role of adipose secreted factors and kisspeptin in the metabolic control of gonadotropin secreti

Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx

Ngày tải lên : 19/02/2014, 13:20

... enthalpies of binding and stoichiometries were determined from the binding isotherm by ﬁtting a : binding model to the data using the software provided by the manufacturer Results Reaction of fosfomycin ... replacement of R120 by lysine reduces the probability of forming the fully closed form of the protein The results obtained with the K22V/R120K double mutant protein point toward a central role of arginine ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino...

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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt

Ngày tải lên : 07/03/2014, 04:20

... The motif present in DptF is GLDSV, indicating that this putative ACP domain is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence To determine ... carrier proteins (ACPs) [14,15] The genes dptE and dptF are localized immediately upstream of the NRPSs of A21987C The resulting proteins DptE and DptF were predicted to be involved in the lipidation ... Assay Fig In vitro phosphopantetheinylation of apo-DptF and apoAcpK Coomassie blue-stained SDS–PAGE gel (left) and in- gel ﬂuorescence (right) of the ﬂuoresceinyl-ACP (+) indicates the reaction...

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Báo cáo khoa học: Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3) docx

Ngày tải lên : 07/03/2014, 06:20

... advantage of the trypsin-sensitive region situated in the linker domain of Abcb1a Following trapping in the absence or presence of Vi and mild-trypsin treatment, the trypsin degradation products of the ... in the glutamine (length of the side chain maintained) and asparagine (shorter side chain) mutants, then trapping in the absence of Vi now occurs [39] (Fig 3); this is also the case when the ... crucial role Another notable feature of the single-site IC mutants (including the glutamine substitutions) [39] is the fact that, in the absence of Vi (± drugs) labeling of the enzymes with the mutation...

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Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt

Ngày tải lên : 30/03/2014, 14:20

... ADAM10 and TACE are involved in the shedding of APP, neither ADAM is involved in the shedding of ACE Furthermore we show that APMA can distinguish between the shedding of ACE and APP Materials and ... expressing ACE were transfected with the ASOs and then exposed to APMA and the levels of soluble ACE in the medium examined (Fig 5) APMA caused a twofold increase in the shedding of ACE from the ... ADAM10 and TACE play a role in the a-secretase shedding of APP, neither protease was responsible for the shedding of ACE APMA stimulates the shedding of ACE but not APP The effect of the organomercurial...

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Báo cáo khoa học: Role of the surface charges D72 and K8 in the function and structural stability of the cytochrome c6 from Nostoc sp. PCC 7119 potx

Ngày tải lên : 30/03/2014, 20:20

... kU0 and the Gibbs energy of unfolding at [urea] (DGU0) In the mutant series, the overall height of the energy barrier for the rate-determining step of the folding ⁄ unfolding transition is mainly ... along the C-terminal a helix to E68 and Y76 Interestingly, one of the side chain oxygens of D72 appears to be hydrogen-bonded to the backbone N atom of G6, bridging the crossing between the N- and ... on the structural model from [35] along the N-terminal a helix involving the amino acids V4 ⁄ N5, and S11 ⁄ A12 The side chain of D72 is part of an acidic patch, together with the residues D2 and...

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báo cáo sinh học:" Community-owned resource persons for malaria vector control: enabling factors and challenges in an operational programme in Dar es Salaam, United Republic of Tanzania" ppt

Ngày tải lên : 18/06/2014, 17:20

... Fourfifths (81%; 52) of the respondents stated they had no other source of income All of those with another source of income (19%, 12) were involved mainly in petty trading Of the interviewed CORPs, ... understanding of the role that the CORPs play within this programme, and the operational prerequisites for these to contribute effectively in terms of representing the community voice, mobilizing the ... analysis and drafting of the manuscript All authors have read and approved the final manuscript 21 Competing interests We declare that none of the investigators has any conflict of interest None of the...

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Báo cáo khoa học: " The role of marine salt and surfactants in the decline of Tyrrhenian coastal vegetation in Italy" ppt

Ngày tải lên : 08/08/2014, 19:21

... trees of P pinea, P tobira, Q ilex and A opalus growing When interpreting the results of the chemical analysis of rainwater and deposits it is necessary to bear in mind the interactions between the ... However part of the chlorides absorbed by the needle are released during rinsing In the rainwater samples there can be interferences with atmospheric dust and dry deposits of nonmarine origin In any ... those with the greatest impact the system because of the amount of salt and surfactants they transport, occur rather infrequently within the total number of samples examined Finally, the ratio...

