Ngày tải lên :
20/02/2014, 11:20
... 0. 014 mmol, 14 %) 1H NMR d 7.6–7.9 (m (16 H, P+–ArH and H -11 ), 7.46 ( 1H, s, H- 6), 6.49 ( 1H, s, H- 9), 4 .1 4 .2 ( 2H, m, Ar-O-CH2), 3. 71 ( 3H, s, O-CH3), 3.4– 4.0 ( 5H, m, P+–CH2, H -11 a and H- 3), 1. 75 2. 4 ... H- 3), 1. 75 2. 4 ( 8H, m, O-CH2-CH2, P+–CH2-CH2, H -1 and H -2) p.p.m., 31 PNMR d 25 . 65 p.p.m ESMS found (M+) 56 3 .24 69 calculated for C3 5H3 6O3N2P (M+) 56 3 .2 4 58 H (300 MHz) and 31P ( 12 1 MHz) NMR spectra ... expression (Fig 1) For the DNA alkylating reagent we chose the antibiotic (11 aS)-8hydroxy-7-methoxy -1 ,2, 3 ,11 a-tetrahydro- 5H- pyrrolo [2, 1c] [1, 4]benzodiazepin -5- one; (DC- 81 ) [1, 25 ] This DNAalkylating...