the major histocompatibility complex a paradigm for studies of the human genome
Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt
Ngày tải lên :
18/06/2014, 16:20
... separated to expose the zygoma and squamosal bone A burr hole of 1.5 × mm was made using a mm micro-drill rostal to the anterior junction of the zygoma and the squamosal bone The dura mater was ... Transplantation Seven days after the induction of focal cerebral ischemia, animals were anesthetized with an intra-peritoneal injection of 400 mg/kg chloral hydrate (Pharmaceutical Plant of Tiantan ... completion of behavioral assessments Tracking of BrdU+ NSC revealed that a majority of the donor cells engrafted to the infarcted areas of the cortex, hippocampus, striatum and parenchyma near the third...
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Báo cáo khoa hoc:"The porcine Major Histocompatibility Complex and related paralogous regions: a review" ppsx
Ngày tải lên :
09/08/2014, 18:21
... load and may increase the risk of HTLV-I-associated myelopathy The outcome of hepatitis B and papilloma virus infections has also been associated with HLA alleles The role of certain HLA antigens ... the spontaneous reappearance of the malignant melanoma also seemed to correlate with an ancestral SLA haplotype [22] In contrast, segregation analysis of melanocytic 124 P Chardon et al lesions ... sequence The sequencing of the class I region was essential for the unravelling of the overall SLA class I organisation In particular, it permitted individual characterisation of all class I genes,...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 2
Ngày tải lên :
14/09/2015, 14:07
... TTA gg CTg AAT gAA CCC TgC TCT gg TgA ATA ACA AAT ggg CAA ACC CCT AAg AAT gTg CCC TgT CC gAg CAA Agg gCT gAA gAT TAT g ACT CTg CCT TTC CTC ATC AAA C TCC TCA TCA ACA CCA CTT TCT g TCC CAA ggA ... CTT AAg TT DRB1-09 CAg gAA ACA gCT ATg ACC TgA CCA gCA CgT TTC TTg AAg CAg gAT AAg TT DRB1-52.1 CAg gAA ACA gCT ATg ACC CCC ACA gCA CgT TTC TTg gAg TAC YCT A DRB1-07 CAg gAA ACA gCT ATg ACC TgA ... Agg AAA CAg CTT ATg ACC TgA gAC gCA CgT TTC TTg gAg CAg gTT AAA C DRB1-01 DRB1 CAg gAA ACA gCT ATg ACC TgA AgA CCA CgT TTC TTg gAg gAg g CAg gAA ACA gCT ATg ACC TgA gAC gCA CgT TTC TTg Tgg SAg...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 3
Ngày tải lên :
14/09/2015, 14:07
... was calculated and plotted against physical distance LD was calculated using both the D′ coefficient (blue shaded area) as well as r2 (red shaded area) The averaged pairwise LD value across the ... single HLA-B partner (e.g HLA -A* 3303, HLAC*0302, HLA-DRB1*0301) Overall, there is a tighter linkage between HLA-C and HLA-B alleles as compared to HLA -A or HLA-DRB1 Each HLA-C allele has a dominant ... determined at each locus A number of HLA alleles stand out as being very common in the population, for example the HLA -A* 1101 allele is present at a frequency of 30% The most common allele at the HLA-B...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 4
Ngày tải lên :
14/09/2015, 14:07
... had an average minor allele frequency of 8%, compared to an average of 4% for the other 216 This result suggests that although the overall performance of the 1877-SNP map in capturing HapMap variation ... capture the variation of the 1877 SNPs in the Singaporean Chinese population The results are tabulated in Table 3.8 below Table 3.8 Transferability of HapMap tag SNPs HapMap Panel* Number of tag SNPs ... with the same set of criteria: selecting the minimal set of tags such that all test SNPs can be captured by a tag with an r2 or at least 0.8 Tag SNPs were also generated by treating the East Asian...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 5
Ngày tải lên :
14/09/2015, 14:07
... and the haplotype that tags a HLA allele with the maximum r2 was taken as the tagging haplotype for that particular allele The results are shown in Table 3.9 Using single-SNP tags, most HLA alleles ... tags however perform much better than single tags 25 of the 26 HLA alleles were tagged with an r2 of at least 0.8, with a mean maximum r2 value of 0.95 In some cases the performance is dramatically ... HLA Alleles (See legend on the next page) A HLA-G - HLAA HLA-F Telo HLA -A A*3303 A* 0207 A* 1101 A* 2402 A* 0203 A* 0201 HLA-C B HLA-B LTA BAT2 C*0102 C*0801 Recombination Rate (cM/Mb) Extended Haplotype...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 6
Ngày tải lên :
14/09/2015, 14:07
