therapeutic approaches in aphasia rehabilitation

Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches Edited by Ghazala Hayat pot

Ngày tải lên : 17/03/2014, 02:20

... paresthesia (including tingling) but not interfering with function Grade Sensory alteration or paresthesia (including tingling), interfering with function but not interfering with ADL Sensory Disabling ... dynamin-dependent endocytosis For example, interaction between dynamin and cortactin, SH3-domain containing actin binding protein that binds also F-actin and actin-regulating Arp2/3 complex (Ammer & Weed, ... 1997), intersectin (Zamanian et al., 2003), and sorting nexin (Ramachandran & Schmid, 2008) Actin binding proteins, such as cortactin and Abp1, also contain SH3 domain and bind to dynamin PRD...

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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot

Ngày tải lên : 30/03/2014, 09:20

... Wnt/βcatenin and cadherin pathway genes including N-cadherin and P-cadherin but low E-cadherin protein expression This finding demonstrated the highgrade serous ovarian cancer contained messenchymal ... mitogen activated protein kinase (MEK) inhibitor such as CI-1040 was used to test the potential therapeutic agent in in vitro ovarian cancer cell line (51) This cell lines containing KRAS or BRAF mutations, ... contained in the book Publishing Process Manager Dimitri Jelovcan Typesetting InTech Prepress, Novi Sad Cover InTech Design Team First published March, 2013 Printed in Croatia A free online edition...

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báo cáo hóa học:" Inflammatory mechanisms in ischemic stroke: therapeutic approaches" potx

Ngày tải lên : 18/06/2014, 15:20

... originally described as mediators for regulating the innate and adaptive immune systems Cytokines are thus upregulated in the brain in a variety of diseases, including stroke In the brain, cytokines ... system are engaged in bi-directional crosstalk Moreover, mounting data suggest that in the brain, as in peripheral organs, inflammatory cells participate in tissue remodeling after injury Microglial ... pathways in acute ischemic stroke has become an important area of research in translational medicine Cytokines and brain inflammation Cytokines are a group of small glycoproteins that are produced in...

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PERIPHERAL NEUROPATHY – ADVANCES IN DIAGNOSTIC AND THERAPEUTIC APPROACHES potx

Ngày tải lên : 27/06/2014, 10:20

... paresthesia (including tingling) but not interfering with function Grade Sensory alteration or paresthesia (including tingling), interfering with function but not interfering with ADL Sensory Disabling ... dynamin-dependent endocytosis For example, interaction between dynamin and cortactin, SH3-domain containing actin binding protein that binds also F-actin and actin-regulating Arp2/3 complex (Ammer & Weed, ... 1997), intersectin (Zamanian et al., 2003), and sorting nexin (Ramachandran & Schmid, 2008) Actin binding proteins, such as cortactin and Abp1, also contain SH3 domain and bind to dynamin PRD...

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báo cáo khoa học: "P-loop mutations and novel therapeutic approaches for imatinib failures in chronic myeloid leukemia" pps

Ngày tải lên : 10/08/2014, 22:20

... of point mutations within the ABL kinase domain of BCRABL Such mutations inhibit the ability of imatinib to bind to BCR-ABL by corrupting the binding sites or preventing the kinase domain from ... present at baseline before second-line treatment Dasatinib and nilotinib have differential activity against certain mutations, including those of the P-loop Clinical resistance to dasatinib has been ... Cowan-Jacob SW, Lee FY, Heinrich MC, Deininger MW, Druker BJ: In vitro activity of Bcr-Abl inhibitors AMN107 and BMS354825 against clinically relevant imatinib-resistant Abl kinase domain mutants Cancer...

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Tài liệu Neural Networks and Neural-Fuzzy Approaches in an In-Process Surface Roughness Recognition System for End Milling Operations pptx

Ngày tải lên : 23/01/2014, 01:20

... manually inspecting machined surfaces at ﬁxed intervals A surface proﬁlometer containing a contact stylus is used in the manual inspection procedure This procedure is both time-consuming and labor-intensive ... laboratories in the state of Iowa (including Winnebago Co in Forest City; Delavan Inc in Des Moines; Sauer-Sundstrand Inc in Ames), point to the feasibility of in- process surface roughness recognition ... before or during machining The primary objective was to train the fuzzy system by generating fuzzy rules from input–output pairs, and combining these generated and linguistic rules into a common...

