what indian tribes were involved in the trail of tears
Risks Involved in the Use of Herbal Products
Ngày tải lên :
25/10/2013, 05:20
... exists in the antioxidant and other
bioactivities of flavonoids, which are powerful in assays conducted in vitro; the
14 Risks Involved in the Use of Herbal Products 353
commonly found in over -the- counter ... to inhibit phase I and induce phase II carcinogen metabolizing enzymes
that initiate carcinogenesis. They also inhibit the promotion stage of carcinogen-
esis by inhibiting oxygen radical-forming ... consistent in classifying the antioxidant capacity of the
polyphenol-rich beverages in descending order: Punica granatum L. (pomegranate)
14 Risks Involved in the Use of Herbal Products 361
ephedrine...
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Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
Ngày tải lên :
20/02/2014, 11:20
... involving
the C-terminal part of the polypeptide chain (Fig. 7). In the
latter, differences in the conformation of the loop between
Fig. 6. Stereo picture of the model of the
a-carbanion/enamine intermediate ... presence of DNA-binding
proteins involved in regulation of the gene expression of indole-3-
pyruvic acid decarboxylase, a key enzyme in indole-3-acetic acid
biosynthesis in Azospirillum lipoferum ... model of the a-carbanion/enamine intermediate of the
substrate indole-3-pyruvate with ThDP in the active site of
IPDC was built based on the three-dimensional structure of
the corresponding intermediate...
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Tài liệu Báo cáo Y học: Identification of a set of genes involved in the biosynthesis of the aminonucleoside moiety of antibiotic A201A from Streptomyces capreolus pdf
Ngày tải lên :
21/02/2014, 01:21
... proteins
implicated in the biosynthesis of the aminonucleoside moiety
of A201A. Here we report the sequencing of a total of
6946 bp, which include the ata genes most likely implicated
in the biosynthesis of this ... be implicated in the
biosynthesis of the aminonucleoside moiety of puromycin
[6–8]. Interestingly, their organization is identical to that of
the pur cluster, with the exception of pur6, which ... shown)
[33,34]. In contrast, its similarity to type III PKSs, which
lack this domain, is scant. This domain promotes the
binding of the acyl-CoA initiation unit to the ketosynthetase
domain of the PKSs...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
Ngày tải lên :
22/02/2014, 07:20
... synthesis and we can only
state that the latter certainly does not exceed the rate of
amylopectin synthesis. The increase in crystallinity wit-
nessed during these first 12 h is in line with the ... from the
results listed in Table 1 that most, if not all, of the amylose is
synthesized in vivo when the rate of amylopectin synthesis
becomes minimal. At these moments the rates of amylopec-
tin ... amylopectin-to-amylose synthesis ratios [42].
The structure of starch in these mutants closely mimics that
obtained in the experiments reported here.
In the absence of amylopectin synthesis we were...
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Báo cáo khoa học: Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) ppt
Ngày tải lên :
08/03/2014, 10:20
... a
major site of interaction with UDP-GalNAc, Cys214 is also
involved in binding.
PCMPS and DFP modification of the serine-mutants
of GalNAc-T1
We also examined the sensitivity of the three serine mutants
to ... cysteine residues not involved in the formation of
a disulfide bond), by cysteine-specific labeling, to study the
mechanistic involvement of the conserved cysteine residues
in the function of GalNAc-T1. ... whether the cysteine residues modified by
PCMPS are involved in the binding of UDP-GalNAc,
we treated recombinant GalNAc-T1 with PCMPS in the
presence of either UDP-GalNAc or UDP. To increase the
sensitivity...
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Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc
Ngày tải lên :
16/03/2014, 22:20
... degree of protection by ADP sug-
gests that the mitochondrial injury is caused by open-
ing of the mPTP. There is evidence that ADP inhibits
opening of the mPTP by occupying binding sites
located in ... reperfusion in
brain.
There is a growing body of information concerning
the mechanism of ROS generation by the respiratory
chain in mitochondria. Complex I and complex III
were identified as generators of ... H
2
O
2
in the incuba-
tion medium during H ⁄ R performed in the presence or
absence of 3.5 lm Ca
2+
. The mitochondrial incuba-
tions were carried out in the cuvette of the lumines-
cence spectrophotometer...
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Báo cáo khoa học: Factors involved in the assembly of a functional molybdopyranopterin center in recombinant Comamonas acidovorans xanthine dehydrogenase pot
Ngày tải lên :
16/03/2014, 23:20
... of XDH requires the incorporation of the
MPT center, placement of the terminal sulfur ligand on the
Mo, and the incorporation of two [2Fe)2S] centers and an
FAD into the recombinant enzyme. Therefore, ... of the level of culture aeration
on the expression of recombinant protein. Raising the
cellular redox potential by increasing aeration levels is
expected to reduce the level of cysteine and increase ... stoichiometric and independent of the presence
of xdhC, and their data suggest that the level of MPT
sulfuration is lower in the absence of xdhC than in its
presence. Assuming that the level of incorporated...
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Báo cáo khoa học: RNA-binding properties of HCF152, an Arabidopsis PPR protein involved in the processing of chloroplast RNA pdf
Ngày tải lên :
17/03/2014, 10:20
... only one,
the atpF intron, while CRS2 is involved in the splicing of
nine of the 10 chloroplast group IIB introns [6,15,37].
