... actuates a hand piece and forearm trough (T) attached to a user's arm (A) back and forth along a linear track A sixaxis force sensor (F) measures the interaction forces between the user andthe ... statically counterbalanced so that it does not gravitationally load the arm The hand piece consists ofa trough for the forearm anda cm diameter cylinder placed in the palm ofthe user's hand ... the outpatient population at the Rehabilitation Institute of Chicago and from a participant database (Table 1) A power analysis indicated that with ten subjects in each group there would be a...
... (ANOVA) For the first data analysis, treatment and time were the independent factors using all 23 subjects The second analysis separated and analyzed the data according to gender The third analysis ... cardiovascular effects of C aurantium has been due, at least in part, to a lack of understanding ofthe differences in the pharmacokinetic and pharmacological properties between p-synephrine and ... breakpoint of 15 0 mg caffeine per day to separate the two groups Statistical significance was established at p
... et al., 2008; Cui and Jahng, 2004; Kamiya and Hirotsuji, 19 98; Nagare et al., 2008; Sakai et al., 19 97; Saktaywin et al., 2005; Suzuki et al., 2006; Yasui et al., 19 96; Yasui and Shibata, 19 94) ... adsorption column andthe backwash water, was circulated back to the anaerobic tank andthe oxic tank at an appropriate rate (Table 1) Table Operational conditions The hydraulic retention time ... (Fig 1B) During 15 2 days operation ofa lab-scale reactor, the operational conditions were optimized by changing the amount of sludge to be ozonated andthe recirculation ratio ofthe residual...
... concentration of an alkyl nitrite on the horizontal axis and peak area on the vertical axis The concentration ofthe analyte in a specimen is calculated using the calibration curve i Assessment and some ... with a 25 G × 1 needle (0.50 × 25 mm, Terumo, Tokyo, Japan and other manufacturers) and rapidly injected into GC iv Quantitation: a 0.25 mL ofthe same matrix e (without an analyte), 0.5 mL ofthe ... injection to GC, and from the standard solution to a test specimen) In principle, the sampling, extraction and GC analysis should be made at low temperature, in a gastight stateand in a short time...
... (a) a TIC and mass chromatograms; (b) an EI mass spectrum ofthe t-BDMS derivative of EMPA; (c) a CI mass spectrum ofthe same derivative of EMPA data of animals According to the reports by the ... GC/MS analysis for DAEMS in serum (a) a total ion chromatogram (TIC) anda mass chromatogram; (b) an EI mass spectrum of DAEMS; (c) a CI mass spectrum of DAEMS Poisoning case, and toxic and fatal ... construct a calibration curve for DAEMS consisting of peak area ratio of DAEMS to IS on the vertical axis and DAEMS concentration on the horizontal axis A peak area ratio obtained from a test specimen...
... 18 8 Cannabinoids and their metabolites GC analysis of cannabinoids in plant specimensa Reagents and their preparation • • • Extraction and purification of cannabinoids [3]: Cannabis sativa ... of ∆9-THC -11 -oic acid in urine at 50 ng/mL by immunoassay andthe identifiable value ofthe acid by mass spectral measurements at 15 ng/mL Cases of analysis [13 ] Case 1: A 22-year-old male was ... ∆9-THC -11 -oic acid after the TMS and methyl ester-TMS derivatizations 19 1 19 2 Cannabinoids and their metabolites ⊡ Table 2 .1 Diagnostic ions in mass spectra of ∆9-THC -11 -ioc acid, 5α-cholestane and...
... time ofa peak ofa specimen with that ofthe authentic standard and also by the confirmation ofthe absence of such a peak in a blank specimen An HPLC chromatogram for the authentic compounds ... commercially available (GL-SPE Vacuum Manifold, GL Sciences, Tokyo, Japan and some manufacturers in USA); it enables the attachment of 12 cartridges, andthe simultaneous washing, elution and drying ofthe ... specimen obtained from a healthy subject andthe urine specimens spiked with 0 .1 mL each ofthe standard solutions (2, and 20 µg/mL) are also handled in the same way as above ii Each ofthe above solution...
... ofa case J Forensic Sci 24:768–7 71 3) Tanaka J, Horigome H, Imai H et al (19 96) A case of severe methemoglobinemia for a newborn baby caused by well water Jpn J Pediatr 49 :16 61 16 65 (in Japanese) ... (19 71) Methemoglobinemia associated with well water JAMA 216 :16 42 16 43 11 ) Colomy HH (19 87) Cyanosis in infants caused by nitrates in well water JAMA 257:2788–2792 12 ) Fan AM, Steinberg VE (19 96) ... listlessness and metabolic acidosis coma, convulsive attack and hypotension death A poisoning case [4] An unidentified male was found naked from the waist up in a park at about 10 :00 p m.; he was suffering...
