consequences of stress in the secretary pathway the er stress response and its role in the metabolic syndrome
Báo cáo y học: "The organisation of the stress response, and its relevance to chiropractors: a commentary" pdf
... Hypothalamic efferents The output system involves the recognition of the stress response, and engages both the neuroendocrine and neuronal pathways [13] The higher centres consisting of the cerebral ... Neurons of the NTS project to the paraventricular nucleus, and other hypothalamic nuclei among other destinations [15] The NTS has other viscerosensory fibres terminating on catecholaminergic neurons, ... parts of the brain stem, with numerous fibres terminating in the caudal brainstem lateral tegmentum, including the locus coeruleus, parabrachial nuclei, nucleus subcoeruleus, and the solitary and...
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The Health Risks and Consequences of Trafficking in Women and Adolescents pot
... number of ethical questions and safety concerns for the victim, others close to her, and for the interviewer In the process of gathering information there is the danger that the safety and individual ... were interviewed in private by a member of the research team In Albania, the Netherlands and Ukraine, the support organisation was also the study partner In Thailand, the study partner was the ... transfer, harbouring or receipt of persons by means of threat or use of force or other forms of coercion, of abduction, of fraud, of deception, of the abuse of power, or of a position of vulnerability...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... cDNA and its derivatives generated by PCR were cloned into pGEX-4T-2 The KIND domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal ... v-KIND KIND2 binding resides within residues 702–744 of MAP2 Residues 456–487 in the KIND2 domain of v-KIND contain the core MAP2 binding module To identify the core MAP2-binding site within the ... that the core sequence critical for the specific MAP2 binding resides within the 32 residues (amino acids 456–487) of the v-KIND KIND2 domain To examine whether the MAP2 binding core site of v-KIND...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... histidine residues are central to copper binding in many proteins they probably form part of the copper binding sites in this protein Although there are four histidines in the C-terminal, another ... understanding what causes the loss of appropriate metal binding might be crucial for the understanding of the role of amyloidogenic proteins in a number of neurodegenerative disorders Copper binds ... occured A binding isotherm was fitted to the data, expressed in terms of the heat change per mole of ligand against the ligand to macromolecule ratio From the binding isotherm values for the reaction...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... (Software Inc) and the BLAST network server of the National Center for Biotechnology Information (NCBI) were used to analyze the nucleotides and deduce the amino acid sequences in determining ... values were determined by incubating the diluted recombinant proteins in the standard reaction mixture in the presence of increasing concentrations of PPi (0.05–0.5 mM) at 55 °C Data were fit to the ... member of the Family I soluble PPases We also provide information concerning the kinetics and properties of the enzyme More strikingly, we show a novel role of the PPase enzyme in the development and...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... that the lack of interaction between VBARP and Nef is not due to the lack of input proteins To further confirm that a physical interaction exists between Vpr and VBARP in vivo, we tested this interaction ... pairs of each exon is marked on top of the boxes representing the exons Exon numbers are derived from the genomic sequence, after designating the first coding exon number and counting all other exons ... distribution of VBARP is independent of the cycling stage of the cells Identification of biological function(s) of VBARP using a siRNA assay To examine the role of endogenous VBARP in the regulation of...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... PEX13 and (so far only identified in yeast) PEX17 Several other peroxins are involved in the subsequent steps of the import The import of matrix proteins seems to involve a cascade of interactions ... mammalian cells and plants as a component of the docking complex and a point of convergence of the PEX5- and PEX7-dependent import pathways [15–17] The N-terminal part of PEX14 interacts with the repeated ... and that the amino-terminal domains of the two peroxins were responsible for this interaction The role of TbPEX14 in glycosome biogenesis received further confirmation by analysing the subcellular...
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Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx
... function of relaxin-3 is considered to be different from that of other relaxin proteins involved in the growth and remodeling of reproductive and other tissues during pregnancy [10] In the mouse and ... to the dense-core vesicles in the perikarya, and it was also observed in the synaptic terminals of axons [12] The NI comprises a distinct cell group in the caudoventral region of the pontine periventricular ... relaxin-3 B-chain ⁄ INSL5 A-chain [20] In the brain, there is generally a close correlation between relaxin-3-positive nerve terminals and RXFP3 expression; however, the density of expression of...
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AN INTERNATIONAL PERSPECTIVE ON THE FUTURE OF RESEARCH IN CHRONIC FATIGUE SYNDROME ppt
... CFS and possibly subsets of the disease may be useful in monitoring CFS In the context of CFS, this pertains to our lack of understanding and inability to define areas of treatment, suggesting ... decreases in cytotoxic activity of Natural Killer (NK) cells and perturbations in cytokine levels 2.4.1 Cytokine and chemokine genes Cytokines and their genes are vital for sustaining and regulating innate ... is involved in the function of dopamine in the prefrontal cortex of the human brain thus it is involved in frontal lobe functioning (Meyer-Lindenberg et al., 2005) The inability of most CFS patients...
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Báo cáo y học: "Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren’s syndrome" pdf
... of whether there are differences in the IgV chain gene repertoire of CD19+ B cells by comparing two immune compartments, the peripheral blood and the inflamed parotid gland, a target tissue in ... blood, and evidence for the accumulation and retention of these antigen-experienced B cells in the parotids, together with new findings of the role of chemokines and chemokine receptors, permitted ... CD5, further supporting the hypothesis of homing and activation of specific B cells in the glands B cell malignancies and Sjögren’s syndrome In contrast to the focal sialadenitis of the minor (labial)...
