structural features of the dan protein
Báo cáo Y học: A novel gain-of-function mutation of the integrin a2 VWFA domain docx
Ngày tải lên :
08/03/2014, 22:20
... Structure of the C-terminal region of a2 VWFA domain, in the presence (B) or absence (C) of collagen peptide ligated The arrow indicates the position of the E318 side chain, which is altered by the ... form part of the ligand binding site In addition to the effects on ligand binding, the mutation also affected the use of cations by the ligand binding site Although the precise nature of the atomic ... for the enhanced collagen I binding, but the size of the residue is less important The decreased binding of Fig E318 moves between the ‘open’ and ‘closed’ forms of a2 VWFA domain (A) Alignment of...
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Some aspects of American culture and society in the twentieth and twenty-first centuries through a number of selected short literary works
Ngày tải lên :
07/11/2012, 15:01
... the differences in the behaviors and attitudes of the grandmother, the father and the mother and the children at least cause discontent to one another The grandmother held the floor most of the ... is the outsider of the events and describes from the points of view of one character in the story.) - Theme is the message of the story that the author wants to send to readers The message is often ... with the grandmother Regarding the children, they disapproved of the decision of their grandmother but, as the youngest in the family, their reaction did come to no where Finally, it was the grandmother...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
Ngày tải lên :
14/02/2014, 18:20
... onethird of all mutations in the BTK gene are missense and some of these reduce the stability of the protein This is exemplified by mutations in the BTK motif of the Tec homology (TH) domain [18] ... that the PH–TH domain differences between BTK–SYK and ITK– SYK fusion proteins lead to differential phosphorylation levels of the fusion proteins themselves, as well as the downstream adapter proteins ... identify individuals with mild disease, thereby providing the missing data The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has...
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báo cáo khoa học: " pax1-1 partially suppresses gain-of-function mutations in Arabidopsis AXR3/IAA17" pdf
Ngày tải lên :
12/08/2014, 05:20
... (ventral) surfaces, and the transition from the juvenile to the adult phase of vegetative development is marked by the onset of trichome production on the abaxial surfaces of the leaves [46] Under ... the pax1-1 single mutant and participated in the design of the study DR generated the AXR3::GUS reporter line OL participated in the design and coordination of the study and helped to draft the ... explanation for the more complex set of interactions observed is that the effects of PAX1 on other members of the Aux/IAA family are indirect Since Aux/IAA genes regulate each others' transcription,...
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Báo cáo khoa học: The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence doc
Ngày tải lên :
07/03/2014, 02:20
... recruited to the p16 promoter by ZBP-89, we examined the binding of HDAC3 and HDAC4 in different regions of the p16 promoter upon knockdown of the endogenous ZBP-89, and the results showed that the binding ... addition of 40 lL of protein A–agarose for another h The beads were resuspended in 100 lL of 2· loading buffer and boiled for 10 The proteins were separated on a 12% SDS ⁄ PAGE gel and then transferred ... overlapping binding sites, thereby decreasing promoter activity and transcription intensity [4] Others include the ability of ZBP-89 to recruit the coactivator p300 to the promoter of the target gene,...
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Báo cáo hóa học: " Existence results for a class of nonlocal problems involving p-Laplacian" pot
Ngày tải lên :
20/06/2014, 22:20
... with the proof of Lemma 3.1, we know that J satisfied the (C) condition □ Sum up the above fact, from Lemma 2.4 and Remark 2.1, Theorem 2.2 follows from the Lemma 3.3 to 3.5 Acknowledgements The ... F(x, u)dx = −∞ Then the problem (1.1) has least three distinct weak solutions in W1,p(Ω) Theorem 2.2 If the following hold: (M ) The function M that appears in the classical Kirchhoff equation ... http://www.boundaryvalueproblems.com/content/2011/1/32 Page of hypotheses (F0), (F1), (F2) and (1.2) are clearly satisfied f (x, u) = arctan u + u , + u2 hypotheses (F3), (F4) and (F5) and (1.2) are clearly satisfied Proofs of the theorems Let...
