Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
... profile of many cell cycle markers, re-flecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and consistent feature of Alzheimer ... neurofibrillary tangles, BRCA1 was absent, yet BRCA1 was present in all cases of Alzheimer disease. These findings not only further define the cell cycle reentry phenotype in Alzheimer disease but also indicate ... for neuronal cell cycle are un-clear. In this regard, given that a dysregulated cell cycle is a characteristic of cancer, we speculated that altera-tions in oncogenic proteins may play a role in...
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Tài liệu Báo cáo Y học: Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor pot
... 1–346) was linked via a single glycineresidue to the N-terminus of human CNTF (amino acids1–186). Recombinant Hyper-CNTF protein was expressed in COS-7 cells. Hyper-CNTF efficiently induced dose-dependent ... signal transducingb subunits thereby initiating cytoplasmic signaling. Cellsthat only express signal transducing but no ligand bindingsubunits for these cytokines are refractory to stimulation.An ... themembrane-proximal cytokine binding domain [33] and the14 N-terminal nonhelical and presumably flexible aminoacids of CNTF (amino acids 1–12) [34] were linked by oneadditional glycine residue. The resulting...
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Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf
... and Western blot analysisYeast protein extracts were obtained by direct lysis of yeastcells in 2 · SDS gel-loading buffer by a freeze/thawing cycle and boiling, according to Sambrook and Russell ... GalAD-ARpeptide fusion proteins in the yeast protein interaction system. (B) Interaction of GalAD-ARpeptides with AR.LBD in the presence of 1 lMDHT in the yeast proteininteraction system. In each experiment ... DNA-binding domain; DHT, dihydrotestosterone; E2,estradiol; ERa, estrogen receptor a; GalAD, Gal4 transactivatingdomain; GAlDBD, Gal4 DNA-binding domain; LBD, ligand-bindingdomain; N/C interaction,...
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Báo cáo y học: "Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections"
... 14distress syndrome within 30 days following inclusion.The secondary endpoint was overall survival within 30days following study inclusion. Outcomes were assessedduring hospital stay at days 3, 5, ... family ofnatriuretic peptides regulates a variety of physiologicalparameters [51]. In septic states, ANP levels may mirrorboth, the inflammatory cytokine response correlatedwith the severity of infection, ... primary and hospital care. The ultimate clinicalutility of a biomarker is defined by the degree it improvesclinical decision making and adds timely informationbeyond that of readily available information...
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Báo cáo y học: "The evolving story of medical emergency teams in quality improvement"
... disclosure and analysis.Many academic centers are increasingly recognizing engage-ment in quality improvement as a distinct career pathway[15]. Involving such physicians in METs will likely facilitate ... pathway. Involving such physicians in medicalemergency teams will likely facilitate the dual roles of these as aclinical outreach arm of the intensive care unit and in identifyingproblems in care ... the process used in the presentstudy to be less reproducible than the incident investigationsthat hospitals currently routinely employ .In summary, the methodology described by Iyengar andcolleagues...
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Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"
... Turkey 4. Yuzuncu Yil University Faculty of Science, Department of Chemistry, Van, Turkey 5. Yuzuncu Yil University, Faculty of Medicine, Department of Cardiology, Van, Turkey Corresponding ... concentrations may be increased in patients with CAD. Key words: coronary artery disease; trace element; heavy metal; vitamin INTRODUCTION Coronary artery disease (CAD) is a leading cause of morbidity ... Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease Aysegul Cebi1, Yuksel Kaya2, Hasan Gungor3, Halit Demir4, Ibrahim Hakki Yoruk4, Nihat Soylemez2, Yilmaz Gunes5,...
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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
... drainage system of the frontal sinus depends on its embryologic development [2,13]. The drainage usually occurs directly into the frontal recess [14] or into the frontal recess by way ... Tomogra-phy Findings in Chronic Rhinosinusitis Patients with and without Allergy. Asian Pac J Allergy Immunol. 2006;24:123-7. 7. Schaeffer J. The Embryology, Development and Anatomy of the ... frontal sinus is usually found in individuals of the same age [11,12]. Because the left and right frontal sinuses develop independently, a significant asym-metry between these sinuses...
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Báo cáo y học: "Refractive Status and Prevalence of Refractive Errors in Suburban School-age Children"
... of China Corresponding author: Dr Zheng-Qin Yin, Southwest Hospital, Southwest Eye Hospital, Third Military Medical Univer-sity, Gaotanyan 30, Shapingba District, Chongqing 400038, China; ... aged 6-15 years in Yongchuan, a socio-economically repre-sentative area in Western China. We carried out a door-to-door survey and actual eye examinations, including visual acuity measurements, ... movement examinations, eye drop instillation, cyc-loplegic retinoscopy, and fundus examination. The quality of examination for each station was controlled by the leading investigators....
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Báo cáo y học: " Evaluation of Lumbar Facet Joint Nerve Blocks in Managing Chronic Low Back Pain: A Randomized, Double-Blind, Controlled Trial with a 2-Year Follow-U"
... stimulating the fa-cet joint capsule. Surprisingly, they53 also showed that the introduction of physiologic saline into the zyga-pophysial joint reduced the stimulation pathway from the intervertebral ... and validity of radiofrequency neurotomy for chronic lumbar zygapophysial joint pain. Spine (Phila Pa 1976). 2000; 25: 1270-7. 32. Merskey H, Bogduk N. Lumbar zygapophysial joint pain. In: Classification ... chronic spinal pain. Pain Physician. 2009; 12: E71-120. 12. Manchikanti L, Singh V, Pampati V, et al. Is there correlation of facet joint pain in lumbar and cervical spine? Pain Physician. 2002;...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... activity of nitric oxide synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in ... involvement in pathophysiol-ogy of hypobaric hypoxia in brain (42-43). In this study the increased activity of NOS in anoxia may represent predominantly the nNOS form. In inflam-matory conditions microglia ... arginine by this enzyme in anoxia. However in re-perfusion group arginase activity was significantly increased and that may be responsible to curtail the supply of arginine for NO production in...
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