... and Class I regions, most probably reflecting the common lineage of the HLA -A0 2 haplotypes Although the DBB (A2 -B57-DR7) and MCF (A2 -B15-DR4) Caucasian haplotypes carry HLA -A0 2 alleles too, the ... Traherne et al 2006, Horton et al 2008) set out to completely sequence Caucasian CEHs, providing a wealth of variation data of the MHC in the Caucasian population The high-resolution SNP map of ... identify a consensus haplotype due to recombination (local CEHs) Large gaps are seen in of the Caucasian CEHs (APD, DBB, MANN, MCF and SSTO), as the sequence coverage of the MHC in these haplotypes...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 7
Ngày tải lên :
14/09/2015, 14:07
... A A A A A A A A A A A A A A A A A A A A A A A A G G G G G G G G G G G G A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A ... A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A C C C C C C C C C C C C C C C C C C C C A A A A A A A A A A A A A A A A ... TT AG AG AG AG AG AG AG AA AA AA AA AA AA AA AA AA AA AA AA AG AG AG AG AG AG AG GG GG GG GG GG GG GG GG GG GG GG GG AG AG AG AG AG AG AG AA AA AA AA AA AA AA AA AA AA AA AA AG AG AG AG AG AG AG...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 8
Ngày tải lên :
14/09/2015, 14:07
... such as Graves’ disease, myasthenia gravis and psoriasis, as well as nasopharyngeal carcinoma (Chan et al 1978, Lu et al 1990, Chan et al 1993, Ren et al 1995, Vejbaesya et al 1998) The disease ... China, Singapore and Taiwan, it has a high frequency in indigenous populations in the Americas, Australia and Asia It is also found with a frequency of at least 5% in several Caucasian populations ... populations also reflect well the genealogy between the populations, with the Japanese population showing high correlation, followed by the Caucasians and the Africans The transferability of HapMap...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 1
Ngày tải lên :
14/09/2015, 14:07
... Introduction 1.1 The Human Major Histocompatibility Complex (MHC) 1.1.1 Features of the Human MHC The human Major Histocompatibility Complex (MHC) is a gene dense segment on the short arm of the human chromosome ... ultimately spurious association signal for HLA -A3 in hereditary haemochromatosis For the majority of the MHC associated diseases, establishing a causative relationship between a disease and a MHC ... SLE and myasthenia gravis (Price et al 1999) Another example of a disease associated CEHs in the Caucasian population is the A3 B7-DR15 haplotype that is associated with SLE and hereditary haemochromatosis...
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báo cáo hóa học: " Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation" potx
Ngày tải lên :
19/06/2014, 22:20
... thank the Oklahoma Medical Research Imaging Core Facility for their assistance and Mrs Marilyn Bonham-Leyba for assistance with manuscript preparation References 10 Pramatarova A, Laganiere J, Roussel ... in large part by the ALS Association; the Oklahoma Center for the Advancement of Science and Technology (HR02149RS); and the National Institutes of Health (AG20783, NS044154) We thank the Oklahoma ... immunosorbent assays (ELISAs; Cayman Chemical, San Diego CA USA) Nitrite assay Cell culture medium was assayed for NO2- by the Griess assay as described [8] Samples were mixed 1:1 with a mixture of equal...
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Báo cáo y học: "Outcome of crisis intervention for borderline personality disorder and post traumatic stress disorder: a model for modification of the mechanism of disorder in complex post traumatic syndromes" ppsx
Ngày tải lên :
08/08/2014, 23:21
... psychotherapy that, in turn, may repair the mechanism of crises, thereby making medication unnecessary Some authors explain the limitations of pharmacotherapy by the nature of BPD and complex ... guidance from the research staff about the criteria for each rating The nurses' judgment was based on review of the medical record, as a summary of all staff accounts Although the nurses assigned ... patients mislearn from their private experiments faster than they make progress in therapy with analysis of the transference and of scenarios of old betrayals The crisis intervention of the Cape...
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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc
Ngày tải lên :
09/08/2014, 01:24
... chronic phase In the chronic phase, there was a shift towards higher levels of macrophages in nasal and laryngeal cartilage than in the trachea The control mice had less than 5% macrophages T cells ... as the substrate and the amount of antibody was estimated as absorbency at 405 nm by using a Titertek Multiscan filter photometer All plates detecting the same antigen were analyzed at the same ... Arthritis Research & Therapy Vol No Hansson et al inflammatory attack of the nose and respiratory tract, phenomena that are commonly seen in RP patients There are also morphological similarities,...
