... DJ, O’Connor CM: Reduction in heartfailure events by the addition of a clinical pharmacist to theheartfailure management team: resultsofthe Pharmacist in HeartFailure Assessment Recommendation ... Terrin M, Forman S, Gottlieb SH: A randomized trial ofthe efficacy of multidisciplinary care in heartfailure outpatients at high risk of hospital readmission Journal ofthe American College of Cardiology ... structure the delivery of care for those groups of patients Because of this, we believe that for interventions whose goal is to improve the performance of a clinical system to be most effective, they...
... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... therapy twice-weekly for three weeks Therapy was then discontinued and tumor growth was monitored for several weeks Therapy significantly restricted solid tumor growth throughout the course of ... collected at the University of Pennsylvania or the University of Michigan After obtaining informed patient consent, ascites was collected either intraoperatively or at the time of therapeutic...
... be demonstrated by further clinical study Additional studies appear warranted forthe use of Apatone as a co–adjuvant, or for emerging salvage chemotherapy in thetreatmentof late stage prostate ... linear spline with knots at -60 weeks, the start of Apatone therapy and end oftherapy ( ) indicate where patients went off Apatone or started alternative therapy Table PSA Velocity and Doubling ... chemotherapy in our inclusion criteria forfailureof standard therapy A patient was required to have a biopsy with proven prostate cancer and successive rises in PSA to be included in thestudy The...
... advantage for small bowel was observed with IMRT in their study where they defined the CTV as a part ofthe whole GTV Additionally, the presence ofthe tumor shifted small bowel outside ofthe PTV ... practice for several localisations Therefore we decided to evaluate this innovative technique forthetreatmentof retroperitoneal sarcomas We found in the frame of our dosimetric study better DVH results ... maximal dose of 124% inside the PTV This hotspot wouldn’t have been observed if we had covered 95% ofthe volume by 95% ofthe dose Nevertheless, we may wonder whether the presence of these hotspots...
... V20 of 59% and V10 of 73% It is possible that sparing ofthe femoral heads and/ or other organs comes at the cost of increasing dose to the iliac crests Theresultsof our study reinforce the ... Contribution of conformal therapy in thetreatmentof anal canal carcinoma http://www.ro-journal.com/content/2/1/41 24 25 26 27 28 29 with combined chemotherapy and radiotherapy: resultsof a phase II study ... M: Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in thetreatmentof locally advanced anal cancer: resultsof a Page 10 of 11 (page number not for citation purposes)...
... between the date ofthe first PDSA cycle and the end date oftherandomizedevaluation Recorded data included whether the patient had been naturalistically referred or referred as part oftherandomized ... aimed forthe most efficient use ofstudy resources for evaluating the process and effectiveness of an implementation method, rather than the effectiveness of CCM, we predicated our design on the ... for many patients, antidepressant treatment or psychotherapy began only a short time before the sevenmonth follow-up survey Furthermore, while 81% ofrandomizedevaluation patients eligible for...
... died Therefore, the efficacy rate was 88% The median follow-up time was 35 months (range 13-47 months), and the 3-year overall survival rate was 92% Patients rapidly achieved reconstitution of ... significantly, the hematopoiesis recovery time did not significantly differ between the two groups (Table 1) (P > 0.05 using a ttest) There was no durable donor engraftment nor GVHD Therefore the umbilical ... patient data and samples; FKperformed the statistical analysis All authors have read and approved the final manuscript Conflict of interests The authors declare that they have no competing interests...
... determined for objective pharmacodynamic evaluationof oxidative stress and disease progression during therapy [35,42] Therefore, the levels of MDA, PC, TAS and HCY were measured in the patients' ... higher levels of functioning and associated QoL Patients were asked to rate the level of their present health condition In order to provide a basis forthe assessment of achieved results, the scores ... statistics were repeated without the values of these subjects The analysis resulted in the same slight changes in the total score and subscores ofthe TQ as well as in the same audiometric findings...
... received all six doses ofthestudy drug, 28 ofthe 31 subjects (90%) in the 400 mg IV ibuprofen treatment group received all six doses ofthestudy drug, and 23 ofthe 28 (82%) in the placebo group ... immediately before dosing and for all temperature measurements during thetreatment period Treatment consisted of one dose ofstudy drug every four hours, for a total of six doses Assessments of temperature, ... secondary endpoints, 21 of 30 (70%) of subjects in the 200 mg IV ibuprofen group, and 19 of 31 (61%) of subjects in the 100 mg IV ibuprofen group, compared to of 28 (32%) ofthe placebo group had...
