check the copper filling factor
Role of poly (ADP ribose) polymerase 1 and copper homeostasis factor, antioxidant protein 1 in the maintenance of genomic integrity
... instability These findings reiterate the importance of tight regulation of copper levels in the cellular milieu for proper biological function We then further explored if specific factors in the copper ... excess copper in the cell, the protein moves to the plasma membrane of the cell and aids in excreting the excess copper (Dierick et al., 1997; Petris et al., 1996; Yamaguchi et al., 1996) Thus the ... due to the deficiencies in the activity of the essential cuproenzymes On the other hand, Wilson’s disease is caused by a genetic mutation in the Atp7b gene It results in the inability of the liver...
- 204
- 1,390
- 0
Tài liệu Bank Credit - A Study of the Principles and Factors Underlying Advances Made by Banks to Borrowers docx
... likelihood of loss to the creditors of the bank Or stating the same fact in other words, the larger the surplus or other liabilities to the shareholders, the greater is the loss that a bank can ... at the Hanover National Bank, effecting the withdrawal of no cash; but the great bulk of the checks drawn by the borrowers of the $10,000,000 against the proceeds of their loans would reach the ... Brokers' Paper The Rise of the Credit Department The First Phase of the Development of Credit Research The Development of the Credit Department since 1900 The Underlying Forces The Rise of the New Business...
- 383
- 820
- 0
Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf
... contrast, the chimeras possessing only the mouse HSF3 activation 4116 domain did not induce their expression Furthermore, the C-terminal activation domain of human HSF1 [43–45] was swapped with the ... the expression of these genes was not induced in HSF1-null lens cells Surprisingly, HSF4 was required for the expression of half of the genes, in part by facilitating the binding of HSF1 to the ... HSF1 [19] These observations implied that a balance of the monomer and trimer HSF affects the amount of HSF bound to the HSE in vivo, but even a small amount of the trimer could regulate the gene...
- 14
- 687
- 0
Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
... functionality and phylogeny However, the nature of the connections between these factors needs to be understood at the level of the protein domain The global properties of the HTFN topology are partially ... instructions The remaining TFs contained in the database did not form subgraphs and appeared isolated The relatively small size of the connected graph compared with all the entries in the database ... connections between modules, as shown by the tiny lines in the topological overlap matrix The algorithm weights the (topological) association of any node to the others, and it is possible to build...
- 12
- 511
- 0
the weakness of factors affecting sales activities at the website
... the opinions about the services When the customer raises any question about the service, the salesperson will make the adjustment to balance the expectation of the customer and the right of the ... force As the salary is the most important motive influencing the performance of the employees, the company should modify the salary regulation for the staff The company must pay the employees the ... to the customers This helps a lot in enhancing the sales activities of the company However, the motivation from the company not have enough strength to encourage them their best Following the theory...
- 35
- 438
- 0
Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc
... transcription factors as the mutation of the CRE site within the COX-2 promoter or the expression of a dominant negative mutant of CREB reduces inducibility of the COX-2 promoter [9,12–14] The transcription ... Pu.1 [19] The multiple activation modalities observed across the different studies as well as the similarity of the recognition sites of the NFAT and Ets factors led us to investigate the potential ... synergistically on the COX-2 promoter As the NFAT factors have been reported as activators of COX-2 [6], we evaluated whether ESE-1 and NFAT could cooperate in the context of the COX-2 promoter The )170...
- 12
- 519
- 0
Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx
... lower panels show the binding isotherm and the best-fit curve according to the three sequential binding sites model BIAcore analysis of the GS–TnrA interaction The results of the immunoprecipitation ... with their receptors [17] The divalent cations Mg2+ or Mn2+ were previously shown to negatively affect the binding of ATP to GlnK [12] Therefore, we investigated the binding of TnrA to GlnK in the ... binding to TnrA GlnK–TnrA interaction in the presence of mm ATP On the other hand, 2-oxoglutarate did not influence the GlnK–TnrA interaction, either alone, in the absence of divalent metals, or in...
- 11
- 596
- 0
Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... Nck [72] The binding of these proteins could prevent the interaction of the Ca2+ ⁄ CaM complex to the receptor if the CaMBD were occluded at least in part Nevertheless, the docking of these adaptor ... that the R645–R657 peptide competes to disrupt the interaction of the JM region with another non-identified region in the receptor [67] The non-identified region of the receptor to which the JM ... result of the interaction of the distal segment of the JM, particularly the E663–S671 residues, with the C-terminal lobe of the kinase domain of the apposed monomer [48,69], as well as the stabilizing...
- 16
- 459
- 0
The Copper-Clad World pot
... wriggled over the floor, brushing their ankles clammily Behind them there was the roar of another explosion and the shouting of angry voices The guards were in the secret chamber and hot on their trail ... was the effects of the pink gas Even with the misshapen guard down there in the engine room the power of his will was effective The devil must be an Ionian, he thought But how in the name of the ... shuffling clumsily across the copper plates Hazily he knew he was with the others in an airlock; the hiss and the throbbing of pumps told him that Under the great dome there was the latticework of a...
- 81
- 246
- 0
Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
... factors that may be involved in mediating the effect of insulin on HO-1 expression, including heat shock transcription factor- 1 (HSF-1), hypoxia-inducible factor- 1 (HIF-1) and NF-E2-related factor ... shown a direct link between the PI3K ⁄ Akt pathway and HO-1 regulation in PC12 cells [29,30] This may be through nuclear factor E2-related factor- 2 (Nrf2), a member of the cap’n’collar family of ... need to be identified [35] In the setting of organ transplantation, intervention to upregulate HO1 could be directed at the donor, the harvested organ ex vivo or the recipient and would clearly...