... and BE after derivatization Setting up of cutoff values are very common in USA and Europe as a part of QC (quality control) and QA (quality assurance) system; the idea is useful to suppress the ... methods of administration, the relative amounts of unchanged cocaine, EME and BE excreted into urine are 1 14 %, 12 –60 % and 14 –55 % of total amount of cocaine administered, respectively [16 , 18 , 19 ] ... interval (period between death and autopsy) andthe in vitro interval (period between sampling and analysis) are variable; the hydrolytic rate of cocaine shows great variation Usually, the metabolism,...
... about A 10 -mL volume of ethanol and 10 mL distilled water are passed through a Sep-Pak C18 cartridge using a 10 -mL volume glass syringe to activate the cartridge at a flow rate not faster than ... concentration in the horizontal axis and peak area ratio of pentazocine to IS in the vertical axis The peak area ratio ofa test specimen is applied to the calibration curve to obtain its pentazocine ... concentration Assessment ofthe method > Table 5 .1 shows EI mass spectra of pentazocine and IS The base peaks unfortunately appeared in a low mass range at m/z 70 and 59, respectively Therefore, the...
... Tokyo, pp 10 8 10 9 (in Japanese) 2) The Pharmaceutical Society of Japan (ed) (19 92) Standard Methods of Chemical Analysis in Poisoning – With Commentary – Nanzando, Tokyo, p 43 and p 15 1 (in Japanese) ... method An EI mass spectrum of LSD is shown in > Fig 6 .1 The molecular ion appears as the base peak Fragment peaks can be observed at m/z 2 21, 207, 18 1and 16 7 The fragmentation pathways are shown ... blood and urine, because its amount to be ingested is as small as about 10 µg and LSD is rapidly metabolized in human bodies As metabolites of LSD, 2-oxo-LSD, 3-, 13 - and 14 -hydroxy-LSDs and an...
... MDMA 11 0, MA 1. 7, ketamine MDMA 13 0 MDMA 65 MDMA 98 MDMA 16 0 MDMA 93 MDMA 90 MDMA 13 0 MDMA 14 0 MDMA 52 MDMA 89, MA 1. 0, AP 6.9, ketamine, caffeine MDMA 60 MDMA 98 MDMA 28, MDEA 49 MDA 86 8 .1 8.2 ... Nishikawa M et al (19 91) Determination of methamphetamine and amphetamine in urine by headspace gas chromatography/mass spectrometry Anal Sci 7 :19 –22 25) Shima N, Kamata T, Nishikawa M et al Examination ... from the intestinal tract and reaches its peak concentration in plasma about h after oral administration [ 21, 22] The doses of 50, 75 and 12 5 mg in the usual “recreational” range for healthy human...
... than The calibration curve is composed of PCP concentration on the horizontal axis and peak area ratio of PCP to IS on the vertical axis The peak area ratio ofa test specimen is applied to the ... to a 15 -mL glass vial g vi The vial is capped with a Teflon-coated silicone rubber stopper and sealed with an aluminum cap vii The vial is heated at 10 0 °C for 15 on a heating block and mL ofthe ... Lee LF, Halzhauer LB et al (20 01) Analysis of urine samples in cases of alleged sexual assault: case history In: Salamore SJ (ed) Benzodiazepines and GHB: Detection and Pharmacology Humana Press,...
... selected A 1- mL volume of methanol and mL distilled water are passed through an Oasis HLB cc cartridge (Waters, Milford, MA, USA) to activate it The above supernatant fraction obtained at the step ... 44:93 10 5 6) The Pharmaceutical Society of Japan (ed) (19 92) Standard Methods of Chemical Analysis in Poisoning – With Commentary, 4th edn Nanzando, Tokyo, pp 15 0 15 8 (in Japanese) 7) Hattori H, Yamamoto ... into the cartridge at a flow rate not greater than mL/min The cartridge is washed with mL distilled water, andthe target compound and IS are eluted with mL acetonitrile The eluate is evaporated...
... cases, and toxic and fatal concentrations Notes a) When GC/MS, HPLC and LC/MS are compared for analysis of haloperidol and bromperidol, the LC/MS seems ofthe best choice for their trace analysis ... Poisoning cases, and toxic and fatal concentrations ⊡ Figure 2.3 HPLC-DAD chromatograms for the authentic haloperidol (HP) and reduced haloperidol (RHP) (10 0 ng/mL each) (A) and for a serum extract ... Butyrophenones HPLC analysis Instrument: an SPD-M1 0A photodiode array detector (DAD), a CTO -10 A column oven, an SIL -10 A autosampler and an LC -10 AD pump system (all from Shimadzu Corp., Kyoto, Japan) HPLC...
... bromide and urea: g of 2-bromohexanoyl bromide (Aldrich, Milwaukee, WI, USA) and an equimolar amount of urea are placed in a 10 0 mL volume eggplant-shaped glass flask and warmed in a water bath to ... and urine by high-performance liquid chromatography with a multiwavelength UV detector and thin-layer chromatography J Anal Toxicol 15 :12 3 12 5 5) Tanaka E, Nakamura T, Nagashima A et al (20 01) ... water and eluted with mL of dichloromethane/methanol (9 :1) vi After removal ofa small amount ofthe upper layer (aqueous phase) of eluate with a Pasteur pipette, the organic eluate is evaporated...