udp glucuronosyltransferases and their role in metabolism and disposition of carcinogens
Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
Ngày tải lên :
19/02/2014, 18:20
... metalloproteinases in vitro and eliminates production of avb3 integrin, a protein missing in normal melanocytes but often manufactured during the invasive phase [141] Hsp27 over expression in melanoma ... identified, and the role of ATP-dependent chaperones in substrate release and refolding revealed sHSPs operate in the front lines of cell defense, protecting proteins during stress and providing opportunities ... disorganized and aggresome-like inclusions develop in cultured nonmuscle cells deficient in desmin, again demonstrating inclusion body construction independent of intermediate fialments [62] Interestingly,...
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Aggregate bankruptcy probabilities and their role in explaining banks’ loan losses doc
Ngày tải lên :
22/03/2014, 20:21
... Recycling (code 370), Manufacture of coke, refined petroleum and nuclear fuel (code 230), Mining of metal ores (code 130), Tanning and dressing of leather (code 190), Manufacture of office machinery ... component of banks’ financial strategy Lending margin reflects credit risk, goals for long-term profitability, administration costs and costs of funding The size of risk included in the lending margin ... enterprises in Mining of coal (code 100) and in Manufacture of coke, refined petroleum (code 230) There are only few of them in the database and they are registered in less than a half of the counties...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
Ngày tải lên :
23/03/2014, 04:20
... nm and Kd2 = 3.9 nm) The removal of GST had no effect on PonA binding, but altered DNA binding The presence of USP was necessary for strong ligand–EcR binding, and the presence of cofactors and ... isoforms in D melanogaster [139], and probably multiple EcR isoforms exist in several, but not all, insect species In all cases described so far, the isoforms vary in their amino-terminal domain ... residues lining the inside of the pocket The interaction between the 20-OH group of PonA and the OH group of the tyrosine amino acid residue are observed in three EcRs (Tyr408 of HvEcR, Tyr296 of BtEcR...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
Ngày tải lên :
18/06/2014, 15:20
... pathway, bypassing the Golgi [103] Several S100 proteins bind the tetramerization domain of p53, and some also bind the negative regulatory domain of p53 Binding of the tetramerization domain of p53 ... Vitamin D-dependent calcium-binding protein, intestinal CABP, Calbindin-3, and Calbindin-D9k [113] It is primarily a monomer in Page of 21 (page number not for citation purposes) Journal of Translational ... to consider their role in cancer and inflammation S100 proteins are a family of over 20 proteins expressed in vertebrates exclusively and characterized by two calcium binding EF-hand motifs connected...
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PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH potx
Ngày tải lên :
28/06/2014, 11:20
... marker of DNA-degradation in cancer Isothiocyanates and the indole-3-carbinols interfere categorically in the metabolism of carcinogens thus causing inhibition of procarcinogen activation, and thereby ... groups of saponins and these include: steroid saponins and triterpene saponins Saponins are soluble in water and insoluble in ether, and like glycosides on hydrolysis, they give aglycones Saponins ... codeine, atropine, morphine, ergotamine, cocaine, nicotine and ephedrine (Fig 1) Amino acids act as precursors for biosynthesis of alkaloids with ornithine and lysine commonly used as starting...
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báo cáo khoa học: "A Review of Metallothionein Isoforms and their Role in Pathophysiology" ppsx
Ngày tải lên :
09/08/2014, 01:24
... zinc The other is MT 1A, a member of a protein family that links zinc and redox metabolism Changes in the availability of zinc ions modulate insulin signaling and redox processes Both zinc and ... diabetic laboratory animals and in humans The above findings indicate that differences in the cellular availability of zinc in both insulin producing b-cells and in insulin target cells are associated ... replace insulin in mammalian cells cultured in serum-free media [18] The actions of zinc are intracellular because zinc increases the phosphorylation state of the insulin receptor, and hence, protein...
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Báo cáo y học: "Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease" ppsx
Ngày tải lên :
09/08/2014, 13:22
... with increasing severity (c-f), and in the destructive phase of collageninduced arthritis (g, h) is shown Severity scoring was done on sections stained with hematoxylin and eosin Boxes indicate ... BMP7 stainings Arrows indicate BMP7-positive cells in synovium, and arrowheads indicate BMP7-positive cells in articular cartilage Asterisk indicates gradual clearing of the synovial lining layer ... associated with discrete BMP7 staining in the lining layer of synovium (Figure 5b) and in superficial chondrocytes in the articular cartilage (Figure 5b) With increasing severity (Figure 5c,e), BMP7...