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CHARACTERIZATION OF INHIBITORS OF ALDEHYDE DEHYDROGENASE 2 IDENTIFIED THROUGH A HIGH-THROUGHPUT DOCKING APPROACH
Ngày tải lên :
24/08/2014, 09:58
... site where they may promote interaction with other molecules or they can control the catalytic activity of the enzyme through allosteric affects Also these cavities can facilitate proteinprotein ... binding to the coenzyme binding site, rather than within the substrate binding site as originally hypothesized To test this hypothesis, we examined the ability of these compounds to compete for the ... Alcoholism estimates the incidence of alcohol abuse to be about 4.6% of the general population and alcohol dependency to be about 3.8% of the population (99) There is no single pharmacotherapeutic agent...
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Báo cáo y học: "Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics"
Ngày tải lên :
26/10/2012, 09:07
... monstration of the T1 weight relaxation times The or ted rdinate of the g graph in the upper part shows the rela axation times [msec], the axis of the abscissa represents th concentratio of the dilut ... nuclear spin of the rare earth element In this sceh nario, the whereabo outs of the u unpaired d-ele ectron of the res spective mole ecule is also o importance [54] In of e the case of Sc@C82 the probabi ... (7) compound with the nitride cluster fullerene GdxSc3-xN@C80 Synthesis of the [tetracyclo-3,5-dioxo-4-aza-9,12tridecadiene] dienophile (7) compound The steps of the synthesis of the dienophile...
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Tài liệu Báo cáo khoa học: C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism doc
Ngày tải lên :
14/02/2014, 14:20
... [15] Sequencing of the cDNA (from mRNA) of Erv-C from the leaf of the plant in our laboratory [16], and comparison of the cDNA-derived amino acid sequence with other members of the family reveal ... structure of the CT-extension with the mature catalytic domain (rmErv-C+CT) shows that the extension peptide blocks some of the unprimed subsites of the enzyme (Fig 7) The interface area of the CT-extension ... used the clone of Erv-C which was constructed from the cDNA (mRNA) of the leaf of the plant [16] and the deletion mutant of that has been generated by eliminating the last 24 amino acids at the...
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Tài liệu Controlling Fine Particulate Matter Under the Clean Air Act: A Menu of Options pdf
Ngày tải lên :
17/02/2014, 11:20
... use the results of site-specific source testing as the basis of their emissions inventory Much of the emissions inventory is based upon the application of emissions factors The development of emissions ... increases the heating value of the fuel This lowers the transportation cost of the fuel per unit of energy, offseting the costs associated with the coal washing Coal washing also reduces the maintenance ... host of others Furthermore, the Act divides responsibility for various types of sources and air pollutants between the states and localities on the one hand, and the federal government on the other...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
Ngày tải lên :
22/02/2014, 04:20
... added to the cells, and then the cell suspension was sonicated in a bath-type sonicator for 5min The amount of protein of the solubilized cells was determined with a bicinchoninic acid protein ... degrees of inhibition of NO production with Ro31-2880 and GF109203X were approximately 70 and 30%, respectively Effects of TS on the amount of PKCa We further examined the effects of TS on the amounts ... activation of NADPH oxidase [32] As the activation of NADPH oxidase is reported to be associated with the activation of PKC [33,34], the PKC-dependent mechanism of TS-induced enhancement of NO production...
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Tài liệu Playing through: A Guide to the Unwritten Rules of Golf potx
Ngày tải lên :
22/02/2014, 08:20
... apart from the course as well These interactions are all an integral part of the game, but they aren’t codified in the USGA’s The Rules of Golf In other sports, the focus is clearly on the competition—not ... Amazingly, once the laughter on the green subsided, everyone in the group calmly made their putts .The men, of course, teased me about the incident for the rest of the round Fortunately, no other foursomes ... As they walk up to the eighteenth green on Sunday, they acknowledge the gallery’s applause with a gracious tip of the hat When the match is over, they never fail to take off their hats as they...
