risk and risk benefit evaluations in biomedical research
Knowledge discovery in biomedical research and drug design the development and application of biological databases
... rationalized and focused experiments The interaction between molecules, including protein-protein, proteinnucleic acids and protein-ligand, is normally identified by binding experiments and kinetic ... biomedical research The introduction of data mining in biomedical research in turn enables the development and application of the data mining technology in biopharmaceutical industry (in general, ... academic and company scientists And because of the efforts of these scientists and funding agencies such as NIH in USA and EMBL in Europe, Bioinformatics became more and more prominent and diverse Biomedical...
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tracer kinetics in biomedical research
... This includes not only understanding mechanisms of physiological processes, but diagnosis and treatment In addition, its introduction in the study of genomics and proteomics is key in understanding ... worked in close collaboration with colleagues in biomedical and pharmaceutical research for a number of years applying and refining mathematical modeling techniques to a variety of problems In addition, ... processes involved in designing and analyzing tracer kinetic studies starting from the steps involved in choosing an isotope, or isotopes, for a tracer, or tracers, through formulating models...
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ETHICS IN BIOMEDICAL RESEARCH potx
... benefits of the research, and ensure a fair distribution of risks and benefits (4) We can obtain valid informed consent by structuring the process of obtaining consent within the linguistic and ... framework for assessing vulnerability in biomedical research Her starting point is in a historical model originally produced to evaluate the different policies of protecting and empowering persons with ... pharmaceutical industry for funding, and most universities in the developed and developing world receive inadequate funding to conduct research without the support of industry Second, because industry...
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MANUALS IN BIOMEDICAL RESEARCH VOL 3 - A MANUAL FOR BIOCHEMISTRY PROTOCOLS pot
... seep in and bind to the proteins The gel is then destained to remove the unbound dye The dye binds to the protein and not the gel, and hence the protein bands can be visually seen The binding ... varying with time, making the reading stable and reliable The reaction involves protein with the alkaline copper tartrate and the Folin reagent The protein residues, especially, tyrosine and ... Size for 5in x 8. 5in chap-b Gel Staining 27 Protocol 6: (1) Transfer the gel gently into a tray containing staining solution (2) Shake the gel for hr on a rocking shaker Have a rapid staining microwave...
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Báo cáo y học: "Technical phosphoproteomic and bioinformatic tools useful in cancer research" potx
... proteins (e.g lactoglobulin bovine, casein bovine) TiO offers increased capacity compared to IMAC resins in order to bind and elute mono-phosphorylated peptides TiO2 exploits the same principle ... normal carbon-12 (12C) When the cells are growing in this medium, they incorporate the heavy arginine into all of their proteins All of the arginine containing peptides are now Da heavier than their ... depicted an integrin-modulated phosphorylation network during cell-ECM protein interactions and revealed novel regulators for cell adhesion and migration, discovering that integrin-ECM interactions...
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Báo cáo y học: " The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: development and descriptive data" potx
... is growing recognition, both within England and internationally, of the importance and urgency of establishing robust policies, standards and best practices governing the sharing of data in general, ... record is used and maintained by multi-disciplinary professionals and consists of both structured data (such as dates, integers and pick-lists) and unstructured free text (including written assessments, ... defined set of psychiatric services originating from a defined population' [1] In a UK context, greater health service evaluation, increased research into the effectiveness of individual- and...
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Parallel and distributed computing techniques in biomedical engineering
... which is very common in research in computational fluid dynamics; and biomedical image processing, which is increasingly playing an essential role in research in diagnostic and clinical experiments ... University of Singapore combination of biological science research and engineering discipline has resulted in the fast growing area of biomedical engineering, which is also known as bioengineering Of ... of Singapore v Abstract Biomedical Engineering, usually known as Bioengineering, is among the fastest growing and most promising interdisciplinary fields today It connects biology, physics, and...
