Báo cáo khoa hoc:" Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece" docx

... steroid binding receptor (MARRS)[8]. Certain polymorphisms of the VDR gene may modify vitamin D function and metabolism and have been exam-ined in studies evaluating the role of vitamin D on ... osteoporosis. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor (VDR) gene in 69 patients with MS and 81 age and sex-matched healthy individuals. Genotyping of Taq-I(rs731236) ... unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.responsible for the BMD determination using DXA in the laboratory ofnuclear medicine and...

Báo cáo y học: "Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish wome" pdf

... radiographs' readings. HR conceived of the study andparticipated in its design. PLA conceived of the study and par-ticipated in its design and coordination. All authors read andapproved ... unrestricted use, distribution, and reproduction in any medium, provided the original work is cited.AbstractWe examined whether polymorphisms of the vitamin D receptor (VDR) gene was associated with individual ... [10,11]. Genetic factors affect-ing bone density may therefore play a role in the developmentof OA.The vitamin D endocrine system, consisting of the steroid vita-min D, the vitamin D receptor (VDR)...

Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus" potx

... and murine lupus [2]. It has beendemonstrated that patients with SLE have a lower level of 25hydroxyvitamin D3 than do healthy controls [3]. In addition,high-dose 1,25-dihydroxyvitamin D3 ... purposes)droxyvitamin D3 directly inhibits synthesis and secretion of IL-2 [15,16] and IFN-γ [17,18] and also inhibits immunoglobulinproduction [19]. Genomic actions of 1,25-dihydroxyvitamin D3 are ... cytokinepredominance, both Th1 and Th2 cytokine may be involved in the pathogenesis of SLE [21]. Mononuclear cells of patients with SLE have defects in IL-2 signal transduction anddecreased production...

Báo cáo khoa hoc:" Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study" ppt

... conditions. Patients and methodsWe recruited 45 patient with DDH and 20 patients withPPA. In all patients, a diagnosis of DDH or PPA was madeon the basis of clinical and radiographic examination. ... hip (DDH) and primaryprotrusion acetabuli (PPA) with Vitamin D receptor polymorphisms Taq I and Fok I and oestrogen receptor polymorphisms Pvu II and Xba I. 45 patients with DDH and 20 patients ... estra-diol and vitamin D receptor gene polymorphisms as a possi-ble determinant of growth in male and female infants. J ClinEndocrinol Metab 1998, 83:3563-3568.24. Granchi D, Stea S, Sudanese...

Báo cáo khoa học: Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A ⁄sodium butyrate-induced and 5-aza-2¢-deoxycytidine-induced PTEN upregulation ppt

... PI, propidium iodide; PTEN, phosphatase and tensinhomolog deleted on chromosome 10; siRNA, small interfering RNA; TSA, trichostatin A; VD3, 1,25-dihydroxyvitamin D 3;VDR, vitamin D receptor. FEBS ... active form of vitamin D, 1,25-dihydroxyvitamin D 3(VD3), belongs to the secos-teroid hormone family, which controls calcium andKeywords1,25-dihydroxyvitamin D 3; 5-aza-2¢-deoxycytidine; gastric ... expressionthrough vitamin D receptor. In addition, our evidence showed that vita-min D receptor, Egr-1 and p300 induced PTEN expression in a synergisticfashion. Furthermore, we found that the histone deacetylase...

Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples pptx

... maintained in 10% fetal bovineserum-supplemented Dulbecco’s modiﬁed Eagle’s medium(DMEM) (Hyclone, Logan, UT, USA); MDA-MB-231 cellswere maintained in 10% fetal bovine serum-supplementedL-15 ... elevated by inhibiting endogenous miR-22 in MDA-MB-231 cells (Fig. 2F). Interestingly, the reduc-tion in ERa protein levels was markedly greater thanthe reduction in ESR1 mRNA levels determined ... suppressors andoncogenes by directly regulating genes involved in related pathways. Unrestrained cell proliferation andderegulated cell death underlie neoplastic progression in almost all cancer...

báo cáo khoa học: " Seed storage protein gene promoters contain conserved DNA motifs in Brassicaceae, Fabaceae and Poaceae" ppt

... identified including three TFs of the B3 DNA-binding domain family, namely ABSCISIC ACIDINSENSITIVE3 (ABI3), FUSCA3 (FUS3) and LEAFYCOTYLEDON2 (LEC2), and a HAP3 subunit of theCCAAT-box binding ... associated with soybean genes coding for dif-ferent subunits of glycinin, β-conglycinin or 7S globulin(Table 2). Similar results were obtained in Arabidopsisand rice (Additional file 2), where ... based onsoybean promoters, and for motif discovery in Poaceae weused a background model based on rice promoters. Back-ground models were computed using the Seeder::Back-ground perl module...

Báo cáo khoa hoc:" A method to optimize selection on multiple identiﬁed quantitative trait loci" docx

... QTL, allowingfor non-additive effects at the QTL, including dominance, epistasis and gameticimprinting. The method derived here was applied t o optimizing selection ontwo linked QTL in a companion ... the mean breeding value of individuals with QTL geno-type m in generation t,andBVijmtis the individual’s polygenic breeding valueestimate. In the index,BVijmtis deviated from the mean ... is in linkageequilibrium with the QTL.Strategies for the use of identiﬁed or marked QTL in selection have generallyfocused on selecting individuals for breeding based on the following index...

báo cáo khoa học: "Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data" ppt

... 0.74 0.49aThe 12 -gene set includes HLA -DRB1 and 11 additional validated susceptibility genes.bThe 350 -gene set includes HLA-DRB1 and 349 additional genes identified in the genetic profile.Table ... marker showed an independenteffect in addition to the preceding markers that werealreadyplacedinthemodel.Thesecondtestsoughttoexamine multicollinearity in between markers due to LD(type III ... indepen-dent effect and multicollinearity. Markers that did notshow additional independent effects were removed. Thisexpanded set of independent markers was then placedinto a regression model...

báo cáo khoa học:" The well-being and treatment satisfaction of diabetic patients in primary care" doc

... manuscript. EA coordinated data collectionand contributed to the manuscript. SO coordinated data collection and con-tributed to the manuscript. HK coordinated data collection and contributed tothe manuscript. ... Petter-son et al found that patients with longer diabetes dura-tion were generally more depressed and lacking in energy,positive well-being, and general well-being [15]. We couldnot find a significant ... study [22], 45%of patients in the Vermont Diabetes Information SystemTrial [29], and 43.7% of patients in the study by Spann etal [2]. Patients treated with insulin had higher depression andlower...

Xem thêm