the role of cyclooxygenase 2 epidermal growth factor receptor and aromatase in malignant mesoth

Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

Ngày tải lên : 09/08/2014, 01:21

... bone metabolism and repair remains unclear Review of the evidence To determine the role of COX -2 in bone repair, investigators have studied fracture healing in animal models of COX -2 inhibition or ... effects of an absence of COX -2 Thus, withdrawal of the drug in a patient might lead to a restoration of prostaglandin synthesis and a normal bone repair process Another point relates to the use of indomethacin ... COX-1-null and COX -2- null mice, they demonstrated the essential role of COX -2 in both endochondral and intramembranous ossification Moreover, the healing of stabilized tibia fractures in COX -2- null...

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Báo cáo y học: "Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients" pdf

Ngày tải lên : 11/08/2014, 08:21

... 44 :26 0 -26 5 20 21 22 23 24 25 26 27 28 29 30 31 32 Hallbeck AL, Walz TM, Briheim K, Wasteson A: TGF-alpha and ErbB2 production in synovial joint tissue: increased expression in arthritic joints Scand J ... affected joints and involved in the pathology of RA In previous studies, we investigated the involvement of bone marrow in the pathology of RA An increase in myeloid cells expressing abnormal ... error bars indicate the 90th and 10th percentiles, respectively The upper and lower edges of each box indicate the 75th and 25 th percentiles, respectively, and the line inside the box shows the median...

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Báo cáo khoa học: " Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma" docx

Ngày tải lên : 09/08/2014, 09:20

... (< 20 % of the sample exhibiting staining); (21 40% of the sample exhibiting staining); (41-60% of the sample exhibiting staining); (61-80% of the sample exhibiting staining), and (81-100% of the ... exhibiting staining); (41-60% of the sample exhibiting staining); (61-80% of the sample exhibiting staining), and (81100% of the specimen stained), we found that while the benign and atypical meningiomas ... participated in identifying cases, acquisition of the data and in drafting the manuscript JI participated in the acquisition of the data and in drafting the manuscript TH participated in the design of the...

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báo cáo khoa học: "Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case report" docx

Ngày tải lên : 11/08/2014, 02:22

... first-line metastatic therapy in February 20 02 for four months The chemotherapy regimen was then changed to 40 mg/m2 vinorelbine plus 600 mg/m2 gemcitabine on days one and eight in a 21 -day cycle and ... of metastatic lesion in the liver taken in 20 02 Page of Figure Magnetic resonance imaging scan taken in 20 03 The hepatic lesion has disappeared of trastuzumab treatment during pregnancy and the ... remission in the liver but relapsed in the central nervous system within two months of withdrawal of trastuzumab maintenance therapy [9] Support for the importance of maintaining HER2 suppression...

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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc

Ngày tải lên : 06/03/2014, 09:22

... might not be involved in the allosteric regulation of ligand binding afﬁnity in the receptor [86] Interestingly, the occurrence of in- frame tandem duplication of exons 18 25 ⁄ 18 26 in the EGFR gene ... activation of the EGFR, where the C-terminal lobe of the kinase domain of one of the monomers forming the dimeric receptor interacts with the N-terminal lobe of the apposed monomer [19,47,84] Of relevance ... A (19 92) Calmodulin inhibits the epidermal growth factor receptor tyrosine kinase J Biol Chem 26 7, 1 523 7–1 524 5 52 Martı´ n-Nieto J & Villalobo A (1998) The human epidermal growth factor receptor...

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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx

Ngày tải lên : 17/03/2014, 11:20

... 114, 22 55 22 63 Takata, H., Kato, M., Denda, K & Kitamura, N (20 00) A Hrs binding protein having a Src homology domain is involved in intracellular degradation of growth factors and their receptors ... Biol Chem 27 2, 20 538 20 544 27 Ebner, R & Derynck, R (1991) Epidermal growth factor and transforming growth factor- alpha: diﬀerential intracellular routing and processing of ligand -receptor complexes ... between the PDGF receptor and members of the src family of tyrosine kinases Cell 62, 481–4 92 Dahl, M.E., Arai, K.I & Watanabe, S (20 00) Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor...

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Báo cáo khoa học: "Effect of β -mercaptoethanol or epidermal growth factor supplementation on in vitro maturation of canine oocytes collected from dogs with different stages of the estrus cycle" ppsx

Ngày tải lên : 07/08/2014, 18:20

... maturation [20 ] Furthermore, studies indicate that EGF induces oscillations in calcium efflux in COCs of mice, and also promotes the synthesis of GSH within the oocyte [8] The role of calcium ... serum [25 ,29 ], gonadotrophin [15] or steroid hormone [15] The present study investigated the effect of βME or EGF supplementation on the base of the stages of the estrus cycle of the ovaries, and ... [3, 12] The EGF is one of many growth factors found throughout the body, including growing antral follicles within the ovary, and has shown to stimulate DNA synthesis and cell proliferation in...

