the public switched telephone network is designed to be available 99 999 of the time
Báo cáo khoa học: Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190 pot
Ngày tải lên :
16/03/2014, 00:20
... corresponding to the pK
a
acetyl
of the
active site Cys. This unchanged pK
a
acetyl
of the active
site Cys in Y190F could be ascribed to dipole–dipole
interaction between the para-hydrogen of Phe and the
aspartyl ... TS-I). If, however, the
pK
a
transacetyl
of the His is significantly lower than that of
the conjugate acid of the attacking arylamine, then
deprotonation is favored to follow the tetrahedral inter-
mediate ... His107 (Fig. 1). This
Tyr is highly conserved [34–36] in all the NAT sequences
reported to date, with the only exception being the iso-
form banatB from Bacillus anthracis, where a His is at
the...
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Tài liệu GPON Migration Ensuring my Network is Ready to Migrate to GPON doc
Ngày tải lên :
21/12/2013, 08:17
... will the network migrate from one PON flavor to the next
as bandwidth demand continues to rise.
GPON Migration
Ensuring my Network is Ready to Migrate to GPON
Ensuring my Network is Ready to ... characteristics – but they may also be quite
different. The spectral attenuation refers to the loss of
a signal as a direct correlation between the wavelength
and the distance traveled. The lower the ...
design. This applies equally to overbuilds, Greenfield
applications, or even a migration network. To be profitable,
it’s imperative to understand the impact of the decisions
made early in the planning...
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Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc potx
Ngày tải lên :
16/03/2014, 23:20
... different mechanisms to control the aggregation
states of these substrates and supports our original
hypothesis that mammalian cellular factors enable
endogenous proteins to be presented to the c-secretase
complex ... then
ligated into the HindIII ⁄ BamHI site of p3XFLAG-CMV-14
and the resulting vector named SPC99-3FLAG. The follow-
ing primer pairs were used to amplify the C99-3FLAG
sequence from SPC99-3FLAG: ... zinc-bind-
ing domain may be present in the Ab sequence of C99,
we hypothesized that zinc may affect the oligomeriza-
tion state of C101-3FLAG. Therefore, the molecular
mass of C101-3FLAG before and after...
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Báo cáo Y học: Barley a-amylase Met53 situated at the high-affinity subsite )2 belongs to a substrate binding motif in the bfia loop 2 of the catalytic (b/a)8-barrel and is critical for activity and substrate specificity pot
Ngày tải lên :
31/03/2014, 08:20
... view of the
global structure of the AMY2 (top) and TAA (bottom) complexes
[16,17]. The inhibitors are in green and the arrow indicates the nitrogen
(in dark blue) that corresponds to the oxygen of ... characterize the number of recognized
substrate glucosyl residues, the binding affinity of individual
subsites, and the position of the bond to be cleaved [31–34].
The spatial distribution of binding ... the
transglycosylation/hydrolysis ratio of that enzyme. This
explanation may also apply to the AMY1 mutant,
although the shape of the binding cleft of S. fibuligera
a-amylase is very similar to that of TAA [60]...
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báo cáo sinh học:" Empowering health personnel for decentralized health planning in India: The Public Health Resource Network" ppt
Ngày tải lên :
18/06/2014, 17:20
... Health Resource Network is an effort
towards this end.
Discussion
The Public Health Resource Network
Started in 2005, the Public Health Resource Network
(PHRN) is an innovative distance-learning ... decentral-
ized governance of systems of planning and delivery, at
least at the level of the district. In India, a district is the
smallest administrative unit. The country has 604 districts
across its ... managers
towards strengthening the public health system in their
districts, and assisting in the emergence of state and dis-
trict resource groups for this purpose;
ã empowering civil society to create...
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Comparing the cultural and linguistic analysis of the English word “meal” and words relating to it in contrast with Vietnamese equivalents.
Ngày tải lên :
15/04/2013, 15:11
... rice, the guest often stops and says he or she is full even if s/he is
starving. To respond thoughtfulness towards the host, the guest can serves a
little of the other dishes to another to family ... teaspoonful for the pot. Boiling water is poured into the
pot and the tea is left for about five minutes before the host serves the guest.
Even there are the adages from the side of the Victorian about ... vestigial the presence of the napkin is, because the
purpose of table manners is to preserve cleanliness and proper appearance. As
soon as the meal is served, the diners remove the napkin from their...
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Tài liệu Báo cáo " STABILITY OF THE ELASTOPLASTIC THIN ROUND CYLINDRICAL SHELLS SUBJECTED TO TORSIONAL MOMENT AT TWO EXTREMITIES " pptx
Ngày tải lên :
13/02/2014, 04:20
... given
in table 1.
The calculating results based on the elastic theory are presented in table 2. Figure
1 is graph of the elasto-plastic instability case . The comparison between the elasto-plastic
instability ... on the theory of elastoplastic p rocesses the above mentioned
problem has been solved by approach simulation of instability form of the cylinder (see
[1],[5]). In this paper, the solution of ... based on the elastic theory is reliable.
c) The expression of deflection δw in (3.1) has exactly described real bending form of
structure.
This paper is completed with financial support from the National...
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Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx
Ngày tải lên :
14/02/2014, 21:20
... cells sensitized them to
the toxicity of extracellular dopamine. Neuronal expression of p25a thus
holds the potential to sensitize the cells toward dopamine and toxins
carried by the dopamine transporter.
Structured ... neurons of the sub-
stantia nigra pars compacta is responsible for the
major motor symptoms of PD. The neurotransmitter
DA has been hypothesized to play a major role in this
selective loss of dopaminergic ... risk of
oxidative stress, as DA can auto-oxidize at the neutral
pH of the cytosol and thereby form toxic DA-quinone
species, superoxide radicals and hydrogen peroxide.
The low pH in the DA storage...
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