clinical utility of serological markers and thiopurine drug monitoring in ibd an evidence based review
Is Lactobacillus GG Helpful in Children With Crohn’s Disease? Results of a Preliminary, Open-Label Study docx
... index including subjective reporting of abdominal pain, general well-being, and diarrhea and physical findings, including linear growth and laboratory parameters (hematocrit, serum albumin, and ... only in randomized double-blind placebocontrolled trials in large numbers of patients that significant, solid evidence of efficacy can be reached Until then, use of this and any probiotic in inflammatory ... scope of this preliminary investigation to address the question of underlying mechanisms of action of this probiotic in Crohn’s disease In conclusion, and fully acknowledging the limitations of an...
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Infliximab therapy in pediatric Crohn’s disease: a review docx
... frequent relapses and less than favorable maintenance of clinical remission Since CD may progress from intestinal inflammation to strictures and penetrating disease, including fistulas and abscess ... histologic and endoscopic disease activity and in inducing and maintaining remission in patients with active CD ACCENT I was a multicenter randomized double-blind international trial studying retreatment ... response and also loss of response Risk factors for development of HACA are single and episodic infusion, female gender, long gap between first and second infusion, and previous infusion Clinical and...
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Báo cáo Y học: Structural study on lipid A and the O-specific polysaccharide of the lipopolysaccharide from a clinical isolate of Bacteroides vulgatus from a patient with Crohn’s disease ppt
... Science and Culture of Japan (13670289 to T K.), grants and contracts from International Health Cooperation Research Ó FEBS 2002 (11A-1) from the Ministry of Health and Welfare of Japan, and ÔResearch ... compositional analysis, the sugars were determined as GlcN and designated GlcNI and GlcNII in order of the 1H chemical shift of the anomeric proton (H1) The downfield shift (d ¼ 5.34 p.p.m.) and the coupling ... observed The 1H- and 13C-NMR spectra of the OPS-rich fraction are shown in Fig Two anomeric signals were mainly observed, and the corresponding sugars were designated as a and b in order of 1H chemical...
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CROHN''''S DISEASE pdf
... result of protein cross-linking between mucin monomers Cross-linking occurs following disulfide bonding between cysteine-rich D domains in the NH2- and COOH-termini of the proteins Membrane mucins ... laminin LM-332 and LM-511 production in HIEC cells However in combination, a synergistic effect of TNF and IFN was observed on both laminin LM-332 and LM-511 production at protein and transcript ... neutrophils during injury and inflammation is balanced by several proteinase inhibitors, including α1-anti-trypsin, soluble leukocyte protease inhibitor (sLPI), and elafin ((Perlmutter and Pierce,...
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Báo cáo sinh học: "Mycobacterium avium subsp. paratuberculosis linked to Crohn''''s Disease and Paratuberculosis" pot
... μg/ml in human and bovine strains and of >2 μg/ml for bovine and animal isolate Rifabutin MIC was very similar to rifampin Also ethambutol generated a MIC of 2–8 μg/ml in human strains and 4–16 ... streptomycin the MIC range was of 0,5-2 μg/ml in both animal and human strains, for ciprofloxacin it was at 0.5–16 μg/ml, independently of the source of isolation, while rifampin produced a MIC of 0.5–1 ... MICs of two other drugs were 2–16 μg/ml and 2–32 μg/ml for ethambutol and clarithtromycin respectively Susceptibility data on human and animal isolates were carefully compared and summarized in...
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Báo cáo y học: "Adalimumab - an effective and promising treatment for patients with fistulizing Crohn’s disease: a case series" pdf
... for the induction and maintenance of remission in patients with moderate to severe CD, and safe and efficacious in regaining a medical response in patients intolerant or non-responsive to infliximab ... results in the significant and complete healing of draining fistulas in active FCD Furthermore, the long-term healing of draining fistulas was maintained over two years from the baseline of the ... Activity Index (CDAI) score of 320 and a Peri-anal Disease Activity Index (PDAI) score of 14 An examination under anesthesia revealed complex peri-anal disease and non-cutting drainage setons were inserted...
