administration u s department of health and human services provides the table of valid genomic biomarkers in the context of approved drug labels 2007 http www fda gov cder genomics genomic biomarkers table htm
Use of upconversion fluorescent nanoparticles for simultaneous imaging, detection and delivery of sirna
... diagnostic assays since the same light source is used for simulataneous excitation of these nanoparticles and also their emission bands are narrow without overlapping The emission spectra of the ... that specifically targets integrin αvβ3-positive tumor vasculature was intravenously administered into mice bearing subcutaneous U8 7MG human glioblastoma tumors The tumor fluorescence intensity ... This thesis is hereby submitted for the degree of Doctor of Philosophy in the Division of Bioengineering at the Faculty of Engineering, National University of Singapore This thesis, either in...
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In vitro and in vivo evaluation of transferrin conjugated lipid shell and polymer core nanoparticles for targeted delivery of docetaxel
... nanocarriers will vary with tumor types and anatomical sites (ii) The high interstitial fluid pressure of solid tumors avoids successful uptake and homogenous distribution of drugs in the tumor (Heldin ... tumors selectively through the leaky vasculature surrounding the tumors (2) Schematic representation of the influence of the size for retention in the tumor tissue Drugs alone diffuse freely in and ... microtubules by binding specifically to β-tubulin In contrast, the taxanes prevent the microtubules from depolymerisation by binding to the β-tubulin subunits of the microtubules during the mitotic...
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báo cáo khoa học: " Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts" potx
... wall synthesis [41] CesA subunits assemble in rosettes and these rosettes produce glucan chains The rosettes assemble into microfibrils along the plasma membrane [40] Patches of cellulose Page of ... on the source of protoplasts (i.e plant species as well as the source tissues such as leaf, cotyledons, young shoots, suspension cells) and the voltage applied, losses of 50% viable protoplasts ... mixing of protoplasts and CPNs and could increase the percentage of transfected protoplasts We also observed CPNs binding to debris in the cell cultures The nature of the debris is a mixture of...
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Báo cáo hóa học: " Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution" docx
... within seconds to minutes through the reticuloendothelial system (RES) Imparting a stealth shielding on the surface of these drug delivery systems prevents plasma proteins from recognizing these ... http: / /www. nanoscalereslett.com/content/6/1/563 In vitro drug release study Figure shows the drug release behaviors of the MMCmPEG-FA-NPs in pH 6.3, pH 7.4, and pH 8.3 PBS at 37°C, respectively As the result showed, the drug releases were ... nudes were employed in the biodistribution investigation To investigate the distribution of four kinds of NPs in various organs, the nudes were sacrificed immediately after 12 h of intravenous...
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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt
... this feature is promising in terms of the stability of solutions of CuCNPs over long periods of time, Cu release cannot simply be a function of pH but must also depend on the presence of ligands ... dried CuCNPs is shown in Figure 2A The amount of Cu bound to CuCNPs was investigated using several analytical techniques including: inductively coupled plasma mass spectrometry (ICP MS), X-ray ... including cancer, cardiovascular disease, arthritis, diabetes, Alzheimer s disease, and Parkinson s disease [27] Cancer cells use ROS to suppress apoptosis, accelerate proliferation, induce metastasis...
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Báo cáo hóa học: " Oral Delivery of DMAB-Modified DocetaxelLoaded PLGA-TPGS Nanoparticles for Cancer Chemotherapy" potx
... of differences was assessed using Student s t-test and was termed significance when P < 0.05 Results and Discussions Characterization of PLGA-TPGS Random Copolymer The chemical structure of the ... containing 0.1% w/v Tween 80) to form a suspension Tween 80 was used to increase the solubility of docetaxel in the buffer solution and avoid the binding of docetaxel to the tube wall The suspension ... chemotherapy using docetaxel as a therapeutic drug due to its excellent therapeutic effects against a wide spectrum of cancers and its commercial success as one of the top-selling anticancer agents Reports...
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Báo cáo hóa học: " Fluorescence Modified Chitosan-Coated Magnetic Nanoparticles for High-Efficient Cellular Imaging" pdf
... spots at the surface of some spheres, which suggests that the distribution of the c-Fe2O3 nanoparticles is not concentrated in the core of the spheres, which corresponds well to the size of the ... multi-treating tools However, the synthetic procedure in previous studies requires the multi-step chemical treatments Thus, we synthesize a simple and stable nanoprobe that exhibits magnetic and fluorescence ... diagnosis in vivo as well as monitoring of living cells in situ [15–17] Fluorescent dye molecules and quantum dots (QDs) are most predominantly used for biological staining and optical labeling...
