Báo cáo khoa học: New insights into evolution of crustacean hyperglycaemic hormone in decapods – ﬁrst characterization in Anomura pdf

... (2008) 103 9–1 052 ª 2008 FEBS. No claim to original French government works New insights into evolution of crustacean hyperglycaemic hormone in decapods – ﬁrst characterization in Anomura Nicolas ... the moult-inhibiting hormone (MIH) [13].Type II subfamily peptides include moult-inhibiting hormone (MIH), vitellogenesis-inhibiting hormone (VIH) and mandibular organ-inhibiting hormone (MOIH). ... possi-bility of using CHHs as molecular data in phyloge-netic analyses, in spite of their short sequence. In addition, the ever-increasing number of completeinsect genomes available in databanks increases...

Báo cáo khoa học: New insights into structure–function relationships of oxalyl CoA decarboxylase fromEscherichia coli pptx

... typical bindingfold of ThDP enzymes, comprising three domains of the a ⁄ b type, designated as the PYR domain (residues 1–1 90), the R domain (residues 19 1–3 68) and the PPdomain (residues 36 9–5 64) ... S-acetyl pantetheine part of acetyl CoA,and consequently the model for the inhibitor remainsincomplete. The nitrogen atom of the amino group of the adenosine ring of PADP interacts with residueN404. ... withnitrogen atoms of the adenine ring and the c-carboxylgroup of the side chain of residue D302, the d and xnitrogen atoms of the guanodino group of R158 interactwith the hydroxyl groups of ribose,...

Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

... 6–8 ) and glycine/NaOH (pH 9–1 1).The remaining activity of 5 ng of RVV-X was determined bymeasuring the clotting time on a coagulation analyser.Biotinylation of RVV-X and far-western blottingThe ... modeling revealEchis coagulation factor IX/factor X-binding proteinhas the Ca-binding properties and Ca ion-independentfolding of other C-type lectin-like proteins. FEBS Lett531, 22 9–2 34.24 ... erythroagglutinating phytohaemagglutininlectin, 5 0–6 0% of the total glycans are deduced tocarry a bisecting GlcNAc, consistent with the detection of a substantial amount of 3,4,6-Man in a ratio of ...

Báo cáo khoa học: New insights into the P-glycoprotein-mediated efﬂuxes of rhodamines doc

... kaÁCið3Þ In this work, the rate of P-gp-associated efflux of rhodaminewas calculated at the steady-state, taking into account thefollowing points: (a) the diffusion (in ux and efflux) of rhodamine ... cells in K+-buffer were incubated withrhodamine. In fact, when cells are incubated with rhodam-ine, before reaching the steady state, rhodamine continu-ously enters into the cells. According ... among the resistance factor, kinetics of uptake, and kinetics of the P-glycoprotein-mediatedefflux of doxorubicin, daunorubicin, 8-(S)-fluoroidarubicin, andidarubicin in multidrug-resistant K562...

Báo cáo khoa học: New insights into Fragile X syndrome Relating genotype to phenotype at the molecular level docx

... ‘hydrophobic platform’involved in RNA recognition. They had observed sucha mode of KH domain–RNA interaction in the cocrys-tal structure of the KH3 domain of NOVA bound toan in vitro selected ... toassociate into ribonuclear protein (RNP) particles of abnormal density, perhaps by disruption of protein–protein interactions [15]. To summarize, three mainhypotheses have been proposed to explain ... presence of an elaborate H-bonding net-work between the two C-terminal helices of one KHdomain and the b-sheet of the preceding KH motif.The contiguous arrangement of the KH1-KH2domains in NusA...

Báo cáo khoa học: Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138 pot

... onnevirapine binding which we suggest to be optimiza-tion of inhibitor ring stacking interactions withTyr181. Lys101Glu provides an example of an indirectmechanism of inducing drug resistance in ... structural consequences of the mutant side-chain movement include partiallydisrupting the hydrogen bond network involving nevi-rapine, water and side-chain ⁄ main-chain interactions in wild-type RT. ... shifted in position and hydro-gen bonding patterns are perturbed. A set of H-bondslinking waters to the main-chain carbonyl and amidegroups of residue 101 to one of the nevirapine pyridinerings...

Tài liệu Báo cáo khoa học: Structural insights into the substrate speciﬁcity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt

... here.Modes of binding of E-64 with ervatamin-A andervatamin-CThe modes of binding of E-64 with ervatamin-A andervatamin-C have been analyzed and compared withthe structures of other complexes of ... the surface of domain L con-taining the active site Cys. The S3–P3 interactions aremainly governed by side chain interactions, andaccordingly the amino-4-guanidinobutane (P3) moiety of E-64 orients ... P3 moiety of E-64 in each of the of the two ervatamin-C molecules in theasymmetric unit mainly interacts with His61 in bothmolecules (Fig. 2B).The substrate speciﬁcity of ervatamins – acomparison...

Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf

... University, New YorkW30 3–1 B (WT) MATa, ade 2–1 , his 3–1 1,15, trp 1–1 , leu 2–3 ,112,ura 3–1 , can 1–1 00Gift from A. Tzagoloﬀ, Columbia University, New YorkMES8 (D6) MATa, ade 2–1 , his 3–1 1,15, trp 1–1 , leu 2–3 ,112,ura 3–1 , ... leu 2–3 ,112,ura 3–1 , can 1–1 00, qcr6D::LEU2[37]VZ1 (D7) MATa, ade 2–1 , his 3–1 1,15, trp 1–1 , leu 2–3 ,112,ura 3–1 , can 1–1 00, qcr7D::TRP1This studyVZ2 (D7) MATa, ade 2–1 , his 3–1 1,15, trp 1–1 , leu 2–3 ,112,ura 3–1 , ... detectable in theCKL57 strain. We do not know whether the lack of immunoreactivity in the latter strain was due to the inability of the truncated protein to insert into and be stable in theinner...

Báo cáo khoa học: Recent insights into cerebral cavernous malformations: the molecular genetics of CCM pot

... (Fig. 2) [ 9–1 3].The CCM1 gene contains 16 coding exons whichencode for Krit1, a 736-amino acid protein containingthree ankyrin domains and one band 4.1 ezrin radixinmoesin (FERM) domain. CCM2, ... C-terminal part of the phosphotyro-sin binding domain of CCM2 [12]. This mutation hasbeen shown to abolish the interaction of CCM2 andCCM1, strongly suggesting its causality [25]. Only fourinframe ... germlinemutations in CCM lesionsBased on the autosomal dominant pattern of inheri-tance of CCM and the presence of multiple lesions in familial CCM, contrasting with the detection of a sin-gle...

Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx

... anormal number of cells, but instead of building into concentric layers to form the walls of the heart, themyocardial cells form into a single layer, resulting in adilated, thin-walled heart ... insights into a better understanding of disease mechanism. In this minireview, we discuss the contributions of animal models to our growing understanding of the biology of cavernousmalformations, including ... phenotype was seen in only asmall percentage of ﬁsh. Combining this low dose of rap1b morpholino with a similarly low dose of sanmorpholino resulted in a synergistic increase in boththe intracerebral...

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