Báo cáo khoa học: D1 – Extracellular Matrix Proteins docx

... (OBSC)depends on (pro)insulin or insulin-like growth factor-I (IGF-I)Abstracts282 D1 – Extracellular Matrix Proteins D1- 001Sox9 controls both chondrocyte differentiationand proliferationB. de ... establish that integrin-mediatedchondrocyte–ECM interactions are required for multiple steps ofEBF. D1- 003The matrilins – adaptor proteins in the extracellular matrix R. Wagener1, H. W. A. Ehlen1, ... multisub-unit matrix proteins, which are expressed in cartilage but also inmany other forms of extracellular matrix. They participate in theformation of ﬁbrillar or ﬁlamentous structures in the extracellular matrix...

Báo cáo khoa học: Acidic extracellular pH increases calcium inﬂux-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma pot

... 2007)doi:10.1111/j.1742-4658.2007.05848.xAcidic extracellular pH is a common feature of tumor tissues. We havereported that culturing cells at acidic pH (5. 4–6 .5) induced matrix metallo-proteinase-9 expression through phospholipase D, extracellular ... desipramine) and siRNA targeting aSMase ⁄ smpd1 couldinhibit acidic extracellular pH-induced matrix metalloproteinase-9 expres-sion. BAPTA-AM reduced acidic extracellular pH-induced phospho-lipase ... Metas-tasis 21, 41 9–4 25.Y. Kato et al. aSMase and Ca2+inﬂux in acid induction of MMP-9FEBS Journal 274 (2007) 317 1–3 183 ª 2007 The Authors Journal compilation ª 2007 FEBS 3183Acidic extracellular...

Tài liệu Báo cáo khoa học: Type I antifreeze proteins expressed in snailﬁsh skin are identical to their plasma counterparts doc

... families.AbbreviationsAFGPs, antifreeze glycoproteins; AFPs, antifreeze proteins ⁄ polypeptides; IBM, ice-binding motif; ORF, open reading frame;UTR, untranslated region.FEBS Journal 272 (2005) 532 7–5 336 ª 2005 FEBS ... unlikemost other known type I AFPs. Although they areextremely a-helical proteins – determined experiment-ally by CD spectrometry – they possess only moderatethermal hysteresis activity compared with ... Biol Chem 273, 3480 6–3 4812.24 Baardsnes J, Kondejewski LH, Hodges RS, Chao H,Kay C & Davies PL (1999) New ice-binding face fortype I antifreeze protein. FEBS Lett 463, 8 7–9 1.25 Baardsnes...

Tài liệu Báo cáo khoa học: Interactions between M proteins of Streptococcus pyogenes and glycosaminoglycans promote bacterial adhesion to host cells pdf

... the A–B3 region, IgGFc-binding to the S-domain, and albumin-binding to the C-repeats [31].Recombinantly expressed fragments rA–S and rS–C3 are indicated. (D) The M1 protein and the A–S and S–C3 ... representing serotypes M1 (AP1 and 9 0–2 26), M5 andM6 (JRS4) were analysed for binding of125I-labelled DS. Isogenicmutants of AP1 (BM27.6, MC25, BMJ71), of 9 0–2 26 (9 0–2 26emm1::Km), of M5 (DM5) and ... analysedby 3–1 2% gradient SDS/PAGE. The gel was dried and the radioac-tivity was visualized with a Bio-Imaging analyser BAS-2000. Lanes 1–3 represent extracts of epithelial cells and lanes 4–6 represent...

Báo cáo khoa học: Compartmentalized signalling: Ras proteins and signalling nanoclusters pdf

... compartmen-talization of scaffold proteins that are key regulatorsof Ras–Raf–MAP kinase and Ras–PtdIns3K–Aktsignalling.Compartmentalized scaffoldsScaffold proteins contribute to the control ... that in yeastrequires class C vps proteins which are normallyrequired to regulate endosome fusion [ 8–1 0]. Unlikeother small G proteins such as Rabs and Rho proteins, there has been no chaperone ... Ras-interacting proteins. J ProteomeRes 6, 180 6–1 811.5 Omerovic J, Laude AJ & Prior IA (2007) Ras proteins: paradigms for compartmentalised and isoform-speciﬁcsignalling. Cell Mol Life Sci 64, 257 5–2 589.6...