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Magnetic chitosan nanoparticles for removal of Cr(VI) from aqueous solution
... temperature, compared to the other adsorbents (Table 2)), probably relates to the smaller loss of amine groups of chitosan, involved in the cross-linking reaction when using epichlorohydrin as a cross-linker ... capacity of Cr(VI) absorption occurred at pH of The explanation would be addressed as the pH of the aqueous solution affects to stability of chromium speciation and the surface charge of the adsorbent ... was used to detect residue of Cl− The precipitate was then washed with ethanol and dried at 50 °C, in the vacuum oven 1215 of solutions was adjusted by using diluted solution of NaOH and HCl The...
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báo cáo khoa học: "Cationic nanoparticles for delivery of amphotericin B: preparation, characterization and activity in vitro" potx
... rpm/10 minutes), pelleting and resuspension The final fungal cell suspension was prepared by adjusting the inoculum to × 107 cfu/mL and then diluting by a factor of Page of 13 (page number not ... mg/mL PDDA) (Figure 5D) The schematic drawing in Figure 5D illustrates the layered assembly of microbicides in a single supramolecular assembly The first attack comes from the outer cationic polyelectrolyte ... (Figure 7C) revealed the typical profile of aggregated drug The spectrum in Figure 7C indicates a certain amount of monomeric drug not present in the other spectra (Figure 7A and 7B) Possibly,...
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ROMP based polymer nanoparticles for the targeted delivery of antitumor agents
... affecting immature nerve cells, most commonly in the adrenal glands and the sympathetic nervous system ganglia of the abdomen Common drugs used to treat neuroblastoma: Cisplatin -hearing loss and ... apoptosis Tissue invasion & Metastasis Sustained angiogenesis Infinite replicative potential Selectivity of existing cytotoxic chemotherapy for malignant cells over healthy cells is low, resulting ... Ifosfamide Side effects associated with treatment: Nausea, vomiting, hair loss, mouth sores, depression of immune system, bone marrow suppression Most common cancer in infants with 650 new cases...
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Delivery of proapoptotic biomolecules and drugs using amphiphilic block copolymer nanoparticles for anti cancer therapy
... almost intuitive for clinicians Table 1.1 shows some of the various combinations of small molecule drugs and antibodies that have been used in clinical studies Table 1.1 Examples of clinical studies ... increase dose-related side effects and limits the possible dosage As such, the use of drug combination can help evade such problems by reducing the dose of individual agents used [67] Besides the ... dose used, one of the important factors that can greatly interfere with the success of the treatment is the dose scheduling of the drugs involved Appropriate scheduling of drug exposure enables...
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Carboxymethyl chitosan functionalized magnetic nanoparticles for disruption of biofilms of straphylococcus aureus and escherichia coli
... lenses, gingivitis, and the less common but more lethal processes such as endocarditis, infections in cystic fibrosis and infections of permanent indwelling devices such as joint prostheses and ... mg/mL) and CMCS (0.34 mg/mL) on (a) S aureus and (b) E coli suspensions (106 cells/mL) The controls refer to the bacterial suspensions without CMCS or CMCS-MNPs 36 Chapter Results and Discussions ... biofilms in sterile PBS without addition of CMCS or CMCS-MNPs), there is a decrease in the number of viable cells in the S aureus biofilm throughout the 48 h incubation period This finding was consistent...
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Tài liệu KRONE - Catalogue - HighBand - For Broadband delivery - HK- Jun 2000 pdf
... economic prosperity and business expansion, drive the demand for broadband communications infrastructure HIGHBAND allows you to deliver tomorrow s services to your customers today! HIGHBAND T Y P ... R E S Carry the sheath of the cable to the back of the module considering the minimum bend radius as per current standards Prior to termination fan wires with a minimum excess of 20mm over the ... ol Netw Subscr ibe r In te - Distribution Boxes - Building Distribution Frames - Network Interfaces - Protection - Automatic Copper Cross-Connect AUTO CU CC Closures al Splitters ouplers Connection...
