Báo cáo khoa học: Modelling and simulating interleukin-10 production and regulation by macrophages after stimulation with an immunomodulator of parasitic nematodes potx

... factor.DiscussionWe modelled the production and regulation of IL-10via ERK and p38 signalling by macrophages after Av17 stimulation. Quantiﬁcation of IL-10 in the super-natant over a certain time course ... Modelling interleukin-10 production and regulation FEBS Journal 276 (2009) 3454–3469 ª 2009 The Authors Journal compilation ª 2009 FEBS 3469 Modelling and simulating interleukin-10 production and regulation ... regulation by macrophages after stimulation with an immunomodulator of parasitic nematodes Ana Soﬁa Figueiredo1, Thomas Ho¨fer2, Christian Klotz3, Christine Sers4, Susanne Hartmann3,Richard...

Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor ppt

... Theinhibition of HGFA by PCI is competitively impaired by APC in the presence of heparin. Figure 2 shows apossible mechanism of PCI-mediated regulation of HGFA and regulation of the protein ... by pretreatment with antibody against humanPCI. The regulation of HGFA by PCI was also shownin humans, as PCI levels were observed to decrease and levels of HGFA–PCI to increase in plasma of ... presence and absence of heparin.Structural analysis of APC–PCI and HGFA–PCI formationTo study the different effects of heparin on APC–PCI and HGFA–PCI formation, three-dimensional models of both...

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... family kinases in health and disease – loss -of- function of BTK and ITK and the gain -of- function fusions ITK–SYK and BTK–SYKAlamdar Hussain1,2,*, Liang Yu1,3,*, Rani Faryal1,2, Dara K. ... and Rlk ⁄ Txk in T lym-phocytes: cross -regulation of cytokine production and T cell fates. FEBS J 278, 1980–1989.41 Qi Q, Kannan AK & August A (2011) Tec familykinases: Itk signaling and ... largepopulations are analyzed, will also identify individuals with mild disease, thereby providing the missing data.The phenotype of XLA and thepotential of BTK and ITK inhibitorsThe outcome of defective...

Tài liệu Báo cáo khoa học: a-enolase: a promising therapeutic and diagnostic tumor target ppt

... occursat an early stage of tumorigenesis, as illustrated by thedetection of high titers of autoantibodies in patients with early-stage cancer [64], and correlates with theprogression of malignant ... to leukemia, pancreaticcancer and normal pancreas, and one of them is theonly acetylated residue in cervix tumor. Three acetyla-tions are common to both leukemia and pancreaticcancer, whereas ... proﬁles in pancreatic adeno-carcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.Cancer Res...

Tài liệu Báo cáo khoa học: Paradoxical interactions between modiﬁers and elastase-2 Patricia Schenker and Antonio Baici docx

... concentration of enzyme active sites was determined by titration with MeOSuc-AAPV-CH2Cl and measurement of Fig. 6. Inhibition of elastase-2 by H-TNVV-OMe (amino acids 60–63 of eglin c) with and without ... co-poly-mers of the 4- and 6-sulfate isomers (Ch4S, Ch6S) with various compositions and mean molecular masses thatdepend on animal species and tissue. Figure 1 shows theinhibition of elastase-2 by naturally ... presence of Ch4S were signiﬁcantly different from those in their absence(one-way analysis of variance and Tukey multiple comparison test). One-way analysis of variance also showed that all values of...

Tài liệu Báo cáo khoa học: How disorder inﬂuences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx

... finalelongation step of 10 min at 72 °C.All PCR products (NTAIL, PNT and SIC1) weredigested with DpnI and purified by precipitation with ethanol, restricted with ClaI and NcoI, checked by agarose(0.8%, ... ellip-ticity values per residue of proteins 1 and 2, respectively, and n1 and n2correspond to the number of residues of proteins 1 and 2.When recording spectra of equimolar (4 lm each) proteinmixtures, ... thecontent of a-helices, b-strands, b-turns and unorderedregions of the individual intrinsically unstructured proteins and GFP moieties.Analytical gel filtration and calculation of StokesradiiGel...

Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf

... gametogenesis and neuro-genesis, in the maintenance of sensory and ciliatedtissues, and in immune responses [12–14]. HSF1- and HSF3-mediated mechanisms of cellular adaptation toheat shock have been analyzed ... except for human HSF3.Expression of classical heat shockgenes induced by two heat-responsiveHSFs After the identiﬁcation of mammalian HSF1 and HSF2 [20–22], and of chicken HSF1, HSF2 and HSF3[23], ... (1995) Heat shock transcription factors: struc-ture and regulation. Annu Rev Cell Biol 11, 441–469.4 Fernandes M, O’Breien T & Lis JT (1994) Structure and regulation of heat shock gene promoters....

Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

... the enhanced uptake of rhodaminedyes inhibited the efﬂux of these dyes from the cells.The efﬂux of rhodamine 123 and TMRM was inhib-ited by NBD-Cl and MK571 and, to a lesser extent, by ATP ... medium by centrifugation through an oilcushion and dissolved prior to determination of theamount of dyes associated with them. The advantages of such an assay are that: (a) it is quantitative; ... Differential modulation of the human liverconjugate transporters MRP2 and MRP3 by bileacids and organic anions. J Biol Chem 278, 23529–23537.39 Reid G, Wielinga P, Zelcer N, van der Heijden I,...

Tài liệu Báo cáo khoa học: A facile method for expression and puriﬁcation of the Alzheimer’s disease-associated amyloid b-peptide pdf

... buffer supplied with the enzyme, and contained Aba, Abb and Abcat40 nm each, and the start and stop primers Abstart and Abstop at 600 nm each, and 200 lm each of dATP, dCTP,dGTP and dTTP. The ... the length and complexity of the puriﬁcation procedure. Moreover, as with thestudies by Lee et al. [21] and Subramanian and Shree[42], there was no rigorous assessment of the purity of the product ... level of Ab is controlled by its produc-tion, degradation and clearance, and it is proposedthat a defect leading to over -production or decreasedclearance causes an accumulation of Ab and that...

Tài liệu Báo cáo khoa học: DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling pptx

... signaling and loss of apoptosis [141].Silencing of FASL and TRAIL-R1, TRAIL-R2 and Caspase-8 expression by DNA methylation has beenlinked to resistance of small cell lung cancer cells toFASL and ... mem-brane raft composition, on the one hand [91,172–178] and the DNA-methylation status [26–28] of many genes (e.g. FAS and CLU), on theother hand. EGCG can bind to GpC-rich regions of DNA. ... dynamics and oncogenic Ras signalingInsights from FAS, FAS ligand and RASSF1ASamir K. Patra1,* and Moshe Szyf21 Cancer Epigenetics Research, Kalyani, India2 Department of Pharmacology and Therapeutics,...

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