the role of pro inflammatory cytokines in memory processes and neural plasticity

Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt

Ngày tải lên : 07/03/2014, 03:20

... deal of interest has been devoted to dissecting the role of the endocannabinoid system in physiology as well as in pathological processes The system incorporates the endocannabinoids, their synthetic ... to the many other classes of anti-excitotoxic drugs tested thus far in clinical trials and certainly may provide the basis for other failures in the future [6] Therefore, a better design of protective ... Endocannabinoids and CB receptors in experimental models of cerebral ischemia In the past 10 years, numerous studies have addressed the role of the endocannabinoid system in stroke and in the mechanisms...

11
385
0

Báo cáo khóa học: Collectins Players of the innate immune system docx

Ngày tải lên : 07/03/2014, 15:20

... collectins depend on the density of carbohydrate ligands on the microbial surface [83] on the one hand, and on the degree of oligomerization of the collectin [66], on the other Clustering of glycoproteins ... of the binding of a single C-type CRD with a monosaccharide ligand is in the order of 10)3 M, whereas the Kd of binding of collectin trimers and higherorder multimers to polyvalent ligands is in ... Viruses Binding of collectins to viruses is especially interesting because viruses make use of the host cell machinery for the synthesis, folding and transport of proteins to the site of Ó FEBS...

21
353
0

Paradoxical roles of the immune system during cancer development docx

Ngày tải lên : 15/03/2014, 01:20

... preventing apoptosis of cells with malignant potential, and second, by stimulating production of pro- inflammatory cytokines by cells of myeloid origin in tumours These pro- inflammatory cytokines then ... characterized by chronic infiltration of innate immune cells in the stromal tissue25,26 (FIG 2) Interestingly, the profile of infiltrating inflammatory cells in skin is distinct from that in cervix — pre-malignant ... T-helper-1 cytokines and anti -inflammatory T-helper-2 cytokines7 4; therefore, the nature and balance of surrounding stimuli might determine which type of NK-T-cell-induced T-helper response dominates and...

17
527
0

Cancer of the Brain and Other Central Nervous System doc

Ngày tải lên : 22/03/2014, 17:20

... Tumors of the spine were the most common site with other CNS cancers, although malignant meningiomas of the brain had worse survival than those with malignant tumors in the spine Brain and other ... 80 Brain cancer occurring in the frontal lobes (25.8% of total), temporal lobe (20.1% of total), parietal lobe (14.6% of total) and overlapping lesions of the brain (19.8% of total) were the most ... overlapping lesions of the brain were the most common locations in the brain Malignant tumors in cerebrum and tumors in the occipital lobe had the worst survival at years For the other CNS cancer...

14
366
0

Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf

Ngày tải lên : 23/03/2014, 07:20

... are known to protect the brain against focal ischemia [35] In order to investigate the role of the endocannabinoid system in the neuroprotection afforded by estrogen, the effect of acute treatment ... receptor binding in cortices and striata did not change following h of MCAo, either in the absence or in the presence of h of reperfusion (data not shown) Fig Endogenous levels of AEA (A) and activity ... upregulation of NAPE-PLD activity lead to increased levels of AEA, which in turn may play a role in the pathophysiology of damage occurring in the ischemic brain More interestingly, we found that the...

12
460
0

Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx

Ngày tải lên : 24/03/2014, 04:21

... capable of binding to the cytoplasmic domain of the siglec-10 protein The binding of SHP-1, however, was missing from the Y667F mutant indicating this to be the preferred tyrosine for interaction ... binding of any of the adherent cell types Binding assays with siglec-expressing COS7 cells Results for COS7 binding experiments are shown in Fig 5C There was a signiﬁcant increase in binding of ... binding, however, was only diminished by < 50% in the Y667F mutant, indicating that SHP-2 may be binding both to the tyrosine at position 667 and to other tyrosines in the cytoplasmic tail of...

14
540
0

brain facts a primer on the brain and nervous system - the society for neuroscience

Ngày tải lên : 08/04/2014, 13:13

... form the hindbrain, midbrain and forebrain The ﬁrst signs of the eyes and then the hemispheres of the brain appear later How does all this happen? Although many of the mechanisms of human brain ... which process vision, and neurons lining the back of the eye As in a camera, the image on the retina is reversed: objects to the right of center project images to the left part of the retina and ... VISION The cornea and lens help produce a clear image of the visual world on the retina, the sheet of photoreceptors and neurons lining the back of the eye As in a camera, the image on the retina...

