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Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... proteinswithin the cell. We found this translocation to bedependent on the final amino acids of the receptorprotein. Similar to the other PDZ domain interactionsthat have been shown to be abolished by ... signal is impaired.We finally examined the effect of deletion of the components of the PDZ binding motif on the signal-ing properties of the receptor in Ca2+imagingexperiments. Truncation of the ... summary, when the interaction betweenMUPP1 and OR2AG1 is inhibited by over-expressing the interacting PDZ domains, the resulting response ofOR2AG1 to odorant is modified in that the rapiddecay...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... Fentonreaction with the iron metal at the active site. The presenceof iron is therefore a prerequisite for its effect and suggeststhat the absence of reactivity with the MnSOD mutants is due to the lack ... identified to distinguish between FeSOD andMnSOD [7]. The position of the glutamine residue, which is structurally equivalent in the enzymes, is contributed by the N domain of FeSODs (Q69) and the C ... a shift in the position of Y34 and a twist in the ring of the metal-binding H81. Thermostability is not a new phenomenonamongst SODs; those isolated from hyperthermophilicorganisms, for example,...
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Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf
... translocation; this latter function appears tobe the only one that is common to all bacteria. In Yer-sinia, the increased synthesis of LcrV triggered by the activation of the system leads to the titration ... pathogen-specific, and theirdifferent characteristics and cellular fates influence the distinct infectious phenotypes of the source microor-ganism [2]. In this review, only the translocons from the three ... of the individualtranslocator proteins to the outside of the system is unknown (for clarity, the hydrophilic partner is depicted in Fig. 1 as being the first molecule to belocalized). Within the...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... & Moller DE (2002) The mechanisms of actionof PPARs. Annu Rev Med 53, 409–435.20 Bishop-Bailey D & Hla T (1999) Endothelial cell apop-tosis induced by the peroxisome proliferator-activatedreceptor ... induced apoptosis, Akt-1decrease and caspase-3 cleavage (Fig. 6B–D).Discussion The function of PPARc in adipogenesis is well estab-lished [19]. However, in many other types of cell, the activation ... adipocytes, adipogenesis may be the dominant effect of PPARc agonists, whereas in matureadipocytes, apoptosis may be induced by PPARcagonists. These effects may change the balance of adi-pocyte...
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Tài liệu cwnaTMCertified Wireless Network AdministratorOfficial Study GuideEndorsed by the Wireless LAN AssociationIndustry Approved!TMExam PW0-100Objective-by-Objective coverage of the CWNA certification examVendor-neutral wireless network trainin pptx
... introduce to the network administrator make them indispensable. There are two different types of building-to-building connectivity. The first is called point-to-point (PTP), and the second is called ... weighing the subject areas and ensuring that the weighting is representative of the relative importance of the content. This section outlines the exam objectives for the CWNA exam. ! The ... used by the manufacturers. The author and publisher have made their best efforts to prepare this book, and the content is based upon final release software whenever possible. Portions of the...
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Tài liệu Báo cáo khoa học: The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis ppt
... brain. The solubilization of the ICD ofRNF13 and the presence of the putative NLS on the C-terminal side of the TM domain are consistent with the possibility that the ICD, released from the mem-brane ... released by proteolysis from the TM anchor localized approxi-mately in the middle of the protein.RNF13 is a type I integral membrane protein By isolating microsomes and stripping them of periph-eral ... RNF13 is sub-ject to unexpected proteolysis that releases both the PA domain and the RING domain from the mem-brane, providing a biochemical basis for understanding the regulation of this family...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
... Kmvalues is exclu-sively displayed by the tetramer forms, and low-efficiency kinetics with high Kmvalues is displayed by the dimer forms. These observations strengthen the previous hypothesis that ... lgÆmL)1indicate thatdissociation of the tetramer to the dimer is a slowlyprogressing process. This is supported by the kineticbehaviour of the recombinant enzyme as shown inFig. 5D, where the enzyme ... kDa (see Table 1). Therefore, it can be concludedthat the nature of the base is insignificant for the tetra-merization effect. The next goal was to determine the role played by the sugar and phosphate...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... malignancies. One of the most prevalent primary cellular defence mechanismsagainst chemotherapeutic agents is the membrane-bound transporter [1]. The defining feature of thesetransporters is their ability ... Originally, the impetus for the switchin binding site affinity and orientation was thought tobe the energy produced by nucleotide hydrolysis. In the case of ABCB1, this was revised through the obser-vations ... pumps is assumed to correspond to the outward-facing confor-mation. The energy produced by the hydrolysis ofATP is harnessed for the resetting of the transporterto the initial high-affinity, inward-facing...
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Tài liệu Báo cáo khoa học: Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase pdf
... synapsis of the complexes promotes the juxtaposition between the opposing DNA ends,prior to their processing and ligation [44]. However,this scheme cannot fully explain the evidence for the in ... the mechanism for the condensed process of prebioticcharged polymers and has been established as a condi-tion interactive with the external environment duringtheir continuous synthesis and breakdown ... which is likely to pre-dispose to an irregular rejoining. Given high fluidityand self-organization, one speculation is that the struc-tural essence of the nuclear foci could be illustrated by the...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
... fgl2 mRNA. The left side of the figure is the sequence ladderusing the same primer and the pM166 clone astemplate. Arrow indicates the nucleotide that is matched to the band present in the primerextension ... sufficientfor the basal expression of the fgl2 gene. This finding is consistent with the observation that fgl2 is constitutivelyexpressed in cultured endothelial cells, as well as in the primary endothelial ... in some cells and tissues is known to play this role, suchas in the CNS [9]. The biological importance of constitutivefgl2 expression is exemplified by the observation that the fgl2–/–mouse...
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Tài liệu Báo cáo Y học: The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region ppt
... egg extract. The mature eggs of m ost vertebrates stay at the m etaphaseof the second meiotic division until they meet sperm. In thatphase, the nuclear envelope is dispersed in the cytop lasm ... that the binding of the RS region to chromatinDNA is superior to the binding of the NM region to the chromatin p rotein because the binding mode of NK,which contains the NM and RS regions, is ... 4nM(data not shown). These resultsindicate that the increase in the affinity of NK to chromatin is an ATP-dependent reaction, and is caused by a kinase(s)in the c ytosol. Then, authentic p rotein...
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Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
... that induced by cross-linking of the T cell antigen receptor, despite the absence of the c-chain. A possible explanation for this is provided by the observation that the CD3 chain of the T-cell ... indirectly the expression of FcRc-chain. It is unclear whether the increase in expressionwith PMA is an effect of the phorbol ester over the plasmidpromoter or whether it is a cellular response to the ... latter is not required for recognitionof the receptor by the snake venom. This illustrates the dualmechanism of the complex, with one subunit, namelyGPVI, responsible for binding to the ligand,...
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