the pathophysiology of skeletal muscle ischemia
Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx
Ngày tải lên :
19/02/2014, 16:20
... acting on either
side. The decreased open time constant together with
the decreased number of the open events led to the
decrease of the open probability. The voltage-depend-
ence of the inhibitory ... the idea
that 100 lm EGTA total in the cis side prevents the
binding of any Gd
3+
ion to the regulatory calcium-
binding sites located on the cis side of the RyR1. Fol-
lowing the recovery, the ... tion of 5.6 ± 0.3 lm for Gd
3+
and a Hill coefficient
of 4.7 ± 0.8.
We have also tested the effect of Gd
3+
on the lumi-
nal side of the reconstituted channel. To decrease the
possibility of the...
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Tài liệu Report on The Management of Non-Muscle-Invasive Bladder Cancer ppt
Ngày tải lên :
14/02/2014, 21:20
... recur-
rence of these tumors. There is no evidence that
any intravesical therapy affects the ultimate rate
of progression to muscle- invasive disease.
Because there is risk of progression to muscle-
invasive ... one-third of
the distance from the basement membrane to the
detrusor muscle is a discontinuous, wispy layer of
smooth muscle called the muscularis mucosa.
The muscularis mucosa, when parts of it ... is such that the probabili-
ty (Bayesian) of the true value being outside the
interval is 5 percent. The width of the confidence
interval indicates the degree of uncertainty about
the estimated...
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Tài liệu The pathophysiology of tuberculosis - Tuberculosis: back to basics ppt
Ngày tải lên :
15/02/2014, 13:20
... rculosis
Oldtuberculin
s.c.on the back
Fever,rigors ,necrosis and
sloughing of the skinlesion,
anddangerousnecrosis of
othe rlesionsinlungsorspine.
2448hrs
The
The
“
“
Kochphenomenon
Kochphenomenon
”
”
inman
inman
Beijing ... eminationbycoughing
•90% of the Tlymphocytesin the lesionsdonotneedtobe
theretocontrolbacterialproliferation.
•TheseunnecessaryTlymphocytescauseimmunopathology
•Howdotheydoit?
Thisimmunopatholo ... IL4downregulatesprotectivemacrophagefunctio ns
• ThereismoreIL4inTBincountrieswithin30degreesNorthorSouth of the equator
• Theseare the areaswhereBCGvaccinefailsandmortalityfrom...
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Báo cáo khoa học: Cardiac ankyrin repeat protein is a marker of skeletal muscle pathological remodelling pot
Ngày tải lên :
07/03/2014, 03:20
... was
checked at the time of muscle excision by visualization of
abnormal gait of the limb and by verifying the disconti-
nuity of the sciatic nerve at the thigh. The TA, EDL and
soleus muscles were ... type of fibres composing the muscle. In the
C3-null model, the quadriceps muscle is unaffected by the
disease, the EDL and TA muscles are weakly affected,
and the soleus and psoas muscles are the ... reflect the muscle impair-
ment specificity – which varies between models – and
the type of fibres composing the muscle (see Experi-
mental procedures).
The results of qRT-PCR showed that the level of
NF-jB-p65...
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Báo cáo khoa học: Mapping contacts between regulatory domains of skeletal muscle TnC and TnI by analyses of single-chain chimeras potx
Ngày tải lên :
16/03/2014, 18:20
... the N domain of TnC binds
in a calcium-dependent manner to the C domain of TnI, releasing the
inhibitory effect of the latter on the actomyosin interaction. While the crys-
tal structure of the ... representation of the structural dis-
position of TnC and TnI in the light of recent results
from our group and others. The N terminus of TnI is
displaced around the C domain of TnC [17,18,20]. The
inhibitory ... that
solving the structure at the atomic level of the chime-
ras studied here will lead to the identification of the
functional domain of TnC and TnI, as well as com-
plement the crystal structure of the...
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Chemical neurolysis in the management of muscle spasticity
Ngày tải lên :
01/11/2013, 10:20
... spasticity 159
the back with the ultrasound probe at the level of L1–
L4. The thickness and width of the muscle are then
determined. The block is made in the medial part
of the muscle near the vertebral ... head of the
fibula. Each of these divisions gives off three to five
terminal branches in the proximal fifth ofthe muscle.
The middle and distal branches enter deep into the
muscle and supply the ... 4 ml of the neurolytic agent
into the muscle belly of the adductor longus the nee-
dle should be advanced to a depth of 4 to 5 cm to
reach the adductor brevis where a further 3 to 4 ml
of the...
