... dur-
ing lipid raft isolation. Moreover, these studies have
provided some insights into the significance of the
localization ofthe P2X
7
receptors in lipid rafts regard-
ing the regulation of intracellular ... (glycero-)sphingolipids. In addition the
fatty acid chains ofthe phospholipids composing
these rigid domains are generally more saturated than
those inthe lipids ofthe surrounding membrane. In
fact, this ... muscarinic receptors, endo-
thelin receptors, rhodopsin) are located in lipid rafts
[65–70] where they are in close proximity to their
transducing GTP-binding protein (Gs, Gi, Go, Gq and
transducin...
... Properties ofthe iron-binding site ofthe N-terminal lobe of
human and bovine lactotransferrins. Importance ofthe glycan
moiety and ofthe non–covalent interactions between the N- and
C-terminal ... Archimedesweg, Leiden, the Netherlands
Lactoferrin (LF) is an iron-binding glycoprotein of the
innate host defence system. To elucidate theroleof N-linked
glycosylation in protection of LF against proteolysis, ... such as the pancreatic
enzyme trypsin has been suggested [19,20].
The experiments described herein further elucidate the
roleof N-linked glycosylation inthe protection of lactofer-
rin against...
... a
well-defined hyperintensity mass inthe cervical area. The shape of
the uterine cervix is distorted inthe DWI (arrowhead). d On the
ADC map the tumor is hypointense (arrow) and the normal ... imaging technique (SENSE factor
of 2). Imaging time of DWI was 90 s for 20 slices.
Detection of uterine malignancy
The ADC values of uterine cancers are lower than of
normal tissue. On the other ... with uterine leiomyomas and a
bleeding cyst. a Axial T2-WI shows an area of hypointensity in the
center ofthe cystic component (arrow). b On T1-WI with fat
suppression the area inthe cystic...
... documents and find that the fea-
ture vectors corresponding to some of these docu-
ments (particularly the short ones) have all zeroes
in them. In other words, none ofthe bigrams from
the training set ... cap-
turing two different situations, one in which the
author himself likes the movie, and inthe other,
the author’s cousin likes the movie. The over-
generalization resulting from these “stemmed” ... rating of ≤ 2 (out of 5)
or ≤ 1.5 (out of 4).
614
Finally, previous work has also investigated fea-
tures that do not fall into any ofthe above cate-
gories. For instance, instead of representing...
... maintained in multiple accounts within the organisation. The organisation is in some sense
wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same
information. ... take into account inthe assessment ofthe security risks to − and privacy impact on −
the delivery of online services, and in determining appropriate levels of security.
Inthe case of sensitive ... managing and protecting digital identities, with
a view to strengthening confidence inthe online activities crucial to the growth ofthe Internet Economy.
The primer is a product ofthe Working...
... used to describe the binding
isotherms obtained previously for the b-casein 1–25 phos-
phopeptide in this pH range, and the same model was
adapted to fit the binding isotherm of OPN 1–149 mea-
sured ... mixture of scattering from copolymer micelle-like nanoclus-
ters and free peptide. The scattering ofthe nanoclusters was obtained by subtracting the scattering ofthe free peptide from the total ... growth
in the extracellular matrix of mineralized tissues. These
include long phosphorylated sequences in, for example,
phosphophoryn, the C-terminal sequence of OPN and
the N-terminal sequence of...
... for the central roleof ADAM10 and confirming that
TACE has a minor roleinthe a-secretase cleavage of APP
in human cells.
During the course ofthe present study it was reported
using an RNA interference ... cells inthe absence or presence of
APMA. Following this second incubation, the level of
sAPPa inthe medium was examined (Fig. 4A,B). There was
no significant difference inthe level of sAPPa inthe ... acid-based
metalloprotease inhibitors [14] inthe presence or absence
of APMA. Inthe majority of cases there was little difference
between the effect of inhibitors on the constitutive shedding
of ACE and the APMA-induced...
... to the combined
epitope contributed by the α2 and α3 domains of the
heavy chain and β2m, dependent on the presence of pep-
tides inthe peptide-binding groove [40-42]. The levels of
open conformers ... Beta2-
microglobulin promotes the growth of human renal cell car-
cinoma through the activation ofthe protein kinase A, cyclic
AMP-responsive element-binding protein, and vascular
endothelial growth ... suggesting that most ofthe exoge-
nous β2m binds to open forms of HLA class I. However,
residual β2m bound even inthe presence of HC-10, likely
Binding of exogenous β2m tips the balance of open...
... than inthe inheritance case in that no sharing map is
involved; an attempt to vm_write one mapping ofthe memory object would merely replace that mapping, rather than
reflecting it in other ... validation - Finally, the kernel informs the hardware physical map module ofthe new virtual
to physical mapping.
With the exception ofthe hardware validation, all of these steps are implemented in a ... knowledge
structures to be built, maintained and accessed using these techniques.
8.1. Emulating Operating System Environments
During the 1960’s the notion of a virtual machine base for operating systems development...