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Báo cáo khoa học: "The role of photoperiod and temperature in the induction and the release of dormancy in Pinus sylvestris L. seedlings" potx

Ngày tải lên : 09/08/2014, 02:21

... at the start of night prolongation, or 12 wk, an important role in the possibility of the buds to attain a deeper stage of dormancy Only the 12 wk old plants of northern origin had no flushing ... the chilling requirement to break winter dormancy in Scots pine has been stressed (e.g., Wareing, 1951; Vegis, 1965; Sarvas, 1974) In the following,I will use the working definition of dormancy ... (Fig 2) The same was true for the higher temperature 25/15°C compared with 25/5°C Dormancy breaking treatments of and wk had a dramatic influence, hastening the tilushing rate, especially in the...

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Báo cáo y học: "Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis" pptx

Ngày tải lên : 09/08/2014, 06:22

... refused, and the remaining 74 were included Patients receiving lipid-lowering and antidiabetic medications were excluded The baseline clinical and routine laboratory characteristics of the included ... cardiovascular risk factors when assessing the differences in biomarkers of endothelial dysfunction between patients and control individuals Of interest, the body mass indices were similar in both groups, ... Subjects (Medical) of the University of the Witwatersrand and the Milpark Hospital We recorded traditional cardiovascular risk factors in both RA patients and control individuals using previously...

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báo cáo khoa học: "Transcriptional analysis of cell growth and morphogenesis in the unicellular green alga Micrasterias (Streptophyta), with emphasis on the role of expansin" pot

Ngày tải lên : 11/08/2014, 11:21

... consist of two domains and a secretion signal The N-terminal expansin domain and the C-terminal expansin domain are homologous to the catalytic domain of glycoside hydrolase family 45 (GH45) proteins ... participated in the synchronization and RNA-extraction and in the interpretation of the data JG and LDV participated in the design of the experiments DI and WV conceived and supervised the study ... (ACTAGT) of the vector pSA405A under the control of the chlorophyll a/b-binding protein encoding gene of the desmid Closterium and was C-terminally fused to the green fluorescence protein gene...

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Báo cáo khoa học: "The role of body mass index and diabetes in the development of acute organ failure and subsequent mortality in an observational cohor" doc

Ngày tải lên : 13/08/2014, 03:20

... independent variable in the analysis and could not explain the results even though the infection rate and the duration of mechanical ventilation were not increased in the obese group Studies of critically ... determine the role of DM in modifying the effect of obesity Materials and methods Study population The Atherosclerosis Risk in Communities (ARIC) study is a prospective, population-based study of the ... prepared in collaboration with investigators of the ARIC study and does not necessarily reflect the opinions or views of the ARIC study or the NHLBI The coauthors had full access to all of the data in...

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Báo cáo y học: "The role of ATP and adenosine in the control of hepatic blood flow in the rabbit liver in vivo" pps

Ngày tải lên : 13/08/2014, 13:20

... prosthesis inserted into the portal vein and the inferior vena cava of the in vivo rabbit model Figure Diagram of silastic H-shaped prosthesis inserted into the portal vein and the inferior vena cava of ... relating the readings to the wet weight of the liver, determined at the end of each experiment The "buffering capacity" of the HA was expressed in % as: [Increase in HA flow / Decrease in PV ... occlusion of the portal vein for the insertion of the mesocaval shunt and data from these preparations have therefore not been included Group The effect of intra-portal ATP Livers from another group of...

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Efficiency Of Economic Linkage Between Enterprises And Farmers In The Southeast Region - The Current Situation And Affecting Factors

Ngày tải lên : 13/08/2015, 10:01

... analyzed by using SPSS and AMOS software to test the quality of the scale, the relevance of the model and study hypotheses of the relations between the independent and dependent variables in the research ... investigating the factors that affect the efficency of the cooperation and the last part is the general information about the interviewees The Current Situation and the factors affecting the efficiency ... bring about the success of the linkages Hypothesis H3: In condition of agricultural production in the Southeast region, sharing the benefits and risk impacts positively on the results of linkage...

