quantification of drug action
Tài liệu Color Atlas of Pharmacology (Part 6): Quantification of Drug Action ppt
Ngày tải lên :
26/01/2014, 19:20
... 60). Use of
radiolabeled drugs bound to their re-
ceptors may be of help in purifying and
analyzing further the receptor protein.
56 Quantification of Drug Action
Lüllmann, Color Atlas of Pharmacology ... of ligands, the kinetics of inter-
action, and the characteristics of the
binding site itself.
In studying the affinity and number
of such binding sites, use is made of
membrane suspensions of ... 20
1
2
3
4
Frequency of dose needed
Lüllmann, Color Atlas of Pharmacology © 2000 Thieme
All rights reserved. Usage subject to terms and conditions of license.
Quantification of Drug Action 55
B. Concentration-effect...
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Báo cáo y học: "Risk and Benefit of Drug Use During Pregnancy"
Ngày tải lên :
02/11/2012, 11:12
...
higher occurrence of one or some CA-groups after the use
of the given drug due to the specificity of teratogens.
Recall bias may act for all CAs similarly.
Secondly, the use of the drug under study ... in the origin of
isolated CAs based on polygenic-environmental
interaction, i.e. multifactorial etiology.
III. Teratogenic risk of drugs is exaggerated.
The exaggeration of drug teratogenicity ... Teratogenic drugs cannot cause CAs if the
exposure is in the first month of gestation and in general
after the third month of pregnancy. However, the
fetotoxic effect of some drugs should...
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Another Piece of the Action
Ngày tải lên :
06/11/2012, 16:13
...
one of them would reproduce the works of Shakespeare. Shakespeare was one thing, but two groups of
monkeys knocking out a Preamble to the Constitution? Even on Earth the Constitution of the ... high number of humanoid species encountered in
such a relatively small part of our galaxy.” He was simultaneously praised by some and denounced by others.
As one of his examples, he offered the ... “Cancel that.” He took an audible inventory of his
surrounding. There was the hum of life support, the ticking of an antique clock, and the snoring of a
companion sleeping beside him that were...
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Tài liệu Quantification of the Health Effects of Exposure to Air Pollution: Report of a WHO Working Group pdf
Ngày tải lên :
17/02/2014, 11:20
... journal of epidemiology, 151: 440–448 (2000).
18. COMEAP. Quantification of the effects of air pollution on health in the United Kingdom.
Department of Health Committee on the Medical Effects of ... All indicators of disease and health-related quality of life plausibly related to the exposures
of interest should be considered in the planning of health impact assessments of air
pollution, ... the lack of
knowledge about the timing of air pollution effects (e.g. critical ages, duration of exposure and
persistence of effects) will add uncertainty to the impact assessment of chronic...
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FACING THE REALITY OF DRUG-RESISTANT TUBERCULOSIS: CHALLENGES AND POTENTIAL SOLUTIONS IN INDIA pot
Ngày tải lên :
05/03/2014, 11:20
... from the time of target identification to regulatory approval of a new drug is 90 percent. Half
of drugs fail even in phase III clinical trials. The average cost of developing a new drug is more ... based on the total amount of money
available for anti-TB drugs sold in India, 75 percent of first-line drugs and 100 percent of
second-line drugs were being used outside of the RNTCP.
10
...
Treatment of Drug- Resistant TB, 22
Improving Health System Performance to Address the Challenge of
Drug- Resistant TB, 25
Potential Innovations and Action Items, 26
3 THE GLOBAL BURDEN OF DRUG- RESISTANT...
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Atmospheric volatile organic compound measurements during the Pittsburgh Air Quality Study: Results, interpretation, and quantification of primary and secondary contributions pot
Ngày tải lên :
05/03/2014, 21:20
... 0.59
Importance of factors
Fraction of variance 0.44 0.10 0.09 0.08 0.06 0.06
Cumulative variance 0.44 0.54 0.63 0.71 0.77 0.83
a
The degree of association between measured compounds and each of the six ... Photochemical production of secondary organic
aerosol (SOA) depends on the chemical state of the atmo-
sphere, both in terms of oxidative capacity, and in term of
the quantity and nature of gas phase organic ... SO
4
2À
0.85
N
acc
c
0.70
Importance of factors
Fraction of variance 0.42 0.10 0.08 0.07 0.05 0.04
Cumulative variance 0.42 0.53 0.60 0.67 0.73 0.77
a
The degree of association between measured compounds and each of the six...
