the role of host genetic variation in hiv infection and its manifestations

A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx

Ngày tải lên : 22/03/2014, 18:20

... bridging the A’ and G b-strands of the I27 protein during the main unfolding barrier.[39] To further validate this view and gain insight into the role of solvent hydrogen bonds in protein unfolding, ... measure the elongation of b-strands A’ and G for unfolding the I27 protein in D2O The pulling coordinate for the separating b-strands is defined as the distance between the first amino acid of strand ... unfolding of one of the I27 modules in the chain Unfolding then extends the overall length of the protein, relaxing the pulling force to a low value As the slack in the length is removed by further...

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Báo cáo hóa học: " The role of single N-glycans in proteolytic processing and cell surface transport of the Lassa virus glycoprotein GP-C" ppt

Ngày tải lên : 20/06/2014, 01:20

... for correct folding and intracellular transport of viral glyco- proteins, as shown for instances for influenza hemagglutinin [19] In order to investigate the importance of the individual N-glycosylation ... we determined the effect of the individual N-glycans on the maturation cleavage by analysing the presence of the cleaved subunit GP-2 Disruption of the N-glycosylation sites within the GP-1 mutants ... H-resistance of the Lassa virus glycoprotein is only acquired when the glycoprotein is cleaved into its subunits This observation is in contrast to findings for the LCMV glycoprotein where an...

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Báo cáo y học: "The role of transposable element clusters in genome evolution and loss of synteny in the rice blast fungus Magnaporthe oryzae" pdf

Ngày tải lên : 14/08/2014, 16:21

... Recombination rate was measured by identifying the physical locations of nine genetic markers on the chromosome and using them as a basis for delineating eight intervals spanning chromosome The ... was in the form of TEs, with simple sequence repeats and other types of repeats comprising less than 1% of the total repetitive DNA content In terms of number of elements, diversity (number of ... genome, all of which are found on chromosome and make up 8.8% of the sequence We analyzed the distribution of TEs in chromosome by defining non-overlapping 100 kb intervals across the sequence and measuring...

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Common genetic variation in nephrin (NPHS1) and its associations with renal and type 2 diabetes mellitus related traits

Ngày tải lên : 03/10/2015, 20:58

... reported in the pancreatic β-cells of humans NPHS1 was found to be localised to the plasma membrane and surface of insulin vesicles of the β-cells A role of NPHS1 in the pathway of insulin exocytosis ... plasma membrane and the surface of insulin vesicles in the β-cells and promotes insulin secretion in response to glucose [78] A higher expression of NPHS1 in mouse insulinoma (MIN6) cells was ... Introduction Aims of study Aim 1: To investigate the association of NPHS1 SNPs with renal traits including eGFR and albuminuria in T2DM Chinese patients in Singapore These patients were from the Singapore...

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Báo cáo y học: "Role of the eosinophil count in discriminating the severity of community-acquired pneumonia in HIV-infected patients" pps

Ngày tải lên : 13/08/2014, 11:22

... prognostic value of eosinopenia was not tested We therefore cannot ascertain the value of this marker to predict mortality in the ICU Concerning the severity of infection, Perello and colleagues ... colleagues there was no noninfection group enrolled (HIV patients without CAP) to test the value of eosinopenia in the diagnosis of sepsis (CAP) among HIV- infected patients Gil and colleagues showed in ... hypothetical mechanism of eosinopenia, which is the migration of eosinophils to the inflammatory site [7,8], we think it may be interesting if Perello and colleagues used the eosinophil cutoff value (40...

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Genetic analysis of the role of ARP2 3 complex in border cell migration in drosophila melanogaster

Ngày tải lên : 10/09/2015, 15:48

... form the structural core of the complex, with the remaining subunits surrounding them ARPC2 and ARPC4 contact the mother filament, whereas ARP2 and ARP3 associated with the pointed end of the ... prevent the binding of capping factors to the barbed end (Kovar et al 2003) FH1 contains polyproline sequences and interacts with profilin (Chang et al 1997) Since profilin binds to actin monomer, ... length of F-actin and limits the number of free barbed ends, which reduces the rate of G-actin monomer depletion Capping proteins therefore reduce the drain on the G-actin pool, allowing more uncapped...

