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![Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc](https://media.store123doc.com/images/document/14/rc/rp/small_luUKRIz7Xm.jpg)
Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc
... Maurice and Erwan Magueur is greatly appreciated This work was supported by grants from the Lorraine Region and Urban Community of Grand Nancy (CUGN) and from the French Ministry of Research and ... and Higher Education PI is a recipient of a Research Fellowship from the French Ministry of Research and Higher Education, and FTY and BEB are Directors of Research at the ´ ´ Institut National ... concentrations of a common food pollutant, B[a]P, caused a rapid, direct and profound inhibition of adipose tissue lipolysis stimulated by epinephrine, dobutamine, salbutamol, BRL37344 and ACTH This...
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BIOTECHNOLOGY MOLECULAR STUDIES AND NOVEL APPLICATIONS FOR IMPROVED QUALITY OF HUMAN LIFE potx
... Azlan1 and Toshio Omori1 of Systems Engineering and Science, Department of Bioscience and Engineering, Shibaura Institute of Technology, 2Department of Biotechnological Research, Ministry of Science ... increasing the pH and therefore the formation of glazing of struvite, carbonate of calcium and/ or apatite, causing the formation of kidney stones In the South-west coast of India, a group of scientists ... gene of C4, E4, G6 and G7 suggested that these may represent of nitrogen-fixing bacteria Due to the similarities of strains C4, E4, E6, G6 and G7 to Azotobacter species and the amplification of...
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Báo cáo y học: " Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4" pot
... intervals for the origin of HTLV-2 as it migrated out of Africa and Asia and into the Americas via the Bering land bridge and 40,000 – 60,000 ya as confidence intervals for the origin of HTLV-1 in Melanesia ... organization and characterization of the HTLV4(1863LE) structural and enzymatic proteins, and the LTR The genomic structure of HTLV-4(1863LE) was similar to that of other PTLVs and included the ... p30II, and p13II (where I and II denote ORFI and ORFII, respectively), have been identified in the pX region of HTLV-1 and are important in viral infectivity and replication, T-cell activation, and...
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Báo cáo y học: " Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy" pps
... localized prostate cancer and metastatic and androgen-dependent (AD) LNCaP and AI C4-2B, DU145 and PC3 prostate cancer cells in vitro and in vivo, without any toxic effect on normal prostate epithelial ... pharmacokinetic profile and bioavailability and greater growth inhibitory and apoptotic effects than those of curcumin on lung, breast and prostate cancer cell lines in vitro and animal models ... radiosensibilizing and chemosensibilizing effects on glioma cells via the up-regulation of p53, p21WAF1 and the inhibitor of growth (ING4), inhibition of NF-B and AP-1 transcriptional activities and stimulation...
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Tài liệu Plug and Play Splitter Architectures Drive Operational Savings doc
... to test both the F1 and the splitter would require breaking a splice, splicing connectors to both the F1 and the splitter, running the tests, cutting off the connectors, and re-splicing the F1 ... two splitter configurations available – pigtail -and- play or plug -and- play Although both offer substantial benefits over straight splicing, the plug -and- play has additional advantages For example, ... a plug -and- play splitter design, the connection is made between the F1 and the splitter simply by plugging the splitter in the backplane of the cabinet Page One argument for the pigtail -and- play...
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Tài liệu TRADITIONAL AND NOVEL RISK FACTORS IN ATHEROTHROMBOSIS pptx
... migration, and differentiation of EPCs and their homing to sites of vascular injury are complex and involve several mediators and receptors, such as P-selectin glycoprotein ligand-1, CXC chemokine, and ... narrowing and irregularity of the luminal surface in erosion The morphologic characteristics include an abundance of SMCs and proteoglycan matrix, expecially versican and hyaluronan, and disruption of ... Immunofluorescence images of thrombus on rabbit femoral artery Representative immunofluorescent microphotographs of thrombi 15 minutes after balloon injury of normal femoral artery and of atherosclerotic...
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Traditional and Novel Risk Factors in Atherothrombosis Edited by Efraín Gaxiola pot
... migration, and differentiation of EPCs and their homing to sites of vascular injury are complex and involve several mediators and receptors, such as P-selectin glycoprotein ligand-1, CXC chemokine, and ... narrowing and irregularity of the luminal surface in erosion The morphologic characteristics include an abundance of SMCs and proteoglycan matrix, expecially versican and hyaluronan, and disruption of ... Immunofluorescence images of thrombus on rabbit femoral artery Representative immunofluorescent microphotographs of thrombi 15 minutes after balloon injury of normal femoral artery and of atherosclerotic...
