transforming growth factorβ1 induced epithelialmesenchymal transition in hepatic fibrosis
Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
Ngày tải lên :
09/08/2014, 08:22
... that in intact G
1
cells (subdiploid cells).
For annexin-V/PI staining 1 ì 10
6
cells were resuspended in
50 àl binding buffer (Roche Diagnostics, Lewes, UK) and incu-
bated with annexin-V/FITC ... physiological
TGF-β
1
activation during blood clotting in patients and control
individuals, and examined whether TGF-β
1
activation was
associated with clinical phenotype, in particular inflammatory
disease ... [19,20] involving protease (plasmin) activation and
interaction of TGF-β
1
with thrombospondin-1. Using an ELISA
assay validated for detection of active TGF-β
1
[15,16], we
determined the increased...
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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
Ngày tải lên :
15/03/2014, 11:20
... either
activate or inhibit protein synthesis and cell growth [2].
The most well defined signaling mechanism regulating
mTOR activity in skeletal muscle is the insulin like
growth factor-1 (IGF-1) ⁄ insulin-dependent ... rapa-
mycin (mTOR) plays a critical role in regulating the
rate of protein synthesis and cell hypertrophy in skele-
tal muscle [3–6]. mTOR is a serine ⁄ threonine kinase of
the phosphatidylinositol kinase-related ... signal-regulated kinase; GAP, GTPase activating protein; GST, glutathione S-transferase; IGF-1, insulin like growth factor-1;
MEK, mitogen-activated protein kinase kinase; mTOR, mammalian target of rapamycin;...
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Báo cáo y học: "Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes" docx
Ngày tải lên :
09/08/2014, 10:22
... of several signaling pathways in transforming growth factor-beta-1 (TGF-β1) -induced expression of the Ank gene. (a) Kinetics of sign-
aling events induced by TGF-β1. Total proteins were extracted ... 1
Effect of transforming growth factor-beta-1 (TGF-β1) on proteins regu-lating inorganic pyrophosphate metabolismEffect of transforming growth factor-beta-1 (TGF-β1) on proteins regu-
lating inorganic ... signal-regulated kinase; MEK-1, mitogen-activated protein kinase/extracellu-
lar signal-regulated kinase kinase 1; p38-MAPK, p38-mitogen-activated protein kinase; PKA, protein kinase A; PKC, protein kinase...
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Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
Ngày tải lên :
22/03/2014, 21:21
... the
cytokines involved in the induction of FXR1 remain un-
characterized. The regulation by the anti -in ammatory
cytokine transforming growth factor-b1 (TGF-b1) of
the proinflammatory cytokine TNF-a ... example, in the stabilization of
chemokine mRNA. TGF-b1 opposes LPS -induced
chemokine stabilization by inhibiting p38 MAPK [33].
To determine whether this signalling pathway was
involved in FXR1 induction, ... demonstrated that FXR1, an mRNA-
binding protein, plays an essential role in this process.
Building on previous work showing that TGF-b1 can
inhibit LPS -induced TNF-a and chemokine production
[33,35],...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
Ngày tải lên :
18/06/2014, 15:20
... Clinical Pharmacology, Naples, Italy
Email: Giovanni Tarantino* - tarantin@unina.it; Paolo Conca - paolo.conca@unina.it; Antonio Riccio - riccio@unina.it;
Marianna Tarantino - tarantin@unina.it; ... Serum concentrations of transforming growth factor-beta1 and ferritin.
Results: High concentrations of transforming growth factor-beta1 were noticed in patients suffering from both fatty liver
and ... its use in clinical settings [1].
The definition of "benignity" concerning FL is wide-
accepted [2] but conceptually difficult to maintain
because the mechanisms, i.e., insulin resistance...
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Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf
Ngày tải lên :
18/06/2014, 16:20
... doxorubicin and
vincristine against Ewing’s sarcoma cells. Clin Cancer Res 2001, 7:1790-7.
30. Martins AS, Mackintosh C, Martín DH, Campos M, Hernández T, Ordóñez JL,
de Alava E: Insulin-like growth ... pathway inhibition by
ADW742, alone or in combination with imatinib, doxorubicin, or
vincristine, is a novel therapeutic approach in Ewing tumor. Clin Cancer
Res 2006, 12:3532-40.
31. Kim WY, Jin ... on IGF1R in GISTs and
discuss the future perspectives in this promising field.
Introduction
Recent years have seen a growing interest in insulin-like
growth fa ctor 1 receptor (IGF1R) in medical...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
Ngày tải lên :
09/08/2014, 01:21
... reduction in inflammation in arthritic
joints, TGF-β1 expression induced fibrogenesis and
muscle edema. In addition, TGF-β1 expression in the ade-
novirally infected synovial lining also resulted in induction
of ... to
confer sustained, intra-articular TGF-β1 expression in both
naïve and arthritic rabbit knee joints. Intra-articular injec-
tion of adenoviral vector expressing human transforming
growth factor ... antigen -induced arthritis (AIA), rabbits
were sensitized to ovalbumin by intradermal injections of 5
mg ovalbumin emulsified in Freund’s complete adjuvant.