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The role of host cell ether lipids in influenza virus infection

Ngày tải lên : 12/10/2015, 17:36

... 1.2.2 Host proteins and their involvement in influenza virus infection .8 1.2.3 Involvement of host metabolism in influenza virus infection 11 1.2.3.1 Glycolytic flux in influenza virus infection ... 1.2.2 Host proteins and their involvement in influenza virus infection Several papers have reported the crucial role of host proteins in influenza virus infection Coombs et al (2010) reported the ... 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)sn-glycero-3-phosphocholine (PC(P-18:0/20:4)) The interest of this project pivots around the involvement of lipids during an influenza virus infection There is still a substantial lack in the understanding of the role...

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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc

Ngày tải lên : 21/02/2014, 01:20

... business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny County West Chester University Institute for Education, Excellence, and ... Collaboration with business and government Economic Development Programs and Initiatives Business accelerators and/ or entrepreneurial initiatives Linking teaching and research to business opportunities ... stable supply of knowledge and skills in high need areas Increase the size, diversity of skills and productivity of the labor force Dimensions of Social and Economic Value Regional public institutions...

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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf

Ngày tải lên : 22/02/2014, 04:20

... with the aim of reducing the spatial constraints originating from the side-chain interactions between Tyr269 and Ala261 (Fig 2C) The main difference between the G261A and G261A/Y269A enzymes is the ... sequences The mutagenesis targets were residues Trp260 and Ala219 of the catalytic site and His135 of the Mg2+ binding site The most striking result was the loss of the psychrophilic character of mutant ... strain TAB5 We particularly attempted to investigate the functional importance of the Gly pair, located in the vicinity of the active site of the cold adapted enzyme and to study its potential role...

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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding afﬁnity pptx

Ngày tải lên : 07/03/2014, 12:20

... Some single VH domains of anti-protein IgG, including HyHEL-10 and D1.3, were known to retain the specificity and affinity to antigen in itself [7,20] At least for these antibodies, the role of the ... or not H39 is dominantly tuning the VH ⁄ VL interaction of other Fvs, including HyHEL-10 In addition, the effect of the H39 mutation on antigen binding has not yet been analyzed The reason for ... between antigen-binding affinity and VH ⁄ VL interaction strength, in other words, an apparent positive correlation of the stability of the Fv–antigen complex and that of Fv in the absence of antigen,...

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Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt

Ngày tải lên : 08/03/2014, 05:20

... keywords, all the inections of the verb are also considered Therefore, the initial query is expanded into: QUERY(Q209): paper AND clip AND (invented OR ) inventor OR invent OR invents) QUERY(Q258): ... alternations improve the recall of the answer paragraphs For example, in the case of question Q221: Who killed Martin Luther King ?, by considering the synonym of killer, the noun assassin, the Q&A system ... Cardie, Vincent Ng, David Pierce, Chris Buckley Examining the role of statistical and linguistic knowledge sources in a general-knowledge que stion answering system In Proceedings of the 6th Applied...

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Báo cáo " THE ROLE OF GIFT RECIPIENT PERCEPTION IN CHANGING BRAND ATTITUDES AND GIVER - RECIPIENT RELATIONSHIP " potx

Ngày tải lên : 14/03/2014, 14:20

... sources of mixed feelings Merton and Barber (1976) described the sociological ambivalence as follows: “ the ambivalence is located in the social definition of roles and statuses, not in the feeling-state ... situational conditions of gift-giving may differ according to characteristics of the gift-giving occasion, whether the presentation of the gift is public, private, or anonymous, and whether the gift is ... (p.21) These results were the same if comparing between male and female behavior is the interesting finding of Othman and Lee’s study Givers will pay different attitude to these factors when choosing...

