cooperation is rewarding if the boundary conditions fit interdisciplinary cooperation in the context of prenatal diagnostics
Tài liệu Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex potx
... this phenomenon It is demonstrated that the formation of the active complex is profoundly in uenced by a single amino acid difference, i.e G252R, in a region within the catalytic domain This is ... differences are conservative [5] A comparison shows that there is a cluster of amino-acid differences in the C-terminal part of the enzyme (Fig 2A) where 13 of 44 amino acids are different Therefore, ... quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 24 Read, S.M & Northcote, D.H (1981) Minimization of variation in the response to different proteins of the...
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Báo cáo khoa học: YidC is required for the assembly of the MscL homopentameric pore potx
... most of the MscL produced during pulse labelling is inserted into the inner membrane, with its periplasmic loop properly located in the periplasm (Fig 2A) Upon lysis of the cells expressing MscL ... proteins to the insertion site in the inner membrane As defective targeting obstructs membrane insertion, the role of the SRP could be investigated by SCAM using strain FF283, which carries the ... the level of MscL–HA in the membranes is equal to that of the non-depleted IMVs This indicates that YidC is required for assembly of the MscL complex (Fig 5) To investigate the role of the Sec...
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Báo cáo khoa học: Structure of Streptococcus agalactiae serine⁄threonine phosphatase The subdomain conformation is coupled to the binding of a third metal ion pptx
... site of a PPM ⁄ PP2C STP and a flap domain conformation very different to that in HsSTP [9] This raises the question of whether the difference in conformation of the flap domain is related to binding ... implications of the M3 binding and flap subdomain conformations to the catalytic mechanism are discussed below The role of the third metal in catalysis In MtSTP [9], Ser160 takes part in binding M3 ... conformation is linked with the binding of the third metal ion suggesting, like Pullen et al [9], that rearrangement of the flap domain in HsSTP might lead to binding of a third metal ion The implications...
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IS LOOKISM UNJUST?: THE ETHICS OF AESTHETICS AND PUBLIC POLICY IMPLICATIONS potx
... viewpoint, see Etcoff (1999) In our society aesthetic capital, like other kinds of capital, is unequally distributed Lookism is like racism, classism, sexism, ageism and the other –isms in that ... at the physical presence of others We judge people on the basis of their attractiveness within seconds of meeting them In the literature we find that the lookist response, insofar as we can isolate ... increasing sensitivity to discrimination, it is gaining status as a discussable issue in public policy We will review the tradition of ethical thinking about aestheticism in general and lookism in...
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What is known about the effectiveness of economic instruments to reduce consumption of foods high in saturated fats and other energy-dense foods for preventing and treating obesity? docx
... consumption of their substitute foods and their complementary foods Increases in the price of rice raised consumption of wheat flour and coarse grains Increases in the price of pork led to increases in ... (all of which are included in this synthesis.) Of all of the studies on consumer incentives, only four assessed long-term results (none involving weight loss), none of which retained their attained ... at the farmers markets over years (51) Food provision Another economic instrument is provision of food of specific types and portions There is a small body of evidence supporting the use of this...
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Cancer Research UK’s strategy 2009–2014: Cancer Research UK’s aim is to reduce the number of deaths from cancer. Our future plans are ambitious, but they are in line with the challenge and the responsibility we face. docx
... increased our work in this field, with the number of new trials started rising from seven in 2000 to 49 in 2007, reflecting the gathering pace of scientific discovery and its application in the ... in training most of the medical oncologists practising in the UK We will build on this to address the current deficit in clinician scientists working at the translational interface and in cancer ... provision of relevant training in our Institutes and Centres and working in partnership where possible - Maintain our current investment in training schemes while modifying the existing portfolio...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... for the control (r32 alone, Fig 2C) The inhibitory action of CIIIC on the proteolysis of r32 by HflB was also assayed in the presence of CIIIC (60 lm) instead of CIII (Fig 2B) It is clear that in ... case the proteolysis, with 85% of r32 remaining undigested after 80 (Fig 2C), was inhibited more effectively than with intact CIII The above experiments on the inhibition of the proteolysis of ... proteolysis of r32 by HflB requires ATP The proteolysis of r32 by HflB is very rapid and requires the DnaK–DnaJ–GrpE chaperone machine in vivo [18–20] However, this proteolysis is much slower in vitro,...
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Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot
... reproduced in in vitro conditions if nNOS digestion by calpain is carried out in the presence of HSP90 [27] This finding can also explain the large extent of digestion of eNOS in aorta, in which, in association ... previously to induce an increase in the level of [Ca2+]i and a correlated calpain activation [28] This increase in [Ca2+]i is more intense in aorta than in brain Under these conditions, in brain, no ... milli-calpain isoforms were reduced to a limited extent in brain, whereas, in aorta (Fig 2B), the decrease in the two protease isoforms was more pronounced Moreover, in brain, the natural inhibitor of...
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báo cáo hóa học:" A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study" pdf
... overall infection rates of this group of patients The baseline characteristics of the both patient groups are outlined in Table http://www.translational-medicine.com/content/7/1/100 The mean age of ... patients with abdominal surgery but without signs of infection or inflammation Secondly, an evaluation of the association of the MIF polymorphisms with the survival of severe sepsis patients was ... shows the genotype and allele distribution of both polymorphisms in the three groups The carriage of the allele 173C was significantly associated with carriage of the -794 CATT7 microsatellite (Fisher's...
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báo cáo hóa học:" HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmission" potx
... importance of postnatal transmission But it is easy to misinterpret these numbers because of shifting denominators Transmission rates are expressed as the number of infected infants divided by the number ... with the terrible fear of transmitting HIV to their infants A mother living in Soweto participating in an early infant diagnosis programme typifies the dilemma: "I told myself that just like in ... effectiveness of this approach was demonstrated in the MTCT-Plus programme in Cote d'Ivoire [8] This is a win-win intervention that treats the mother while preventing transmission It is important...
