roles of security manager in an organization
Tài liệu Báo cáo khoa học: Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus doc
... alanine scanning of theL-CDR3 and H-CDR3 loops of antibody mAb4E11.This scanning allowed us to identify the residues of these loops that contributed to the energetics and kinet-ics of the interaction ... systematicscanning of the CDR3 loops of mAb4E11 by mutagen-esis of their residues into alanine (Ala scanning). Theaffinities of the purified mutant Fab fragments of mAb4E11 for its antigen were ... Thorn KS (1998) Anatomy of hot spots in protein interfaces. J Mol Biol 280, 1–9.32 DeLano WL (2002) Unraveling hot spots in bindinginterfaces: progress and challenges. Curr Opin StructBiol...
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Báo cáo khoa học: Roles of conserved arginines in ATP-binding domains of AAA+ chaperone ClpB from Thermus thermophilus pptx
... exam-ine the roles of the conserved arginines, Arg322 (P2)and Arg323 (P1) of AAA-1, and Ar g747 (P1) of AAA- 2,and determined that the arginines of TClpB are notinvolved in nucleotide binding ... these three arginines in TClpB.By combining an arginine mutation with the WalkerAmutation in the other AAA+ module, we tested the roles of the arginines in ATP binding and hydrolysis in each module. ... arginines are not involved in nucleotide bindingTo examine the roles of conserved arginines, we gener-ated three mutants of TClpB: R322A [1R ⁄ A(P2)],R323A [1R ⁄ A(P1)], and R747A (2R⁄ A). In...
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Báo cáo khoa học: Flexible nets The roles of intrinsic disorder in protein interaction networks potx
... Biology and Bioinformatics, Indiana UniversitySchool of Medicine, Indianapolis, IN, USA2 School of Informatics, Indiana University – Purdue University Indianapolis, IN, USA3 Laboratory of Statistical ... interaction with Cdk2 andcyclin A: 1, domain 1 interacting withcyclin A; 2, a linker helix involved in bindingboth cyclin A and Cdk2; 3, domain 2 inter-acting with Cdk2 [122]. Blue and dark yellowhorizontal ... capable of bind-ing many different partners. An interesting consequence of the capability of IDproteins and regions to interact with different bindingpartners is the potential for polymorphism in...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... one-third of all solid tumors[20]. During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, includingheparin-binding EGF (HB-EGF), transforming growthfactor (TGF)-a and ... Shedding of membrane-anchored ligands of EGFR(HB-EGF, TGF-a and amphiregulin)ADAM10 Shedding of E-cadherinMMP-9, -2, -14 Activation of TGF-bMMP-7 (anchored to CD44) Shedding of HB-EGFCancer ... theirmain roles focus on ectodomain shedding and nonpro-teolytic functions, such as binding to adhesion mole-cules, integrins and interacting with phosphorylationsites for serine ⁄ threonine and...
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Báo cáo khoa học: Different roles of functional residues in the hydrophobic binding site of two sweet orange tau glutathione S-transferases pdf
... of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.40 Laemmli UK (1970) Cleavage of structural proteinsduring the assembly of head of ... PEI and PKI mutants were obtained by replacingArg89 of GSTU1 (REI) with Pro89, and Glu117 of the PEI mutant with Lys117, respectively. Steady-statekinetic analysis of purified RKI and RKV mutantsshowed ... induction of distinct glutathione transferases of wheat by xenobioticsand by pathogen attack. Plant Physiol 102, 1193–1201.17 Dean JD, Goodwin PH & Hsiang T (2005) Induction of glutathione S-transferase...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
... of alanineor glutamine for Glu182 blocks binding of PDP1 andPDP1c to the L2 domain. As can be seen in Fig. 2A, adistinct pocket exists in the center of this set of residues.Binding of PDP1c-Ca2+to ... higherrates of phosphorylation of the E2-bound E1. Binding of a kinasedimer to a lipoyl domain containing a reduced lipoyl group fosters afurther increase in kinase activity (PDK* state). Binding of ... by the L1 domain of E2 and L3 domain of E3BP(Fig. 1) and reduction and acetylation of the lipoyl groups of these domains enhance PDK4 activity. PDK1 binds tothe L1 and L2 domains of E2 (Fig....
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The Roles of the Aesthetic in Mathematical Inquiry doc
... pattern emerging in a sequence of numbers; a point of coincidence found in a group of lines; a large change resulting from a small variation; a finite realthing proved by an infinite, possibly ... particularly attuned to things analogous, he alsowants to and enjoys finding analogies—they are aesthetically pleasing to him. Thewealth of analogies evident in his initiation into triangle geometry satisfies ... playing is aesthetic insofar as the mathematician is framing an area of exploration, qualitatively trying to fit things together, and seeking patternsthat connect or integrate. Rather than being...
