... to be related to the expression of granuphilin ⁄ slp4 in insulin-producing cells [28]. More-over, miR9 and other neuronal miRs includingmiR125b and miR128, are involved inthe Alzheimer’disease ... miRs are then incorporated into the RNA-induced silencing complex and bound to the 3Â-UTR of its target mRNA to induce either mRNA degrada-tion or translational inhibition [2,14,15]. Interestingly,unlike ... amplifiedusing the primer pairs listed in Table 1, and then sequencedto determine the orientation ofthe fragments inthe repor-ter vector. These constructs were then transfected into P19cells...
... affecting the activity of ricin A chain (Eur. J. Biochem. 271 ) 1 57 involved the modification of arginyl residues 196, 213, 234and 235 [9]. Of theses residues, only Arg213 is in the vicinity ofthe ... UK).R258R213R180N78D75E 177 R134Y123Y80N122R258R213R180N78E 177 D75R134Y123Y80N122R258R213R180N78D75E 177 Y123Y80N122R134R258R213R180N78E 177 D75Y123Y80R134N122ABFig. 1. Models of hexanucleotide binding inthe active site of ... crystal-lography. Protein Eng. 5, 77 5 77 9.16. Chaddock, J.A. & Roberts, L.M. (1993) Mutagenesis and kineticanalysis ofthe active site Glu 177 of ricin A chain. ProteinEngineering 6, 425–431. 17. Day,...
... which the funds of funds data are included inthe other fund categories; (3) net sales of non-UCITS are included in "other" funds, except net sales of special funds, which are shown in ... 4,342 -5 .7% 4,1 17 -0.6%Denmark 72 ,325 1.2% 70 ,4 27 2 .7% 65,856 9.8%Finland 51,440 0.9% 51,680 -0.5% 48,066 7. 0%France 1,1 07, 504 18.6% 1,132, 372 -2.2% 1,068,141 3 .7% Germany 230 ,79 2 3.9% 238 ,73 6 ... DDoommiicciilliiaattiioonn The combined assets ofthe investment fund market in Europe, i.e. the market for UCITS and non-UCITS, increased by 0.9 percent inthe second quarter of 2012 to stand at EUR 8,4 37 billion,...
... stability of Pe Hb relative to other more autoxidizable globins. Areliable indicator ofthe dynamic stability of distal hemepockets in globins is the rate of reorientation ofthe aromaticrings inthe ... E7 as the source ofthe H-bond to ligand on the basis of apartial sequence, which had indicated a Tyr on the distalE-helix. The similarity in the 1HNMRspectraofthethree globin complexes in ... between the projection ofthe tilt ofthe z axis on the xÂ,y plane (dened direction of tilt of z and the x axis), and j % a + c denes the location ofthe rhombic (x, y) axes. The orientation of the...
... best further the cause of an invigorated poli-tics of landscape? Reasserting the importance of landscape aesthetics A fine mess we’re in, JackieA clearing inthe bush The trees are all ... philosophy of aesthet-ics: is landscape quality inherent inthe landscape or inthe eye of the beholder?’, Landscape and Urban Planning 44 (4): 177 –198.LUND, K. (2005): ‘Seeing in motion and the touching ... disempowering effect on local inhabit-ants, at worst obliterating them from the history of the landscapes in which they live and from whichthey make their living.History provides many instances of...
... Hospital, including PHC data ofthe statements made by the mid-wife in her records ofthe check-up ofthe mothers during the pregnancy ( 17) . In the follow-up at the age of seven, n= 191 children of ... suffering neonatal death and those living outside the region, were included inthe study. At the age of seven, all of them still living inthe region were included in a follow-up of their ... period, that their parents negated their ever having had asthma. Study limitations An implication of our findings regards the qual-ity ofthe information given to the parents when the Int. J....
... 90% ã 3 7 Tụi bit mt bộ gỏi lỳc nào cũng thích chạy ra hiên trướcnhà. Mẹ cô bé phải chạy theo, nhắc bé đi vào trong. Một lầncô bé ra ngoài hiên nhưng lúc đó bà mẹ đang bận nên khôngchạy theo ... Biểu đồ 7 Thói quen và các định nghĩa ở trang 5 07. Hãy kiên nhẫn.Làm từ từ. Hãy tôn trọng khả năng nhận thức của mỗi thànhviên trong gia đình. Đừng áp dụng ồ t tt c nhng iu bn3 4 ã 7 THểI QUEN ... chúng tôi thấy việctuân theo những nguyên tắc này rất khó. Nhưng nếu khôngtuân theo thì còn khó hơn rất nhiều”. Gieo nhân nào, gặt quảấy, những hành động không tuân theo nguyên tắc sẽ gây ranhiều...
... regard to providing value beyond the intrinsic value ofthe product. SOCIAL MEDIA AND THE 7 STEPS OF BUILDING A NEW MEDIA STRATEGY CAPABILITIES: DIGITAL AND SOCIAL MARKETING STRATEGY AND ... lead back to the center of your strategy – your website; the digital embodiment of your brand. OLD MARKETING MODELTarget the Audience and use interruptive techniques to convince. It was ... APPLEGOOGLENORDSTROM’SSTARBUCKSNIKEINNOVATIONACCESS TO INFORMATIONCUSTOMER SERVICEGREAT COFFEESPORTS PICK ONE.WHAT IS THE POINT OF THIS INITIATIVE IS IT AWARENESS? SALES? CUSTOMER LOYALTY?...
... wake at 6 a.m., but nap for two hours or so inthe early afternoon. Thus the influence on one's sleep pattern is worthy of consideration when choosing an occupation. ...
... households, but the number of hours women work inthe home rises to 52 per week, much of it, on doubt, due to childcare responsibilities. Interestingly, when there are three or more children inthe household, ... children enter the household, however, the inequality becomes even more pronounced. In families of 1 - 2 children, men maintain approximately the same number of hours of unpaid work as in childless ... actually represents a decrease. The data suggest that the increased presence of women in the paid work force has yet to lead to an increased role for men inthe home. ...
... process, helps determine production planning. A product's design is not only the result of product research, but is also influenced by testing and market research. If the testing stage (after ... assembly and inspection) reveals unacceptable problems in the finished product, then adjustments will have to be made to the product's design. Similarly, market research, which examines the extent ... serves to foster future sales by devising suitable advertising for the goods. Thus the reality of consumer goods manufacturing goes well beyond a simple linear production process. ...
... variety of routes including pronuclear microinjection and SMGT [74 , 75 , 76 ]. Inthe context of human germline gene therapy, such vectors offer the potential advantage of eliminating the threat ... within the posterior part ofthe nuclear area ofthe head, the inference being that binding of DNA by the sperm is followed by internalisation [49, 50]. Int. J. Med. Sci. 2004 1(2): 76 -91 ... 13], then 1 in 8 ofthe resulting individuals would contain no transgene sequences, another 1 in 8 would contain transgene sequences in 100% of their cells, and the remaining 6 from 8 individuals...