination and implementation strategies and interpretation of the results of rigorous evaluations" ppt
... intervention has been carried out Additional file 1: Use of theories and constructs in studies Details of the studies that used theories (and constructs), the theories and constructs used and level and ... effect of the construct it should be measured pre- and postintervention (or post-intervention only in both a control and study group) and changes in the construct should be analysed in relation to ... of studies that provided an explicit rationale for their interventions Conclusion Greater use of explicit theory to understand barriers, design interventions, and explore mediating pathways and...
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Báo cáo y học: " Disrupting the rhythm of depression: design and protocol of a randomized controlled trial on preventing relapse using brief cognitive therapy with or without antidepressants" pptx
... of aftercare; e.g continuation of AD, non-controlled tapering and discontinuation of AD, both in primary and secondary care Recently, the preventive effects of CT in primary care have been confirmed ... participants to describe past and current treatments for depression, their attribution of relapse and recurrence and use of AD If participants meet all inclusion and none of the exclusion criteria for the ... by telephone for inclusion and exclusion criteria (and sends information and a written consent form if participant responded through media) Does the participant meet screening criteria and is willing...
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Báo cáo y học: "Do pediatric intensivists and radiologists concur on the interpretation of chest radiographs" docx
... subsequent alterations in patient management were made by PI on the basis of the official interpretation of radiograph An interpretation was considered concordant if the PI reading was consistent with ... effusions and airleaks), the position of invasive support devices (eg endotracheal tubes and central venous catheters) and any therapeutic interventions performed Formal review and interpretation of ... PI An interpretation was discordant if, in the opinion of the PP, the interpretation of the PI did not coincide with the formal interpretation by the PR Discordant interpretations were further...
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ASSESSMENT OF HIV, AFB (+) TB CONTRACTION AND EFFICACY OF INTERVENTION MEASURES ON INTRAVENOUS DRUG USERS IN DAKLAK PROVINCE, 2011 2012
... voluntarily HIV consultation and test ARV treatment and caring for HIV infected persons; Information, education and risk reduce consultation; giving out condoms and control on sexual transmitted ... among IDUs regarding the damage of HIV and TB as well as HIV/TB coinfection Expanding and deploying of intervention programs on HIV infection such as giving out clean needles and condoms Expanding ... methods HIV tests were conducted at Prevention of HIV center of Daklak and Institute of Hygiene and Epidemiology of Tay Nguyen Test of AFB in oral fluid samples were conducted in Tuberculosis and Lung...
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commentary on design and construction of reinforced concrete chimneys (aci 307-98)
... Concrete Institute 307-69 Specification for the Design and Construction of Reinforced Concrete Chimneys 307-88 Standard Practice for the Design and Construction of Cast-in-Place Reinforced Concrete ... Structural Concrete 505-54 Standard Specification for the Design and Construction of Reinforced Concrete Chimneys 550R-93 Design Recommendations for Precast Concrete Structures American Society of Civil ... site and modal response calculations The modifications were approved in 1969 and the specification was designated ACI 307-69 In that specification, the commentary and derivation of equations were...
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commentary on standard practice for design and construction of concrete silos and stacking tubes for storing gran
... construction operation, the amount of admixture may be adjusted in the field to suit the ambient conditions and so maintain a constant rate of rise for the forms COMMENTARY ON DESIGN AND CONSTRUCTION ... ancilliary structures Concentrated loads at the transition between the cylindrical and converging section of a flow channel COMMENTARY ON DESIGN AND CONSTRUCTION OF CONCRETE SILOS AND STACKING TUBES ... COMMENTARY ON DESIGN AND CONSTRUCTION OF CONCRETE SILOS AND STACKING TUBES 313R-17 Fig 7-A For the effect of a single tendon, a method based on analysis of the wall as a beam on an elastic foundation...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose