transforming growth factorβ regulation of immune responses
Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
Ngày tải lên :
07/03/2014, 01:20
... go to only one of the
two daughter cells, leaving the other relatively clear of
such signaling byproducts. A deeper understanding of
the role of microtubules in the regulation of Smad
trafficking ... dissection of the molecular mechanisms
of TGFb family signaling and the functional conse-
quences thereof on cell responses.
As far as Smad trafficking is concerned, although
the dynamic nature of such ... complexity and
depth of understanding of TGFb signaling increase, a
most critical aspect of the whole signaling pathway
remains the sequence of specific steps and the
establishment of the complete...
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Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
Ngày tải lên :
22/03/2014, 21:21
... anti-inflammatory
cytokine transforming growth factor-b1 (TGF-b1) of
the proinflammatory cytokine TNF-a via the induction
of FXR1 is the focus of this article.
TGF-b1, a member of the large transforming growth
factor-b ... tube: 20 lL of Optimem, 5 lgof
each plasmid, and 6 lL of Lipofectamine LTX (Invitrogen)
and incubated at room temperature for 30 min. This mixture
was then added slowly to cells in 1 mL of Optimem. ... Molecular Medicine, School of Medical Sciences, University of Bristol, UK
2 Department of Clinical Sciences South Bristol, Academic Unit of Ophthalmology, University of Bristol, UK
Introduction
Tumour...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
Ngày tải lên :
31/03/2014, 23:20
... Cell-specific regulation of human arylhydrocarbon
receptor expression by transforming growth factor-b
1
. Mol.
Pharmacol. 59, 716 724.
22. Do
ă
hr, O. & Abel, J. (1997) Transforming growth factor-beta ... its down -regulation by
TGF-b
1
.
DISCUSSION
The inhibition by TGF-b
1
of SeP expression is to date the
only known regulation of this protein by a factor other than
the availability of selenium. ... Overexpression of Smad 3 and 4, but
not of Smad 2, resulted in a marked down -regulation
of SeP mRNA expression. Similar effects were observed
for luciferase expression under control of a human SeP-
promoter...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
Ngày tải lên :
18/06/2014, 15:20
... biopsy-proven diagnosis.
Measurements: Serum concentrations of transforming growth factor-beta1 and ferritin.
Results: High concentrations of transforming growth factor-beta1 were noticed in patients suffering ... Medical
School of Naples, Department of Biochemistry and Medical Biotechnology, Naples, Italy and
4
Federico II University Medical School of Naples,
Department of Neurosciences, Section of Clinical ... whether both the forms of non-alcoholic fatty liver disease were really dissimilar, evaluating the
serum profile of two key parameters, indexes of severity.
Methods: A total of 123 patients (57...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
Ngày tải lên :
19/06/2014, 22:20
... degradation of Aβ42. Also
ibuprofen has been shown to reduce plaque-associated
and soluble Aβ42 in mice over-expressing the Swedish
mutation of human APP [15,16]. The lack of effect of ibu-
profen in ... Identification of the thioflavin-S-positive material will
facilitate the full appraisal of the clinical implication of the effects of anti-inflammatory drugs, and provide a more thorough
understanding of ... obstruction of CSF clearance by
meningeal fibrosis [34,35]. Other examples exist of
hydrocephalus caused by growth factor-induced fibrosis
[36]. The site and mechanism of action of pioglitazone...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
Ngày tải lên :
09/08/2014, 01:21
... Robbins
1
1
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
2
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, ... clinical
applications of transforming growth factor-beta (TGF-beta).
Growth Factors 1993, 8:1-9.
3. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB:
Transforming growth factor-beta in ... sequence analysis of simian transforming growth
factor-beta cDNA. DNA 1987, 6:239-244.
5. Miller DA, Pelton RW, Derynck R, Moses HL: Transforming
growth factor-beta. A family of growth regulatory peptides.
Ann...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 01:22
... 1
Network-based analysis of downregulated genes in the functional category of immune responseNetwork-based analysis of downregulated genes in the functional category of immune response. (a) Network ... 2
Network-based analysis of upregulated genes in the functional category of immune responseNetwork-based analysis of upregulated genes in the functional category of immune response. (a) Network ... pathophysiol-
ogy of SLE.