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báo cáo hóa học:" Functional bracing for delayed union of a femur fracture associated with Paget''''s disease of the bone in an Asian patient: a case report" pot
... reported incidence of 3-4% in the adultpopulation [1-3]. Interestingly, it is extremely rare in Africa and Asia, and rarely occurs in Japanese individuals[3-6].Although the etiology of Paget's ... Guidelines for diagnosis and management of Paget's disease of bone in Japan. J Bone Miner Metab 2006, 24:359-367.7. Kanis JA: Pathophysiology and treatment of Paget's disease of bone ... and KS have been involved in drafting the manuscript.All authors read and approved the final manuscript.Author Details1Department of Orthopaedic Surgery, Gifu University Graduate School of...
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báo cáo hóa học:" Unicameral bone cyst of the lunate in an adult: case report" docx
... patient and wrote themanuscript. MS and TA participated in writing and design of the manuscript.They also drafted the manuscript. All authors read and approved the finalmanuscript.Conflict of interest ... M, Oka Y: Cystic lesion in carpal bone. Hand Surg 2000, 5:25-32.6. Athanasian EA: Aneurysmal bone cyst and giant cell tumor of bone of the hand and distal radius. Hand Clin 2004, 20:269-81.7. ... [3]. The main indication for surgical inter-vention is to prevent or treat a pathological fracture[1,3]. In our case herein, in dications for surgery were clini-cal history of pain and radiographic...
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Summary phd thesis in philosophy roles of the government in the integration of economic growth with ecological environment protection in vietnam nowadays
... capacity of management and control of behaviors of individuals andorganizations in economic activities with the aiming of protecting and recoveringthe ecological environment. In terms of methodology, ... plays an important role in issuing the undertakings, policies, laws and organizing, building the team of professional staff that is in charge of performing the management of resources andenvironment. ... team of professional staff by planning,training and developing skilled staff and Government officials. Then, there will bea team of skilled staff, ensuring the continuing hierarchy in terms of...
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Different roles of functional residues in the hydrophobic binding site of two sweet orange tau pps
... of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.40 Laemmli UK (1970) Cleavage of structural proteinsduring the assembly of head of ... PEI and PKI mutants were obtained by replacingArg89 of GSTU1 (REI) with Pro89, and Glu117 of the PEI mutant with Lys117, respectively. Steady-statekinetic analysis of purified RKI and RKV mutantsshowed ... induction of distinct glutathione transferases of wheat by xenobioticsand by pathogen attack. Plant Physiol 102, 1193–1201.17 Dean JD, Goodwin PH & Hsiang T (2005) Induction of glutathione S-transferase...
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Báo cáo toán học: "Dense Packings of Equal Disks in an Equilateral Triangle: From 22 to 34 and Beyond" pptx
... packings, the distance of thedisk center to the boundary of this enclosing triangle is the distance to the line between bondswith the left side of the triangle and disk 24, and is 0.0317185 of ... compute and report d(n)to15significantdecimaldigits.Disk packings in equilateral triangles differ from those in squares or circles in that fortriangles there are an in nite number of values of n ... absence of gravitation and friction, the disks move along straight lines, colliding with each other and theregion walls according to the standard laws of mechanics, all the time maintaining a...
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Báo cáo lâm nghiệp: "Canopy structure and spatial heterogeneity of understory light in an abandoned Holm oak woodland" pps
... mean height of individual HolmTab le I. Mean and standard deviation (SD) of canopy height, number of stems and basal area for the 900 1-m2sampling points of the studyplot, and mean and standard ... (tree- andshrub-dominated zones) are indicated on the map. Distances shown in the axes are in m.vegetation in many current Mediterranean ecosystems, whereabandoned woodlands and shrublands develop ... Madrid, Spain.Mean elevation of the zone is 640 m a.s.l. and it experiences a dry,continental, Mediterranean weather with a mean annual tempera-ture of 14.8◦C and an annual precipitation of 420...
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Báo cáo lâm nghiệp: "Effects of soil mechanical treatments combined with bramble and bracken control on the restoration of degraded understory in an ancient beech forest" pptx
... Statsoft Inc., STATISTICA (data analysis software system), version6, Statsoft Inc., Tulsa, 2001.[59] Stieperaere H., Fransen K., Standaardlijst van de Belgischevaatplanten, met aanduiding van ... variables in the Pteridium stand. Harrowdid not have any effect on the considered soil parameters. Bothdisc and rotary ploughing induced an overall lowering of soilnutrient index and soil compaction, ... trails and haul roads on understory plant richness and compo-sition in management forest landscapes in Upper Michigan, USA,For. Ecol. Manage. 175 (2003) 509−520. Soil mechanical treatments in...
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