... exacerbated when one considers that millions of cells, each with its own intrinsic rhythm, partici-pate in this ‘mob action’, and yet a meaningful globaloutcome emerges. It is fascinating that in ... cou-pling, in that store-generated changes in [Ca2+]carerequired to activate inward membrane current, with theresulting membrane depolarization activating oradvancing the phase of other ... cytosolicIns(1,4,5)P3concentration causing generation of oscil-lations in cell 2. Importantly, although the frequency of the oscillations in cell 2 might be different to that of cell 1, coupled oscillator interactions...