... 3469
MINIREVIEW
Making senseof G-quadruplex and i-motif functions in
oncogene promoters
Tracy A. Brooks
1,2,3
, Samantha Kendrick
3
and Laurence Hurley
1,2,3
1 University of Arizona, College of Pharmacy, ... the formation of a
G-quadruplex and i-motif upstream of the Bcl-2 P1
promoter prevents the binding of WT-1 and abro-
gates the transcriptional repression, thereby allowing
activation of Bcl-2 transcription. ... the increasingly observed complexity of
G-quadruplex (G-rich strand) and i-motif (C-rich
strand) folding patterns and structures in the promoter
regions of oncogenes. Accompanying minireviews...
... aspects of the way we make sense of
marketing information. So, at the risk of high vulgarisation and trivialisa-
tion of a vast topic, below we have outlined seven key insights about the
nature of ... Evidence 51
Softer evidence here to stay 53
Making `faith' decisions 54
The quality of qualitative research 63
Understanding the overall analysis approach adopted 74
Making judgements and decisions ... the role of decision -making based on proper
business or policy objectives, and in possession of all the relevant facts.
Again, this book provides practical illustrations of the dangers of
misinterpretation...
... normally parsed and
execution is branched to a number of handlers such as a Standard Device request handler, a Standard
Interface request handler, a Standard Endpoint request handler, a Class ... Intel which puts more of the burden on
software (Microsoft) and allowing for cheaper hardware and the OHCI (Open Host Controller Interface)
developed by Compaq, Microsoft and National Semiconductor ... speeds, a full speed mode of 12Mbits/s and a low speed mode of 1.5Mbits/s.
The 1.5Mbits/s mode is slower and less susceptible to EMI, thus reducing the cost of ferrite beads and quality
components....
... tedious task of explaining them. We provide only those pieces of information
which are essential to understanding Japanese. In other words, we are trying to
help you make senseof Japanese grammar ... front of [the statue of] Hachiko around 6 yesterday.”
Rokuji-goro Hachikoo-mae-ni ita-n-desu.
“I was in front of [the statue of] Hachiko around 6.”
Hachikoo-mae-ni ita-n-desu.
“I was in front of ... appears at the end of a Japanese sentence, we actually
mean by the word “verb” one of the following three types of verb-like minimal
sentences:
1. Verb
2. Adjective + copula (
-desu and its variations)
3....
... monetary policy and oversees the activities of Reserve banks.
Board oF governors
makingsenseOF THE FEDERAL RESERVE
3
THE FEDERAL RESERVE SYSTEM
isit a Federal Reserve bank, and you’ll see that ...
banking panics; its mission has since expanded into fostering a healthy economy.
Why a Federal reserve system
makingsenseOF THE FEDERAL RESERVE
1
MAKINGSENSEOF THE FEDERAL RESERVE
17
1. Who created ... banks
and international organizations that do banking business
in the United States. The Federal Deposit Insurance
Corp. (FDIC), the Of ce of the Comptroller of the
Currency (OCC) and the Of ce...
... the report of the third of four workshops part of a project jointly run by RAND
Corporation and the Global Futures Partnership of the CIA’s Sherman Kent Center for
Analysis. The task of the project ... single-point failure, and strategic
warning – in the senseof understanding Al Qaeda and the likelihood of an attack – was good.
Immediate tactical warning was bad, but it always will be, and trying too ... talked of his fear that France’s Muslims sought to create the Islamic Republic
of France. And he was serious. Few Americans know about 1919, the end of the
caliphate and the carving up of the...
... ripe) andof society (understanding
gestation and child care, resolving conflicts which threaten group cohesion
and continuity). All of these developments augur the use of the logic of
common sense, ... supposed to make
of all things—birth and death, accident and illness, the plentitude or
scarcity of game, the pleasure of sex and the pain of childbirth, peace and
conflict. Most of all, they may ... “pertaining to sense perception” and “sensitive perception”, and by
the time of St. Paul’s letters, mature insight and understanding, as in “all
discernment” and “wise insight” and “moral acumen”....
... FLOOD: ANALYSIS OF MASSIVE AND COMPLEX GENOMIC
DATA SETS 26
8 SUMMARY 30
REFERENCES 31
APPENDIX: WORKSHOP PROGRAM AND ATTENDEES 33
Contents
32 MAKINGSENSEOF COMPLEXITY
Sager, B., and D. Kaiser. ... relationship between the
level of DNA synthesis in a cell and the integrated activity of the ERK2 enzyme.
2
After understanding
such basic elements of cell signaling and control, one may then be ... as that of Garrett Odell, of the University of Washington,
1
“Dynamical Modeling of Complex Biomedical Systems,” sponsored by the Board on Mathematical Sciences and Their
Applications and the...
... Computer-enabled “thinking tools” offer great promise in enhancing analysts’ range
of analysis by blending deductive and inductive modes of thought and processing
huge amounts of data. Yet, it is important ... not the
terrain,” and models are models, not reality.
Framing the Task
This is the report of the second of four workshops part of a project jointly run by the RAND
Corporation and the Global Futures ... talked of his fear that France’s Muslims sought to create the Islamic Republic
of France. And he was serious. Few Americans know about 1919, the end of the
caliphate and the carving up of the...
... speaker-dependent
(SD) and speaker-independent (SI) transcripts. For
all of the algorithms, the target number of segments
is set to the reference number of segments.
boundaries along the span of the lecture and ... complete paths and also portions of other paths.
We compute the aggregate distortion score D(x, y)
of two blocks x and y by summing the distortions of
all alignment paths that fall within x and y.
Matrix ... in
505
Proceedings of the 45th Annual Meeting of the Association of Computational Linguistics, pages 504–511,
Prague, Czech Republic, June 2007.
c
2007 Association for Computational Linguistics
Making Sense of...
... SECURITY
POPULATION AND AGING
PUBLIC SAFETY
SCIENCE AND TECHNOLOGY
SUBSTANCE ABUSE
TERRORISM AND
HOMELAND SECURITY
TRANSPORTATION AND
INFRASTRUCTURE
WORKFORCE AND WORKPLACE
Making Senseof Data-Driven ... use of,
perceived usefulness of, and support received for
using different types of data.
• Interviews and focus groups. In all of the studies,
researchers conducted detailed case studies of ... include software, item banks, and other
services allowing teachers and districts to produce
classroom assessments and interim progress tests
aligned with state standards and tests—is “one of the...