an emerging concept for the legal analysis of the governance of science
Báo cáo hóa học: " Strategy Escalation: An emerging paradigm for safe clinical development of T cell gene therapies Richard Paul Junghan" pdf
... under Strategy 3, an appropriate dose escalation plan affords the best chance to define an optimal biologic dose (OBD) to establish proofof -concept anti-tumor activity and conditions of safety to ... immortalization For infusion protocols, the impact on quantity is incremental and manageable (versus the quantum changes for engraftment) and likely does not create new types of risks for 1st or 2nd ... Prostate Cancer Research Program and from the US Army Breast Cancer Research Program for the development and elaboration of this essay These concepts were originally presented at the 2nd "Cellular Therapy...
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báo cáo hóa học:" The HIV-1 Non-subtype B Workgroup: An International Collaboration for the Collection and Analysis of HIV-1 Non-subtype B Data" pot
... instruments and uniform protocols, is essential to the analysis of non-B resistance This is crucial as access to antiretroviral therapy in the developing world increases within the next few years, and ... established an international workgroup for the collection and analysis of RT and protease sequences and data from persons infected with non-B HIV-1 subtypes Currently, the workgroup consists of investigators ... subtypes B and C reverse transcriptase and protease sequences Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections; February 811, 2004; San Francisco, California...
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Báo cáo y học: "An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data" pot
... One advantage of this is that both high- and low-confidence probesets can be included in the initial analysis, since they can later be excluded if necessary on the basis of, for example, their ... known software products for standard arrays, and their major analytical aims overlap with those available in exonmap and BioConductor/ R, that is, differential expression analysis and splicing analysis ... possibility of low-level 'leaky transcription' [8-10] At the time of writing a total of 31,718 genes are represented in the Ensembl human database, of which 11,241 (35%) have more than one annotated transcript...
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Designing an esp syllabus for the second-year students of library study at the national teachers training college
... students and other subjects at any other levels of English language proficiency would be beyond the scope The significance of the study It is hoped that the study can be both practically and theoretically ... needs but its restricted to the area of language not the whole of language And the criticism falls on its static procedure and it can only cover the surface of the performance 1.2.4.2 Skills- centered ... out that the initial step in the process of designing a syllabus is to carry out a needs analysis to assess the needs of the learners Basing on the result of this analysis, the aim and the objectives...
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Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc
... analysis, and the determination of released ammonia The coupled enzyme assay revealed the mechanism of the deamination reaction and the subsequent metabolism, including the deamination step The ... deaminases [6,8,27] or to any other sequences available in FASTA and BLAST database programs at the DNA Data Bank of Japan Recently, we reported the cloning and sequencing of the gene encoding 4-amino-3-hydroxybenzoate ... spectrophotometer and spectra were recorded every (C) Enlargement of the original plots shown in (B) present in cell extracts of succinate/glucose-grown cells; therefore, the synthesis of the enzyme...
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Báo cáo khoa học: Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases pot
... active form and were not further modified before kinetic analysis Enzymatic activity of all wild-type EPH RTKs and EphA3 mutants (N830A and K785N) were determined using the ADP-Quest Kit and following ... domain and the EPHOPT peptide did not result in the full ordering of the AL; instead, the N-terminal part of the AL was found ordered to residue Asp774, whereas the C-terminal part of the AL ... between the EphA3 kinase domain and the EPHOPT substrate not effect large conformational changes in the N- or C-terminal lobes of the kinase (Fig 2A) There is slight movement in the aF–aG loop in the...
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solvothermal reactions- an original route for the synthesis of novel materials
... properties of the selected solvent can also play an important role for orienting the structural form of the final material Lu et al [24] have underlined that the solvothermal synthesis of MnS can lead ... important for either the synthesis of novel materials, the preparation of nanostructured particles for nanotechnologies or the elaboration of bio-inspired materials for applications in Biosciences ... concentration of the precursors The interactions between reagents and solvent play an important role in the solvothermal reactions The selection of the solvent plays a key-role through the control of the...