- 12
- 377
- 0
Báo cáo khoa học: The 3¢-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR ppt
... proteins and the 3¢-UTR of the MARCKS mRNA (A) The MARCKS 3¢-UTR, the stop codon UAA of the coding sequence (CDS) and the poly(A) sequence are depicted The box within the 3¢-UTR marked the identified ... ARE-containing mRNAs in the nucleus and transports them as RNPs to the cytosol [16,22,65,75] It is likely that HuR together with other factors is involved in nucleo-cytoplasmic shuttling of the MARCKS mRNA ... of the same size as the complex between His6-HuD and the 52 nt CU-rich RNA (Fig 4E, lanes 2–7) Based on these results, it was tempting to speculate that the high expression of members of the...
- 16
- 754
- 0
Feasibility Study – The critical success factor in project management pot
... operational phase • Other issues : copy right, social issues, trade name, ( if any) cost to manage these issues? • Training requirements/cost to make sure the operation • Risk factor risk management ... design • Until the time of F/S completion, project owner just spent around 5% of total project cost • If F/S confirm that the project is feasible, project owner may invest and they shall spend ... : (1) We employ the professional consultant to proceed F/S and we need one or two good experts to carry out double check (2) We have good experts as project team and proceed the F/S by ourselves...
- 22
- 1,259
- 0
Báo cáo khoa học: Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor–factor VIIa–factor Xa–tissue factor pathway inhibitor pptx
... the sTF mutants was compared with that obtained with the wild-type cofactor and is hereafter referred to as the cofactor activity The ability of the sTF variants to support FX activation in the ... Morrissey, J.H & Johnson, A.E (1997) Tissue factor positions and maintains the factor VIIa active site far above the membrane surface even in the absence of the factor VIIa Gla domain A fluorescence ... situated in the N-terminal portion of the TF2 domain, i.e close to the TF1 domain at the level of EGF1 in FVIIa in the sTF–FVIIa complex (Fig 1) Binding of FXa caused blue shifts in the fluorescence...
- 7
- 450
- 0
Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... with EGF or TGFa before the cells were washed and Hrs was immunoprecipitated from the lysate We chose to stimulate the cells with the growth factors for min, as the growth factor- stimulated phosphorylation ... that the N-terminal part (residues 1–289) and the C-terminal part (residues 287–775) were both phosphorylated, with the latter showing the relatively highest phosphorylation Together with the ... While EGF remains bound to the receptor at the acidic endosomal pH, thus activating the receptor kinase, transforming growth factor a (TGFa) rapidly dissociates and leaves the EGF receptor inactive...
- 7
- 343
- 0
Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... investigate, if the function of the membrane-proximal domains of gp130 is limited to ensure the correct spacing between the CBM and the membrane, each of the domains was replaced by the corresponding ... of the GCSFR The replacement is assumed to compensate for the shift of the ligand-binding epitopes of the receptors The domain architecture of GCSFR is identical to that of gp130; moreover these ... C-terminally to the CBM that play specific roles in activation of the receptor by these two cytokines The ligand independent activation of the D5-GCSFR chimera occurs in both the absence and the presence...
- 11
- 583
- 0
Báo cáo khoa học: Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo ppt
... is the major structural component of the extracellular matrix [1,2] Damage to the blood vessel endothelium results in exposure of fibrillar collagens I and III, both abundant in the sub-endothelial ... several receptors, and the relative contributions of each of them have been intensely investigated [3–5] The initial tethering of platelet to the extracellular matrix is mediated by the interaction ... observed before reaching the final complex state The significance of the two-step binding reaction of the aegyptin– collagen interaction and the possible contribution of the elongated structure...
- 15
- 416
- 0
The Harvard Classics Volume 38, by Various Copyright laws are changing all over the world. Be sure to check the copyright laws for your country before downloading or redistributing this pdf
... as it were, the soil; the tenets of our teacher are, as it were, the seed; instruction in youth is like the planting of the seed in the ground at the proper season; the place where the instruction ... against the wall, their features all changed, and they neither saw, heard, nor spake, and their clothes were still smouldering where the gunpowder had burned them As I was looking at them with ... extensive travel He is said, though the evidence is unsatisfactory, to have taken part in the efforts to check the great plague which devastated Athens at the beginning of the Peloponnesian war He died...
- 1,509
- 611
- 0
Báo cáo khoa học: Control of transferrin expression by b-amyloid through the CP2 transcription factor pdf
... transcription factors, including nuclear factor- jB and activator protein-1 [34,35] These observations raise the possibility that Ab modulates the transcriptional activity of CP2 To determine whether the ... (Fig 5A,B) Taken together, these findings suggest that Ab enhances the ability of CP2 to bind to the transferrin promoter To determine whether Ab increases CP2 binding affinity to the transferrin promoter, ... (TF-luc mut3) and the forward primer given above for the TF-luc WT construct The amplified promoter sequences were cloned into the HindIII sites of the pGL4.12 basic vector and then FEBS Journal...
- 12
- 371
- 0
Buying a new car? Check the warranty before you sign… doc
... that the fault was there when you bought it In these circumstances you can ask the dealer to repair the car free of charge or replace it Before you buy ask the salesperson these questions • Is the ... www.smmt.co.uk) The code from the SMMT, who represent all sectors of the automotive industry in the UK, says that you are free to get your car serviced anywhere in the UK and still benefit from the manufacturer’s ... the SMMT code which permits servicing by independent garages? • How much will the servicing costs be? (Compare them to other garages in your area) • How much leeway is there if I cannot get the...
- 6
- 306
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25