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báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis" pps
Ngày tải lên :
10/08/2014, 10:21
... different roles in angiogenesis: Ang-1 and Ang-4 are agonist ligands for Tie2 and induce tyrosin phosphorylation of Tie2, while Ang-2 and Ang-3 are antagonist ligands They bind to Tie2 without inducing ... underlying the localization of maspin and its interaction with Ets-1 warrant further investigations In this study we employed IHC to evaluate the expression of Ets-1, Ang-2 and maspin in clinical ... expression of maspin in ovarian carcinoma Clin Cancer Res 2002, 8:2924-2932 doi:10.1186/1756-9966-30-31 Cite this article as: Lin et al.: Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their...
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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
Ngày tải lên :
12/08/2014, 02:20
... factor in T4 and is involved in the transcription of structural proteins [45] Homologues of the T4-genes g33 and g45 which are also involved in late transcription in T4 are all found in Clokie ... hyroxymethyl cytosine or that they glycosylate their DNA In addition all of the r genes in T4 that are known to be involved in superinfection and lysis inhibition [45] are missing in cyanophage genomes, ... in S-PM2, P-SSM4 and S-RMS4 speD encodes S-adenosylmethionine decarboxylase a key enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising...
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báo cáo khoa học: " Functional analysis of B and C class floral organ genes in spinach demonstrates their role in sexual dimorphism" pdf
Ngày tải lên :
12/08/2014, 03:21
... recombination of the masculinizing and feminizing factors by chromosomal linkage and inversion The result is the establishment of sex determining superloci that allow for segregation of male and ... the initiation of the floral meristem and later in the stamens or carpels, but not in the sepals [40] Spinach B class genes define organ identity and are involve in sexual determination and sexual ... analysis of these genes in their native context SpAGAMOUS retains floral organ identity and meristem determinacy functions in spinach A single C class gene has been previously described in Spinacia...
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Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx
Ngày tải lên :
12/08/2014, 18:20
... arteries of rats with hypoxia-induced pulmonary hypertension J Clin Invest 1995, 96:1823–1833 23 Morrell NW, Morris KG, Stenmark KR: Role of angiotensin-converting enzyme and angiotensin II in development ... subunits in pulmonary artery smooth muscle cells J Clin Invest 1997, 100:2347–2353 Author’s affiliation: Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins ... HIF-1 IGF-binding protein-2 HIF-1 IGF-binding protein-3 HIF-1 Interleukin-6 NF-IL6 Lactate dehydrogenase A HIF-1 Nitric oxide synthase-2 HIF-1 NIP3 HIF-1 Ornithine decarboxylase Not determined p21...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
Ngày tải lên :
12/08/2014, 18:21
... sections) Understanding the regulation of TLR expression will provide further insight into their tissue distribution and their role in combating infection There has been an initial report of the TLR4 ... This expanding IL-1R1-like family includes murine and human proteins, Drosophila (fruit fly) proteins, and a plant (tobacco) protein [7,8] In Drosophila, Toll is involved in the rapid and transient ... feature of being involved in host responses to injury and infection [8] Most notably, in humans these include not only the receptor and accessory protein for IL-1, but also the IL-18 receptor and...
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Báo cáo y học: "Psychosocial factors and their role in chronic pain: A brief review of development and current stat" ppsx
Ngày tải lên :
13/08/2014, 13:22
... surprising that the on-going evolution of the understanding of the non-physical aspects of pain has been applied to the areas of screening for, intervening in and predicting those at risk of developing ... a role for the cognitive-evaluative process in the modulation of pain Since the mid 1970's proponents of cognitive theory studied the influence of the meaning of pain to patients, and examined ... respondent pain may eventually evolve into operant and persisting pain if the environment offers pain contingent reinforcement Pain behaviour may also be learned by observing "pain models" i.e., individuals...
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Bees and their role in forest livelihoods A guide to the services provided by bees and the sustainable harvesting, processing and marketing of their products
Ngày tải lên :
03/06/2015, 08:41
... can gain from training in how to harvest, render and market beeswax BEE–MAINTAINING Harvesting of a bee colony nesting in a tree would be described as honey hunting The piece of tree cut and, ... about sources of training, markets, research findings, and raises their awareness of the industry and available opportunities Concerning financial capital for beekeeping Access to finance is essential ... world’s remaining huntergatherers, often at the margin of the farming world The colonies of honeybees are nesting in the wild and, depending on species, may be nesting in tree cavities, in trees,...