Figure 4
Effect of cytokines or -estradiol on the expressions of interferon-inducible genesEffect of cytokines or -estradiol on the expressions of interferon-inducible...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
Ngày tải lên :
09/08/2014, 07:20
... tibia.
Figure 3
Percentage of cells expressing transforming growth factor (TGF)-beta in medial and lateral tibial cartilagePercentage of cells expressing transforming growth factor (TGF)-beta
in ... RT, Heydemann A, Izumi T, Reddi AH: Regulation of the
expression of the type-II collagen gene in periosteum-derived
cells by three members of the transforming growth factor-beta
superfamily. J ... measurements, analyzed
Figure 8
Effect of transforming growth factor (TGF)-beta deprivation on intrinsic cartilage repair capacityEffect of transforming growth factor (TGF)-beta deprivation on...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
Ngày tải lên :
09/08/2014, 08:22
... an in vitro measure of the in vivo
efficiency of TGF-β
1
activation
To examine the ability of SLE patients and control individuals
to activate TGF-β
1
, a ratio of levels of TGF-β
1
in freshly ... development of early
atherosclerosis.
Introduction
Transforming growth factor (TGF)-β
1
is the most potent natu-
rally occurring immunosuppressant [1]; it is produced by all
cells of the immune system ... proliferation and the fate of cells through apoptosis.
In TGF-β
1
knockout mice [2] lack of TGF-β
1
initiates indiscrim-
inate loss of self-tolerant T cells. Consequential dysregulation
of B cell activity...
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Báo cáo khoa học: MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-jB1 ppt
Ngày tải lên :
07/03/2014, 00:20
... suppression of malignant
phenotypes, suggesting the role of miR-9 in the growth
inhibition of malignant cells.
The fundamental function of miRNA is to regulate
their targets by direct cleavage of the ... results indicated that the expression
level of miR-9 had an influence on cell growth. To fur-
ther validate the antiproliferative effect of miR-9 on
the growth of ES-2 cells, a colony formation assay ... by
inhibition of protein synthesis, according to the degree
of complementarity with their target 3Â-UTRs. Identi-
cation of miRNA target genes has been a great
Fig. 5. Dysregulation of NF-jB1 in...
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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
Ngày tải lên :
24/03/2014, 03:21
... model of ErbB-1, based on the
structure of the type-1 insulin-like growth factor receptor
[33], shows that the N-terminal part of domain II is involved
in a lobe of domain I [34]. Domain II of ErbB-1 ... F. (1993) A 40-kDa epidermal
growth factor /transforming growth factor a-binding domain
produced by limited proteolysis of the extracellular domain of the
epidermal growth factor receptor. J. Biol. ... receptor-binding
specificities. The first group consists of EGF, transforming
growth factor a, and amphiregulin, all of which bind
directly to ErbB-1. The isoforms of neuregulin (NRG, also
known as heregulin...
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transforming growth factor-beta protocols
Ngày tải lên :
11/04/2014, 07:14
... and properties
of the cellular receptor for transforming growth factor type `. Biochemistry 25,
3083–3091.
3. Massagué, J. (1987) Identification of receptors for type-` transforming growth
factor. ... Measurement of Active TGF-
`
27
39. Sato, Y. and Rifkin, D. B. (1989) Inhibition of endothelial cell movement by
pericytes and smooth muscle cells: activation of a latent transforming growth fac-
tor-`1-like ... (1997) Transforming growth factor-` signal-
ing in epithelial cells. Pharmacol. Ther. 75, 21.
16. Jin, G. and Howe, P. H. (1997) Regulation of clusterin gene expression by trans-
forming growth...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
Ngày tải lên :
09/08/2014, 01:23
... limit
anti-tumour or microbial immune responses. A strategic
manipulation of T
R
cells might thus be used either to
enhance or to dampen immune responses as required.
The identification of molecular markers, ... Mason D: Regulatory T cells in the control of
autoimmunity: the essential role of transforming growth
factor beta and interleukin 4 in the prevention of autoimmune
thyroiditis in rats by peripheral ... characterisation of such autoimmune preventa-
tive cells now leaves no doubt of the existence of T
R
cells
as crucial mediators of self-tolerance in both animal
models and humans.
Review
A paragon of self-tolerance:...
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