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Tài liệu Osteoporosis in Men: The Effects of Gender on Skeletal Health Second Edition pptx
Ngày tải lên :
14/02/2014, 21:20
... males there is a thinning of
trabeculae [13]. Some of the other functions of osteoblasts
and osteocyte proteins will be discussed later.
The cells responsible for the turnover of bone, the osteo-
clasts, ... remodeling and regulate the turnover of the
mineralized matrix. They remove bone by producing acid
and couple that with the transport of chloride out of the
cell. The acid dissolves the mineral (see ... used
for the prediction of the increase in BMD or the decrease in
the fracture risk during the treatment. There is also no study
which has assessed the potential use of BTM to improve the
compliance...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
Ngày tải lên :
16/02/2014, 09:20
... increase in apoptosis [73]. The authors of this study
ascribe the regulation of outgrowth of limb buds and
patterning of the digits to the chicken AP-2.
The role of AP-2a was further studied in zebrafish.
It ... embryogen-
esis, because of the severe skeletal defects in growth
and the development of face and limbs [17–19]. Don-
ner et al. tried to link the expression of AP-2a in these
tissues to upstream ... further analyze their interactions with AP-2 and the
functional role of these in chondrocytes.
Furthermore, it is speculated that in melanoma,
where AP-2a acts as a tumor suppressor, the loss of
AP-2a...
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Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
Ngày tải lên :
18/02/2014, 13:20
... particular, p21 is a direct target of
SREBP [20]. The role of SREBP-1a in the regulation of
cell growth and the cell cycle might be biphasic and
complex, and needs to be further investigated.
SREBP is ... resistance [48]. The exact roles of SREBP-1c ⁄
ADD1 are not yet fully defined.
SREBP and parasympathetic function
in heart
Parasympathetic stimulation of the heart involves
activation of GIRK1 ⁄ 4, ... adipogenesis [44]. The roles of
SREBP-1c in adipogenesis are currently controversial.
Physiology and pathophysiology of the SREBP family H. Shimano
618 FEBS Journal 276 (2009) 616–621 ª 2008 The Author...
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Tài liệu Báo cáo khoa học: Subproteomics analysis of Ca2+-binding proteins demonstrates decreased calsequestrin expression in dystrophic mouse skeletal muscle pdf
Ngày tải lên :
19/02/2014, 16:20
... In
contrast, the exp ression o f major i on-regulatory muscle
components, such as the Na
+
/K
+
ATPase, the SERCA1
isoform of the sarcoplasmic reticulum Ca
2+
ATPase, and
the a
1
-subunit of the dihydropyridine ... analysis of Fig. 3 and the 1D i mmunoblotting of Fig. 4.
As the full-length Dp427 isoform of dystrophin does not
enter the second dimension of conventional 2D gels, the
expression level of a-dystroglycan ... This cofactor of the t ranscription en-
hancer factor TEF-1 appears to be a new c omponent of the
myogenic programme that promotes muscle differentiation
[40]. As a result of the overlap with other...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
Ngày tải lên :
22/02/2014, 04:20
... degrees of
inhibition of NO production with Ro31-2880 and
GF109203X were approximately 70 and 30%, respectively.
Effects of TS on the amount of PKCa
We further examined the effects of TS on the amounts ... [20–23], the mechanism of the TS effect
still remains unclear. Therefore, we investigated in detail the
effect of TS on NO production in the VSMC system. The
investigation would further give ... inhibited the
enhancing effect of TS on LPS/IFN-induced NO produc-
tion. Furthermore, TS enhanced the amount of PKCa in
VSMC. From these results, we concluded that the enhan-
cing effect of LPS/IFN-induced...
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Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt
Ngày tải lên :
05/03/2014, 23:20
... must, then, be present
in this preparation. Of particular importance is the
finding that exogenous cADPR failed to increase the
spontaneous release of ATP in the absence of CD38.
In other words, the ... determine the
mechanisms of purine-mediated presynaptic neuromod-
ulation in the bladder.
The enhancing effect of cADPR on the spontaneous
release of ATP is not caused by activation of
membrane-bound ... determine whether low concentrations of
cADPR can affect the amounts of released ATP in the
bladder. We found that a low nanomolar concentration
of cADPR enhances the spontaneous overflow of ATP,
but...
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