... min. The recov-ery of surface binding sites was determined as describedabove. Interestingly, during the first 15 min of incuba-tion, surface binding recovered to 76%. However, incu-bation of ... [4,6]. These interactions are not restricted to the binding of the peptide agonist to its cognatereceptor, but also lead to agonists accumulating in the tumor cell after internalization of the ... Notably, the amount of the internalizedpeptide corresponds to 80% of the cell surface-boundpeptide, suggesting that most of the agonist-occupiedreceptors were engaged in endocytosis in the presenceof...