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Báo cáo khoa học: " The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications" pptx

Ngày tải lên : 09/08/2014, 10:20

... survival and pattern of relapse in patients with Page of (page number not for citation purposes) Radiation Oncology 20 06, 1:11 21 22 23 24 25 26 27 28 29 30 31 32 33 advanced head and neck carcinoma ... release of transforming growth factor α activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection ... growth factor receptor in patients with squamous cell carcinoma of the head and neck Cancer 1996, 78: 128 4- 129 2 Baumann M, Krause M: Targeting the epidermal growth factor receptor in radiotherapy:...

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Báo cáo y học: "Role of epidermal growth factor receptor activation in regulating mucin synthesis" pdf

Ngày tải lên : 12/08/2014, 18:20

... with ovalbumin causes goblet-cell metaplasia in rodents [22 ], and the T-helper -2 cytokines interleukin-4 and interleukin-13 have been implicated in this process [23 ] In interleukin-5-knockout ... Davis DE: Involvement of the epidermal growth factor receptor in epithelial repair in asthma FASEB J 20 00, 14:13 62 1374 31 Harkema JR, Hotchkiss JA: In vivo effects of endotoxin on intraepithelial ... 14:341–3 52 Aikawa T, Shimura S, Sasaki H, Ebina M, Takishima T: Marked goblet cell hyperplasia with mucus accumulation in the 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 airways of patients...

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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf

Ngày tải lên : 18/02/2014, 13:20

... The tyrosine kinase inhibitor ZD1839 (‘Iressa’) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells Cancer Res 61, 7184–7188 FEBS Journal 27 6 (20 09) 125 5– 126 5 ... c-Abl tyrosine kinase in the stress response to DNA-damaging agents Nature 376, 785–788 22 Davis RJ (20 00) Signal transduction by the JNK group of MAP kinases Cell 103, 23 9 25 2 23 Chang NS (20 01) ... signaling route by which the EGFR tyrosine kinase inhibitor AG1478 induces apoptosis in PC-9 cells There is a general agreement on the hypothesis that the inhibition of ERK1 ⁄ MAPK and ⁄ or PtdIns3K...

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Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx

Ngày tải lên : 07/03/2014, 00:20

... miR- 122 51 169 621 4494 51 62 909 10 713 538 9069 620 5 5990 303 6483 29 9 21 099 1309 1661 11 565 3379 1536 21 710 11 620 315 27 2 29 20 21 505 5450 28 71 43 82 16 23 6 68 82 9 822 14 071 13 905 723 7 666 ... role of miR- 125 a-5p in lung carcinogenesis and to examine the clinical relevance of our ﬁndings, we investigated the expression of miR- 125 a-5p in a panel of lung cancer patient samples together ... Table S2) Interestingly, among them, some miRNAs, such as miR-16, miR-143, miR -20 0b, and miR -20 5, were shown to be involved in human cancer [8 ,20 ,21 ] In view of our ﬁndings here and the results of...

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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx

Ngày tải lên : 17/03/2014, 17:20

... Choi et al (Eur J Biochem 26 9) 21 22 23 24 25 26 27 roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans J Clin Invest 97, 6 42 648 Petersen, K.F., ... at % 2, % 3, and > h from the start of glucose infusion For the calculation of glycogen C6 changes, data acquired within h of the start of the glucose infusion was not included to avoid any in uence ... detected in the glycogen C1 and C6 resonances Net synthesis of glycogen in the liver is visible from the natural abundance signal increase of glycogen C2–C5 The resonance of glycerol C1 and C3 at 62. 5...

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Báo cáo khoa học: Mutation of epidermal growth factor receptor is associated with MIG6 expression docx

Ngày tải lên : 30/03/2014, 01:20

... (20 04) Activating 525 0 15 16 17 18 19 20 21 22 23 mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to geﬁtinib N Engl J Med 350, 21 29 21 39 ... Christofori G (20 08) Modulation of endocrine pancreas development but not FEBS Journal 27 6 (20 09) 523 9– 525 1 ª 20 09 The Authors Journal compilation ª 20 09 FEBS T Nagashima et al 24 25 26 27 28 29 ... repositories, including the KEGG pathway database, PubMed abstracts and the Entrez Gene database, including GeneRIF ErbB and MAPK signaling pathway-related genes FEBS Journal 27 6 (20 09) 523 9– 525 1 ª 20 09 The...

