Ngày tải lên :
06/03/2014, 04:20
... sense of
humour: the informationdemandsingenomicsarestaggering. The genomecontains
twokinds of digitalinformation,onethatencodes the proteinandRNA‘molecular
machines of life’,and the otherbeing the regulatorynetworksthatspecifyhowthese
genesareexpressedintime,spaceandamplitude.
DNAinformationislayeredandarrangedinahierarchy,startingwith the gene,
then the RNA, then the protein, then the protein interactions, then the protein
complexes,then the networks of proteincomplexes ina cell,then the tissues and
organs,then the individualorganism,followedbypopulationsand the ecosystemsin
whichtheylive.Inthiskind of discoveryscience,masteringsuchvastquantities of
informationtoanswerimportantquestionsisaskillandanart.
And the hardware? The firstautomatedsequencingmachinetookaday,in1986,
tosequence250 of the threebillionbasepairs.Ittook the humangenomeproject
tenyearstosequence the humangenome,twoyearsshorterthanpredicted;and the
privatecompanyCelerawithitsso-calledshotgunapproachtooklessthan the public
consortium’s ... was
preservedinArabicmanuscripts’(Lewontin1995:148).
Thereisnoquestionthat the libraries of Alexandriawerecentralto the cityand
the broadregionincludingwhattodayis the Middle-East,NorthAfricaandmuch of
CentralandWesternEurope;thattheywerenot the onlyonestoexistbutwerepart
of alargerset of institutionstoemergefrom the concatenations of cultural,scholarly
andotherareas of learningandapplication of whatwerethen the advancedsocieties
of thispart of the world.
The agency of theirruinisnotsocertain,neitherisitclearwhatitwasinvolume
andsubstance ... Or,
perhaps,itrelatedtotradingwithneighbours,or,moreonadeeplyexistentiallevel,
observing the astronomical,with,asGeorgesIfrahputsitsobeautifullyin the Universal
history of numbers,afascinationwith the regularity of the phases of the moon, the eternal
return of dayandnight, the cycle of the seasons’or,wemightadd,given the context, the
ellipticalphases of the tides of greatandmarvellousoceans(Ifrah2000:xvi).
In the history of counting, the SanandKhoiperhapsjoinedotherhumanbeingsand,
inobservingthatbirdshavetwowings,animalsfourlegs,andtheytenfingerstotheir
handsandtentoestotheirfeet,developedanumberingsystemusingtheirfingersortoes
as the baseten, the mostcommontype of countingfoundamongearlierpeoples.
Orperhapstheyjoined the Mayans,Aztecs,CeltsandBasqueswholookeddown
attheirfeetandrealisedthattheirtoescouldbecountedlikefingersandchose the
muchmoreunusualarithmeticbase of 20.
SCI...