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Báo cáo y học: "Perforated Meckel’s diverticulum presenting with combined bowel and urinary obstruction and mimicking Crohn’s disease: a case report" pps
... 19:734-737 Brown RL, Azizkhan RG: Gastrointestinal bleeding in infants and children: Meckel’s diverticulum and intestinal duplication Semin Pediatr Surg 1999, 8:202-209 Bani-Hani KE, Shatnawi NJ: Meckel’s ... manuscript DWL reviewed the manuscript and provided surgical specimens and expertise TCS reviewed the manuscript and provided pathology expertise All authors read and approved the final manuscript ... adequate exposure, and therefore, a laparotomy was unavoidable and proved definitive in facilitating both diagnosis and management in our patient Conclusions As illustrated in our case and supported...
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Báo cáo y học: "Perforated Meckel’s diverticulum presenting with combined bowel and urinary obstruction and mimicking Crohn’s disease: a case report" doc
... 19:734-737 Brown RL, Azizkhan RG: Gastrointestinal bleeding in infants and children: Meckel’s diverticulum and intestinal duplication Semin Pediatr Surg 1999, 8:202-209 Bani-Hani KE, Shatnawi NJ: Meckel’s ... manuscript DWL reviewed the manuscript and provided surgical specimens and expertise TCS reviewed the manuscript and provided pathology expertise All authors read and approved the final manuscript ... adequate exposure, and therefore, a laparotomy was unavoidable and proved definitive in facilitating both diagnosis and management in our patient Conclusions As illustrated in our case and supported...
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Báo cáo y học: "Acute panuveitis with hypopyon in Crohn''''s disease secondary to medical therapy: a case report." pptx
... the case in this subject[9] Previous studies reported pharmacokinetic interactions when combining rifabutin and clarithromycin leading to an increase in rifabutin levels, resulting in an increase ... D, Mushatt D, Drusano G: Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virusinfected volunteers Antimicrobial agents and chemotherapy 1998, ... Open clinical trial of rifabutin and clarithromycin therapy in Crohn's disease Dig Liver Dis 2002, 34(1):22-28 Hafner R, Bethel J, Power M, Landry B, Banach M, Mole L, Standiford HC, Follansbee...
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Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt
... extracted using phenol:chloroform:isoamyl alcohol, followed by chloroform, and precipitated in 100% ethanol After air drying, the pellet was resuspended in TE buffer and its quantity and integrity ... epithelium of the ileum and colon with differentiated cells being sloughed off into intestinal lumen staining most vividly (Figure 1A,1B,1C) Examination of the intracellular staining pattern ... occurred in the terminal web of the epithelial cell and in the lateral junctions of the cells The localization of CSF1R in actin-rich areas of the cell is not surprising in view of data from in vitro...
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Báo cáo y học: "Granulomatous cheilitis associated with exacerbations of Crohn''''s disease: a case report" potx
... adolescents Orofacial granulomatosis in the paediatric population may be an initial manifestation of CD The interesting points regarding the clinical manifestations and the course of our patient ... with the activity of the intestinal disease, being quite prominent in periods of exacerbation of CD and retuning to almost normal appearance during periods of remission Competing interests The author(s) ... the clinical exacerbations of CD and that the administration of corticosteroids resulted not only in improvement of bowel symptoms but also in diminishment of the size of the lip swelling Another...
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Báo cáo y học: "Colonic adenocarcinoma revealing Crohn''''s disease: a case report Case report" pdf
... examinations of our patient and in formulating the diagnostic strategy All authors participated in writing and revising the manuscript All authors read and approved the final manuscript Acknowledgements ... mimic those of the underlying disease, the recognition of cancer arising in an inflamed bowel becomes difficult Thompson et al [12] recognized the occult nature of intestinal cancer in Crohn's ... consent was obtained from the patient for publication of this case report and any accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this journal...
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báo cáo khoa học: " Musings on genome medicine: Crohn’s disease" potx
... again detected, including NOD2 (nuclearbinding oligomerization domain containing 2; usually associated with structuring disease), IL23R (receptor for interleukin 23) and PTPN2 (protein tyrosine ... Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Nathan and Orkin: Genome Medicine 2009, 1:103 103.3 10 11 12 13 14 15 Working Party ... for the invaluable advice and assistance of Drs Ramnik Xavier, Mark Daly and Alan Leichtner References Loftus EV Jr, Schoenfeld P, Sandborn WJ: The epidemiology and natural history of Crohn’s...
