... University
Regional Learning Alliance – workforce development and
training/collaborations with business and industry; meeting the
training and education needs of businesses within 60 mile radius
in Northern Allegheny ... $28,000 in average annual salary)
Preserving Value
Continuing education is important to preserving the market value
of specialized education – particularly in professional fields
Continuing education ... University
Small Business Initiative inthe Frehn Center for Management;
offering information and assistance to individuals and groups
planning to start a new business
Indirect Contributions...
... designed on the basis of side-chain packing criteria
from a modelled structure ofthe enzyme resulted in restor-
ation ofthe energy of activation to the levels ofthe native
enzyme and in an increased ... that the E
a
value in this
temperature range is considerably lowered. On the basis of
the model, the behavior ofthe G261A variant can be
interpreted in terms of constraints introduced by the ... respectively. By introducing an Ala residue inthe place of
Gly it is expected that the conformational flexibility of the
main chain can be constrained with a minimum perturba-
tion ofthe local structure,...
... antigen in itself [7,20]. At
least for these antibodies, theroleofthe V
L
domain
might be to increase the affinity by supporting the V
H
domain. The phenomenon may also be observed in
the chain ... clarify
the effect ofthe interface mutations on the antigen-
binding affinity. To investigate systematically this
unsought relationship between the antigen-binding
affinity of Fv and the V
H
⁄ V
L
interaction ... Although the
Fv was designed based on HyHEL-10, it is not clear
whether or not H39 is dominantly tuning the V
H
⁄ V
L
interaction of other Fvs, including HyHEL-10. In
addition, the effect ofthe H39...
... example, inthe case of question
Q209: “Who invented the paper clip ?”, the
expected answer type is PERSON and so is the
subject ofthe verb invented , lexicalized as the
nominalization inventor. ... mountain; (b) lava IS-PART of vol-
cano, and moreover it is a part coming from the
inside; and (c) fragments of lava have all the prop-
erties of lava, the following question semantic
The Roleof ... Question-Answering Track
Experiments using PIRCS. Proceedings ofthe Text Re-
trieval Conference (TREC-9), pages 26–35, 2000.
Dan Magerman. Statistical decision-tree models of parsing.
In Proceedings of the...
... giving is instrumental in
maintaining social ties and serves as a
mean of symbolic communication in social
relationship.
Most ofthe researches before and after
the appearance of Sherry’s model ... described in
details the stages ofthe whole gift-
exchange processes, researchers have
examined the influence of many variables
within these stages. This model divides
gifting activities into ... their brand attitude, may
suggest an interesting implication for the
new brand advertising strategy. Instead of
focusing on the content ofthe message
which only emphasizes the benefits of...
... portion ofthe
savings in that account for school and whether log of net worth or categorical net worth is included
in the model. Moreover, when youth savings is included in regression models, ...
school.
Conley (2001) finds that a doubling of net worth results in an 8.3% increase inthe probability of
attending college. Further, when net worth is included inthe model, Black youth are ... youth.
Youth savings. Youth were asked in 2002 whether they had a savings or bank account in their name. If
they had an account, they were also asked whether they were saving some of this money...
... that the increase of Glc6P inthe presence of
S4048 was caused by the inhibition of Glc6P hydro-
lysis inthe absence of detectable changes in glucose
phosphorylation.
S4048 causes inactivation of ... glu-
cokinase and hexokinase I in distinct pools [3,24], or
by the involvement of mechanisms, additional to
Glc6P, in mediating the effects of glucokinase over-
expression. As glucokinase binds ... control of glycolysis and glycogen synthesis by glucokinase overexpres-
sion. The validity of S4048 for testing theroleof Glc6P was supported by
its lack of effect on glucokinase binding and...
... documents and find that the fea-
ture vectors corresponding to some of these docu-
ments (particularly the short ones) have all zeroes
in them. In other words, none ofthe bigrams from
the training set ... cap-
turing two different situations, one in which the
author himself likes the movie, and inthe other,
the author’s cousin likes the movie. The over-
generalization resulting from these “stemmed” ... rating of ≤ 2 (out of 5)
or ≤ 1.5 (out of 4).
