... esurface of d-ACTX-Hv1a (Fig. 6). The positively chargedLys3, Lys4, Arg5, and Lys10 of d-ACTX-Hv1a are orientedsimilarly to Lys8, Arg58, Lys62, and Arg18 of LqhaIT. The aromatic Trp7 and Tyr25 ... selectivity of the toxins to receptor site-3 may result from either variations at the bioactive surface, or other, yet unidentified, structuraldifferences. In search for possible resemblance of molecularexteriors, ... allosterically affects receptorsite-3 by shifting it from the l ow t o the high affinity state,increasing both scorpion a-toxin affinity and receptor sitecapacity [20,21,28]. Together these results...