... analogues 115 4.15 Methology suitable forthe radiosynthesis ofthe E isomer of CA-1 121 4.16 Radiosynthesis ofthe E isomer of CA-1 123 4.17 Scale-up synthesis of OXi8007 124 4.18 Proposed nitrogen ... among the most important of which is the formation ofthe mitotic spindle, involved in the alignment of replicated chromosomes to the equatorial plane to promote further segregation ofthe chromosomes ... Although chemotherapy is used as a primary treatment or as an adjuvant to the other therapies, it often has unpleasant side effects because ofthe limited selectivity that these drugs have for cancer...
... 100% relief of their pain in 86% ofthe patients with a median relief period of months The range of relief varied from zero days to up to 13 months forthe facet injection group None ofthe lumbar ... median period of pain relief being months The range of relief forthe radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Ofthe 14 patients ... should be incapable of re-innervating the joint In this study we investigate the long-term efficacy of facet debridement forthetreatmentof chronic back pain originating in the facet joint MATERIALS...
... follow-up ResultsThe author acknowledges that there are no conflicts of interest or financial benefits with theresultsofthestudy All twelve patients (10 males, females) completed the surgery ... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae...
... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost ofthe chemicals should be minimized if the same quantitativeness can be achieved Theresults ... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each ofthe samples were divided into two One of them was for DNA extraction and was washed ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...
... experimental resultsofthe CARS process forthe municipal wastewater treatmentThe technical feasibility of this process was demonstrated, and the process optimization was performed In addition, the ... in the PO43 P removal These results revealed that the selection ofthe operational parameters ofthe CARS process had a great influence on the overall system performance Adsorptive capability of ... al., 2004), the present study showed that the Freundlich isotherm equation (Fig 7) also matched the experimental results well The obtained values ofthe constant characteristics forthe two models...
... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival ofthe patients in the cetuximab monotherapy arm ofthe RCT The data from the monotherapy arm NICE ... negligible if further active treatment was not available Therefore theresults seen in the single-arm cetuximab studies for these outcomes could be interpreted as an effect ofthe drug It also ... effectiveness evidence from the bevacizumab studies and noted that the age ofthe population in the largest study was lower than the age of patients normally receiving chemotherapy in England and...
... reviewer reconciled theresultsofthe first two reviewers in the case oftherandomized trials 29 Forthe other study designs, theresultsofthe two reviewers were averaged The quality assessment ... reviewer reconciled theresultsofthe first two reviewers; forthe other study designs, theresultsofthe two reviewers were averaged The overall score was the percentage ofthe maximum possible ... reported on the efficacy and/or effectiveness of hydroxyurea treatmentof hematologic diseases, the toxicity of hydroxyurea in thetreatmentof any disease, and the barriers to thetreatmentof sickle...
... (COX) In these enzymes, the redox potential ofthe metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential ofthe metals ... that the interaction between Ab and these metals can promote the formation of Ab oligomers, aggregates and fibrils [48,52–55] Metal mediated oligomerization of Ab may therefore contribute to the ... within the physiological ranges that could be expected within the brain The capacity for metals to facilitate this process may therefore be a critical factor in the Ab mediated pathology of the...
... trademarks of Intel Corporation or its subsidiaries in the United States and other countries *Other names and brands may be claimed as the property of others *Other names and brands may be claimed as the ... liability forthe implementation of these methods as implemented within the customer’s own manufacturing environment Furthermore, any third party suppliers named herein are provided for informational ... liability forthe quality of third party supplier products and services and cannot guarantee the correct or suitable operation of third party products The hardware vendor remains solely responsible for...
... the inclusion of lysine residues in the protein sequence ofthe A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... across the ER membrane to the cytosol [91,92] To date, we are unaware of direct evidence for transport of PE through the Sec61p translocon Additional support forthe hypothesis that PE exploits the ... understanding ofthe PE intoxication pathway can be complicated by the use of recombinant immunotoxins Much ofthe information accumulated over years ofstudy concerns PE-based RITs rather than native...
... evidence forthe optimal period oftreatment and number of treatments? We found evidence forthe efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The basis ofthe ... outcome of physical therapy? What is the optimal period oftreatment and number of treatments? What is the effectiveness of physical therapy in clinical practice settings and can the findings in the ... exercise dosage is the critical factor is unclear The optimal length oftreatment and the number oftreatment episodes could be useful information forthe marketing of physical therapyfor SUI Some...