basic principles of clinical pharmacology ppt
Chapter 005. Principles of Clinical Pharmacology (Part 2) ppt
... P-glycoprotein, the product of the normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5-2). The extent of absorption may be reduced because a drug is incompletely released from its dosage form, undergoes destruction at its site of administration, ... aInhibitors affect the molecular pathway, and thus may affect substrate. bClinically important genetics variants described. A listing of CYP substrates, inhibitors, and inducers is maintained at http://medicine.iupui.edu/flockhart/table.htm....
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PRINCIPLES OF CLINICAL PHARMACOLOGY Second Edition potx
... the basic principles of clinical phar-macology currently are being applied in the process of drugdevelopment.Journals Clinical Pharmacology and TherapeuticsBritish Journal of Clinical Pharmacology Journal ... (1)BACKGROUND Clinical pharmacology can be defined as the study of drugs in humans. Clinical pharmacology often iscontrasted with basic pharmacology. Yet applied is amore appropriate antonym for basic ... effective use of medicine can be traced back at least to RudolphBucheim (1820–1879), who has been credited with1 PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION20 Principles of Clinical Pharmacology Therefore,...
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Chapter 005. Principles of Clinical Pharmacology (Part 1) pps
... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of the discipline of clinical...
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Chapter 005. Principles of Clinical Pharmacology (Part 3) docx
... intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology (Part 3) Clinical Implications of Altered Bioavailability Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than any physiologic space. For example, the volume of distribution of digoxin and tricyclic antidepressants is hundreds of liters, obviously...
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Chapter 005. Principles of Clinical Pharmacology (Part 4) ppsx
... Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of several ... volume of distribution of lidocaine is reduced. Therefore, lower-than-normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid toxicity. Rate of Intravenous ... prevent elimination by very rapid (t1/2 of seconds) uptake into erythrocytes and endothelial cells before the drug can reach its clinical site of action, the atrioventricular node. Plasma...
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Neuroimmunology of the Skin Basic Science to Clinical Practice ppt
... [48].4.2 Receptors of Innate ImmunityThe cells of the innate immune system rely on a series of germ line-encoded receptors to accomplish the tasks of rapid response to and eradication of invading ... the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other ... way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version,...
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Basic & Clinical Pharmacology ppt
... The rate of absorption is determined by the site of administration and the drug formulation. Both the rate of absorption and the extent of input can influence the clinical effectiveness of a drug. ... metabolism of more than 50% of the clinically prescribed drugs metabolized by the liver. The involvement of individual P450s in the metabolism of a given drug may be screened in vitro by means of selective ... extrapolations must be considered tentative. Chapter 5. Basic & Clinical Evaluation of New Drugs Basic & Clinical Evaluation of New Drugs: Introduction * Acknowledgment: I thank Wallace...
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Tài liệu Principles of Public Speaking ppt
... 30-Jan Interviews, a preparation for Speech of Introduction A, J 2-Feb SPEECH OF INTRODUCTION S, F 4-Feb SPEECH OF INTRODUCTION S, F 6-Feb SPEECH OF INTRODUCTION S, F, J 9-Feb Organizing the ... incorporate each of the previous speaking purposes, with the additional task of cooperating in a team of approximately 4 to craft an extended presentation (no more than 45 minutes) on a topic of your ... outside of our class and write a thoughtful critique of the speaker. In 2-3 pages, you should discuss topics such as the strengths and limitations of the speaker’s style, organization of content,...
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Tài liệu OECD Principles of Corporate Governance ppt
... Part Two Annotations to the OECD Principles of Corporate Governance 9 © OECD 2004 OECD Principles of Corporate Governance The OECD Principles of Corporate Governance were originally ... board, subject to the approval of the shareholders. Some companies issue preferred (or preference) shares which have a preference in respect of receipt of the profits of the firm but which normally ... the possibility of market manipulation. OECD PRINCIPLES OF CORPORATE GOVERNANCE – 33 © OECD 2004 A. Basic shareholder rights should include the right to: 1) secure methods of ownership...
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Tài liệu OECD Principles of Corporate Governance pptx
... 92-64-01597-326 2004 02 1 POECD Principles of CorporateGovernanceOECD Principles of Corporate GovernanceSince they were issued in 1999, the OECD Principles of Corporate Governancehave gained ... corporate officers may not only violate the rights of stakeholders but also be to the detriment of the company and its shareholders in terms of reputation effects and an increasing risk of future ... board. Each of the sections is headed by a single Principle that appears in bold italics and is followed by a number of supporting sub -principles. In the second part of the document, the Principles...
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