58
515
0

Design of a near infrared spectrophotometry brain imaging system

Ngày tải lên : 16/04/2014, 01:56

... mspgcc-4.4.3, and then programed to the device using the TinyOS software 4.2 The Sensor The sensor was ﬁrst designed by selecting the components The main problem was sourcing the LEDs with the desired ... spending the time to ﬁnd the required infrared LEDs and allowing for the purchase of them in low quantity The developers behind the mspgcc project deserve a large thank you for porting the GCC ... sent the message ’S’, to message the device to begin acquiring data The program then receives the data The data is split into two parts the upper bit and the lower bits when it is received The program...

88
330
0

scientific american - 1993 09 - special issue - life, death, and the immune system

Ngày tải lên : 12/05/2014, 14:50

... disease All these Þndings intensiÞed interest in one of the most central and baÝling SIR GUSTAV J V NOSSAL is director of the Walter and Eliza Hall Institute of Medical Research and professor of medical ... residence mainly in the lining of the reproductive organs in females and in the epithelium of the tongue in both sexes These cells carry a TCR called gamma Subsequent waves emigrate for the most ... diÝerentiate They give rise to successive kinds of T cells that populate the lining (epithelium) of the skin, various oriÞces (such as the mouth and vagina) and the organs that connect with them (the...

119
910
1

báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx

Ngày tải lên : 18/06/2014, 15:20

... examined the role of IL-12 in AST induced angiogenesis inhibition in vivo Here we show that the ability of AST to inhibit angiogenesis is dependent on the presence of an intact IL-12 signaling ... analyses, the addition of IL-12 blocking antibodies restored cellular infiltration and vessel formation in the gels containing AST (Fig 1c) Role of IL-12 in AST induced angiogenesis inhibition The ... by a single stimulus to levels at times reaching that of the potent combination of IFNγ and LPS was quite remarkable Interestingly, the combination of AST and IFNγ/LPS was additive only in the...

8
477
0

Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx

Ngày tải lên : 18/06/2014, 22:20

... insight into the processes underlying the possible immune stimulating effect of vaccination with SPPV, the ex-vivo levels of IL-12, SOD in splenic macrophages, and the magnitude of splenocyte proliferative ... RD, Thein P: The effectiveness of the paramunity inducer Baypamun (PIND-ORF) for the prevention and metaphylaxis of an experimental infection with the infectious bovine rhinotracheitis virus in ... vaccine In Proceedings of the tenth Conference 5–7 November 1996 Faculty of Veterinary Medicine, Assiut Univrsity, Egypt; 1996:111-118 Trinchieri G: Interleukin-12 and the regulation of innate...

7
353
0

Báo cáo hóa học: " Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury" ppt

Ngày tải lên : 19/06/2014, 08:20

... RL and MA contributed to the design of the study, the software development and the interpretation of the results CC contributed to the design of the study, to the assessment of patients, to the ... transferences in sitting and standing position, which is an essential process in standing balance rehabilitation [24,25] The system calibrates the maximum excursion of the patients and adapts the range of ... required to maintain their soles on the WBB In sitting position, the patients sit directly on the WBB In the study presented in this paper, the patients play with the system in standing position...

10
732
0

Báo cáo hóa học: " Brain-Computer Interface Controlled Functional Electrical Stimulation System for Ankle Movement" doc

Ngày tải lên : 19/06/2014, 08:20

... ) > T2, the BCI-FES system transitions to idling state (pink block) during the training procedures revealed that the EEG power in the μ, b and low-g bands were responsible for encoding the differences ... conceived the study and the design of the BCI-FES system, oversaw the experiments, and co-wrote the article PTW and CEK carried out the experiments, collected and analyzed data, and proofread the article ... alternating 10-sec epochs of idling and repetitive dorsifiexion of the optimally chosen foot (see Training Procedure section) to induce BCI-FES mediated dorsifiexion of the contralateral foot Since the...