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AN ENGLISH GRAMMAR FOR THE USE OF HIGH SCHOOL, ACADEMY, AND COLLEGE CLASSES pot
... the above cases are shiftings of the use, of words rather than of their meaning We seldom find instances of complete conversion of one part of speech into another When, in a sentence above, the ... have lost their original meanings The word vixen was once used as the feminine of fox by the Southern-English For fox they said vox; for fromthey said vram; and for the older word fat they said ... hand for every pupil to observe without the use of apparatus of any kind while the use of them also lies within the personal experience of every one.—DR RICHARD MORRIS The proper study of a language...
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The imPact of high and groWing government debt on economic groWth an emPirical inveStigation for the euro area docx
... over the period of the analysis, as well as for economic and monetary regime changes, such as the creation of the monetary union and the introduction of the euro A list of the variables used in the ... in the analysis: Austria, Belgium, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, and Spain The table shows the estimated coefficients and their significance ... Britannica, the national debt of England was initiated to finance the British participation in the war of the Grand Alliance with France during 1689-1697 In the United States, the newly-formed federal...
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Báo cáo khoa học: "AN EXPERT SYSTEM FOR THE PRODUCTION OF PHONEME STRINGS FROM UNMARKED ENGLISH TEXT USING MACHINE-INDUCED RULES" pdf
... account of the selection of these features is beyond the scope of this paper, an example of an input word and the appropriate attribute values should give the reader a better grasp of the word-level ... again in the same context, the SEL would contain the exception to the transcription rule, prohibiting the application of the stress rule The information from the SEL (and from the CEL at the clusterlevel) ... whose branch nodes would be tests of the form "if has-fur is true then branch-left else branch-rlght" and whose terminal nodes would be of the form "the animal in question is a mammal." The premls...
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Báo cáo khoa học: "An Intermediate Representation for the Interpretation of Temporal Expressions" ppt
... motivate an intermediate form of representation that represents a ‘context-free’ semantics of the expression The role of the recognition process is then to compute as much of the semantic content of ... Hobbs and Feng Pan 2004 An ontology of time for the semantic web ACM Transactions on Asian Language Information Processing, 3(1), March M Negri and L Marseglia 2005 Recognition and Normalization of ... Proceedings of the Coling/ACL2006 Workshop on Annotating and Reasoning about Time and Events L Ferro, L Gerber, I Mani, B Sundheim, and G Wilson 2005 TIDES 2005 Standard for the Annotation of Temporal...
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AN EMERGING GIANT: PROSPECTS AND ECONOMIC IMPACTS OF DEVELOPING THE MARCELLUS SHALE NATURAL GAS PLAY ppt
... the Department of Energy and Mineral Engineering at the Pennsylvania State University Dr Watson is also the Chairman of the Technical Advisory Board to Oil and Gas Management of the Pennsylvania ... and how the functioning of these industries affects local economies The following sections estimate the economic impacts of the industry during 2008 and for the next decade The emergence of the ... with a summary of our major findings, an analysis of the net revenue impacts of a proposed severance tax, and a discussion of policies that affect the long-term health and vitality of the industry...
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Báo cáo hóa học: " An analytical model for the intercell interference power in the downlink of wireless cellular networks" ppt
... approximated analytical expression for the pdf and the cumulative distribution function (cdf) of the intercell interference power; • We propose a semi-analytical method for the estimation of the pdf of the ... comparing the moments of the estimates to the exact moments of the distribution which can be derived analytically Using this methodology, we are able to provide a very good estimate of the pdf of the ... (from the integral-form cdf), followed by non-uniform partitioning, and then inversion, of the cdf Then, we generate a typical set for N interferers using an appropriate combination of the (weighted...