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Coronary Artery Disease – New Insights and Novel Approaches Edited by Angelo Squeri pdf
... particles vary in size and density, mainly because of differences in the number of apolipoprotein (apo) particles and the amount of Chol ester in the core of HDL molecule The majority of lipoprotein ... turnover and calcium mobilization often present in diabetic patients, contribute to enhanced risk of small vessel occlusions and accelerated development of atherothrombotic disease of coronary, ... and syndrome X, as components of the metabolic syndrome37 Their presence is often accompanied by increased TGs and low HDL While overproduction of VLDLs by the liver and increased secretion of...
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx
... salt bridge between D29 and R87 of one subunit and R8 of the other subunit Thermodynamic analyses of the dimeric PR molecule indicates a Gibbs energy of dimer stabilization of 10 kcal/mol at 25 ... increasing concentrations of TSAOe3T, resulting in loss of dimer stability of 4.0 and 3.2 kcalÆmol)1 for p66/p51 and p66/p66 forms of HIV-1 RT, respectively [44] This loss of energy is not sufficient ... through modification of their amino-acid composition and the addition of a hydrophobic moiety, such aminocaproyl or palmitoyl, to the N-terminus of the peptide [20] The development of these Ômore potentÕ...
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Báo cáo khoa học: "Formal aspects and parsing issues of dependency theory Vincenzo Lombardo and Leonardo Lesmo" potx
... W ) and two integers g and v is a word object of the grammar Given a grammar G, the set of word objects of G is Wx(G)={ ~tXv/ IX, v_>0, xe W u {e} } A pair consisting of a category X (e C) and ... has a n u m b e r of elements which depends on the maximum length of the chain of predictions Since the number of rules is O(n), the size of the stack is O(n) The elements of T-stack contain ... the d-quads Both IX and vindices are null (0), and T-stack is empty ([]) The body consists of an external loop on the sets Si (0 < i < n) and an inner loop on the single items of the set Si Let...
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Báo cáo khoa học: Investigation of leucine-rich repeat kinase 2 Enzymological properties and novel assays pptx
... implicated in PD, and understanding its properties and functions will aid in our understanding of disease pathology and progression Experimental procedures Chemicals and reagents All compounds and proteins ... that of G2019S LRRK2, which had an apparent Km of 134 ± lm (P < 0.01; Fig 4C) 35 LRRKtide 32P incorporation Activity of wild-type and G2019S mutant forms of LRRK2 A LRRKtide 32P incorporation of ... 20- Fig Characterization of LRRK2 proteins (A) Coomassie Bluestained gel of lg of each GST–LRRK2 protein preparation separated by SDS ⁄ PAGE (B) Western blot of 0.5 lg of wild-type (WT) LRRK2...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... transcription caspase-6, and caspase-3 Cleavage of Bid and release of cytochrome c and apoptosis-inducing factors from the mitochondria are also observed Coexpression of wild-type htt exon and Hippi decreases ... dominant nature of the disease suggests a toxic gain -of- function of the mutated protein that disrupts normal cellular functions and causes neuronal death [3] Loss -of- function of the wild-type ... models, brains of transgenic animals, and post-mortem brains of HD patients [2] Aggregate formation is enhanced with the increase in the number of glutamines in vitro and in vivo, and is believed...
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Goethe and the Molecular Aesthetic ppt
... parts of the brain, so that there is an integration not only of various kinds of sensory data like touch and sight, but also of sensory data with higher order thinking processes and of both of these ... well-versed in his work and saw its relevance to her own, not only in terms of issues of biology but of issues of how science is done as well In both Natural Philosophy and The Mind and the Eye, she ... aesthetic is a major part of scientific inquiry, especially in the development of ideas and the shaping of them He sees an indication of this in the link between artistic talents and scientific talents...
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Erectile Dysfunction – Disease-Associated Mechanisms and Novel Insights into Therapy Edited by Kenia Pedrosa Nunes potx
... Changes of adrenal hormones The role of adrenal hormones and their changes are not well established in the etiology of ED Studies have correlated the low levels of dehydroepiandrosterone with ED Androstenedione ... degree of contraction of the cavernosal smooth muscle Mechanisms in Erectile Function and Dysfunction: An Overview determines the functional state of the penis 16 The dynamic interplay of vasoconstrictors ... levels of cGMP result in vasodilatation of arteries and sinusoidal spaces of the corpus cavernosum, by decreasing intracellular calcium concentration, which is due to activation of PKA and PKG,...