The expression of CRS2 in E. coli together with the
corresponding RNA ... parts
containing different amounts of PPR motifs were analyzed in a UV-
crosslinking assay to [
32
P]BDd RNA. Increasing amounts of proteins,
asindicatedinthefigure,wereUV-crosslinkedtotheRNA.Astained
polyacrylamide ... shown, were analyzed in the UV-crosslinking
competitive assays, as shown in D. The IC
50
of each RNA was
determined by plotting the data (D). The location of the high affinity
binding site in the...
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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf
Ngày tải lên :
22/03/2014, 21:20
... confirmed the results obtained in the
pull-down assays, showing that there is a physical
interaction between the N- and C-terminal domains of
SSIII in vitro.
Mapping of the CD-binding region in the
N-terminal ... D3 domains,
respectively, but not the individual starch-binding domains, are involved in
the interaction with the catalytic domain. We also determined that the resi-
dues W366 and Y394 in the D2 ... acids of the N-terminal
region responsible for SSIII regulation. We found
evidence indicating that two regions, D(316–344) in
the D2 domain and D(495–535) in the D3 domain, are
involved in the interaction...
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Báo cáo khoa học: Cell death-inducing DFF45-like effector, a lipid droplet-associated protein, might be involved in the differentiation of human adipocytes pdf
Ngày tải lên :
23/03/2014, 03:20
... analyses of the relative
levels of the indicated proteins after wes-
tern blotting (as in D) were carried out. Simi-
lar experiments were performed five times
and the intensity of the individual ... subcellular compartments other than lipid droplets.
The expression of CIDEC is elevated during the
differentiation of adipocytes
To gain further insight into the roles of CIDEC in
adipocyte differentiation, ... of interest in the study
of adipocyte biology [1]. Owing to an imbalance
between energy intake and expenditure, obesity is often
characterized by an increase in both the size and the
number of...
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
Ngày tải lên :
23/03/2014, 04:20
... ⁄ ))]. These results indicate
that a functional deletion of Synoviolin causes a change
in the intracellular trafficking of NCT.
Effect of Synoviolin on the production of Ab
NCT is one of the essential ... Synovi-
lin-mediated ubiquitination also regulates the traffick-
ing of NCT within the Golgi compartment, because
the maturation of the sugar modification of the pro-
tein occurs within the Golgi ... experiments. m integrin b1, mature integrin b1; im integrin b1, immature integrin b1. Right panel: the band intensities were
quantified, and the percentage mature NCT level in the cell membrane...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
Ngày tải lên :
29/03/2014, 21:20
... binding to
titin by improving the accessibility of the titin-binding
domain. Interestingly, the importance of CARP inter-
action for its function was recently demonstrated in a
Fig. 3. Calpain ... [3,14,15]. Two of these
regions, the N2A region and the M line, are involved in
the transmission of mechanical signals to signaling path-
ways. In the M line, mechanical stimulation activates
the interaction ... NF-jB
pathway and an increase in muscle fiber apoptosis [8].
The participation of NF-jB signaling in the pathogen-
esis of LGMD2A is therefore an interesting possibility.
The findings obtained in the present...
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Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt
Ngày tải lên :
30/03/2014, 04:20
... residues were individually mutated. (C) The spa-
cial proximity of active site residues in the L-domain and connecting
region II which are potentially involved in the binding of
D-glucose
in the super-open ... binding; (b) to identify the active
site residues involved in the binding of Glc to the
super-open state (Fig. 1C) of this two domain [large
(L) and small (S)] enzyme, and thus the site of initia-
tion ... amino acids in the L-domain (residues
N204, D205, N231, E256 and E290) and the S-domain
(residues T168 and K169) (Fig. 1B). To identify the
contact residues involved in the initial binding of...
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Báo cáo khoa học: Towards understanding the functional role of the glycosyltransferases involved in the biosynthesis of Moraxella catarrhalis lipooligosaccharide ppt
Ngày tải lên :
30/03/2014, 08:20
... correlations
were conspicuous in the
1
H-
13
C-HSQC spectrum.
Examination of the anomeric
13
C line of residue C
in the 120 ms
1
H-
13
C-HSQC-TOCSY spectrum
revealed the location of the remaining ring ... investigate the function of the
glycosyltransferase enzymes involved in the biosynthesis of lipooligosaccha-
ride of M. catarrhalis and to gain some insight into the mechanism of sero-
type specificity ... strain (as
proposed by Edwards et al. [5]). The elucidation of the
biosynthetic pathway of LOS structures of known
serotypes will allow further examination of the role of
LOS in pathogenesis. In...
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Báo cáo khoa học: Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus potx
Ngày tải lên :
30/03/2014, 09:20
... Engineering, Graduate School of Engineering, Tohoku University, Miyagi, Japan
The structure of membrane lipids is the most striking
characteristic of the Archaea (one of the three domains
of ... centrifuga-
tion of the cell lysate, whereas the other two were
found in the precipitate. Therefore, in this study, we
attempted to purify the recombinant protein encoded
in AF0464 in order to understand ... the protein arose from the
translation from Met at the 24th position of the expec-
ted full-length of the archaeal enzyme (except for the
polyhistidine-tag). In contrast, a distinct protein of
slightly...
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