Báo cáo y học: "Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo" ppt
Báo cáo y học: "Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis" potx
... role in inflammation and joint destruction [11–13].DNA containing unmethylated CpG motifs has beenreported to have immunostimulatory properties [14–16], and the presence of this type of DNA in ... Sollentuna, Sweden) and the bands were revealed bysilver staining. The gels were scanned and the intensity of each band on the gel was analyzed with IPLab Gel soft-ware (BioSystematica, Plymouth, UK). ... death vary with the severity of arthritis and theuse of cytotoxic drugs. Nevertheless, it does demonstratethat inflamed joints contain more than enough mtDNA toinduce the type of inflammation...
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Báo cáo y học: " Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness" pot
... weobserved a sustained increase in Rrs, Ers, G and H, but not in RN (Figure 3). This effect did not spontaneouslyreverse during a period of 10 minutes of tidal ventilation, but respiratory mechanics ... determine airway mechanics and expiratory flow limitation during methacholine responses, and that the combination of the two techniques offers a refined control and an improved reproducibility of ... concomitantly by both techniques at baseline and following doubling concentrations of aerosolized methacholine (MCh; 31.25 - 250 mg/ml). The effect of the NPFE manoeuvre on respiratory mechanics...
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Báo cáo y học: " The Beijing genotype and drug resistant tuberculosis in the Aral Sea region of Central Asia" pot
... Beijing genotype, with 55% of these strains appearing in clusters compared to 25% of non-Beijing strains. The percentage of Beijing strains increased with increasing drug resistance among both ... patients with a non-Beijing and a Beijing strain determined here, might point to specificproperties of the Beijing genotype. In the majority of casesidentified, the fingerprint pattern typical for ... Beijing genotype (Fig. 2).The majority of Beijing genotype isolates showed the typ-ical spoligotype pattern (hybridization to all of spacers35–43 and no hybridization to spacers 1–34) and...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... throughphagocyte production of transforming growth factor-β and IL-10. In addition, Gas-6 on apoptotic cells binding to receptor kinases of Tyro 3 family (mer, tyro and axl) down-regulate inflammatory cytokines, ... role of TLR9 inhibition in lupus.Targeting type I interferons in systemic lupuserythematosusThe parallel discoveries of the role of TLRs in stimulating typeI IFNs, of pDCs as the primary source ... containing immunostimulatorycomplexes more readily, and induce inflammatory signals in part by releasing high mobility group box (HMGB) proteins(discussed further below) [51,52]. Thus, the type of...
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Báo cáo y học: "Cardiovascular risk factors and acute-phase response in idiopathic ascending aortitis: a case control study" pptx
... Therapy Vol 11 No 1 Chowdhary et al.Page 2 of 6(page number not for citation purposes)insufficiency murmur, hypertension, coronary artery disease,hyperlipidemia, and symptoms of polymyalgia ... presence of hypertension, diabetes mellitus (types I and II), hyperlipidemia, family history of aneurysms, and smok-ing. Presence of hypertension, hyperlipidemia, or diabetesmellitus at the time of ... of surgical thoracic aneurysm repair in thisstudy were female gender and active smoking. We did not findany difference in the prevalence of hypertension, hyperlipi-demia, or family history...
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Báo cáo y học: "Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis" docx
... that invasive tenosynovium is more hypoxicthan noninvasive RA tenosynovium, or indeed than normal ten-osynovium [12]. Intriguingly, hypoxia has been shown toupregulate gelatinases (MMP-2 and ... that invasive teno-synovium was significantly more hypoxic (median oxygentension 3%, 26 mmHg) than either noninvasive tenosynoviumor joint synovium in the same RA patients, suggesting thathypoxia ... a hypoxia-induced gene in car-cinoma cells [33].The objective of our study was therefore to examine the poten-tial in vivo consequences of hypoxia in RA in terms of synovialinvasion, by exposing...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
... RA. NOD1 and NOD2 have been shown to beexpressed in RA synovial tissue samples, and the microbialligand for NOD2, muramyl dipeptide, has been detected in RA synovium [29,30]. Using NOD1 and NOD2 ... be beneficial for the treatment of SLE;however, endosomal TLR signaling certainly appears to beinvolved in SLE pathology. Interestingly a polymorphism in Mal, the signaling adaptor used by TLR2 ... humanity.Competing interestsWJM and AEP are employees of Opsona Therapeutics, adrug discovery and development company focused on therole of TLRs and inflammasome signaling in humanimmunology....
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Báo cáo y học: "Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program" pptx
... imple-mentation; and, finally, assessment of effectiveness and sustainability. Each NCCCP pilot site is currently engaged in the initial phases of its implementation, assessing and defining the innovation ... multi-layeredassessment of organizational innovation and performance which includes mapping the evolution of site development as a means of understanding the inter- and intra-organizational change in the pilot, and ... of restructuring and improving the administration of theNCI-sponsored clinical trials program within academic-based and community settings. NCI published its strategicplan in 2006, outlining...
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Báo cáo y học: " Perceived protein needs and measured protein intake in collegiate male athletes: an observational study" potx
... Actual Protein Intake. The RDI, maximum beneficial level of protein intake, and the mean actual protein intake as determinedby 3-day food record analysis in grams of protein per kg of bodyweight ... dietary protein intakes of 2.6 g/kg/day duringresistance-exercise training in young males did notresult in larger increases in strength or body massbeyond those that occurred with a protein intake ... protein intake, and themean perceived protein needs, as determined by protein menuselection, in grams of protein per kg of body weight per day.Fox et al. Journal of the International Society of...
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Báo cáo y học: "Mast cell tumours and other skin neoplasia in Danish dogs - data from the Danish Veterinary Cancer Registry" potx
... neoplasms located in the skin wassimilar to data of a Norwegian study [1]. In an Ameri-can study including both benign and malignant neo-plasms, the proportion of tumours located in the skinwas much ... reported, and theirgrade was reported in 51 cases. The diagnostic tool wascytology in 49 cases and histopathology in 65 cases.Only in two cases another diagnostic tool was chosen. Of the graded ... Duff BC: Skinneoplasms of dogs in Sydney. Aust Vet J 1987, 64:161-164.17. Pakhrin B, Kang MS, Bae IH, Park MS, Jee H, You MH, Kim JH, Yoon BI,Choi YK, Kim DY: Retrospective study of canine cutaneous...
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