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NUTRITIONAL ASPECTS and CLINICAL MANAGEMENT of CHRONIC DISORDERS and DISEASES doc
... visiting professor at the Universities of Cape Town, Tel Aviv, and Lyon, and at the Pasteur and Weizmann Institutes He is a fellow of the American Association for the Advancement of Science and of the ... Prevention and Treatment, Jana Parízková and Andrew Hills Alcohol and Coffee Use in the Aging, Ronald R Watson Handbook of Nutrition in the Aged, Third Edition, Ronald R Watson Vegetables, Fruits, and ... He is a member of numerous professional societies and has been on the editorial boards of The American Journal of Physiology, The Journal of Nutrition, and The American Journal of Clinical Nutrition...
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Báo cáo khoa học: Mechanistic aspects and redox properties of hyperthermophilic L-proline dehydrogenase from Pyrococcus furiosus related to dimethylglycine dehydrogenase⁄oxidase potx
... ion of FAD cofactor with an m ⁄ z peak of 787 identical to that of the authentic FAD standard The m ⁄ z peak at 825 represents the K+ adduct of released FAD cofactor The m ⁄ z peaks of 348 and ... detailed report of the kinetic and spectroscopic properties of this novel type of PRODH Results Analysis of a and b subunit sequences Sequence analysis of both subunits suggests the presence of an ADP-binding ... encode a new member of the hyperthermophilic class of PRODHs that couples the oxidation of l-proline to the reduction of a noncovalently bound FAD and the production of P5C Oxidation of enzyme-bound...
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Báo cáo khoa học: Structural aspects and biological properties of the cathelicidin PMAP-36 pot
... 2005 FEBS M Scocchi et al Structure and antimicrobial activity of PMAP-36 Fig CD spectra of the synthetic PMAP36 peptides Spectra of PMAP-36(1–35)2 (A) and of the truncated fragment PMAP-36(1– ... TFE (– –), and with 25% (–ÆÆ–ÆÆ–) and 50% (v/v) TFE Table shows the antimicrobial activity of the monomeric and dimeric peptides towards several Gram-positive and Gram-negative bacteria and two ... ATCC 27853, and clinical isolates of P mirabilis, C albicans and C neoformans Bacteria and fungi were maintained on MH agar or on solid Sabouraud agar dextrose medium, respectively, and were subcultured...
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Imaging of the Breast – Technical Aspects and Clinical Implication Edited by Laszlo Tabar pptx
... intensity of T2-weighted images and the presence of cysts improved the diagnostic accuracy, with a sensitivity of 91% and a specificity of 65% (Baltzer et al., 2011) Fig Example of the added value of ... all other modalities and for all tumor types: it detected 95% of the cases of invasive ductal carcinoma, 96% of the cases of invasive lobular carcinoma, and 89% of the cases of ductal carcinoma ... based on consensus opinions of professionals and experts from the executive committee of the Society of Breast Imaging and the members of the Breast Imaging Commission of the ACR These recommendations...
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Báo cáo khoa học: Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes Formation of modified and oxidized particles pot
... glucose and two aldehydes (MG and GA) in inducing lipid and protein oxidation and antioxidant depletion of LDL particles as well as glycation of the apoB protein by measuring specific parameters of ... moieties of LDL in the presence of glucose and lM Cu2+ proceeded slowly with complete destruction of a-tocopherol (TOH; Fig 1A) occurring between and w These results correlate with loss of free ... of oxidation of these samples, accumulation of CEO(O)H was detected and reached a maximum (170 nmolÆmg)1 apoB) by weeks The small increases in the rate of oxidation observed in the presence of...
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Báo cáo khoa học: "ON REPRESENTING GOVERNED PREPOSITIONS AND HANDLING "INCORRECT" AND NOVEL PREPOSITIONS" ppt
... (4) blends, and (5) substitution of a semantically appropriate preposition for a syntactically determined one A small percentage of the non-standard use of prepositions appears to be random 1.3 ... APPLICATIONS OF THIS WORK In a theoretical linguistics f o r u m (Blejcr and Flank 1988), we argued that these examples of the use of non-standard prepositions to mark arguments (1) represent the kind of ... of prepositional case marking, and thus facilitate handling non-standard and novel use of prepositions to mark arguments The second contribution is our typology of errors in preposition usage...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25