ccr1 ccr2 and ccr5 mrna expressing cells in relation to the stage of demyelinating activity
báo cáo hóa học: " A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells" pot
... attenuates HSV-induced inflammatory cytokine production by primary glia To confirm the functional status of DAI in glial cells and to begin to determine the relative importance of this innate immune ... shown) and is therefore unlikely to be a contributing factor to neuronal cell death Irrespective of the mediator(s) involved, our findings directly implicate DAI in the initiation of inflammatory ... analysis, and drafted the manuscript VSC participated in the performance of the in vivo viral infections and the isolation of CNS cells MM participated in the preparation of viral stocks and determination...
- 12
- 529
- 0
Báo cáo toán học: " Synthesis and anti-HSV-1 evaluation of new " docx
... virus titre of each sample was determined in terms of 50% tissue culture dose (TCID 50/mL) by endpoint dilution Cytotoxicity The cytotoxicity of the compounds was tested in Vero cells using two methods, ... effect of HSV-1 in Vero cells, at micromolar concentrations, and were minimally toxic to Vero cells resulting in a good SI The MTT assay indicated that compound 1h exhibited a low cytotoxicity ... nearly the same antiviral effects were evaluated for cytotoxicity in Vero cells EC50 and the selectivity index (SI) were determined in parallel Several of the new compounds prevented the cytopathic...
- 24
- 433
- 0
Đáp án đề thi thử đại học toán khối A- lần 1 - THPT Nga Sơn
... 11 ⇔ m = 2011 phương trinh cho có nghiệm Vậy m = 2011 giá trị cần tìm 0,50 II Giải phương trình: 3(2 cos x + cos x − 2) + (3 − cos x)sin x = sin x = ⇔ (2sin x − 3)( sin x + cos x) = ⇔ ... π + kπ (k ∈ ¢ ) 0,50 0,50 0,25 0,25 0,25 0,25 π Tính I = ∫ III π π I =∫ π cot x sin x + cot x cot x sin x + sin x dx dx 0,25 π π → t = 3; x = → t = 3 t t dt = ∫ dt = + t = − + t2 + t2 Đặt t = ... B VI.a M (1;1) C Dễ thấy đường thẳng (d ) : x − y − = không tạo với trục to độ góc 450 nên BC không song song với trục to độ (d ) có hệ số góc , gọi k hệ số góc k = k− = ⇔ 2k − = ⇔ BC ta...
- 6
- 315
- 0
Báo cáo khoa học: A (1fi3)-b-D-glucan recognition protein from the sponge Suberites domuncula Mediated activation of fibrinogen-like protein and epidermal growth factor gene expression pot
... curdlan or laminarin After binding of the carbohydrate to the receptor, the expression of the gene coding for the binding protein increases In turn, the potential scavenger molecule, a fibrinogen-related ... in response to curdlan: Northern blotting To assess the effect of curdlan and its subsequent binding to the cell surface [probably to the (1fi3)-b-D-glucan-binding protein] on the expression of ... expression of the (1fi3)-b-Dglucan-binding protein in the cells of the pinacoderm, can be expected for fibrinogen or the related molecules, e.g ficolins, which are involved in host defense [48] Therefore,...
- 14
- 299
- 0
Báo cáo Y học: Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein doc
... height of the other bars indicates the relative amount of NICN1 mRNA in the other tissues (A) In the human Northern blot, NICN1 signal intensities were normalized with respect to the b-actin signals ... uniform staining of the mouse embryos (data not shown) indicating the presence of Nicn1 transcripts in all tissues of the developing embryos at the investigated developmental stages 5244 B Backofen ... membrane-anchoring domain Fig Alignment of the nicolin amino acid sequences of human, mouse, and dog Dashes represent identical amino acids The positions of the exon boundaries with respect to the protein...
- 6
- 450
- 0
báo cáo khoa học: "Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene" potx
... interaction involves the N-terminus (amino acids 1-40) and midregion (amino acids 323-428) of Menin and requires the N-terminus of JunD (amino acids 8-70) Menin’s tumor suppressor involves direct binding ... described in the literature data It is a point mutation in exon of MEN1 gene, in nucleotide 134 substituting Adenosine to Thymine, changing the Glutamic acid (GAG) to Valine (GTC) in the menin molecule ... Page of adrenalectomy and nephrectomy of the ectopic left kidney Parathyroidectomy was postponed until the development of clinical or laboratory findings compatible to hyperparathyroidism The...