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báo cáo khoa học: "Linkage in cattle between the major histocompatibility complex (BoLA) and the M blood group system" doc
Ngày tải lên :
09/08/2014, 22:23
... for the « M system are obtained by addition of the values for M’ and M,, and we observe a lod-score value always greater than + 3.0 The estimation of the recombination rate between BoLA and the ... for which these animals were tested represent a powerful means of diagnosing incorrect parentage and this was not the case for any of the apparent recombinants Furthermore the fact that so many ... bull VALMIN Table gives the lod-score values obtained for M’ and for the M, factor, and shows clearly the existence of genetic linkage between the BoLA complex and each of » the factors The Z values...
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Báo cáo khoa học: " A rapid and efficient method for studies of virus interaction at the host cell surface using enteroviruses and real-time PCR" potx
Ngày tải lên :
12/08/2014, 04:21
... attachment to CAR, a 46-kDa transmembrane protein that also serves as a receptor for many adenoviruses [17] In addition, some strains of CVB1, and can interact with an additional receptor, DAF, ... amounts of cells and viruses Statistical analyses Individual data pairs were analysed by the unpaired t test, and one-way analysis of variance followed by Dunnetts post-test was used to compare ... NJ drafted and wrote the manuscript MG developed the protocol for the binding assay, radiolabeled and purified the clinical isolate and performed the radioactive measured binding assay SI participated...
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Báo cáo sinh học: "Divergent selection for humoral immune responsiveness in chickens: distribution and effects of major histocompatibility complex types" ppt
Ngày tải lên :
14/08/2014, 19:22
... al, 1991; Pinard and Hepkema, 1992) A MHC genotype was defined as the combination of haplotypes Serological typing was performed on the parents of the 8th generation, on all the females and the ... males of the 8th generation, and on all the birds of the 9th and 10th generations Only the results of MHC typing in the 9th and 10th generations were used in the analysis Segregation of the haplotypes ... between haplotypes The estimated Ab titer of the 114 B-haplotype was significantly lower than the estimate of the 119 B-haplotype in the L line (table V) In the C line, the estimated Ab titer of the...
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Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor docx
Ngày tải lên :
24/03/2014, 00:21
... ortholog of Caenorhabditis elegans (AhR-1C.E.), neither photoaf®nity labeled by a dioxin analog, nor activated by b-naphto¯avone in a yeast system [20]; the rainbow trout AhRa that binds TCDD [21] and ... to the bound state, Arg206 affects the position of Asp212, which in turn undergoes the largest conformational change of all the sidechains [12] Interestingly, although the conformation of the ... of the isolated domain PYP has been previously proposed as an appropriate structural template for AhR, but our analysis of the recently determined structures of the FixL and the HERG PAS domains...
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Teach english, teach about the environment a resource for teachers of adult english for speakers of other languages (ESOL)
Ngày tải lên :
27/05/2014, 07:45
... the Beginning, Intermediate and Advanced levels The backs of the Flash Facts are blank Teachers may use this area to translate the facts into the native language(s) of the student(s) or for additional ... away items rather than throwing these items into the waste stream For a large number of unwanted items, students can hold a garage sale They can also be encouraged to shop at garage sales before ... in their native language Assign students to think of other ways to reduce the waste stream Ask “How can we reduce the waste stream?” Bring the class back together and have the pairs report their...
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Báo cáo hóa học: " The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials" pdf
Ngày tải lên :
18/06/2014, 22:20
... of the translated RDQ High levels of internal consistency across the translated RDQ scales would be evidence of the amenability to translation Analysis revealed that, regardless of language, all ... structured by the trial case record form for each visit and graded = none, = mild, = moderate, and = severe Translation and cultural adaptation The RDQ was translated into Norwegian and Swedish according ... preferably selfadministered The multicenter, multinational nature of pharmaceutical clinical trials also requires questionnaires that are amenable to translation into multiple languages The Reflux...
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Báo cáo hóa học: " Stretching and immobilization of DNA for studies of protein–DNA interactions at the single-molecule level" ppt
Ngày tải lên :
22/06/2014, 18:20
... modifications References H Kabata, O Kurosawa, I Arai, M Washizu, S .A Margarson, R.E Glass, N Shimamoto, Science 262, 1561 (1993) Y Harada, T Funatsu, K Murakami, Y Nonoyama, A Ishihama, T Yanagida, ... external force In their setup, one end of the DNA was chemically attached to a surface and the other end to a magnetic bead held by the magnetic trap The DNA was forced to stretch upward by a hydrodynamic ... triphosphate (dNTP) to the growing chain of DNA for DNAP while RNAP catalyzes the addition of NTP to the growing chain of RNA; and (2) DNAP requires a primer (a short piece of ssDNA annealed to the...
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