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Tài liệu KRONE AccessNET - Opens the Pipe for Broadband Delivery doc
... public access market you’re in, AccessNET has a total connectivity solution tailored to meet the demands of your business AccessNET: The building blocks of your Network In today s fast evolving ... primarily at solving issues in the Local Loop e.g Above and Below ground closure and connection systems, Cross Connection Cabinet solutions (including Remote Cross-Connects), Lightning and Surge protection ... commercial subscribers that solve issues around Network Termination Points, receiving and managing information via POTS, ISDN, xDSL, etc and the primary Distribution Point in the customer s premises I...
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Báo cáo khoa học: NovelN,N¢-diacyl-1,3-diaminopropyl-2-carbamoyl bivalent cationic lipids for gene delivery – synthesis,in vitro transfection activity, and physicochemical characterization docx
... constants, one for each of the ionizable amino groups, resulting in pH titration curves with slopes of lower steepness (C less than unity) The TNS assay was used to ascertain the pKa values of the ... polymethylmethacrylate cuvettes were obtained, using a 633 nm laser, from Gaussian analysis of the intensity-weighted particle size distributions using the instrument software (dispersion technology software ... was measured by uorescence resonance energy transfer using the NBD-Rh FRET pair [26] Lipid mixing occurs in various cellular processes, including lipoplex internalization and fusion of the internalized...
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nanoparticle technology for drug delivery, 2006, p.427
... saturation solubility cs when moving to sizes below mm Because of the strong curvature of the particles, they possess an increased dissolution pressure comparable to the increased vapor pressure of ultrafine ... nanoparticle should be smaller than 300 nm But, just moving in the vessels does not serve the drug delivery purpose The delivery system must reach the site at the destination level This requires crossing ... physical stability of the produced nanosuspensions In the production process the coarse drug powder is dispersed by high-speed stirring in a surfactant/stabilizer solution to yield a macrosuspension...
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Báo cáo hóa học: " Efficient data replication for the delivery of highquality video content over P2P VoD advertising networks" pdf
... This simulation examines the behavior of departure misses, with the unexpected failure of peer departure misses following a random Poisson process During simulation sessions, a default value of ... peers, making them a useful tool for the promotion of advertisements Second, advertising can be obtained not only in the initial stages of searching, but also in the subsequent video sessions In ... channel is the key to success in terms of both advertising effectiveness and VoD service satisfaction using P2P networks Simulation results support the hypothesis that video distortion estimation...
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Báo cáo hóa học: " Functionalized halloysite nanotube-based carrier for intracellular delivery of antisense oligonucleotides" pdf
... surface is composed of siloxane (Si-O-Si) groups, whereas the internal surface consists of a gibbsite-like array of aluminol (Al-OH) groups Even though much less studied than carbon nanotubes, due ... was added, and the suspension was dispersed ultrasonically for 30 The suspension was then refluxed at 120°C for 20 h under constant stirring In the refluxing system, a calcium chloride drying ... discussion The morphologies and structures of HNTs and f-HNTs were first investigated It can be seen from the TEM images (Figure 2a, b) that the HNTs and f-HNTs are hollow tubular structures...
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Báo cáo hóa học: " Catalytic properties of Co3O4 nanoparticles for rechargeable Li/air battery" doc
... type during the electrode fabrication process because of vigorous mixing in making a slurry The crystallinity of the three types of Co3O4 nanoparticles was investigated by XRD As shown in Figure ... competing interests Authors' contributions KS did the synthetic and characteristic works in this journal YJ gave the advice and guided the experiment All authors read and approved the final manuscript ... nanoparticles of various shapes and structures were tested as catalysts of air electrodes for rechargeable Li/air batteries Co3O4 with a spinel structure has attracted a considerable interest as a potential...
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Báo cáo hóa học: "Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol" potx
... release percentage of propofol was calculated The CLE was also tested as control Stability of mixed micelles in bovine serum albumin solution The stability of mixed micelles in bovine serum albumin ... release and stability measurements YZ participated in the experimental setup development, discussions and data analysis All authors read and approved the final manuscript Competing interests The ... embed inside micelles until the micelles decompose, just like the results presented in Table 3, whereas emulsion (CLE) is thermodynamically instable system, partial phase inversion or separation...
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