the standard form of the equation
Tài liệu Supply the correct form of the verbs1 docx
Ngày tải lên :
23/01/2014, 07:20
... live in a snake.
14. My brother managed to kill the snake just at the time when I were almost exhausted.
Supply the correct form of the verbs
1. Cats could fly if they (have) wings.
2. If Peter ... (not,want) to live in a snake.
14. My brother managed to kill the snake just at the time when I (be) almost exhausted. If
he (be) a little late, I (kill) by the snake.
15. Had I know you were ill, ... snake.
14. My brother managed to kill the snake just at the time when I (be) had been almost
exhausted. If he (be) had been a little late, I (kill) would have been killed by the snake.
15. Had...
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Báo cáo khoa học: Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4 doc
Ngày tải lên :
23/03/2014, 15:21
... 4996–5007 ª 2005 FEBS
the backbone and side chain of Asn34 and the side
chain of Lys24. This crystal contact stabilizes the
structure of the leading side of the foot loop.
The putative internal ... C-terminus,
while Arg206 is on the top of the molecule, in the loop
leaving helix 6 and it points in the opposite direction
to the other basic residues (Fig. 2B). The structure of
the NLS is almost identical ... to the side chain of
Asn81. The intervening residues of the C-terminal
extension interact with the neighboring monomer via
hydrophobic contacts.
Comparison with the structure of the soluble
form...
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Báo cáo khoa học: Mapping the binding domains of the aIIb subunit A study performed on the activated form of the platelet integrin aIIbb3 pot
Ngày tải lên :
31/03/2014, 07:20
... [43]. The
present study further illustrates the importance of the eight-
peptide sequence 57–64 in maintaining the inhibitory effect
of the original 20-peptide a
IIb
49–68.
The N-terminal region of ... were
performed in the presence of PAC-1, a ligand-mimetic
anti-a
IIb
b
3
that contains the RYD sequence (an RGD
mimic) in the CDR3 region of the heavy chain. PAC-1
binds to the activated form of a
IIb
b
3
and ... with this lig-
and. The latter is further supported by the finding that the
above peptides did not interfere with the binding of PAC-1
to the activated form of a
IIb
b
3
. Furthermore, a
IIb
313–332
was...
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Báo cáo khoa học: The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein pdf
Ngày tải lên :
31/03/2014, 09:20
... proportion of the
125
I
released (Fig. 7A) may be derived from the diffusion of
low M
r
125
I from the cells. In contrast, the slower release
of
125
I-Tf (Fig. 7B) was consistent with the efflux of the
Fig. ... examining the uptake of the
125
I-sMTf or
125
I-Tf, the
proteins were also saturated with
59
Fe by the procedures
described above. These dual labelling experiments enabled
examination of the uptake of ... increased effi-
cacy of conjugates compared to free agents [49,50]. It is
possible that the use of the conjugate may enable the
delivery of the agent to the lysosomal compartment that
then results in...
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Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx
Ngày tải lên :
18/02/2014, 06:20
... biological function of the pro -form of
bone morphogenetic protein-2 (BMP-2), a member of the transforming
growth factor b (TGFb) ⁄ BLP superfamily. The role of the 263 amino acids
of the pro-peptide ... Furthermore, the pro-peptide
of GDF-8 impairs interaction of the mature part with
its receptors [16]. In the case of BMP-9, the pro-pep-
tide appears not to alter significantly the activity of the
mature ... interested in the role of the 263
amino acid pro-peptide of BMP-2, because evidence
accumulated over recent years has shown that the
pro-forms of growth factors can modulate the activities
of the mature...
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Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt
Ngày tải lên :
18/02/2014, 16:20
... rates) prior to and after the transition of the enzyme to a
more active form, respectively, t is the time and s is the lag-
time. The rate constant, k, for the activation of the enzyme is
obtained ... rate is the initial turnover of the enzyme with a
maximum of k
cat
, S
0.5
is the concentration of substrate S at
half-maximal saturation of the enzyme and n is the Hill
coefficient. Equation ... lip prevented binding of the C-terminal
residues over the active site, or the absence of the
C-terminal residues caused the movement of the lip
(Fig. 1B). In addition, the C
a
chain between amino
acid...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
Ngày tải lên :
19/02/2014, 06:20
... the SH3 domain of Noxo1 participates in
regulation of Nox3, the role of the PX domain in Nox3
activity remains unknown.
In the process of cloning of human Noxo1, some
spliced transcripts of the ... To compare the amounts of
the two variants expressed in the testis, we performed
the PCR using the primers ‘d’ and ‘c’, where the
cDNAs for both Noxo1b and Noxo1c are amplified as
the insert region ... between the pair of primers
(Fig. 2A). The lengths of the PCR products of Noxo1b
and Noxo1c were 225 and 240 bp, respectively. To
delineate the difference in the two products, we subjec-
ted the...