614
Finally, previous work has also investigated fea-
tures that do not fall into any ofthe above cate-
gories. For instance, instead of representing...
... tight
binding affinity was demonstrated towards lauric acid,
resulting inthe synthesis of mainly x-1 hydroxylated
lauric acid, suggesting a roleinthe lipid oxidative
metabolism. Interestingly, the ... enzymes. The FUM6 protein (CYP505B1) inter-
venes in one ofthe first steps in fumonisin synthesis by
hydroxylation ofthe polyketide-amino acid at C-14
and C-15 (Fig. 3). Fum6 deletion mutants of F. ... occurring in the
soil. Furthermore, branched chain fatty acids make up
80% ofthe fatty acid content ofthe Bacillus sp. mem-
branes and when the hydroxylation of these substrates
was studied in...
... to the desire on the part
of firms to hedge cash flows against the effects of interest rate volatility. The
timing ofthe appearance of interest rate swaps, coming as it did during a pe-
riod of ... argue, trading in
interest rate swaps has helped to complete forward markets and to lower the
cost to firms of managing their exposure to interest rate risk.
The Role for Hedging inthe Theory of Corporate ... perhaps the best-known exposition
of this viewpoint, which is based on the principle of comparative advantage.
In international trade theory, the principle of comparative advantage explains
the economic...
... rapidly, causing the unfolding of one of
the I27 modules inthe chain. Unfolding then extends the over-
all length ofthe protein, relaxing the pulling force to a low
value. As the slack inthe length ... stretching a polyprotein re-
sults in a well-defined series of step increases in length, mark-
ing the unfolding and extension ofthe individual modules in
the chain.
[37]
The size ofthe observed steps ... b-strands ofthe I27 protein during the main unfold-
ing barrier.
[39]
To further validate this view and gain insight into
the roleof solvent hydrogen bonds in protein unfolding, we
repeated these...
... of a federation and so are said to operate inthe interest ofthe users
rather than inthe interest ofthe service providers. These service providers are called “relying parties.” In
this model, ... build-
up of profiles that
others hold about him.
Method of linking
accounts/ learning
if they belong to
the same person
There is no linking
between accounts
and no information
flow between them. ... managing and protecting digital identities, with
a view to strengthening confidence inthe online activities crucial to the growth ofthe Internet Economy.
The primer is a product ofthe Working...
... (glycero-)sphingolipids. In addition the
fatty acid chains ofthe phospholipids composing
these rigid domains are generally more saturated than
those inthe lipids ofthe surrounding membrane. In
fact, this ... dur-
ing lipid raft isolation. Moreover, these studies have
provided some insights into the significance of the
localization ofthe P2X
7
receptors in lipid rafts regard-
ing the regulation of intracellular ... muscarinic receptors, endo-
thelin receptors, rhodopsin) are located in lipid rafts
[65–70] where they are in close proximity to their
transducing GTP-binding protein (Gs, Gi, Go, Gq and
transducin...
... suggested by the lack of coincidence of
the changes in relative fluorescence intensity and in
k
and by the hysteresis ofthe reversibility process
(Fig. 4). At the end ofthe transition, the intrinsic ... that of the
wild-type; however, the integrity ofthe calcium bind-
ing site formed by Asp287 and Glu53 is essential for
interaction with the cation in 7.9 m GdmCl.
An interesting finding ofthe ... pfLamA inthe native state, indepen-
dently of their interaction with calcium. Therole of
electrostatic interactions in protein stability has been
widely investigated and the stabilizing effect of...
... Archimedesweg, Leiden, the Netherlands
Lactoferrin (LF) is an iron-binding glycoprotein of the
innate host defence system. To elucidate theroleof N-linked
glycosylation in protection of LF against proteolysis, ... Properties ofthe iron-binding site ofthe N-terminal lobe of
human and bovine lactotransferrins. Importance ofthe glycan
moiety and ofthe non–covalent interactions between the N- and
C-terminal ... such as the pancreatic
enzyme trypsin has been suggested [19,20].
The experiments described herein further elucidate the
roleof N-linked glycosylation inthe protection of lactofer-
rin against...