Báo cáo y học: "Injury severity and serum amyloid A correlate with plasma oxidation-reduction potential in multi-trauma patients: a retrospective analysis" pptx
Báo cáo y học: "Injury severity and serum amyloid A correlate with plasma oxidation-reduction potential in multi-trauma patients: a retrospective analysis" pptx
... Resuscitation and Emergency MedicineOpen AccessOriginal researchInjury severity and serum amyloid A correlate with plasma oxidation-reduction potential in multi-trauma patients: a retrospective ... potential (ORP) in assess-ing the amount of oxidative stress in the plasma of criti-cally ill patients and correlating with plasma paraoxonase-arylesterase activity and plasma protein oxidation ... thestudy was to correlate injury severity with the ORP valuesmeasured in plasma during the course of hospitalization.Additionally, the acute phase reactant serum amyloid A (SAA) was measured and...
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Báo cáo y học: "TGF-β1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels" ppt
... inhibitors of the caspase cascade. Serum wasassociated with an increase in cIAP-1 and Bcl-2, anti-apoptotic proteins. Interestingly, serum wasalso associated with an apparent increase in Bax, ... occasions.SFFCS1%TGF-ββββ1100pMStauro1µµµµMBaxcIAP1XIAPIntact PARPCleaved PARPIntact Caspase3Cleaved Caspase3Bcl-2ββββ-actinββββ-actinββββ-actinββββ-actinββββ-actinββββ-actinSFFCS1%TGF-ββββ1100pMStauro1µµµµMRespiratory ... staurosporin by increasing theexpression of Bax and initiating the cleavage of PARP and caspase 3, all markers of active apoptosis, while it simul-taneously inhibited the expression of Bcl-2 and XIAP.Effect...
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Báo cáo y học: "Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan" pptx
... leukocytesusing a genomic DNA kit (Qiagen) a ccording to themanufacturer’s instructions. Genotyping was achievedusing an assay-on-demand allelic discrimination assay and detection system according ... to participate and is capable ofgiving informed consent; and (3) individual is a self-reported non-aboriginal Taiwanese, and none of the par-ents and grandparents has aboriginal background. ... during disease progression after therapy.AcknowledgementsWe thank Hsuan-Min Chuang, Chu-Cheng Tsai and Su-Ching Liu for thetechnical assistance in preparation the DNA and analyzing thepolymorphisms....
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Báo cáo y học: "Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages" docx
... structures and TLR ligands, such as araLAM and LPS, and pro-inflammatory cytokines, including IL-1β, TNF-α, GM-CSF and IFN-γ.[16, 22, 37, 38] It is plausi-ble that an advantage in pathogen recognition ... neutrophil and macrophage infiltration and decreased levels of TNF- α and macrophage inflammatory protein-2 (MIP2). [49] In another study using transgenic mice with varyingTLR4 DNA copy number, ... human innate immune system. Proinflammatory cytokines, such as granulo-cyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macro-phage colony-stimulating...
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Báo cáo y học: "Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque" potx
... olyDoms database, which inte-grates all coding SNPs in human protein domains.Database constructionThe CMSNP database contains two main datasets, anSNP dataset and an SV dataset, which are ... Malek JA, Manning JM,Antipova AA, Perez DS, Moore MP, Hayashibara KC, Lyons MR, Beaudoin RE,et al: Sequence and structural variation in a human genome uncoveredby short-read, massively parallel ... regions. All data have beenorganized into a MySQL relational database, which isefficient in retrieving data from indexed files.The CMSNP database is loaded in large batches and used primarily in...
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Báo cáo y học: " Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress" pps
... examined other ERstress agents in OASF and RASF. First, we treated cells with tunicamycin, an N-acetyl glycosy lation inhibitor. In RASF, tunicamycin increased autophagy in a similarmanner as ... significantly increased at2 h after treatment with thapsigargin, and reached a maximum after 8 h. In OASF, its expression was sig-nificantly increased at both 12 h and 3 6 h (Figure 2b),causing failure ... its regulatory effect in RASF. In RASF, Ca2+-induced autophagy is re gulated by hydroxy-chloroquine, a routinely used Disease-ModifyingShin et al. Arthritis Research & Therapy 2010, 12:R19http://arthritis-research.com/content/12/1/R19Page...
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Báo cáo y học: " Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation" pps
... enzymaticallyactive and inactive chitinases, acidic mammalian chiti-nase (AMCase) and BRP-39 have been shown to be cru-cial in murine models of allergic inflammation.Specifically, BRP-39 and AMCase ... flow cytometer and data analyzed with FlowJo analysis software (TreeStarInc. and Standford University,PaloAlto,California).The following antibodies were used for flow cytometricanalysis: FITC-conjugated ... Bracke KR, Brusselle GG,Joos GF, Vermaelen KY: Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergicairway inflammation in a...
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Báo cáo y học: " Tenascin-C and alpha-smooth muscle actin positive cells are increased in the large airways in patients with COPD" pot
... believe that the COPD patients in thepresentstudyalsohavefeaturesofremodelinginthe small airways and probably also emphysema. Stu-dies evaluating both large and small airways in a wellcharacterized ... beta-agonist inhaler and two had a short-acting antimuscarinic inhaler. In addition, sixpatients used oral N-acetylcysteine.Each participant gave an informed consent and thestudy had the approval from ... degradation. Can Respir J 1998, 5:48-50.17. Laitinen A, Altraja A, Kampe M, Linden M, Virtanen I, Laitinen LA: Tenascinis increased in airway basement membrane of asthmatics and decreased by an inhaled...
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Báo cáo y học: "Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study" pps
... respectively.Statistical analysis In initial exploratory data analysis, the distributions of allvariables were examined. Means and standard deviationswere calculated for normally distributed continuous vari-ables, ... disease was assessed by cardiac computed tomography. Multivariable regression analysis was used to identify pulmonary symptoms and nonpulmonary parameters associated with PFT abnormalities. Areas ... contributionsDAP participated in the study design, data collection and analysis as well as in writing and editing the manuscript. JTG performed statistical analyses and edited the manuscript. GC participated...
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Báo cáo y học: "Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults" pot
... designed and carried out the study planning,participated in analysis and interpretation of the data, and critically revisedthe manuscript. All authors have read and approved the final manuscript.Dore ... study included a baseline e xamination and follow-up examinations at approximately 2.7 and 5 years. Theresearch conducted in this manuscript is in compliance with the Helsinki Declaration and ... account for thecorrelated readings within an individual and examinethe association between changes in WOMAC scores(pain, function, and stiffness) and continuous changes in BML size. Standard...
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