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Báo cáo khoa học: Crystal structures of the apo form of b-fructofuranosidase from Bifidobacterium longum and its complex with fructose pot
Ngày tải lên :
06/03/2014, 00:21
... enzyme.
The catalytic mechanism of hydrolysis
The fructose present in the crystal structure of the
complex is the result of hydrolysis of raffinose. The
conformation of the sugar observed in the electron
density ... attack on
the anomeric carbon of fructose. The leaving group is
carboxylate of Asp54.
Dimerization
The asymmetric units of the crystals of both the apo
and complexed form of the enzyme consist of dimers
with ... blades in the axis
area are of polar character. The water channel in the
apo form of the enzyme runs along the axis of the
b-propeller through the whole domain and is only
blocked by Cys236 in the...
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Báo cáo khoa học: DNA polymerase e associates with the elongating form of RNA polymerase II and nascent transcripts pot
Ngày tải lên :
07/03/2014, 11:20
... between
the hypophosphorylated initiation isoform IIA and
the hyperphosphorylated elongating isoform IIO that
exhibits reduced electrophoretic mobility compared
with the IIA isoform. Whereas the ... replicases in the eukary-
otic cell [22]. Therefore, we tested the effect of the
replicative state of the cell on the interaction between
Pol e and RNA pol II. A possible confinement of the
interaction ... specifically in the G
1
phase of
the cell cycle. This effect could be attributed to inhi-
bition of transcription of cell cycle-regulated genes at
this phase of the cell cycle [51]. Nevertheless, it...
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Báo cáo khoa học: Purification and structural study of the b form of human cAMP-dependent protein kinase inhibitor pdf
Ngày tải lên :
07/03/2014, 15:20
... regulation of the PKI
and PKI isoforms of the inhibitor protein of the cAMP-dependent
protein kinase. J. Biol. Chem. 272, 20011–20020.
20. Byler, D.M. & Susi, H. (1986) Examination of the secondary
structure ... Characterization of PKI
gamma, a novel isoform of the protein kinase inhibitor of cAMP-
dependent protein kinase. J. Biol. Chem. 272, 18169–18178.
4. Gamm, D.M. & Uhler, M.D. (1995) Isoform-specific ... showedasinglebandbySDS/PAGE
(Fig. 2). The assay of its activity demonstrated that the
purified PKIb inhibited the catalytic subunit of cAPK with
the specific activity of 6.0 · 10
4
unitÆmg
)1
(Fig. 3A) .The K
i
value determined...
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Báo cáo khoa học: The propeptide in the precursor form of carboxypeptidase Y ensures cooperative unfolding and the carbohydrate moiety exerts a protective effect against heat and pressure pot
Ngày tải lên :
07/03/2014, 21:20
... effect on the thermal
unfolding of proCPY.
The P
m
value for CPY was higher than that of its
unglycosylated form, though the DV and DG
P
values were
almost the same. The P
m
value of proCPY was ... the corresponding values of
proCPY and Dgly proCPY (Fig. 2B), indicating that the
precursor form was less thermally stable than the mature
form, regardless of the carbohydrate moiety.
After the ... unfolding of the unglycosylated
form.
At high pressure, in the glycosylated forms the carbohy-
drate moiety of CPY and proCPY would be hydrated to
compensate the volume contraction and the protein...
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Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
Ngày tải lên :
16/03/2014, 10:20
... iden-
tified as the major and the minor forms of the holo-
ACP structure, on the basis of their percentage contri-
butions (65% and 35%, respectively) to the overall
structure of the protein. The structures ... both forms have the same amino acid
sequence, and they have similar secondary structures, it was found that the
– DG of unfolding of the holo form was lower than that of the apo form at
all the ... unfolding
thermodynamic parameters of the two forms are given
in Tables 1–3. In the entire experimental regime, it is
seen that the holo form presents better stability than
the other form (Fig. 4C). The...
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Báo cáo khoa học: "TWO THEORIES FOR COMPUTING THE LOGICAL FORM OF MASS EXPRESSIONS" doc
Ngày tải lên :
24/03/2014, 01:21
... true of
unions of elements of the semilattice). These predicates are
not only true of the conventional kinds but also of
conventional servings such as the bottle of wine on the
table or the ... speaking, the theories view
the kinds of M as forming an upper semilattice of kinds
with M at the top. This is a "formal" semilattiee in that
the union of any two elements of it is ... for the two theories
of mass terms. The p-rules are for the semantic
occurrence approach while the s-rules are for the syntactic
expression approach. The ontological underpinnings of these
theories...
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