- 7
- 412
- 0
Báo cáo y học: "Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells" pot
... complement of various prostaglandin synthases, and expression of prostaglandin receptors [16] Here, depletion of PIN1 and inhibition of calpain each caused overinduction of both COX-2 and iNOS The consequences ... than zVF for calpain relative to cathepsin activities [29,30], also increased the induction of COX-2 in KD and Control cells zVF did not increase the induction of COX-2 mRNA in cells treated with ... of COX-2 in the cycloheximidetreated KD cells, allowing zVF to further suppress turnover It may also explain the ability of calpain inhibitors to increase induction of COX-2 in both KD and Control...
- 9
- 457
- 0
Báo cáo y học: "Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein" doc
... 12 amino acid residues However, the reported finding that the HTLV-1 Gag protein could bind to a amino acid domain of CD82 (another tetraspanin member) and use this interaction to enter the host ... have other compensating strategies to overcome the delay of viral infectious cycles due to capsids aggregating in the nucleus in the absence of CTMP-7 The tetraspanin superfamily member proteins ... Alto, CA, USA) and pBV220 (China CDC) were produced and purified according to standard protocols for further plasmid construction The primers used to obtain the sequences of the UL35 gene and...
- 12
- 302
- 0
Báo cáo khoa học:" A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" docx
... also resistant to HSV-1 infection [24-28] The factors involved in the resistance of DCs and macrophages to productive HSV-1 infection are not known The aim of our study was to determine if STAT1 ... grown in GM-CSF containing media were infected with 10 PFU/cell of McKrae At the indicated times post infection the cells were harvested and reacted with Annexin-V or 7-ADD dye to analyze apoptosis ... compared to the permissiveness of APCs in STAT1-/- mice to HSV-1 replication, did not appear to play an important role in protecting mice against either death or corneal scarring STAT1 is one of the...
- 13
- 266
- 0
Báo cáo khoa học: " A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" pps
... also resistant to HSV-1 infection [24-28] The factors involved in the resistance of DCs and macrophages to productive HSV-1 infection are not known The aim of our study was to determine if STAT1 ... grown in GM-CSF containing media were infected with 10 PFU/cell of McKrae At the indicated times post infection the cells were harvested and reacted with Annexin-V or 7-ADD dye to analyze apoptosis ... compared to the permissiveness of APCs in STAT1-/- mice to HSV-1 replication, did not appear to play an important role in protecting mice against either death or corneal scarring STAT1 is one of the...
- 13
- 468
- 0
Đại số 10 ban A từ tiết (1-21)
... đồ thị hàm số minh hoạ cho học sinh ? Hãy biểu diễn hàm số a) ;b) không dấu giá trị tuyệt đối ( gọi học sinh lên bảng) * GV gọi học sinh vẽ đồ thị hàm số mặt phẳng to độ, học sinh khác trả lời ... (0;8) ? Vẽ đồ thị hàm số vừa tìm đợc ( học sinh vẽ đồ thị ) * GV gọi học sinh đứng chỗ trả lời câu hỏi để có câu trả lời cho 23, học sinh trả lời ý to n: ? Cho hàm số y = f(x) Khi tịnh tiến đồ ... cầu: - Củng cố to n kiến thức tập hợp - biết vận dụng phép to n tập hợp biết dùng biểu đồ Ven để biểu diễn quan hệ tập hợp phép to n tập hợp - rèn luyện kĩ thực hành giải dạng to n liên quan...
- 46
- 407
- 0
ĐỀ THI THỬ ĐẠI HỌC CAO ĐẲNG NĂM 2010 MÔN TOÁN KHỐI A ĐỀ 1
... ( x2 + ) Giải phương trình : sin x sin 3x + cos3 x cos 3x =− π π ta n x − ta n x + 6 3 π π π π Điều kiện : sin x − sin x + cos x − cos x + ... a n x + = t a n x − cot − x = −1 6 3 6 6 3 sin x sin 3x + cos x cos 3x 1 Phương trình : = − ⇔ sin x sin 3x + cos3 x cos 3x = 8 π π ta n x − ta n x + 6 3 ... B,C ∈ (0; π ), A + B + C = π t a n t a n + t a n t a n + t a n t a n = 2 2 2 C A−B C Khi P = sin A + sin B − cosC = cos cos − cos2 + 2 C A−B A−B P = −2(cos − cos ) + + cos2 ≤ 2 2 2 2π 2− π C...