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ECONOMIC AND SOCIAL CONSEQUENCES OF DRUG ABUSE AND ILLICIT TRAFFICKING doc
Ngày tải lên :
08/03/2014, 06:20
... year,
125
estimates of the number of drug- related deaths of injecting drug users
(IDUs) amount to a maximum of 200,000 cases per annum globally. Officially reported cases of
SARM are significantly ... of all seizure cases, suggesting that such stimulants are one of the most
"dynamic" groups of illicit drugs in terms of growth within the category of psychotropic
17
prevalence of drug ... the price level, which may offset most of the quantity
increases of a specific drug.
9
Office of National Drug Control Policy, What America’s Users Spend on Illegal Drugs, 1988-1993,
Washington...
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POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc
Ngày tải lên :
09/03/2014, 00:20
... the many off-label uses of FDA-approved drugs. In
14
Contents
1.0 Introduction 1
2.0 Background 3
2.1 Use of Drug Compendia in Coverage Determinations 3
2.2 Definition of Conflict of Interest, ... conflicts of interest exist in the production of drug
compendia?
2. What practices and policies have drug compendia instituted to protect
against bias introduced by conflict of interest?
15
DRUGDEX ... conflict of interest, or components thereof, that might pertain to
conflict of interest in compendia; and (2) published reports of conflict -of- interest
issues with regard to the writing of guidelines...
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Quantification of vitamin e and ç oryzanol components in RiceGermandBran
Ngày tải lên :
15/03/2014, 15:33
... structures of the compounds
investigated in this study. LC-UV chromatograms of the
dichloromethane fractions of RG and FFRB from LC-MS/MS
analyses are presented in Figure 2. A total of 23 components
of ... and a wavelength of 290 ( 10 nm was
used for the quantification of vitamin E components. The levels
of three tocopherols were calculated on the basis of the standard
curves of their corresponding ... replicate
determinations.
RESULTS AND DISCUSSION
Extraction and Fractionation of Phytochemicals in Rice
Germ and Bran. The phytochemicals (24.8%, w/w) obtained
from extraction of RG with ethanol, methanol, and...
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Addressing the Threat of Drug-Resistant Tuberculosis potx
Ngày tải lên :
23/03/2014, 11:20
... pipeline
of new drugs with shorter, simpler regimens for drug- sensitive TB, and ide-
ally, novel mechanisms of action that are equally effective against MDR and
XDR and drug- sensitive strains of TB. ... Organization of This Report, 18
2 THE GLOBAL SPREAD OF MULTIDRUG-RESISTANT
AND EXTENSIVELY DRUG- RESISTANT TUBERCULOSIS 19
Scope of the Problem, 19
Underreporting of MDR TB in Africa, 25
The Threat of ... president of the National Academy
of Sciences.
The National Academy of Engineering was established in 1964, under the charter
of the National Academy of Sciences, as a parallel organization of outstanding...
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Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
Ngày tải lên :
23/03/2014, 15:20
... demon-
strate strongly dependent mechanism of action of ACE active cen-
ters in the reaction of the hydrolysis of tripeptide substrates.
However, the hydrolysis of decapeptide angiotensin I proceeds
independently ... Konvalinka
1,2
1
Department of Biochemistry, Institute of Organic Chemistry and
Biochemistry, Academy of Sciences of the Czech Republic, Prague,
Czech Republic,
2
Department of Biochemistry, Faculty of Natural
Sciences, ... site
and the sub sites of interaction. The total understanding of these
interactions can be a important tool for drug design against bac-
terial proteases.
B1-029P
Expression of GCPII in human astrocytoma
P....
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Chemical Aspects of Drug Delivery Systems pptx
Ngày tải lên :
28/03/2014, 10:20
... “lozenge
”
of
I
to
2
mm thickness containing
5
-
I0
mg
of
prostaglandin
EZ
releasing into
buffer
at
pH7 at
37
“C.
By the use of concentration profiling, the fraction of the contained ...
mobility
of
the tissue. Consequently, the sublingual area is used mainly for the delivery of
drugs
which require a rapid onset
of
action such as glycexyl trinitrate (given in the form of
quick-dissolving ... molecular weight of
18.
An
impurity of
0.1
%
w/w water
in
the formulation would contain the same number
of active hydrogens as
33.3%
w/w of a poly(ethy1ene oxide) of molecular weight...
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