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Tài liệu Local Economic and Employment Development Policy Approaches in OECD Countries, A Review docx

Ngày tải lên : 15/02/2014, 00:20

... achieve economies of scale and critical mass in training provision by combining training needs, reducing course duplication and aligning training curricula to industry demand  Austrian K-Plus competence ... disadvantaged social groups in rural areas, screening individuals with an interest in selfemployment, providing the most apt with business advice and training, assisting those choosing to reverse to wage ... most interesting initiatives in the field of skills upgrading are the “training voucher” scheme implemented in North-Rhine Westphalia (NRW), Germany, and Pennsylvania’s Industry Partnerships Training...

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Tài liệu Hemodynamics – New Diagnostic and Therapeutic Approaches Edited by A. Seda Artis pdf

Ngày tải lên : 19/02/2014, 23:20

... being specific, increased dimension in the renal vein is regarded as a non-specific finding Thrombus inside the vein can be monitored in this pathology using gray-scale US No blood flow findings ... Diagnostic and Therapeutic Approaches interactions between several regulatory pathways (renin–angiotensin, kallikrein–kinin, and prostaglandin–thromboxane) are in fact responsible for intense, postobstructive ... the minimal amount of caloric requirement needed to sustain life including heart beating, lungs breathing, and body temperature normal in a resting individual The purposes of the fitness training...

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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf

Ngày tải lên : 06/03/2014, 09:22

... effect in a telomere level should not be ruled out In vivo data on the recently described quadruplex-binding ﬂuoroquinolone derivative Quarﬂoxin (CX-3543) is included It is currently in clinical ... -(CH2)3- with a terminal cationic nitrogen-containing group such as diethylamine, pyrrolidine or piperidine Structure-based drug discovery does have these few structures as starting points [42–47], ... selective inhibition of cell growth, with normal human cell lines being relatively unaffected; (d) senescence; (e) inhibition of telomerase activity in cells; (f) competitive inhibition of hPOT1 binding...

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THERAPEUTIC HYPOTHERMIA IN BRAIN INJURY pdf

Ngày tải lên : 06/03/2014, 23:20

... problem with surface cooling is cold injury, causing pressure ulcers and Therapeutic Hypothermia in Brain Injury skin breakdown Surface cooling is less efficient in reducing the temperature of ... can be initiated in the prehospital or in hospital setting There are ongoing studies involving prehospital cooling One should be mindful that if prehospital cooling is not followed by in hospital ... ischemia-reperfusion injury leading to intravascular clot formation resulting in microvascular thrombosis in the brain [42,43] Therapeutic Hypothermia could be beneficial in this instance since platelets...

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Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot

Ngày tải lên : 07/03/2014, 10:20

... serum indicating that the therapeutic effect of the vaccine is based primarily on eliciting a humoral response [36,37] The striking biological effect of the vaccine in preclinical testing and ... peripheral sink effect, clearing soluble Ab from the blood stream and inducing efﬂux of Ab from the brain Additional potentially synergistic therapeutic approaches for AD would include blocking the interaction ... diseases In the development of immunotherapeutic approaches targeting a self-antigen, designing a vaccine avoiding auto-immune related toxicity is a major concern The emerging data from AD targeting...

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Báo cáo khoa học: Protein-misfolding diseases and chaperone-based therapeutic approaches pdf

Ngày tải lên : 07/03/2014, 12:20

... Protein responsible Normal No of repeats No repeats in mutant protein Ref Huntingtin Androgen receptor 11–34 11–33 40–120 40–62 [45,75–78] [79] Ataxin Ataxin Ataxin Ataxin Ataxin Atrophin 25–36 ... information in the DNA at one position and causing the cell to produce p53 protein with an error through Protein-misfolding diseases swapping an incorrect amino acid at one point in its polypeptide chain ... abnormal protein trafﬁcking is a1-antitrypsin deﬁciency [9] In almost all cases of protein misfoldingmediated disorders, mutation in the gene (encoding the disease-causing protein) is very common...

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Báo cáo khoa học: "Transparent combination of rule-based and data-driven approaches in a speech understanding architecture" pot

Ngày tải lên : 08/03/2014, 21:20

... probabilities first Call the ordered set T 3.1 Training and decoding Training data for ALTERF is supplied in the form of a text file containing one example per line, in the format (Wavfile) (Atoms) (Transcription) ... tools is postprocessed into internal form For speech data, this first processing stage produces three pieces of information for each line in the training file: a text string, a parsed representation ... interpretation errors on in- domain test data for different amounts of training data and different versions of the system Training and test data both in speech form "Data" = proportion of training...