- 5
- 255
- 0
KỲ KSCL THI ĐẠI HỌC NĂM HỌC 20122013 LẦN 1 ĐỀ THI MÔN TOÁN KHỐI A, A1 SỞ GD&ĐT VĨNH PHÚC
... x0 - 2) 1,0im sin x + cos x + 5sin x - cos x- cos x - = (1) k: cos x p x + k 2p, k ẻ Â. 0.25 (1) sin x + cos x + 5sin x - cos x - =0 0.25 cos x(2 sin x - 1) - (2 sin x - 5sin x + 2) =0 p ... HNGDNCHMMễN:TONư KHIA,A1 I.LUíCHUNG: ưHngdnchmchtrỡnhbymtcỏchgiivinhngýcbnphicú.Khichmbihcsinh lmtheocỏchkhỏcnuỳngvýthỡvnchoimtia. ưimtonbitớnhn0,25vkhụnglmtrũn. ưVibihỡnhhcnuthớsinhkhụngvhỡnhphnnothỡkhụngchoimtng ... 16 sin 2x cos x sin xứ ố ( ) ( ) = ộ tan x + tan x + cot x + cot x ự - 16 sin 2x ỷ ( ) ( ) = tan x + cot x + tan x + cot x - 16sin 2x ổ pử tan x cot x + tan x cot x - 16sin x = 16 (1 - sin x...
- 7
- 1,268
- 33
Tài liệu Đề thi tuyển sinh đại học, cao đẳng năm 2010 môn Toán - Khối A (Đề 1) pdf
... ( x2 + ) Giải phương trình : sin x sin 3x + cos3 x cos 3x =− π π ta n x − ta n x + 6 3 π π π π Điều kiện : sin x − sin x + cos x − cos x + ... a n x + = t a n x − cot − x = −1 6 3 6 6 3 sin x sin 3x + cos x cos 3x 1 Phương trình : = − ⇔ sin x sin 3x + cos3 x cos 3x = 8 π π ta n x − ta n x + 6 3 ... B,C ∈ (0; π ), A + B + C = π t a n t a n + t a n t a n + t a n t a n = 2 2 2 C A−B C Khi P = sin A + sin B − cosC = cos cos − cos2 + 2 C A−B A−B P = −2(cos − cos ) + + cos2 ≤ 2 2 2 2π 2− π C...
- 5
- 440
- 0
Tài liệu Đề và đáp án luyện thi đại học 2010 khối A-B-C-D đề 1 pptx
... ổ 1ử Khong cỏch gia cỏc im cc tiu: d = m - m + = ỗ m - ữ + ị Mind = m = ố 2ứ p Cõu II: 1) PT sin3 x - 2sin 2 x + 3sin x + = sin x = -1 x = - + kp ỡ x - x y + xy - y3 = (1) ù ộx = y 2) Ta ... x > 0, y > 0, x + y = ị < xy Ê ổx + ốy P= ỗ yử 22 + = Du "=" xy x = y = Vy, minP = ữ + xứ xy II PHN T CHN Theo chng trỡnh chun Cõu VI.a: 1) C i xng vi A qua ng thng d ị C(3; 1) ỡB, D ẻ d ... ad1 ợ ỡx = + t ù ớy = + t ùz = - t ợ ộa = - i 2 Cõu VII.a: z1 + z2 = -4i a2 = -2i a = -1 + i Theo chng trỡnh nõng cao Cõu VI.b: 1) (C): x + y - x - y + = ị Tõm I(3; 1), bỏn kớnh R = ỡd ( I...
- 2
- 572
- 1
Tài liệu A resource for reading and words part 1 ppt
... To adapt: To make suitable for To grumble: To complain Generation gap: Failure of the younger and older generations to understand each other To mention: To talk about To be of the opinion: To ... life the old are better in understanding the young the young are worse in adapting themselves to changes they are both living in the same world PASSAGE MEMORY There is no simple answer to the ... so that they could buy themselves lots of balloons and streamers to decorate their house VOCABULARY DEFINITIONS To be impatient for: To long for, to look forward to To bake: To cook in the oven...
- 15
- 706
- 3
Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt
... it is the availability of manganese that is the limiting factor determining the amount of functional metalloradical cofactor obtained In addition, relatives of corynebacteria belonging to the genus ... bulk of larger iron proteins In summary, our protocol led to the enrichment of highly active R2F, in which at least 50% of the original radical concentration of the metallocofactor was retained ... species Here, the source of the native R2F-protein of the C ammoniagenes ribonucleotide reductase were transformants from the reintroduction of the nrdF gene into the strain of its origin description...
- 14
- 872
- 0
Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf
... blotting) the concentrations of the caveolin-1 and caveolin-3 proteins in the caveolae of cells stimulated with IL-1b in order to determine whether caveolin synthesis is also modulated by PUFA incorporation ... role in the regulation of cell proliferation, including SMC, by inhibiting signalling molecules [45–47] Caveolin-3 is the main isoform in muscle cells, including SMC [30] Caveolin-1 and caveolin-3 ... Egr-1 mRNA accumulated in response to IL-1b In contrast, EPA and DHA completely impeded IL-1b-induced egr-1 gene expression In the light of these findings, we wished to determine the ability of the...
- 12
- 499
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25