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Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf

Ngày tải lên : 16/03/2014, 14:20

... selective inhibitor of Glc6P hydrolysis [31], for evaluating the role of Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content and the rate of glycogen synthesis in ... Harndahl et al ¨ levels through the interaction of glucokinase with binding proteins [5,6] The glucokinase regulatory protein (GKRP) is a speciﬁc inhibitor of glucokinase [5] and also a nuclear receptor ... 0.1 vs 1.5 ± 0.1) These results suggest that the increase of Glc6P in the presence of S4048 was caused by the inhibition of Glc6P hydrolysis in the absence of detectable changes in glucose phosphorylation...

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Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc

Ngày tải lên : 17/03/2014, 04:20

... (particularly the short ones) have all zeroes in them In other words, none of the bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model ... and E Hovy 2004 Determining the sentiment of opinions In Proc of COLING, pages 1367–1373 M Koppel and J Schler 2005 Using neutral examples for learning polarity In Proc of IJCAI (poster) D Lin ... relation is capturing two different situations, one in which the author himself likes the movie, and in the other, the author’s cousin likes the movie The overgeneralization resulting from these “stemmed”...

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Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf

Ngày tải lên : 22/03/2014, 16:21

... fumonisin is suggested to be carcinogenic The 17 fumonisin biosynthetic genes are located in a gene cluster and three of them are P450 enzymes The FUM6 protein (CYP505B1) intervenes in one of the ... element in the alk1 promoter The protein complex also binds to 208 other promoters of genes interfering in alkane degradation such as the acetoacetyl-CoA thiolase gene and the yas1 gene itself ... strong indications for the involvement of a bacterial P450 in the hydroxylation of octane in Rhodococcus rhodochrous, the role of bacterial P450s in alkane degradation in addition to the well-established...

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The Role of Interest Rate Swaps in Corporate Finance doc

Ngày tải lên : 22/03/2014, 17:20

... the transaction from the vantage point of firm A, the floatingrate payer The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net cost of the ... Thus, the net cost of the synthetic fixed-rate financing is determined by the swap fixed rate plus the difference between its short-term borrowing rate and the floating-rate index Banks often index the ... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility The timing of the appearance of interest rate swaps, coming as it did during a period of volatile...

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The Role of Digital Identity Management in the Internet Economy doc

Ngày tải lên : 23/03/2014, 23:21

... to take into account in the assessment of the security risks to − and privacy impact on − the delivery of online services, and in determining appropriate levels of security  In the case of sensitive ... maintained in multiple accounts within the organisation The organisation is in some sense wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same information ... 2007, 95% of medium and large-size businesses in OECD countries were using the Internet, with some 25% of individuals buying goods and services on line, and 30% using Internet banking services...

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Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling pot

Ngày tải lên : 30/03/2014, 02:20

... regions within the bulk of ﬂuid membrane and which are enriched in cholesterol and (glycero-)sphingolipids In addition the fatty acid chains of the phospholipids composing these rigid domains are ... than those in the lipids of the surrounding membrane In fact, this fatty acid composition favors a tighter packing of phospholipids and cholesterol, increasing the rigidity of these domains [32–35] ... implications of this subfamily of receptors in cellular signalling make them attractive therapeutic targets The coupling between stimulation of the P2X receptor and the generation of intracellular...

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Báo cáo khóa học: The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis pdf

Ngày tải lên : 30/03/2014, 13:20

... site of the N-terminal lobe of human and bovine lactotransferrins Importance of the glycan moiety and of the non–covalent interactions between the N- and C-terminal lobes in the stability of the ... trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum Unusual resistance of human apolactoferrin to proteolytic digestion ... lactoferrin where the protein has to survive the harsh environment of the gastrointestinal tract Thus, on the basis of this study, rhLF may be preferred over bLF in oral applications of lactoferrins in...

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Beautiful Places: The Role of Perceived Aesthetic Beauty in Community Satisfaction docx

Ngày tải lên : 30/03/2014, 16:20

... for lower income returns and/ or higher costs of housing Ullman (1954) demonstrated the significant influence of desirable living conditions in terms of climate and landscape in explaining regional ... those of the author and may not necessarily reflect the views of the Martin Prosperity Institute, its affiliates or its funding partners Any omissions or errors remain the sole responsibility of the ... work and school environment – helps define an individual’s sense of being in a particular location Other research has focused on the attitude of “being at home” in a community; in other words, the...

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