Báo cáo khoa học: 15 N-Labelled proteins by cell-free protein synthesis Strategies for high-throughput NMR studies of proteins and protein–ligand complexes doc

... proteins and proteins containing non-natural amino acids can be made efﬁciently [ 8–1 0].With the advent of cryogenic probe heads, hetero-nuclear single quantum coherence (HSQC) spectra of proteins ... MINIREVIEW15N-Labelled proteins by cell-free protein synthesisStrategies for high-throughput NMR studies of proteins andprotein–ligand complexesKiyoshi Ozawa, Peter S. C. ... type information, the protein–ligand interaction can be probed by [15N]-HSQCK. Ozawa et al.15N-labelled proteins by cell-free synthesisFEBS Journal 273 (2006) 415 4–4 159 ª 2006 The Authors...

Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf

... of CD95 by matrix metallo-proteinase-7 induces apoptosis resistance in tumor cells.Oncogene 23, 373 2–3 736.29 Mitsiades N, Yu WH, Poulaki V, Tsokos M & Stam-enkovic I (2001) Matrix metalloproteinase-7-mediatedcleavage ... speciﬁc gene expression.J Cell Biol 125, 68 1–6 93.34 Rundhaug EJ (2003) Matrix metalloproteinases, angio-genesis, and cancer. Clin Cancer Res 9, 55 1–5 54.35 Xu J, Rodriguez D, Petieclere E, Kim ... Nat Genet 35, 25 2– 257.54 Mannello F, Tonti G & Papa S (2005) Matrix metallo-proteinase inhibitors as targets of anticancer therapeu-tics. Curr Cancer Drug Targets 5, 28 5–2 98.55 Mannello...

Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

... Natl AcadSci U S A 87, 557 8–5 582.5 Nagase H (1997) Activation mechanisms of matrix metalloproteinases. Biol Chem 378, 15 1–1 60.6 Woessner JF Jr & Nagase H (2000) Matrix Metallo-proteinases ... Chem272, 747 3–7 481.117 Yu WH & Woessner JF Jr (2000) Heparan sulfateproteoglycans as extracellular docking molecules formatrilysin (matrix metalloproteinase 7). J Biol Chem275, 418 3–4 191.118 ... 278, 1 6–2 7.16 Tchougounova E, Lundequist A, Fajardo I,Winberg JO, Abrink M & Pejler G (2005) A key rolefor mast cell chymase in the activation of pro -matrix metalloprotease-9 and pro-matrix...

Báo cáo khoa học: 14-3-3 Proteins regulate glycogen synthase 3b phosphorylation and inhibit cardiomyocyte hypertrophy doc

... antagonists of 14-3-3 proteins by phage display.Biochemistry 38, 1249 9–1 2504.20 Wu CL & Muslin AJ (2002) Role of 14-3-3 proteins inearly Xenopus development. Mechanisms Dev 119, 4 5–5 4.21 Masters ... unphosphorylated motifs:GHSL and WLDLE [ 4–6 ].14-3-3 Proteins have been shown to interact with anarray of partners, ranging from enzymes to structural proteins. Often, these proteins are important in vitalcellular ... Biochimica Biophysica Acta 1547,31 3–3 19.18 Xing HM & Zhang SS (2000) 14-3-3 proteins blockapoptosis and differentially regulate MAPK cascades.EMBO J 19, 34 9–3 58.19 Wang B, Yang H, Liu YC,...

Báo cáo khoa học: Activity of matrix metalloproteinase-9 against native collagen types I and III potx

... Lett 503, 15 8–1 62.8 Ohuchi E, Imai K, Fujii Y, Sato H, Seiki M & OkadaY (1997) Membrane type 1 matrix metalloproteinasedigests interstitial collagens and other extracellular matrix macromolecules. ... expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J BiolChem 269, 1676 6–1 6773.5 Aimes RT & Quigley JP (1995) Matrix metalloprotei-nase-2 is an ... four-bladed beta-propeller. Structure 3,54 1–5 49.48 Woessner JF Jr (1995) Quantiﬁcation of matrix metallo-proteinases in tissue samples. Methods Enzymol 248,51 0–5 28.49 Koshy PJT, Rowan AD, Life PF...

Xem thêm