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HEMODYNAMICS – NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES potx

Ngày tải lên : 14/03/2014, 10:20

... being specific, increased dimension in the renal vein is regarded as a non-specific finding Thrombus inside the vein can be monitored in this pathology using gray-scale US No blood flow findings ... Diagnostic and Therapeutic Approaches interactions between several regulatory pathways (renin–angiotensin, kallikrein–kinin, and prostaglandin–thromboxane) are in fact responsible for intense, postobstructive ... the minimal amount of caloric requirement needed to sustain life including heart beating, lungs breathing, and body temperature normal in a resting individual The purposes of the fitness training...

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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot

Ngày tải lên : 16/03/2014, 01:20

... particularly useful in diagnosing incident cancers in otherwise normal tissues Indeed, this approach discriminates normal and neoplastic tissues in various cancer types, including CLL, breast cancer, ... of essential proteins responsible for accelerating the cell cycle, including cyclin D and retinoblastoma [56,57] Moreover, alterations in the machinery responsible for processing miRNA contributes ... RNA-binding-domain protein that is a homologue of the HIV transactivating response RNA-binding protein (TRBP) The functional strand of the miRNA duplex guides the RNA-induced silencing complex (RISC)...

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Báo cáo khoa học: "Combining Deep and Shallow Approaches in Parsing German" pptx

Ngày tải lên : 17/03/2014, 06:20

... easily be maintained: coordination Conceptually, all the conjuncts are head constituents in coordination, since the conjunction could be missing, and selectional restrictions work on the individual ... selected certain readings become undistinguishable Rather, in order to distinguish a maximum number of readings, pre-modiers must attach to the last conjunct and post-modiers and coordinating conjunctions ... designating the dependent in left-to-right order (e.g for in, for on in example (5)), and a number designating the head in left-to-right (e.g for saw, for man, for hill in (5)) If the links are...

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Novel Therapeutic Concepts in Targeting Glioma Edited by Faris Farassati potx

Ngày tải lên : 23/03/2014, 15:20

... re-entered clinical trial 5.2 Tyrosine kinase inhibitors that target the EGFR TKIs are small molecules that specifically target the kinase domain of tyrosine kinases, preventing binding of ATP ... targeting wtEGFR are have been tested in GBM using systemic administration, including mAb 425 131I-mAb 425 has been used in several clinical trials and clearly demonstrates targeting to GBM following ... 12 Novel Therapeutic Concepts in Targeting Glioma complete excision in the placebo group27 In 2007 Stepp and colleagues reported similar findings with GTR in 65% of patients undergoing FIGS compared...

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gendering world politics issues and approaches in the post-cold war era

Ngày tải lên : 03/06/2014, 01:14

... given increasing recognition Certain introductory IR texts are now including feminist approaches in their overview of the discipline, and edited volumes and some anthologies have begun to include ... debates in IR, thereby demonstrating their difference from feminist concerns Finally, I introduce some feminist IR perspectives, integrating them into the third debate Although much feminist IR ... humanities and philosophy, engaging openly with one another Questioning liberal assumptions that women’s subordination can be diminished by incorporating women into existing institutional structures...

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Báo cáo hóa học: " Circle drawing as evaluative movement task in stroke rehabilitation: an explorative study" potx

Ngày tải lên : 19/06/2014, 08:20

... 1988 Levin MF: Interjoint coordination during pointing movements is disrupted in spastic hemiparesis Brain 1996, 119(Pt 1):281-293 Sukal TM, Ellis MD, Dewald JPA: Shoulder abduction-induced reductions ... mechanisms that are involved in restoration of arm function in order to maximize the effect of future approaches Despite the increasing use of robotic systems in clinical and research settings, it is ... ellipse, Rminor = minor axis fitted ellipse previously used to evaluate training induced changes in synergistic movement patterns during circle drawing of stroke survivors [23,17] In this method,...

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báo cáo hóa học: "Whole-body isometric force/torque measurements for functional assessment in neuro-rehabilitation: platform design, development and verification" pot

Ngày tải lên : 19/06/2014, 08:20

... Journal of NeuroEngineering and Rehabilitation 2009, 6:38 Background One of the main scientific and technological challenges of rehabilitation bioengineering is the development of innovative methodologies, ... undergoing a rehabilitation treatment Such tools should be as fast and cheap to use as clinical scales, which are currently the daily instruments most widely used in the routine clinical practice In ... been included into the design methodology presented in the following section • the impaired foot and toe, • the impaired middle finger, index finger and thumb ADL tasks to be performed during...

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