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Báo cáo hóa học: " An alternative route for the synthesis of silicon nanowires via porous anodic alumina masks" potx
... dimensions These nanoparticles necessarily have a size smaller than the pores of the AAO mask and will be responsible for the constant dimensions of the synthesized nanowires Figure shows the surface of ... structure of the membrane and before the treatment conditions allow the nanowires growth As can be seen there, the catalyst can be observed as small particles inside the porous structure of the mask ... b) and Pt (c, d) as catalyst The inset of (a) shows a histogram of the Si NWs diameter distribution The inset of (b) shows the Au nanoparticle The inset of (c) corresponds to the EDX analysis of...
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Báo cáo hóa học: " Dance-the-Music: an educational platform for the modeling, recognition and audiovisual monitoring of dance steps using spatiotemporal motion templates EURASIP Journal on Advances in Signal Processing 2012," doc
... Section the technological and conceptual performance and future perspectives of the application Instruction method In concept, the Dance -the- Music brings the traditional demonstration-performance ... perform, the tempo of the music, the number of steps per dance figure, the amount of training cycles, etc (see module and 2, Figure 1) Then, the teacher can record a sequence of a repetitive performed ... dots and purple trajectories define the displacement patterns of the right foot, the green dots and yellow trajectories the ones of the left foot, and the black dots and trajectories the ones of the...
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Báo cáo toán học: "An Asymptotic Expansion for the Number of Permutations with a Certain Number of Inversions" docx
... and using the symmetry of the integrand For an integer n ≥ and real numbers a, b and x, let b n I(n, x, a, b) := a =2 sin t xtn3/2 cos sin t dt and π (where all discontinuities of the integrand ... O(n−9/2 ln19 n) The following extension of Theorem (the case m = 3) giving a complete asymptotic expansion of I(n, x) can be immediately read out of its proof the electronic journal of combinatorics ... error term in the first equation holds uniformly for all real numbers x by the comments after (15) and, since | cos(ux)| ≤ 1, the error term in the second equation holds uniformly for all real...
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Báo cáo khoa học: "An experimental system for the quantitative C-labelling 14 of whole trees in situ" pps
... of the total 14 taken up by the plant under conditions of minimum perturbation This was the basis of the system we designed for the labelling of whole trees sen DESCRIPTION AND PERFORMANCES OF ... photosynthesis and ac2 cumulation of a significant amount of heat and water vapour; the rate of photosynthesis can be significantly altered by these modifications in the environment Although the ... transmittance of the plastic materials in the thermal IR range (between 2.5 and 25 μm; Dogniaux and Nisen, 1975), and low convection (closed circuit conditions), the temperature of the air inside the...
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Báo cáo khoa học: "Improved survival following surgery and radiation therapy for olfactory neuroblastoma: analysis of the SEER database" pdf
... Cancer Institute, Buffalo, New York, USA Authors’ contributions MEP and TLM reviewed the SEER database for OFN cases and performed the statistical analysis MEP, TLM, MM, and AKS wrote the manuscript ... surgery and radiotherapy, 68% for surgery only, 35% for radiotherapy only, and 26% for neither surgery nor radiotherapy There was a significant difference in overall survival between the four ... authors reviewed the statistical analysis results, contributed to the interpretation of the results and read and approved the final manuscript Competing interests The authors declare that they have...
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Báo cáo khoa học: "Clostridium difficile-associated diarrhea in radiooncology: an underestimated problem for the feasibility of the radiooncological treatment" doc
... immunosupressed The influence on the feasibility of the radiooncological therapy in terms of interruption or abandonment of the radiotherapy, change of therapy concept and the effect on the feasibility of ... Meta -analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients Radiother Oncol 2009, 92:4-14 43 Foote: The Importance of Planned Dose of ... describes an incidence of 0,1% for Europe and an incidence of 0,1% to 2% for the USA [3] Heinlen et al could found an incidence of 0,6% for the USA in the year 2003 [28] Especially the patients...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25