Arthritis was initiated in both hind knees...
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Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc
Ngày tải lên :
09/08/2014, 01:21
... Mohan S,
Ljunghall S: Circulating levels of insulin-like growth factor-I
and -II, and IGF- binding protein-3 in inflammation and after
parathyroid hormone infusion. Bone Miner 1994, 24:25-31.
33. ... Poli V,
Martini A, Ciliberto G, Fattori E: Interleukin 6 causes growth
impairment in transgenic mice through a decrease in insulin-
like growth factor-I. A model for stunted growth in children
with ... significantly during the
first year in the HRT group compared with the controls.
There is a need to be cautious in interpreting this finding,
since there were significantly more missing OPG samples
in the...
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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
Ngày tải lên :
09/08/2014, 01:23
... 39:968-978.
26. Morales TI: The insulin-like growth factor binding proteins in
uncultured human cartilage. Increases in insulin-like growth
factor binding protein 3 during osteoarthritis. Arthritis ... Holly JMP: Changes in
the local regulation of insulin-like growth factors I and II and
insulin-like growth factor-binding proteins in osteoarthritis of
the canine stifle joint secondary to cruciate ... McCarthy JR, Xie Q, Ling N, Chen C: Quino-
line-carboxylic acids are potent inhibitors that inhibit the bind-
ing of insulin-like growth factor (IGF) to IGF-binding proteins.
Bioorg Med Chem...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
Ngày tải lên :
09/08/2014, 06:22
... effector cells is underscored both in
experimental models and in humans in which the numbers
Review
Transforming growth factor-
ββ
-induced regulatory T cells referee
inflammatory and autoimmune diseases
Sharon ... Beyond
engaging Smad activity, TGF-β triggers the extracellular
signal-related kinase and p38 mitogen-activated kinase
pathways [44] to link additional signaling cascades
involved in modulating cell ... [64,65]. Moreover, in a
dramatic turnaround of allergen -induced asthmatic lung
disease, TGF-β-converted /induced Treg, when transferred
to an asthmatic mouse, suppressed allergen -induced
inflammation...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
Ngày tải lên :
09/08/2014, 07:20
... of various transforming growth factor (TGF)-beta signaling molecules in cartilageStaining of various transforming growth factor (TGF)-beta signaling
molecules in cartilage. Paraffin sections ... Wang
W, Dunander C, Heingard D: Inhibition of interleukin-1alpha-
induced cartilage oligomeric matrix protein degradation in
bovine articular cartilage by matrix metalloproteinase inhibi-
tors: potential ... Boumediene K: Mediation of interleukin-1beta-
induced transforming growth factor beta1 expression by acti-
vator protein 4 transcription factor in primary cultures of
bovine articular chondrocytes:...
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Báo cáo y học: " Aging, osteoarthritis and transforming growth factor-β signaling in cartilage" pps
Ngày tải lên :
09/08/2014, 07:20
... cartilage
in aging mice [2]. This commentary will discuss TGF-β
signaling and osteoarthritis in an experimental investigation in
the mouse. It is important to bear in mind that results obtained
in mice ... catabolic cyto-
kines [1]. The aim of this commentary is to place in context a
recent article in this journal of anabolic growth factor, trans-
forming growth factor-β (TGF-β) signaling in articular ... protein; C-Smad = common Smad (Smad 4); IL = interleukin; LAP = latency-associated protein; MH = Mad homology
domain in the Smads; R-Smad = receptor-activated Smad (Smads 2 and 3 for TGF-β signaling;...
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Báo cáo y học: "Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts" potx
Ngày tải lên :
09/08/2014, 08:23
... H, Oni-
shi Y, Inukai K, Anai M, Fukushima Y, et al.: 14-3-3 protein binds
to insulin receptor substrate-1, one of the binding sites of
which is in the phosphotyrosine binding domain. J Biol Chem
1997, ... in OA Obs, unlike in normal cells. Since there is an
increase in IGF-1 production in OA Obs with a concomitant
decrease of the major insulin-like growth factor binding pro-
teins, namely BP-3, ... activation via IRS-1 in OA Obs. We recently demon-
strated that transforming growth factor (TGF)-β production is
increased in OA Obs [20] and, since this growth factor can
activate PKB in arthritis,...
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Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
Ngày tải lên :
09/08/2014, 10:20
... -0.531
38889_at ZFYVE9 Zinc finger, FYVE domain containing 9 (SARA) -0.538
33831_at CREBBP CREB binding protein, CBP -0.539
38311_at TGIF2 TGFB -induced factor 2 -0.559
1734_at TGFB3 Transforming growth factor, ... protease inhibitors, resulting in enhanced
proteolytic activity [41] and controls cell proliferation by
processing the insulin-like growth factor-binding protein-1
[42]. MMP-11 is, therefore, involved ... Red arrow indicates the cleavage site. CBP,
CREB binding protein; LAP, latency-associated protein; LTBP, latent TGF-β binding protein; P, phosphate; TGFBR, TGF-β receptor; TGIF, TGFB-
induced...
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