14
345
0

báo cáo hóa học: " Application of a hybrid wavelet feature selection method in the design of a self-paced brain interface system" pptx

Ngày tải lên : 19/06/2014, 10:20

... epochs), the size of the NC training feature set was reduced to be the same as the size of the training IC feature sets This was done by randomly selecting epochs from the NC training set Results In ... 2, since the input and output can only take two values: IC and NC), P(xi) is the probability of occurrence of an input state xi, P(yj) is the probability of the output class yj when the input ... from Table 2) The blue line shows the fitness of the classifier as a function of the number of top features We began by training and testing the classifier using only the feature with the highest...

13
530
0

báo cáo hóa học: " Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis" docx

Ngày tải lên : 19/06/2014, 22:20

... of complement anaphylatoxins C3a and C5a are dramatically increased in the CSF enhancing the influx of inflammatory cells into the ventricle and increasing complement biosynthesis and promoting ... emphasise the key role of brain epithelial cells to integrate and further orchestrate the local innate immune response with the production of innate components of the complement system while preventing ... responses to protect the brain against the rather proinflammatory/toxic response in severe bacterial meningitis The severity of the lesioned microenvironment may determine ependymal cell survival and...

9
300
0

báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc

Ngày tải lên : 19/06/2014, 22:20

... is increased in the brain after brain injury which suggests that some of the protective effects of MT-I/II after brain injury are acting directly on the injured brain However, many of the processes ... neurotoxic and can impede the resolution of brain injury [19-21] It is feasible that the number of immune cells entering the CNS can influence the progression of brain injury but the phenotype of the ... extent of injury in wild type and MT-I/II-/- mice The area of the injury site in a μm section taken from the widest point of the injury site was used as a comparative measure of injury size The...

11
460
0

báo cáo hóa học:" Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" doc

Ngày tải lên : 20/06/2014, 04:20

... insight into the processes underlying the possible immune stimulating effect of vaccination with SPPV, the ex-vivo levels of IL-12, SOD in splenic macrophages, and the magnitude of splenocyte proliferative ... RD, Thein P: The effectiveness of the paramunity inducer Baypamun (PIND-ORF) for the prevention and metaphylaxis of an experimental infection with the infectious bovine rhinotracheitis virus in ... vaccine In Proceedings of the tenth Conference 5–7 November 1996 Faculty of Veterinary Medicine, Assiut Univrsity, Egypt; 1996:111-118 Trinchieri G: Interleukin-12 and the regulation of innate...

7
609
0

Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx

Ngày tải lên : 06/08/2014, 19:20

... showing greatest variability included some encoding cytokines controlling both innate immune responses (such as the IL-1 family) and adaptive Th2 responses (such as IL-4 and IL-4R) Strikingly (in ... that there is no certain genetic optimum and that, in an environment with diverse pathogens demanding conflicting response patterns, the fine-tuning effect of multiple allelic variants allows the ... exceptionally susceptible to either infection or pathology, and a deeper understanding of the intimate co-evolution of pathogens and the immune system 10 11 12 13 14 Acknowledgements The author’s research...

4
386
1

Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx

Ngày tải lên : 06/08/2014, 19:21

... subsets, distinguished by the different cytokines they produce (indicated under each CD4 T cell type): the cytokines act on other immune cells, activating them in turn The four known subsets of CD4 ... importantly, in inducing them to secrete the cytokine interleukin (IL)-22 (a cytokine implicated in the defense of mucosal barriers) AhR-dependent induction of IL-22 is seen with several distinct ligands, ... test AhR ligands for their suppressive effect in this autoimmune model with a view to future application in treatment of the disease While the role of AhR in the induction of the cytokine IL-22...

3
335
0

Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf

Ngày tải lên : 07/08/2014, 15:20

... WC1-N4 isoforms The frequency of WC1+ γδ T cells was high in young animals and low in adults There were corresponding differences in the frequency of CD2+ αβ T cells in young and adult animals There ... times (800 × g/3 min) in PBS-HS, then incubated in the dark for 30 minutes at 4oC in 100 µl of a : 200 dilution of fluorescein (FITC)-conjugated goat anti-mouse immunoglobulin (IgG and IgM specific ... molecules should prove useful in study of the response to infectious agents and vaccines [8] ACT1 is expressed within 16 to 24 hrs of stimulation with A similar to the kinetics of appearance of CD25 ACT2...

7
388
0