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Đề tài " Approximating a bandlimited function using very coarsely quantized data: A family of stable sigma-delta modulators of arbitrary order " pptx
Ngày tải lên :
05/03/2014, 23:20
... to (21), exploiting the compactness of the support of Gλ Although we must pay some penalty for the imperfection of the quantizer in all these cases (the constants increase), the precision that ... before, that the proof of a uniform bound (J) for the |un | in the n > recursion simultaneously provides the same uniform (J) bound for the |un | in the n < recursion We then have the following ... From the definition of ν one easily checks that this is indeed the case, completing the proof We are now ready to state and prove our general lemmas, used in the induction argument of the proof of...
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THE EFFECTS OF MEGAMERGERS ON EFFICIENCY AND PRICES: EVIDENCE FROM A BANK PROFIT FUNCTION docx
Ngày tải lên :
06/03/2014, 08:21
... about the data set IV The Profit Efficiency Effects of Megamer~ers The Level of Profit Efficiency We begin discussing the results with some information on the levels of profit efficiency of merging ... of efficiency The use of total efficiency, the ratio of predicted profits to optimal profits (m/m”), corresponds well to the social benefit concept of the real value of output produced less the ... merger In the remainder of the analysis, we focus simply on the total efficiency ranks of the merging banks, rather than dealing with the cumbersome array of components of efficiency or with the level...
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Báo cáo khoa học: Emergence of a subfamily of xylanase inhibitors within glycoside hydrolase family 18 pdf
Ngày tải lên :
07/03/2014, 17:20
... shown in Fig The increase of RU from the baseline represents the binding of the xylanase to the surface-bound inhibitor The plateau line represents the steadystate ⁄ equilibrium phase of the XYNC–inhibitor ... for the first time the functional identification of a rice ortholog of the wheat XIP, originally classified as a rice class III chitinase and analyze the features that allow discriminating the subfamily ... projecting into the glycone subsites of the enzyme’s active site The top of the inhibitor loop is slightly twisted, allowing the GGP(150–152) segment to extend closely parallel to the )3 subsite...
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Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt
Ngày tải lên :
08/03/2014, 10:20
... measure of the rate of oxidation of oxyHb RESULTS The effect of pH on the auto-oxidation of cross-linked Hb was studied The rate of decrease of the concentration of oxyHb increased as the pH was ... in the absence and presence of EDTA, on the oxidation of Hb A0 The mean ± SD of three independent experiments is shown Other conditions as in Fig Our studies of the effect of the structure of the ... comparison of the effects of rough and smooth LPSs of E coli, both in the presence and absence of EDTA (Fig 1) The rate of oxidation was increased in the presence of the LPSs of both the smooth...
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Báo cáo khoa học: Macrocypins, a family of cysteine protease inhibitors from the basidiomycete Macrolepiota procera pot
Ngày tải lên :
16/03/2014, 02:20
... sequence identity The length of the macrocypin (Mcp1) deduced amino acid sequence was 169 residues, with a molecular mass of 19 193 Da, while the length of the representatives of the other four groups ... inhibitor, Mcp) The N-terminal sequence for the lower-molecular-mass protein could not be determined, possibly because of a blocked N terminus The presence of a protein of similar size to that of clitocypin ... coli, and the NH2-MGFE sequence of rMcp1 favours only partial cleavage The far-UV CD spectra of rMcp1 and rMcp4 confirmed the expectation from the sequences that the conformations of the inhibitors...
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Báo cáo khoa học: Efficient synthesis of a disulfide-containing protein through a batch cell-free system from wheat germ pdf
Ngày tải lên :
16/03/2014, 23:20
... were added The amounts of the synthesized polypeptides were determined from the 14C radioactivity of the trichloroacetic acid-precipitated materials The soluble fractions of the synthesized polypeptides ... and the ÔsolubilityÕ was determined as the amount of the soluble fraction divided by the total amount The concentration of the scFv synthesized without [14C]Leu was estimated from that of the ... effect of PDI on the active fraction of the scFv The enzyme was added in the DTT-deficient synthesis solution after h translation, and the reaction was further continued for the same number of hours...
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