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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx

Ngày tải lên : 20/06/2014, 04:20

... transcription factors and targets in osteoblast differentiation and matrix mineralization Exp Cell Res 20 00, 25 7 :21 3 -22 2 28 Chen D, Zhao M, Mundy GR: Bone morphogenetic proteins Growth Factors 20 04, 22 :23 3 -24 1 ... regulation of gene expression from the early phase of osteoblast proliferation to the final steps of mineralization Figure FGF -2 and BMP -2, the yin and yang of mineralization: Contrast of effect of 24 ... abundance of FGF -2 treated cells (Figure 3) we found that in general, BMP -2 maintained the mineralizing RNA profile of igf-1, alp, and bmp -2 and significantly increased expression of other genes...

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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf

Ngày tải lên : 20/06/2014, 07:20

... transcription factors and targets in osteoblast differentiation and matrix mineralization Exp Cell Res 20 00, 25 7 :21 3 -22 2 28 Chen D, Zhao M, Mundy GR: Bone morphogenetic proteins Growth Factors 20 04, 22 :23 3 -24 1 ... regulation of gene expression from the early phase of osteoblast proliferation to the final steps of mineralization Figure FGF -2 and BMP -2, the yin and yang of mineralization: Contrast of effect of 24 ... abundance of FGF -2 treated cells (Figure 3) we found that in general, BMP -2 maintained the mineralizing RNA profile of igf-1, alp, and bmp -2 and significantly increased expression of other genes...

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Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer pdf

Ngày tải lên : 10/08/2014, 05:21

... containing the following mutations: -21 6 G/T, 22 35 -22 49 del, 22 36 -22 50 del, 22 40 -22 57 del, and 25 73 T>G for detecting EGFR mutations in 81 cases of NSCLC The two protocols identified the same 26 mutations, ... mutation(s) L747-S7 52 del L858R -21 6 G/T 22 35 -22 49 del E746-A750 del 22 36 -22 50 del 22 40 -22 57 del 25 73 T>G Adenocarcinoma (n = 26 ) 3 Bronchioloalveolar carcinoma (n = 6) 0 Squamous cell carcinoma (n = ... promoter) rate was 32% (26 of 81) Mutations in exons 18 -21 of EGFR TK domain were detected in 19 (23 %) of the 81 NSCLCs in which there were 12 adenocarcinomas, three bronchioloaveolar carcinomas, two...

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Báo cáo y học: "The role of Qa-2, the functional homolog of HLA-G, in a Behcet''''s disease-like mouse model induced by the herpes virus simplex" pptx

Ngày tải lên : 11/08/2014, 03:20

... might increase the number of NK cells, and the increase of NK cells might play an important role in the pathogenesis of BD Conclusions Qa -2 levels were lower in the PBMC of BD mice than in the ... toward Th2 by promoting the secretion of IL-3, IL-4 and IL-10 while down-regulating the production of IFNγ and TNFα [41-43] In the present study, Qa -2 siRNA increased the IFNγ mRNA levels in the spleens ... rather to down-regulation of Qa -2 In addition, the present results showed that the injection of Qa -2 Figure The frequency of NK cells in BD and BDN mice The frequency of NK cells was analyzed in...

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Báo cáo y học: "Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells" pot

Ngày tải lên : 11/08/2014, 08:22

... endotoxin in the rat Br J Pharmacol 1997, 121 :695-704 Page of (page number not for citation purposes) Journal of Inflammation 20 09, 6 :20 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 ... prostaglandin synthesis [40], and S-nitrosylation of COX -2 activates the enzyme and contributes to cell injury [41, 42] The impact of the co-induction of iNOS and COX -2 in endothelium requires further investigation ... PD 150606 increased the induction of COX -2 in KD and Control MAEC (figure 4B), further suggesting that calpain is responsible for restraining the induction of COX -2 in MAEC In support of this idea,...

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Báo cáo y học: "Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling" pdf

Ngày tải lên : 14/08/2014, 16:21

... Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-akt signaling through downregulation of PDGFR J Clin Invest 20 03, 1 12: 122 3- 123 3 Wu EH, Wong YH: Involvement of G i/o proteins in nerve growth factor- stimulated ... JS: Induction of Cdc25B expression by epidermal growth factor and transforming growth factor- alpha Biochem Pharmacol 20 04, 68 :22 21 -22 27 Kim MJ, Jo DG, Hong GS, Kim BJ, Lai M, Cho DH, Kim KW, Bandyopadhyay ... 0.07 - Protein binding 0. 02 0.06 0.3 0.1 2. 5 0.01 0.06 Protein kinase activity 2. E-03 0. 02 0.3 0.1 4 .2 0.03 0.37 Protein serine/threonine kinase activity 1.E-03 0. 02 0.3 0.1 4.8 0. 02 0. 32 Transferase...

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