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Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" ppsx
... participated in the conception and design of the project and in the analysis and interpretation of data and contributed substantially to the drafting of the manuscript VFP participated in the acquisition, ... on the basis of other metabolic syndrome classification criteria, including those of the World Health Organisation [34], the International Diabetes Federation [35], and the European Group for the ... Irrespective of this, it appears again that the increased frequency of patients satisfying both the hypertensive and hypertrigylceridaemic components of the metabolic syndrome in the steroid-treated...
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Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" pptx
... participated in the conception and design of the project and in the analysis and interpretation of data and contributed substantially to the drafting of the manuscript VFP participated in the acquisition, ... on the basis of other metabolic syndrome classification criteria, including those of the World Health Organisation [34], the International Diabetes Federation [35], and the European Group for the ... Irrespective of this, it appears again that the increased frequency of patients satisfying both the hypertensive and hypertrigylceridaemic components of the metabolic syndrome in the steroid-treated...
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Báo cáo y học: "Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study" pptx
... resulting in increased obesity and alterations in the lipid profile [42,43] One of the most interesting findings from this study, however, is the negative association between methotrexate use and the ... population, altering some of the components of the metabolic syndrome The factors found to associate independently with the metabolic syndrome in RA included older age, higher HAQ scores and less methotrexate ... the findings of this study All of the possible underlying mechanisms of action require further investigation in studies designed specifically for the purpose However, it remains that the observation...
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Epidemiology of palsma lipids and the metabolic syndrome in multi ethnic population
... constitutes the aim of the first study in this thesis 1.6 The role of obesity in the pathogenesis of insulin resistance and the metabolic syndrome 23 Obesity is a key feature of the metabolic syndrome, ... phosphorylation of these serine residues impedes the normal association of IRS-1 with the insulin receptor, thereby impairing downstream propagation of insulin signaling 39, 50 In summary, a number of metabolic ... deposition of LDL in the sub-endothelium of the arteries, where they initiate the process that is atherosclerosis For many years, it was thought that LDL was the predominant lipoprotein involved in the...
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Regulation of DNA (cytosine 5) methyltransferase 1 in the cell cycle and its role(s) in doxorubicin mediated micronuclei formation
... consisting of the C-terminal catalytic domain linked to the N-terminal regulatory domain through a lysine- and glycine-rich (KG) linker domain The C-terminal catalytic domain is highly conserved ... 2005) Interestingly, the N-terminal domain of DNMT1 plays a role in the stabilization of the protein This has been shown by the deletion of the first 118 aa to force initiation of translation at the ... a higher expression of Topoisomerase IIα The SET and RING fingerassociated (SRA) domain of UHRF1 shows preferential binding to hemimethylated CG sites and is responsible for the binding and recruitment...
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Distribution of betaine gaba transporter BGT 1 in excitotoxic brain injury and its role in osmoregulation in the brain
... substrate of BGT-1 in the brain remains to be determined Of particular interest is the elucidation of the role of BGT-1 in excitotoxic brain injury, since under such circumstances of neuronal injury, ... order to gain a thorough understanding of its function in the brain BGT-1 is capable of transporting both betaine and GABA, as examined in Xenopus oocytes and various cell lines But the physiological ... expression and functional changes of BGT-1 in astrocytes in response to hyperosmolarity in vitro and in vivo Overall, the present study has dissected the role of BGT-1 in osmoregulation in the brain...
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Distribution of secretory phopholipase group XIIA in the CNS and its role in lipid metabolism and cognition
... knockdown also resulted in shorter latency timings in the passive avoidance test, and higher number of errors in the attention set-shifting task, indicating deficits in working memory and attention, respectively ... 1989) Together, the activation of both PKC and PLA2 in the pre-synaptic terminals plays significant roles in the induction and maintenance of LTP (Bernard et al., 1994) In addition, studies performed ... expression of PLA2 isoforms, or their physiological roles in specific regions of the brain and CNS The present study was carried out in view of the importance of the importance of PLA2 and its products...
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Báo cáo sinh học: "The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance" doc
... After 40 of incubation non-adherent cells were washed off using BSS buffer The remaining cells were fixed with 4% formalin and stained with 0.5% crystal violet The number of adherent cells was then ... 30,000 per insert and allowed to invade for days After incubation, cells that had migrated through the matrix and adhered to the other side of the insert were fixed in 4% formalin, stained with 0.5% ... then counterstained in Gill’s haematoxylin and dehydrated in ascending grades of methanol before clearing in xylene and mounting under a cover slip Staining was independently assessed by the authors...
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báo cáo hóa học: " Prevalence of stress, anxiety and depression in with Alzheimer caregivers" ppt
... psychological and physical wellbeing of the caregiver and of his/her family Caring is held to be very demanding and emotionally involving The main complaint of caregivers is the lack of support from the ... with the severity of the behavioural disorders and to the duration of the disease Most of the subjects interviewed had to change many of their own habits to meet the needs of the in- patient living ... health of the person who in primis takes care of the patient, and this is also a source of stress The most serious problem concerning the large number of caregivers that consistently suffer from...
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o cáo hóa học:" The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance" docx
... After 40 of incubation non-adherent cells were washed off using BSS buffer The remaining cells were fixed with 4% formalin and stained with 0.5% crystal violet The number of adherent cells was then ... 30,000 per insert and allowed to invade for days After incubation, cells that had migrated through the matrix and adhered to the other side of the insert were fixed in 4% formalin, stained with 0.5% ... then counterstained in Gill’s haematoxylin and dehydrated in ascending grades of methanol before clearing in xylene and mounting under a cover slip Staining was independently assessed by the authors...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25