the role of t antigen and insulin like growth factor 1 in dna repair fidelity

Báo cáo y học: "Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis" pps

Ngày tải lên : 13/08/2014, 08:20

... mediated through changes in the activity of the immune system In this regard, the effect of sepsis and the influence of nutrition on tissue protein metabolism and on the functioning of the growth ... mone receptor PCR measurements of insulin- like growth factor- 1 and the growth hormone receptor Bars represent the mean expression of mRNA of insulin- like growth factor- 1 (IGF-I) and growth hormone ... found that nutrition and the route of nutrition in sepsis differentially influence circulating cytokine profiles and the expression of mRNA of SOCS proteins, of the GHR and of IGF-I The present study...

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báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc

Ngày tải lên : 11/08/2014, 00:23

... B: Diagnostic and prognostic role of the insulin growth factor pathway members insulin- like growth factor- II and insulin- like growth factor binding protein-3 in serous effusions Hum Pathol 2009, ... respectively With the IGF introduced on the circuit, the response in the electrical signal is typically in the range of to 15 % in the normalized units A response of IGF -1 binding to the anti-IGF -1 antibody ... presence of excess IGF-2 provided in the kit The excess IGF-2 saturates the refolded IGFBPs present in the sample, leaving the IGF -1 free to bind the antibodies In contrast, the CNT-FET required...

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Báo cáo khoa học: "Insulin-like growth factor-1 in myocardial tissue: interaction with tumor necrosis factor" pptx

Ngày tải lên : 12/08/2014, 20:20

... IGF-binding protein [13 ] Moreover, TNF-α attenuation of IGF -1 may be involved in phosphorylation of the c-Jun pathway [14 ] On the other hand, it has been suggested that the cytoprotection associated ... Long-term IGF -1 treatment thus leads to hypersensitivity to TNF-mediated signaling events Insulin- like growth factor- 1 and tumor necrosis factor Tumor necrosis factor (TNF)-α is a proinflammatory ... by the PI3-kinase/Akt pathway alone In addition to inhibition of Bax expression, the protective effect of IGF -1 is associated with the inhibition of C-jun N-terminal protein kinase activation...

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Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf

Ngày tải lên : 18/06/2014, 16:20

... http://www.translational-medicine.com/content/8 /1/ 117 Page of growth factors and insulin- like growth factor- binding proteins in relation to disease status and incidence of hypoglycaemia in patients with a gastrointestinal ... doi :10 .11 86 /14 79-5876-8 -11 7 Cite this article as: Pantaleo et al.: The emerging role of insulin- like growth factor receptor (IGF1r) in gastrointestinal stromal tumors (GISTs) Journal of Translational ... domain, or with tyrosine kinase Pantaleo et al Journal of Translational Medicine 2 010 , 8 :11 7 http://www.translational-medicine.com/content/8 /1/ 117 inhibitors that block the intracellular tyrosine...

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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx

Ngày tải lên : 15/03/2014, 11:20

... These observations suggest that the stability of the complex between TSC1 and TSC2 is not a critical factor in determining the function of the TSC1 ⁄ TSC2 protein complex in response to IGF -1 ... TSC1 ⁄ TSC2 protein complex within the cytosolic fraction after IGF -1 stimulation (Fig 2F) The alteration of the distribution of TSC1 and TSC2 proteins was detected within 10 of IGF -1 stimulation, ... consistent with the time scale of Akt and S6K1 phosphorylation (Fig 3) These ﬁndings suggest that IGF -1 treatment leads to a change in the distribution of the TSC1 ⁄ TSC2 protein complex from the...

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Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc

Ngày tải lên : 09/08/2014, 01:21

... significantly during the first year in both study groups, but the rise was not sustained until the end of the trial One hypothesis to explain this finding is that vitamin D3, which affects the immune ... days, and then mg E2 for days The investigators in the rheumatology departments were blinded to the identity of the treatments given Regular medication for RA could be altered by the clinician but ... at the patient’s entry into the study and after 12 and 24 months Statistical analysis Nonparametric tests were used, because the data were not normally distributed Groups were compared using the...

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Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc

Ngày tải lên : 19/02/2014, 06:20

... target of rapamycin (mTOR) [11 ,12 ], whose activation by AKT elicits the phosphorylation of two known regulators of protein synthesis, P70S6K and the eukaryotic initiation factor 4E-binding protein ... is induced by postmitotic expression of insulin- like growth factor I Mol Cell Biol 19 , 311 5– 312 4 James PL, Stewart CE & Rotwein P (19 96) Insulin- like growth factor binding protein-5 modulates ... in which a myristoylated AKT or a kinase-inactive AKT mutated at the ATP-binding site (K179M) were cloned [13 ] After transfection by Lipofectamine 2000 reagent, the mix of stable transfectants...

