the capital city of the cakchiquels
Tài liệu The King''''s Post Being a volume of historical facts relating to the Posts, Mail Coaches, Coach Roads, and Railway Mail Services of and connected with the Ancient City of Bristol from 1580 to the present time pdf
Ngày tải lên :
17/02/2014, 02:20
... affair is a copy of
part of Gascoigne's account, of which the following is a transcript:—
[Pg 20]
THE OFFICE OF THE POSTE.
In the office of William Dodington, Esquire, Auditor of Her Matie. ... forward in the street; on the east side being another
building answerable thereto." These premises served as the Post Office for the long
period of 118 years.
The first half of the present ... parcel of ground situate in the Parish of St Werburgh in
the City of Bristol on the South West side of and fronting to Small Street aforesaid
specified in the plan drawn in the margin of the first...
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Tài liệu Facing Human Capital Challenges of the 21st Century ppt
Ngày tải lên :
18/02/2014, 02:20
... improve the human
capital or skills of a country’s population, or to facilitate the employ-
ment of human capital in diverse sectors of the economy. Table 1.1
provides the categories of reforms ... interest
in human capital and economic initiatives.
12 Facing Human Capital Challenges of the 21st Century
We used the interview notes to provide an overview of the areas of
human capital deficits ... arguably the most
comprehensive in the region; changes initiated in 2002 address the
management and delivery of educational services, the curriculum,
and the quality of teachers and other critical...
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Tài liệu Báo cáo khoa học: Substrate specificity of the pseudouridine synthase RluD in Escherichia coli doc
Ngày tải lên :
18/02/2014, 16:20
... obtained with the transition at posi-
tions 1915 and 1917. These mutations had an effect on
the formation of pseudouridine exclusively at the
mutant position and did not affect either of the other
two ... by
Southern analysis. The rluD::cat strain had a full deletion
of both rluD and yfiH, together with their annotated pro-
moter sequences. The inserted cat cassette had a distance of
90 nt from the ... primer extension. The primer exten-
sion stop on the CMCT treated RNA (+ lane)
indicated the presence of pseudouridine at the particu-
lar position when the stop was not present in the con-
trol...
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Tài liệu Báo cáo khoa học: Ionic strength and magnesium affect the specificity of Escherichia coli and human 8-oxoguanine-DNA glycosylases pdf
Ngày tải lên :
18/02/2014, 18:20
... for the opposite-base speci city of Fpg and
OGG1. Also, although the buffering capacity of KGlu
at pH 7.5 is much weaker than that of KP
i
, the omission
of KP
i
had a rather minor effect on the ... Fig. 2. In the absence of MgCl
2
, the
affinity of Fpg for the THF:C ligand was 1.6-fold higher
than for the THF:A ligand. The presence of Mg
2+
had
little effect on the binding of Fpg to the THF:C ... 0–5 mm MgCl
2
. The C ⁄ A speci-
city of the glycosylase reaction in the absence of KP
i
was usually higher than in the presence of KP
i
due to
less efficient cleavage of 8-oxoG:A; the highest specific-
ity...
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Tài liệu Báo cáo khoa học: An investigation of the substrate specificity of the xyloglucanase Cel74A from Hypocrea jecorina pdf
Ngày tải lên :
19/02/2014, 05:20
... presumably, contain the sites of O-glycosylation,
but we have not identified the specific site(s) or the
form of the O-glycans.
The CD spectrum of Cel74A looks a lot like that of
an unordered protein ... 4, and may be
the basis for the unique mode of action of this enzyme.
More definitive statements await the solution of the
Cel74A structure, which is currently underway.
Conclusions
The xyloglucanase ... incubation with Cel74A, and the proposed cleavage pattern (C) with the
theoretical m ⁄ z value (z in superscript) of the most important fragments (the position of the Gal residues is arbitrary)...
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Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx
Ngày tải lên :
19/02/2014, 12:20
... has
Fig. 5. Analysis of the enzymatic activity of His-CoaB R206Q and A276V. The synthesis of 4¢-phosphopantothenoyl-CMP (–cysteine, upper part of
the figure) and of 4¢-phosphopantothenoylcysteine (+ ... synthesized in five steps from
D
-pantothenate. The Dfp flavoprotein catalyzes the synthe-
sis of the coenzyme A precursor 4¢-phosphopantetheine
from 4¢-phosphopantothenate and cysteine using the ... formation of 4¢-phosphopantothenoyl-CMP (activation
of the carboxyl group of 4¢-phosphopantothenate). In a second step, the amide bond of PPC (shaded in grey) is formed by reaction of
4¢-phosphopantothenoyl-CMP...
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Báo cáo khoa họcRe-engineering the discrimination between the oxidized coenzymes NAD+ and NADP+ in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme specificity of the wild-type enzyme docx
Ngày tải lên :
06/03/2014, 00:20
... than the true value, underlining the impact of quite a
small level of contamination on these results.
Reassessment of the effects of the mutations on
coenzyme speci city
In view of the dramatically ... moiety of the coenzyme resulting
from splitting off the nicotinamide ring, suggesting
that the covalent bond between the nicotinamide and
the ribose of the coenzyme is particularly labile. The
signal ... that
apparent rates of NADP
+
utilization mainly reflected the reduction of con-
taminating NAD
+
, creating an entirely false view of the initial coenzyme
speci city and also of the effects of mutagenesis....
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Báo cáo khoa học: by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site potx
Ngày tải lên :
08/03/2014, 02:21
... applicability of the nucleotide affinity cleavage
technique to study the speci city of the nucleotide binding
sites. Since GTP is a C-terminal-specific nucleotide, we
further analyzed the properties of Hsp90 ... an intact adenine ring; the stick model is the structure of the
kinked ADP in the Hsp90 crystal, the phosphates pointing out of the
domain;Rstandsforphosphates(ATP)orothermoietiesasinNAD
or adenosine ... of ADP [20]. The reason for this
may be that the ATP-bound resin may impose a steric
hindrance to the binding of the terminal phosphate,
therefore Hsp90 adopts an ÔADP-conformationÕ [20] on
the...
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Báo cáo khoa học: Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis docx
Ngày tải lên :
16/03/2014, 02:20
... conformers of the substrate are suitably
oriented to point with the proS-hydrogen atom of the
Cb group towards the catalytic iron. With an iron–
hydroxyl distance of 3.1 A
˚
, the structure of the
VioC•hArg•Fe(II)•succinate ... for the asparagine oxygenase AsnO and other mem-
bers of the clavaminic acid synthase-like superfamily. Additionally, the sub-
strate speci city of VioC was investigated. The side chain of the ... concerning the adenylation domain
(A-domain) speci city of VioF revealed b-ureidoalanine
activation, leading to the proposition of a new model
for the order of the NRPSs during viomycin biosynthe-
sis...
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