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Tài liệu The Early Detection Research Network: Investing in Translational Research on Biomarkers of Early Cancer and Cancer Risk docx
... developing and maintaining a registry of individuals harboring germline mutations for hereditary cancer syndromes; and identifying preneoplastic lesions and early cancer in populations at risk ... multidisciplinary, investigator-initiated projects with a strong administrative and data infrastructure In making cancer biomarkers of early detection and screening ready for large-scale clinical testing, ... on achieving common goals, such as: • eveloping and testing promising biomarkers and technologies to obD tain preliminary information to guide further testing; • valuating promising, analytically...
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Báo cáo y học: " RESEARCH ARTICLE Open Access One-year risk of psychiatric hospitalization and associated treatment costs in bipolar disorder treated with atypical antipsychotics: a retrospective claims database analysis" doc
... aripiprazole and quetiapine patients; and 771 aripiprazole and risperidone patients Baseline characteristics after matching are shown in Table 1, demonstrating that comparable baseline characteristics ... cost-offset in saving from decreased hospitalization risk and associated inpatient costs In particular, the lower risk of hospitalization combined with lower total costs compared to quetiapine represent ... of hospitalization than ziprasidone, olanzapine and quetiapine, and lower mental health costs than ziprasidone and quetiapine in the year following initial prescription Total healthcare costs...
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Báo cáo y học: " Effect of Weight Reduction on Cardiovascular Risk Factors and CD34-positive Cells in Circulatio"
... extracellular water, intracellular http://www.medsci.org Int J Med Sci 2011, water and body mass index were determined for each participant before dieting intervention and each six days following intervention ... decrease in their body mass index in an average of 8.1%±2.0% Changes in total body water had inverse correlation with changes in fat mass (r=0.86) and positive correlation with an increase in fat ... showed that the combination of the 500 calorie per day diet and hCG injections offered a significant benefit to dieters, offering increased weight loss and a decrease in hunger In our study, we...
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The relationship between default risk and interest rates: An empirical study research insight
... valuing risky corporate debt that incorporates both default and interest rate risk, and test its empirical implications Using the changes in the 30-year Treasury bond yield and the changes in ... relationship between credit and interest rate risks plays an important role in both pricing instruments whose values are sensitive to both risks, as well as in managing an institution’s balance sheet ... between credit risk, including the risk of default, migration and recovery, and interest rates Toward this goal, we analyze the relationship between interest rates and default rates using the Moody’s...
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Báo cáo y học: "Maternal use of Loratadine during pregnancy and risk of hypospadias in offspring"
... antihistamines In fact, the risk point estimates for hypospadias were higher with maternal exposure to other antihistamines compared with loratadine Thus, our risk estimates not corroborate the findings ... conception and first trimester : Loratadine Other antihistamines Exposure first and second trimester : Loratadine Other antihistamines Exposure during pregnancy : Loratadine Other antihistamines Crude ... collected by midwives and doctors attending deliveries, contains information on all births in Denmark since January 1973 [24,25] The main data constitute maternal age, self-reported smoking status at...
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Tài liệu Finance and Economics Discussion Series Divisions of Research & Statistics and Monetary Affairs Federal Reserve Board, Washington, D.C.: Interest Rate Risk and Bank Equity Valuations doc
... margins An increase in short-term interest rates significantly boosts banks’ net interest margins because most institutions fund some of their interest-earning assets with noninterest-bearing ... market return and an interest rate risk factor, the innovation in the holding period return on short- and longer-term risk free bonds.5 Thus, in the first stage F-J obtained bank-specific “interest ... 100 basis point increase in the general level of interest rates—an increase in the ratio of net interest income to assets of about one basis point in the subsequent quarter; though seemingly small,...