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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt

Ngày tải lên : 09/08/2014, 01:23

... osteoarthritic chondrocytes with increased expression and synthesis of insulin- like growth factor binding proteins Arthritis Rheum 19 96, 39:968-978 Morales TI: The insulin- like growth factor binding ... inhibit the binding of insulin- like growth factor (IGF) to IGF-binding proteins Bioorg Med Chem Lett 2003, 13 :19 31- 1934 50 Roelfsema V, Lane MH, Clark RG: Insulin- like growth factor binding protein ... (IGF) -1 to IGF-binding proteins (IGFBPs), in insulin- like of NBI- 317 72, a small-molecule inhibitor of the binding of priActivitygrowth rabbit chondrocytes lin -like growth factor (IGF) -1 to IGF-binding...

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Suitability of insulin like growth factor 1 (IGF1) as a measure of relative growth rates in lingcod

Ngày tải lên : 04/09/2015, 17:15

... of growth in lingcod and that further work in the laboratory and in the field is warranted The in situ measurements of IGF1 we made are one of the first evaluations of spatial variation in IGF1 ... Instantaneous growth FIGURE Relationship between instantaneous growth and insulin- like growth factor (IGF1) in juvenile lingcod The significant relationships found in tanks B and C are drawn The ... differences in relative growth rates Insulin- like growth factor is one of the principal hormones that stimulates growth at the cellular level in all vertebrates and shows significant relationships with...

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Nghiên cứu tạo dòng, biểu hiện và thu nhận hIGF 1 (human insulin like growth factor 1) từ escherichia coli

Ngày tải lên : 25/07/2014, 08:29

... Thạc sĩ Sinh học T ng quan t i liệu 1. 1 Nhân t t ng trƣởng hIGF -1 (human Insulin- like growth factor 1) 1. 1 .1 Giới thiệu Trong trình t ng trưởng ph t triển thể t giai đoạn thai nhi đến lúc trưởng ... Peroxidase IPTG IsoPropyl-β-D-Thio-Galactoside hIGF -1 human Insulin- like Growth Factor IGF1R IGF -1 Receptor IGFBP Insulin- Like Growth Factor Binding Protein kDa kilo Dalton LB Môi trường Luria-Bertani ... .13 1. 3 T i gấp cuộn in vitro protein thu nhận t thể vùi biểu t bào E coli 14 1. 4 Tinh chế thu nhận protein t i t hợp 17 1. 5 Thử nghiệm ho t tính sinh học hIGF -1 in vitro...

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Báo cáo y học: "Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts" potx

Ngày tải lên : 09/08/2014, 08:23

... understanding of this tissue is clearly of utmost importance to better understand the etiology of this pathology IGF1 is one of the leading growth factors implicated in bone remodeling [ 31] Interestingly, ... growth factors in OA Obs Competing interests The authors declare that they have no competing interests Authors' contributions FM performed most of the experiments and wrote the first draft of the manuscript ... of its α-subunit and kinase activation This involves the phosphorylation of tyrosine residues of substrate adaptor proteins, principally the insulin receptor substrate (IRS) -1 Other targets have...

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Báo cáo y học: "Targeting insulin-like growth factor axis in hepatocellular carcinoma" ppsx

Ngày tải lên : 10/08/2014, 21:23

... carcinoma; IGF: insulin- like growth factor; IGF -1: insulinlike growth factor 1; IGF-2: insulin- like growth factor 2; IGF-1R: insulin- like growth factor receptor; IGF-2R: insulin- like growth factor ... other tumors The first method targets the ligand to reduce its activity, the second inhibits the function of the receptor, and the third modulates the downstream signals of IGF-1R pathways (Table ... Pachter JA: A novel, potent, and selective insulin- like growth factor- I receptor kinase inhibitor blocks insulin- like growth factor- I receptor signaling in vitro and inhibits insulin- like growth...

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Báo cáo khoa học: " Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury" potx

Ngày tải lên : 12/08/2014, 19:22

... benefit of this to our understanding of myocardial dysfunction in sepsis awaits further study 10 11 12 13 14 15 16 17 18 19 Competing interests R182 None declared Ganz W: Direct demonstration in ... measure of cardiomyocyte activity and health [11 ,12 ] In HIV-infected patients with symptomatic hyperlactatemia receiving antiretroviral therapy, Cote and coworkers [13 ] showed that the ratio of mitchondrial ... with insulin- like growth factor (IGF) -1 for hours The number within each histogram represents the number of hearts processed for that condition The values for mtDNA : nDNA ratio in the controls,...