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HCV functional genomic protein interactions with NS3 and their role in viral replication
Ngày tải lên :
16/09/2015, 17:12
... implicating its involvement in oncogenesis Taken together, most of the viral proteins interact and may affect the activities of host proteins in the long-term The understanding of the interplay ... protein containing the RNA-binding motif reduces the strength of the interaction The NS3-NS3 interaction was also confirmed by co-expressing myc-tagged and flag-tagged NS3 in COS-7 cells and showing ... regards to viral and host interacting proteins of NS3, which may eventually assist in the understanding of the mechanism of HCV replication and pathogenesis Yeast twohybrid assays and co-immunoprecipitation...
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Effect of muscarinic agents on sclera fibroblast and their role in myopia 1
Ngày tải lên :
17/09/2015, 17:20
... isoforms, which display a remarkable affinity to heparin and are also called heparin binding growth factors (HBGF) FGF-2 is an 18Kd protein consisting of 155 amino acids, and an isoelectric point ... reduced in myopic sclera and atropine subconjunctival injection reversed the expression of FGF-2 in the sclera of myopic eyes In vitro • Atropine and pirenzepine (muscarinic antagonists) inhibited ... hr incubation of the cells with up to 100 µM of atropine or pirenzepine The absence of acute toxicity shows that the effect of atropine and 43 pirenzepine in controlling cell number is due mainly...
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Effect of muscarinic agents on sclera fibroblast and their role in myopia
Ngày tải lên :
17/09/2015, 17:20
... produced dark brown stain in apoptic nuclei) B Atropine 0.1 µM C Atropine µM D Atropine 10 µM E Atropine 100 µM Fig10A Immumocytochemistry of mAchR subtypes in human SF in culture Subtype selective ... control Fig10B Protein corresponding to mAchR subtypes m1,m2,m4, and m5 identified in mouse sclera by immunoblotting Subtype selective antibodies bound to specific protein bands in mouse sclera extract ... standard Diagram Mechanism of growth factor action and related events Diagram Interaction between muscarinic and EGF receptors in growth regulation Diagram Mechanism of G protein coupled m1 receptor...
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Báo cáo hóa học: " Some new nonlinear integral inequalities and their applications in the qualitative analysis of differential equations" potx
Ngày tải lên :
21/06/2014, 01:20
... present integral inequalities Main results In the rest of the paper we denote the set of real numbers as R, and R+ = [0, ∞) is a subset of R Dom(f) and Im(f) denote the definition domain and the ... not blow up in finite time Then T = ∞, and the solutions of (46) are global Zheng and Feng Journal of Inequalities and Applications 2011, 2011:20 http://www.journalofinequalitiesandapplications.com/content/2011/1/20 ... this article as: Zheng and Feng: Some new nonlinear integral inequalities and their applications in the qualitative analysis of differential equations Journal of Inequalities and Applications 2011...
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Play and it’s role in the mental development of the child
Ngày tải lên :
23/06/2014, 09:52
... covered in five steps The child, in wishing, carries out his wishes; and in thinking, he acts Internal and external action are inseparable: imagination, interpretation, and will are internal ... examining a piece of candy, putting it in one’s mouth, chewing it, and then spitting it out In play the object, to win, is recognized in advance At the end of play development, rules emerge; and ... Thus, in play the child creates the structure meaning/object, in which the semantic aspect – the meaning of the word, the meaning of the thing – dominates and determines his behavior To a certain...
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Choosing a New Organization for Management and Disposition of Commercial and Defense High-Level Radioactive Materials ppt
Ngày tải lên :
23/03/2014, 00:20
... and protection of society’s essential physical assets and natural resources and to enhance the related social assets of safety and security of individuals in transit and in their workplaces and ... to involve stakeholders and the public) to increase the likelihood of instilling public trust and attracting interest, engagement, and commitment of states, tribes, and local communities in the ... terms and conditions of the NWPA, Congress fully involved itself in site selection, funding, and regulatory decisions and, in so Summary xvii doing, undermined public trust and confidence in the...
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