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Information Contagion and Inter-Bank Correlation in a Theory of Systemic Risk potx
... (constrained) efficient In turn, the systemic risk arising from herding is also (constrained) efficient in our model This is an interesting result since it is in contrast to the inefficiency that arises in ... Scharfstein and Stein (1990) and Rajan (1994), in some detail in Section Scharfstein and Stein’s sequential model of herding is quiet about the variation in herding behavior over the business cycle ... industries in which banks can invest, denoted as and Bank A (B) can lend to firms A1 and A2 (B1 and B2 ) in industries and 2, respectively If in Nash equilibrium banks choose to lend to firms in...
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Báo cáo hóa học: " EQ-5D visual analog scale and utility index values in individuals with diabetes and at risk for diabetes: Findings from the Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD)" potx
... diabetes risk status (type diabetes) Using the methodology of Cavrini and associates and Sitoh and colleagues [18,19], an ordinal variable for the EQ-5D index was created by categorizing the continuous ... compared with other generic HRQoL and utility-based instruments, including the Health Utilities Index Mark and and SF-6D [26,29] In the present study, no clear trend in the EQ-5D VAS scores across ... (analysis and manuscript drafting) of ValueMedics Research; and Tina Fanning (data collection and analysis) of Vedanta Research This study was presented as a poster at the ISPOR 12th Annual International...
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Báo cáo hóa học: " Do bullae and emphysema increase risk of pneumothorax in silicosis?" pot
... pneumothorax in right lung 2: Mixed alveolar and interstitial fibrosis 3: Pleural thickening in right lung 4: Several bullae in right lung 5: Alveolar and interstitial shadowing 6: Paraseptal emphysema in ... of SSP and duration of occupational exposure to silica [24] Our findings support this hypothesis as shown in Table According to an investigation by Bahrami and Mahjub in the stone-grinding factories ... surrounded by a thin wall and less than 10 mm in diameter If an area of emphysema was greater than cm in diameter, this was defined as a bulla Stone grinding process There was the same process in the 20...
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Báo cáo khoa học: " Risk factors for retained placenta and the effect of retained placenta on the occurrence of postpartum diseases and subsequent reproductive performance in dairy cows" potx
... following clinical signs: weakness, cold skin, and favorable response Data collection and processing for determination of the risk factors for retained placenta Data were collected from 805 calvings ... not find a relationship between retained placenta and abomasal displacement [8] The intervals from calving to first service and conception Retained placenta in dairy cows: Risk factors and effects ... partus and gestation length in this report Increased risk of retained placenta (odds ratio = 1.9) in cows with abnormal partus was consistent with numerous previous findings [1,5,818,30,38] In contrast,...
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Báo cáo y học: "Inhaled Corticosteroids, Corticosteroid Osteoporosis, and the Risk of Fracture in Chronic Asthma" pps
... or below Ϫ2.5 as determined by DXA indicates established osteoporosis and an important increase in fracture risk. 2 Tscores in the osteopenic range between Ϫ1 and Ϫ2.5 indicate a need for antiresorptive ... sought routinely in elderly asthmatic patients receiving ICS or prednisone treatment because a majority may exhibit a clinically important (and potentially treatable) increase in fracture risk Furthermore, ... Z-scores indicating no increase in fracture risk. 4 approved doses of a standard formulation of budesonide (without the adrenergic component) in four rather than two divided treatments each day can increase...
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Báo cáo y học: "Cardiovascular risk factors and acute-phase response in idiopathic ascending aortitis: a case control study" pptx
... pre-operative ESR and CRP measurements in the cases and controls are presented in Table ESR was determined in 13 cases and 22 controls The median values were 20 mm/ hour in cases and mm/hour in controls ... role in aortic wall compliance by regulating the elastin/collagen activity [12-14] 17-β-Estradiol increases the elastin/ collagen ratio, reflecting an increase in distensibility of aorta and consequently ... mediate vascular inflammation in predisposed individuals In patients with inflammatory abdominal aortic aneurysms, active smoking and female gender were associated with high-grade tissue inflammation...
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