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Báo cáo hóa học: " Glycerol conversion to 1, 3-Propanediol is enhanced by the expression of a heterologous alcohol dehydrogenase gene in Lactobacillus reuteri" ppt
... reuteri Further engineering of the strain to improve the redox balance and minimize the formation of byproducts like lactate and ethanol could pave the way for maximizing 1, 3-PD biosynthesis Acknowledgements ... marker yield of 1, 3-PD (up by 13%) observed in the clone (Table 3) Interestingly, the specific rates of formation of lactate and ethanol were higher and that of acetate lower in the recombinant culture, ... shown in Figure The expression of the cloned yqhD gene in L reuteri was confirmed using SDS-PAGE analysis of whole cell lysates (Figure 3) A prominent band of ~43 kDa appeared in the recombinant...
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Peace is every step the path of mindfulness in eve
... depth of your consciousness, and it will tend the feeling of pain A mother holding her baby is one with her baby If the mother is thinking of other things, the baby will not calm down The mother ... unpleasant feeling in the same way Transforming Feelings The first step in dealing with feelings is to recognize each feeling as it arises The agent that does this is mindfulness In the case of fear, ... only their tangerine, but also its mother, the tangerine tree With some guidance, they began to visualize the blossoms in the sunshine and in the rain Then they saw petals falling down and the tiny...
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Báo cáo y học: "Relaxin''''s induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint" ppsx
... sites, including the pubic symphysis and synovial joints These findings also suggest that in fibrocartilaginous tissues, including the TMJ disc and possibly the pubic symphysis, relaxin decreases ... of these proteinases to the changes in collagen and glycosaminoglycan (GAG) content in fibrocartilaginous disc explants Our findings are consistent with the hypothesis that relaxin-mediated induction ... of joint tissues to function normally, this modulation of MMPs and resulting matrix loss in the fibrocartilaginous TMJ disc by relaxin might explain the distinct age and gender distribution of...
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Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx
... however, the capacity of licofelone to inhibit the synthesis of IL-1β [6-8] may explain, at least in part, the effect of the drug on the synthesis of cathepsin K R1097 Arthritis Research & Therapy ... for the resorption of the calcified cartilage and subchondral bone in the early phase of the disease [18] Licofelone treatment was shown to reduce the level of synthesis of cathepsin K in both of ... reducing the synthesis of LTB4 and IL-1β by the OA synovium [6] These findings are in strong support of the in situ role played by LTB4 in the structural changes that occur in OA The progression of the...
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Báo cáo y học: "Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis" pdf
... implicated the extrinsic and intrinsic apoptotic pathways in preventing or limiting the effector phase of inflammatory arthritis [27,28] Since the pro-apoptotic protein Bid links the extrinsic to the intrinsic ... examined using a histopathological scoring system to further identify differences in Bid-/- compared to Wt mice following the induction of arthritis There was a 2.0fold increase (p < 0.005) in inflammation ... increase (p < 0.02) in the number of macrophages in the pannus of Bid-/compared to Wt joints There was no statistical difference in average number of macrophages in the synovial lining in Bid-/ - compared...
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Báo cáo y học: " A promoter SNP rs4073TA in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode" docx
... fibrosing alveolitis (n = 71), and normal healthy subjects in the UK [16] These study reported no association of the SNPs of IL8 with the risk of pulmonary fibrosis The Page of Figure Comparison of ... Lin EJ, Lin YP, Sheu ML, Li CP, Chang FY, Chao Y, Yen SH, Lee SD: The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffusetype histopathology ... controls The IL-8 protein level in BAL fluid was significantly increased in the subjects with IPF having the common allele of rs4073T>A compared to those with the minor allele This result indicates...
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Báo cáo y học: " Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study" pptx
... acute inflammatory syndrome frequently complicated by the development of anemia As the incidence of sepsis is high [12], determination of this putative pathway of the development of anemia is of ... with the hepcidin levels on days one to three Discussion In the present study, three novel findings emerged This is the first study to show that: hepcidin-25 is increased during human sepsis; in ... hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin J Clin Invest 2004, 113:1271-1276 11 12 13 14 15 16 17 18 19 20 21 22 Fleming RE, Sly WS: Hepcidin:...
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THE INFLUENCE OF THE KU80 CARBOXY-TERMINUS ON ACTIVATION OF THE DNA-DEPENDENT PROTEIN KINASE AND DNA REPAIR IS DEPENDENT ON THE STRUCTURE OF DNA COFACTORS Derek S.
... mechanism in which the initial radical induced on the DNA produces a single strand break The radical is then transferred to the other strand causing the second break7 Of these two possibilities the ... in DNA binding11 The N3 and N4 groups of the pyrimidine moiety provide sequence specificity of DNA cleavage by binding to the N3- and N2-amino groups of the guanine 5’ to the pyrimidine (py) ... mechanism in which the initial radical induced on the DNA produces a single strand break The radical is then transferred to the other strand causing the second break7 Of these two possibilities the...
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Streptococcus pneumoniae Coinfection Is Correlated with the Severity of H1N1 Pandemic Influenza
... July during the course of an outbreak investigation of pandemic H1N1 influenza in Argentina, were analyzed by MassTag PCR for the presence of potential sources of coinfection, including 33 viral ... multivariable logistic regression analysis stratified by age risk group A model adjusting for the presence in NPS of RSV A, the total number of agents detected in NPS, and the presence of a medical risk factor ... point -of- care institutions on the basis of their review of charts in their own institutions INEI and Columbia University (CU) were provided the following deidentified data: patient age, sex, presence of...
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