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Báo cáo y học: "A 47-year-old man with neuro-Sweet syndrome in association with Crohn’s disease: a case report" ppsx
... predilection and neurological sequelae are infrequent and generally mild The encephalomeningitis may occur in any CNS region, resulting in various central symptoms including headache and altered level of ... contained an infiltrate of neutrophils and nuclear dust was also present These findings supported the clinical diagnosis of acute neutrophilic dermatosis (Sweet’s disease.) On days 4-6 of admission, ... started to improve He was still having headaches and spiking temperatures of up to 38.9°C in the evenings but the skin lesions were settling with decreased tenderness and redness By the seventh day,...
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Báo cáo y học: "Sweet''''s syndrome in a patient with Crohn''''s disease: a case report" pot
... hospital, wrote the manuscript, collected all relevant data, and finalized the manuscript for submission to the journal, ML was involved in giving intellectual advice and reviewing the manuscript Consent ... with continuation of azathioprine and Asacol He was also given a dose of intravenous Infliximab The rash showed no improvement after three days of antibiotics A punch biopsy of one of the skin lesions ... with no evidence of vasculitis Punch dermis ,of a skin lesion showing neutrophilic infiltration Punch biopsy of a skin lesion showing neutrophilic infiltration in the dermis, with no evidence of vasculitis...
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Báo cáo y học: " Takayasu''''s arteritis associated with Crohn''''s disease: a case report" pot
... showed no lesion in the oesophagus, stomach, or small intestine including the terminal ileum and cecum Abdominal CT scan showed thickening of the abdominal aorta (4 mm) and narrowing of renal arteries ... because TA can compromise intestinal vasculature and may present with gastrointestinal bleeding, complicating the diagnosis and perhaps exacerbating the clinical course of patients with IBD [6] Conclusion ... affects the aorta and its vasculature and may compromise intestinal vessels Therefore, it may present with gastrointestinal bleeding and exacerbate the clinical course of patients with inflammatory...
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Báo cáo y học: "Chronic cough associated with Crohn’s disease" pdf
... competing interests Authors’ contributions AHM and SF were the clinicians and GA the radiologist managing the case SF drafted the initial manuscript All authors have read and approved the final manuscript ... common origin of the lung and the gastro intestinal tract from the primitive foregut and similarities in tissue structure suggest a patho-physiologic reason for lung involvement in IBD Clinically ... disease in IBD is rare and involvement is both at a younger age and at an early point in the disease course Pathologically, bronchiolitis is most commonly reported Bronchiolitis obliterans organizing...
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báo cáo hóa học: " Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity" ppt
... [5,6] Many potential new therapies for ulcerative colitis are currently being developed in preclinical testing and clinical trials, including molecules targeting interleukin 12, interleukin 17, and ... diagram of 28 symptom domains in questionnaire and criteria for determining frequent and responsive symptom domains Flow diagram of 28 symptom domains in questionnaire and criteria for determining ... discussed during these group interviews and compared our findings with existing index components [15] We concluded that current indices capture only a portion of clinical symptoms and include several...
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Báo cáo khoa hoc:" Complicated Crohn''''s-like colitis, associated with Hermansky-Pudlak syndrome, treated with Infliximab: a case report and brief review of the literature" pot
... Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial dose of infliximab) Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial ... Improvement of ileitis, healing of ulcers (after wk of the initial dose of infliximab) Improvement of ileitis, healing of ulcers (after wk of the initial dose of infliximab) However, a review of the ... 42-yr-old muslim woman with hallmark findings of HPS presented to the University Hospital of Alexandropoulos in 2005 complaining of an 10-month history of recurrent episodes of abdominal pain worse with...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... ellagitannins, phenolic acids, and anthocyanins Many Vaccinium fruits contain 15–25 distinct anthocyanins (based on the anthocyanidins, delphinidin, cyanidin, petunidin, peonidin, and malvidin) in ... cyanidin, delphinidin, peonidin, malvidin, and petunidin), proanthocyanidins, tannins, catechin (and epicatechin, gallocatechin and epigallocatechin units), flavonols (myricetin, quercetin, and kaempferol), ... aspects of study design, performance, and analysis, with a focus on randomization of the study subjects, blinding of the investigators and study subjects, and the handling of dropouts and withdrawal...
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