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The role of adenosine, adenosine receptors and transporters in the modulation of cell death

Ngày tải lên : 11/09/2015, 16:07

... The number of amino acids comprising the extra- and intracellular loops and the extracellular N-terminal and intracellular C-terminal regions of the bovine A1 receptor are indicated in parentheses ... 28 amino acids The N-terminal of the protein lies on the extracellular side and the C-terminal on the cytoplasmic side of the membrane A pocket for the ligand binding site is formed by the three-dimensional ... Physiological Roles of Adenosine The findings that adenosine can stimulate cAMP formation in brain cells (Sattin & Rall 1970) was the start of a new era of adenosine research, which led to the discovery of...

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The role of cholesterol sequestration and accumulation in the endocytic pathway in development of neurodegenerative diseases

Ngày tải lên : 14/09/2015, 14:06

... and plasticity, brain growth, neuron repair and remodeling, and even maintaining the normal function of this important organ (Dietschy and Turley, 2001; Herz and Bock 2002; Koudinov and Koudinova, ... sterol-sensing elements in the membrane and proteolytic activation of transcription factors that enhance the expression of cholesterol synthesizing enzymes and lipoprotein receptors (Brown and Goldstein, ... orthologs and is referred to as the NPC1 domain Within NPC1 there is a large, cysteine-rich luminal loop (amino acids 855–1098), which contains a ring-finger motif that may mediate protein– protein interactions...

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The Duality of Memory and Communication in the Implementation of a Multiprocessor Operating System

Ngày tải lên : 12/09/2012, 15:05

... Finally, the kernel informs the hardware physical map module of the new virtual to physical mapping With the exception of the hardware validation, all of these steps are implemented in a machine-independent ... surviving the introduction of new hardware architectures and was never able to efficiently support the large body of UNIX software used within the academic community [16] In addition, from the point ... Mach runs on the majority of workstations and mainframes within the Department of Computer Science, and supports projects in distributed computing and parallel processing such as the Camelot distributed...

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Organizing pairwork and groupwork in the context of high school classrooms at pham van nghi upper secondary school, nam dinh province: A case study

Ngày tải lên : 07/11/2012, 14:54

... effect The language proficiency of the the success of a pair teacher work and group The teacher’s ability of organizing The hardship of the students work ? The cooperation of the students The language ... found the work of the students in group of three was ineffective In the time of five minutes they only discuss some information about that place.They must collect information from the other groups ... how to control the kinds of communicative activities and the ways to carry out these activities, the ways to group the students, the appropriate amount of time for them and the purposes of the activities...

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Some aspects of American culture and society in the twentieth and twenty-first centuries through a number of selected short literary works

Ngày tải lên : 07/11/2012, 15:01

... the differences in the behaviors and attitudes of the grandmother, the father and the mother and the children at least cause discontent to one another The grandmother held the floor most of the ... character and setting Technique has to with the structuring of the story into the plot so that the writer can convey the theme and the manipulating of the language in order to express the ideas of the ... from the beginning of the story in her decision where to go, in her introduction of the scenery along the journey While the father, the mother and the children enjoyed going to Florida, The grandmother...

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Globalism and regionalism in the protection of the marine environment

Ngày tải lên : 01/11/2013, 09:20

... Garcia-Amador, ‘Latin America and the Law of the Sea’, in L M Alexander (ed.), The Law of the Sea: A New Geneva Conference Proceedings of the 6th Annual Conference of the Law of the Sea Institute, Kingston, ... Regionalism in the pre-UNCLOS III law of the sea The law of the sea is inherently global The International Law Commission assumed as much in its codiﬁcation of the subject in the 1950s; and the words ... protection of the marine environment in either the Arctic or the Antarctic Secondly, there is nothing in the 1982 LOS Convention or in general international law to inhibit the making of such regional...

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Language and alterity in the thought of Levinas

Ngày tải lên : 01/11/2013, 10:20

... structure of predicative propositions that express the meaning of being and that at the same time retain the inscription of the trace In analysing the said, Levinas brings to the fore the intrinsic binarism ... is the mark of everything that is present’.27 The ‘moving force’ of the showing of saying that brings beings into their own is owning or appropriation that yields the opening of a clearing in ... relations of possession, the realm of economy understood in terms of money, ownership and exchange The calling in question of the I, coextensive with the manifestation of the Other in the face,...

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