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Báo cáo y học: "Insulin like growth factor-I in acute subarachnoid hemorrhage: a prospective cohort study" potx

Ngày tải lên : 13/08/2014, 20:22

... http://ccforum.com/content /14 /2/R75 Figure Pooled IGF-I concentrations in patients with aSAH and in the control group The line represents the cut-off level of 11 nmol/ l The insulin like growth factor- I (IGF-I) ... declare that they have no competing interests Authors' contributions SB, AU and TK participated in study conception, acquisition of data, analysis and interpretation of data, drafting the manuscript ... insulin like growth factor- I In the context of aSAH, it is most interesting that IGF-I presents with major vascular effects, and thus may contribute to the pathophysiological processes in aSAH...

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Báo cáo khoa học: Identiﬁcation of the amniotic ﬂuid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms docx

Ngày tải lên : 07/03/2014, 00:20

... left lane contains the untreated protein and the right lane the sample treated with the protease-containing fraction (B) Histogram representation of the susceptibility to proteolytic degradation ... isoform was incubated with the proteinasecontaining fraction and the samples were then submitted to western blot analysis, together with identical aliquots of the untreated proteins (Fig 9A) The ... degradation process was evaluated on the basis of the ratio between the integrated areas of the intact protein in the treated and untreated samples This value was determined for each isoform and the...

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Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis pptx

Ngày tải lên : 08/03/2014, 22:20

... (19 90) The roles of tyrosines 24, 31, and 60 in the high anity binding of insulin- like growth factor- I to the type insulin- like growth factor receptor J Biol Chem 265, 15 648± 15 652 15 Cascieri, ... combinations of these) exhibited reduced ability to stimulate DNA synthesis in L7 murine ®broblasts compared with IGF-I [14 ] Interestingly, strong correlations between insulin or insulin mutant ... respectively Further mutations have led to the general consensus that the B and C domains contain residues most involved in IGF1R binding, the A domain represents the IGF2R-binding site, while the...

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báo cáo hóa học:" Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients" potx

Ngày tải lên : 18/06/2014, 15:20

... acquisition of data, analysis and interpretation of data, and the writing of this manuscript MAW participated in the analysis and interpretation of data and the writing of this manuscript PJC ... measuring levels of IGFBP-3 and -4 in sera of melanoma patients Abbreviations (IGF): Insulin- like Growth Factor; (IGF1R): Insulin- like Growth Factor- 1 receptor; (IGFBP-3): Insulin- like Growth Factor ... design, and writing of this manuscript IO conceived this study, oversaw its design and coordination, supervised the analysis and interpretation of the data, and writing the 10 11 12 13 Tao Y, Pinzi...

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Báo cáo y học: " Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively" docx

Ngày tải lên : 11/08/2014, 08:22

... longitudinal diameter; (US): ultrasonography; (ALT): alanine aminotransferase; (SD): standard deviation 14 15 16 17 Competing interests The authors declare that they have no competing interests 18 ... defined as the distance between the anterior wall of the aorta and the internal face of the recto-abdominal muscle perpendicular to the aorta When the aortic walls were not visualized as they ... measure the SAAT using a 7.5 MHz probe and VAT using a 3.5 MHz probe, cm above the umbilicus The SAAT was defined as the thickness between the skin-fat interface and the linea alba, and the VAT was...

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Báo cáo y học: " The role of γδ T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice" pps

Ngày tải lên : 12/08/2014, 15:20

... of the inflammatory response to acute epithelial injury and in maintaining and repairing the epithelial barrier [16 ] Chen et al have found that a deficiency of γδ T cells rendered the intestinal ... mice Interestingly the airway responsiveness to methacholine increased in the wild type but not the knockout mice after chlorine exposure, consistent with the difference in the magnitude of the inflammatory ... likely since the inflammatory response to epithelial damage was also attenuated in the γδ T cell deficient mice Our findings are consistent with a role of γδ T cells in determining the magnitude...

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Báo cáo y học: " The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells" potx

Ngày tải lên : 13/08/2014, 13:20

... p 21/ waf1 has two cyclin binding motifs, one at the N- and the other at the C- terminus [20] p 21/ waf1 (mut) is mutated at the N-terminus and is therefore still able to bind to cyclins through the ... by Tax appeared to be in conflict with the role of Tax in promoting tumorigenesis For this reason, the role of p 21/ waf 1in HTLV -1 infected cells was further investigated by determining the binding ... the TATA box [5 ,19 ] p 21/ waf1 differs from other cyclin/cdk inhibitors in that it has two cyclin binding sites, one localized within the N terminus and the other at the C terminus [20] p 21/ waf1 interacts...

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